The network for 'endothelial cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endothelial cell proliferation

The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.997
FGFR2fibroblast growth factor receptor 20.990
EGFRepidermal growth factor receptor0.989
CCR5chemokine (C-C motif) receptor 50.982
CAV1caveolin 1, caveolae protein, 22kDa0.981
RARAretinoic acid receptor, alpha0.979
VEGFAvascular endothelial growth factor A0.978
TGFB1transforming growth factor, beta 10.978
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.972
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.962
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.959
NCF1neutrophil cytosolic factor 10.958
NRP1neuropilin 10.929
BMPR1Abone morphogenetic protein receptor, type IA0.920
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.912
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.912
CCL5chemokine (C-C motif) ligand 50.910
RXRAretinoid X receptor, alpha0.844
IL2RBinterleukin 2 receptor, beta0.815
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.786
FGFR1fibroblast growth factor receptor 10.772
THBS1thrombospondin 10.741
IL4Rinterleukin 4 receptor0.735
MPDZmultiple PDZ domain protein0.706
FGF1fibroblast growth factor 1 (acidic)0.667
EGR1early growth response 10.651
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.582
ANGPT2angiopoietin 20.577
NR4A3nuclear receptor subfamily 4, group A, member 30.553
NCOA1nuclear receptor coactivator 10.536
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.528
BMP2bone morphogenetic protein 20.526
MED25mediator complex subunit 250.508
CXCL9chemokine (C-X-C motif) ligand 90.488
ENGendoglin0.466
FKBP1AFK506 binding protein 1A, 12kDa0.464
EGR3early growth response 30.463
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.457
PTENphosphatase and tensin homolog0.455
CD2CD2 molecule0.442
CCL2chemokine (C-C motif) ligand 20.427
TIMP2TIMP metallopeptidase inhibitor 20.426
FSTL1follistatin-like 10.419
GDAguanine deaminase0.415
EGR2early growth response 20.411
COL5A1collagen, type V, alpha 10.405
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.363
TTRtransthyretin0.336
CREBBPCREB binding protein0.314
RND1Rho family GTPase 10.313
PDGFCplatelet derived growth factor C0.304
BMPR1Bbone morphogenetic protein receptor, type IB0.302
PRKCAprotein kinase C, alpha0.287
CCL4chemokine (C-C motif) ligand 40.277
GDF5growth differentiation factor 50.276
CTGFconnective tissue growth factor0.275
CCL22chemokine (C-C motif) ligand 220.268
PRKCDprotein kinase C, delta0.265
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.253
SORBS3sorbin and SH3 domain containing 30.251
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.251
JAK1Janus kinase 10.250
APOC1apolipoprotein C-I0.246
CCR4chemokine (C-C motif) receptor 40.239
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.228
YAP1Yes-associated protein 10.225
NOXA1NADPH oxidase activator 10.222
CSNK1A1casein kinase 1, alpha 10.221
NR4A1nuclear receptor subfamily 4, group A, member 10.204
ANGangiogenin, ribonuclease, RNase A family, 50.199
INSRinsulin receptor0.197
COL6A1collagen, type VI, alpha 10.193
TGFB3transforming growth factor, beta 30.190
IFNAR2interferon (alpha, beta and omega) receptor 20.187
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.177
PROX1prospero homeobox 10.174
FOSFBJ murine osteosarcoma viral oncogene homolog0.173
CAV2caveolin 20.171
CCR2chemokine (C-C motif) receptor 20.170
IRF4interferon regulatory factor 40.168
DSG2desmoglein 20.168
PBKPDZ binding kinase0.166
CCL7chemokine (C-C motif) ligand 70.165
SETD7SET domain containing (lysine methyltransferase) 70.162
ARRDC3arrestin domain containing 30.160
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.159
IFNGinterferon, gamma0.156
RNASE4ribonuclease, RNase A family, 40.148
GSK3Bglycogen synthase kinase 3 beta0.143
SP1Sp1 transcription factor0.143
CCL13chemokine (C-C motif) ligand 130.142
ADAM17ADAM metallopeptidase domain 170.138
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.137
SNAI1snail homolog 1 (Drosophila)0.137
