The network for 'positive regulation of lymphocyte mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lymphocyte mediated immunity

Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.

NameDescriptionProbabilityFunc Analog Organism
B2Mbeta-2-microglobulin0.988
HLA-Amajor histocompatibility complex, class I, A0.979
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.960
HLA-Cmajor histocompatibility complex, class I, C0.919
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.846
SLAMF1signaling lymphocytic activation molecule family member 10.841
KLRD1killer cell lectin-like receptor subfamily D, member 10.829
SH2D1ASH2 domain containing 1A0.800
TAPBPTAP binding protein (tapasin)0.751
IL4Rinterleukin 4 receptor0.727
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.704
HLA-Bmajor histocompatibility complex, class I, B0.685
CCL5chemokine (C-C motif) ligand 50.681
TRAF3TNF receptor-associated factor 30.678
CD84CD84 molecule0.639
CASP8caspase 8, apoptosis-related cysteine peptidase0.585
CD40CD40 molecule, TNF receptor superfamily member 50.521
CCR5chemokine (C-C motif) receptor 50.521
HLA-Gmajor histocompatibility complex, class I, G0.517
IL2RBinterleukin 2 receptor, beta0.491
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.337
CCL4chemokine (C-C motif) ligand 40.270
GRAP2GRB2-related adaptor protein 20.268
CXCL9chemokine (C-X-C motif) ligand 90.246
TRAF1TNF receptor-associated factor 10.239
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.205
FASLGFas ligand (TNF superfamily, member 6)0.204
ITM2Bintegral membrane protein 2B0.199
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.197
TRAF2TNF receptor-associated factor 20.190
BIRC3baculoviral IAP repeat containing 30.181
IFNGinterferon, gamma0.164
IL23Ainterleukin 23, alpha subunit p190.156
INSRinsulin receptor0.148
SYKspleen tyrosine kinase0.146
TNFRSF9tumor necrosis factor receptor superfamily, member 90.130
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.128
HLA-Emajor histocompatibility complex, class I, E0.123
GBAglucosidase, beta, acid0.121
CXCL10chemokine (C-X-C motif) ligand 100.121
GZMKgranzyme K (granzyme 3; tryptase II)0.117
CD80CD80 molecule0.115
ICAM1intercellular adhesion molecule 10.114
IL2RGinterleukin 2 receptor, gamma0.084
SQSTM1sequestosome 10.078
ENGendoglin0.076
MAP3K7mitogen-activated protein kinase kinase kinase 70.074
KLRC3killer cell lectin-like receptor subfamily C, member 30.074
CCL2chemokine (C-C motif) ligand 20.070
CD22CD22 molecule0.069
CXCL3chemokine (C-X-C motif) ligand 30.067
CFHcomplement factor H0.063
SMURF1SMAD specific E3 ubiquitin protein ligase 10.061
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.059
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.059
KLRK1killer cell lectin-like receptor subfamily K, member 10.058
PRF1perforin 1 (pore forming protein)0.055
CXCL11chemokine (C-X-C motif) ligand 110.055
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.054
TP53BP1tumor protein p53 binding protein 10.054
RIPK2receptor-interacting serine-threonine kinase 20.054
PVRL4poliovirus receptor-related 40.053
CTLA4cytotoxic T-lymphocyte-associated protein 40.053
TRADDTNFRSF1A-associated via death domain0.053
CCR7chemokine (C-C motif) receptor 70.053
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.053
CCL8chemokine (C-C motif) ligand 80.051
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.051
CCR1chemokine (C-C motif) receptor 10.051
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.050
CXCR6chemokine (C-X-C motif) receptor 60.050
HLA-Fmajor histocompatibility complex, class I, F0.050
IRF1interferon regulatory factor 10.050
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.050
NUMBLnumb homolog (Drosophila)-like0.048
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.048
CD8ACD8a molecule0.048
FASFas (TNF receptor superfamily, member 6)0.048
TRAF5TNF receptor-associated factor 50.047
GZMAgranzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)0.044
CCL7chemokine (C-C motif) ligand 70.044
NCSTNnicastrin0.044
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.043
GNSglucosamine (N-acetyl)-6-sulfatase0.043
CCR4chemokine (C-C motif) receptor 40.040
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.038
CASP10caspase 10, apoptosis-related cysteine peptidase0.037
CCL19chemokine (C-C motif) ligand 190.036
KLRB1killer cell lectin-like receptor subfamily B, member 10.035
TNFAIP3tumor necrosis factor, alpha-induced protein 30.035
CCL22chemokine (C-C motif) ligand 220.035
IL10RAinterleukin 10 receptor, alpha0.034
IL18RAPinterleukin 18 receptor accessory protein0.034
KLRC2killer cell lectin-like receptor subfamily C, member 20.034
GNLYgranulysin0.033
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.033
CD86CD86 molecule0.032
NKG7natural killer cell group 7 sequence0.032
TNFtumor necrosis factor0.032
JAK2Janus kinase 20.032
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
zgc:64115zgc:641150.650
nod1nucleotide-binding oligomerization domain containing 10.420
zgc:153921zgc:1539210.374
si:dkeyp-110g5.2si:dkeyp-110g5.20.325
LOC557072caspase recruitment domain-containing protein 11-like0.283
tlr3toll-like receptor 30.276
LOC100000934hypothetical protein LOC1000