TIMP3TIMP metallopeptidase inhibitor 30.135
DVL3dishevelled, dsh homolog 3 (Drosophila)0.131
CCR7chemokine (C-C motif) receptor 70.131
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.130
A2Malpha-2-macroglobulin0.128
CDH5cadherin 5, type 2 (vascular endothelium)0.127
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch3notch homolog 30.983
bmp2bbone morphogenetic protein 2b0.889
kdrlkinase insert domain receptor like0.887
nf1aneurofibromin 1a0.634
dlx5adistal-less homeobox gene 5a0.626
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.364
bmp4bone morphogenetic protein 40.364
prox1bprospero-related homeobox gene 1b0.348
tie2endothelium-specific receptor tyrosine kinase 20.331
col4a6collagen, type IV, alpha 60.308
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.306
vegfaavascular endothelial growth factor Aa0.262
efnb2aephrin B2a0.260
ccm2cerebral cavernous malformation 20.199
dlddeltaD0.197
flt4fms-related tyrosine kinase 40.181
apoblapolipoprotein B, like0.173
nrp2bneuropilin 2b0.166
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.152
hbbe1.1hemoglobin beta embryonic-1.10.151
sox9aSRY-box containing gene 9a0.148
vegfcvascular endothelial growth factor c0.148
cdh5cadherin 50.144
col4a3collagen, type IV, alpha 30.139
dladeltaA0.133
dlbdeltaB0.133
wu:fv91b12wu:fv91b120.122
ccbe1collagen and calcium binding EGF domains 10.117
hey2hairy/enhancer-of-split related with YRPW motif 20.115
zgc:111961zgc:1119610.114
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.104
dlcdeltaC0.098
evx1even-skipped homeobox 10.094
etv2ets variant gene 20.093
ptprbprotein tyrosine phosphatase, receptor type, b0.087
neurog1neurogenin 10.078
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.078
nf1bneurofibromin 1b0.077
lamc1laminin, gamma 10.076
hoxd4ahomeo box D4a0.075
notch2notch homolog 20.075
jag1bjagged 1b0.075
si:ch73-60e21.1si:ch73-60e21.10.072
lama5laminin, alpha 50.070
edn1endothelin 10.069
ahr2aryl hydrocarbon receptor 20.066
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.065
dab2disabled homolog 2 (Drosophila)0.064
aox3aldehyde oxidase 30.060
lmo4aLIM domain only 4a0.058
hmgb2bhigh-mobility group box 2b0.058
mtmr8myotubularin related protein 80.055
emilin1aelastin microfibril interfacer 1a0.053
junbljun B proto-oncogene, like0.052
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.051
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.047
esamaendothelial cell adhesion molecule a0.047
krit1KRIT1, ankyrin repeat containing0.046
eya1eyes absent homolog 10.045
si:ch211-212m21.5si:ch211-212m21.50.044
scinlascinderin like a0.043
prox1prospero-related homeobox gene 10.043
LOC557062hypothetical protein LOC5570620.042
fgfr2fibroblast growth factor receptor 20.042
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.040
renrenin0.039
hand2heart and neural crest derivatives expressed transcript 20.039
emx2empty spiracles homeobox 20.037
cxcr4achemokine (C-X-C motif) receptor 4a0.037
nr4a3nuclear receptor subfamily 4, group A, member 30.037
efemp2EGF-containing fibulin-like extracellular matrix protein 20.036
trpm7transient receptor potential cation channel, subfamily M, member 70.035
alpialkaline phosphatase, intestinal0.035
ntn1anetrin 1a0.035
tgfb1atransforming growth factor, beta 1a0.035
pax2apaired box gene 2a0.035
fgf8afibroblast growth factor 8 a0.034
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.034
mmp2matrix metalloproteinase 20.033
LOC569128hypothetical protein LOC5691280.033
h3f3aH3 histone, family 3A0.033
fmnl2aformin-like 2a0.033
tgfbr2transforming growth factor, beta receptor II0.033
zgc:194131zgc:1941310.032
mrc1amannose receptor, C type 1a0.032
h2afvlH2A histone family, member V, like0.032
dlx3bdistal-less homeobox gene 3b0.031
msxdmuscle segment homeobox D0.031
thbs1thrombospondin 10.030
sulf1sulfatase 10.029
mmd2progestin and adipoQ receptor 100.028
rbp4retinol binding protein 4, plasma0.028
hmgb2ahigh-mobility group box 2a0.028
wtipWilms tumor 1 interacting protein0.027
col1a1acollagen, type I, alpha 1a0.026
ntn4netrin 40.026
mbpmyelin basic protein0.026
e2f7E2F transcription factor 70.026
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.025
stab2stabilin 20.024
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.893
Ctnnb1catenin (cadherin associated protein), beta 10.848
Tgfbr2transforming growth factor, beta receptor II0.826
Acvr1activin A receptor, type 10.643
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.562
Fgfr2fibroblast growth factor receptor 20.549
FosFBJ osteosarcoma oncogene0.545
Flt4FMS-like tyrosine kinase 40.520
Pnpla2patatin-like phospholipase domain containing 20.487
Adrb1adrenergic receptor, beta 10.476
Egr1early growth response 10.435
Engendoglin0.373
Shhsonic hedgehog0.370
Ppargperoxisome proliferator activated receptor gamma0.368
Nodalnodal0.322
Ror2receptor tyrosine kinase-like orphan receptor 20.319
Fbn1fibrillin 10.289
Sox9SRY-box containing gene 90.288
Acvrl1activin A receptor, type II-like 10.273
Csf1colony stimulating factor 1 (macrophage)0.272
Jag1jagged 10.264
Cdh5cadherin 50.248
Vegfavascular endothelial growth factor A0.247
Fgfr1fibroblast growth factor receptor 10.222
Cd44CD44 antigen0.220
Bmpr1abone morphogenetic protein receptor, type 1A0.202
Dusp1dual specificity phosphatase 10.183
Ccr2chemokine (C-C motif) receptor 20.175
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.174
Ccl2chemokine (C-C motif) ligand 20.174
Thbs2thrombospondin 20.170
Smad3MAD homolog 3 (Drosophila)0.168
Fgfr3fibroblast growth factor receptor 30.163
Col1a1collagen, type I, alpha 10.161
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.159
Nos3nitric oxide synthase 3, endothelial cell0.158
Rb1retinoblastoma 10.156
Foxc1forkhead box C10.155
Rargretinoic acid receptor, gamma0.152
Htr75-hydroxytryptamine (serotonin) receptor 70.121
Prrx1paired related homeobox 10.120
Apoeapolipoprotein E0.118
Ptrfpolymerase I and transcript release factor0.115
Apobapolipoprotein B0.114
Retret proto-oncogene0.110
Nos1nitric oxide synthase 1, neuronal0.110
Notch1Notch gene homolog 1 (Drosophila)0.107
Bmp5bone morphogenetic protein 50.105
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.101
Hand2heart and neural crest derivatives expressed transcript 20.099
Apcadenomatosis polyposis coli0.098
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.095
Cdkn1bcyclin-dependent kinase inhibitor 1B0.094
Sox18SRY-box containing gene 180.091
Tcf21transcription factor 210.089
Ptgs2prostaglandin-endoperoxide synthase 20.086
Tgfb2transforming growth factor, beta 20.084
Pcsk5proprotein convertase subtilisin/kexin type 50.084
Nognoggin0.084
Tgfbr3transforming growth factor, beta receptor III0.082
Chrdchordin0.082
Bdkrb1bradykinin receptor, beta 10.080
Vclvinculin0.080
Ptenphosphatase and tensin homolog0.078
Fgf8fibroblast growth factor 80.078
Pax2paired box gene 20.076
Gli3GLI-Kruppel family member GLI30.075
Bdkrb2bradykinin receptor, beta 20.075
Egfrepidermal growth factor receptor0.072
Bmp4bone morphogenetic protein 40.071
Zfp36zinc finger protein 360.069
Itgb1integrin beta 1 (fibronectin receptor beta)0.069
Cav1caveolin 1, caveolae protein0.064
Flt1FMS-like tyrosine kinase 10.063
Cckbrcholecystokinin B receptor0.063
Snai1snail homolog 1 (Drosophila)0.063
Tlr4toll-like receptor 40.063
BrafBraf transforming gene0.063
Itgb3integrin beta 30.060
FcrlaFc receptor-like A0.060
Ccr1chemokine (C-C motif) receptor 10.060
Rnase4ribonuclease, RNase A family 40.060
Smad4MAD homolog 4 (Drosophila)0.060
Thrbthyroid hormone receptor beta0.060
Lmnalamin A0.058
Cyr61cysteine rich protein 610.058
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.057
Btg2B-cell translocation gene 2, anti-proliferative0.056
Tbx3T-box 30.056
Fzd4frizzled homolog 4 (Drosophila)0.055
Tbx1T-box 10.053
Shc3src homology 2 domain-containing transforming protein C30.052
Loxlysyl oxidase0.052
Spry4sprouty homolog 4 (Drosophila)0.051
Bmp2bone morphogenetic protein 20.050
Prrx2paired related homeobox 20.050
Smad6MAD homolog 6 (Drosophila)0.049
Tgfb1transforming growth factor, beta 10.049
Ptpn11protein tyrosine phosphatase, non-receptor type 110.049
Fgf7fibroblast growth factor 70.049
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.339
Dusp1dual specificity phosphatase 10.195
LOC100362824caveolin 2-like0.168
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.130
Ahsgalpha-2-HS-glycoprotein0.081
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.066
Hpxhemopexin0.060
Cav2caveolin 20.059
Fgafibrinogen alpha chain0.059
Col8a1collagen, type VIII, alpha 10.057
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.050
Icam2intercellular adhesion molecule 20.045
Nedd4neural precursor cell expressed, developmentally down-regulated 40.043
Foxd3forkhead box D30.041
Itih3inter-alpha trypsin inhibitor, heavy chain 30.039
Asgr2asialoglycoprotein receptor 20.038
Albalbumin0.037
Vegp2von Ebners gland protein 20.036
Anxa1annexin A10.032
Apoa2apolipoprotein A-II0.032
Myo1bmyosin Ib0.032
Apoa5apolipoprotein A-V0.031
Cald1caldesmon 10.030
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.029
Gpr182G protein-coupled receptor 1820.027
Olr1500olfactory receptor 15000.027
Ambpalpha-1-microglobulin/bikunin precursor0.027
Apcsamyloid P component, serum0.027
Pgrprogesterone receptor0.027
Gsg1lGSG1-like0.027
Ppap2bphosphatidic acid phosphatase type 2B0.026
Inhbainhibin beta-A0.025
Dnm1ldynamin 1-like0.025
A2malpha-2-macroglobulin0.025
Nos3nitric oxide synthase 3, endothelial cell0.025
Foxs1forkhead box S10.024
Smoc2SPARC related modular calcium binding 20.024
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.023
GperG protein-coupled estrogen receptor 10.023
Nraddneurotrophin receptor associated death domain0.023
Marcksmyristoylated alanine rich protein kinase C substrate0.022
Pim1pim-1 oncogene0.022
Foxi2forkhead box I20.021
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.021
Nfianuclear factor I/A0.021
F13a1coagulation factor XIII, A1 polypeptide0.020
Aqp9aquaporin 90.020
Ccl4chemokine (C-C motif) ligand 40.020
Fosl1fos-like antigen 10.020
Mmp2matrix metallopeptidase 20.020
Cgaglycoprotein hormones, alpha polypeptide0.019
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.019
Crhr2corticotropin releasing hormone receptor 20.019
Tff1trefoil factor 10.018
RGD1559896similar to RIKEN cDNA 2310022B050.018
Igf2insulin-like growth factor 20.018
FosFBJ osteosarcoma oncogene0.018
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.018
Pkn2protein kinase N20.018
Leprleptin receptor0.018
Prrx1paired related homeobox 10.018
Procprotein C0.018
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.018
Kng2kininogen 20.017
Jak1Janus kinase 10.017
Sox17SRY (sex determining region Y)-box 170.017
Mapre1microtubule-associated protein, RP/EB family, member 10.017
Pzppregnancy-zone protein0.017
Gpr116G protein-coupled receptor 1160.017
Gcgroup specific component0.017
Fmodfibromodulin0.017
Itgadintegrin, alpha D0.017
Gzmkgranzyme K0.016
Ins1insulin 10.016
Tnni1troponin I type 1 (skeletal, slow)0.016
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.016
Avparginine vasopressin0.016
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.016
Nr4a3nuclear receptor subfamily 4, group A, member 30.015
Mdkmidkine0.015
Mbl1mannose-binding lectin (protein A) 10.015
Ifit3interferon-induced protein with tetratricopeptide repeats 30.015
Mapk1mitogen activated protein kinase 10.015
Cpxm2carboxypeptidase X (M14 family), member 20.015
Alx3aristaless-like homeobox 30.015
Col10a1collagen, type X, alpha 10.014
Trhthyrotropin releasing hormone0.014
Klf6Kruppel-like factor 60.014
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.014
Nr4a2nuclear receptor subfamily 4, group A, member 20.014
C8bcomplement component 8, beta polypeptide0.014
Nrp1neuropilin 10.013
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.013
Mmp9matrix metallopeptidase 90.013
Has2hyaluronan synthase 20.013
Gja1gap junction protein, alpha 10.013
Ptgfrprostaglandin F receptor0.013
Castcalpastatin0.013
Galgalanin prepropeptide0.013
Tsxtestis specific X-linked gene0.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism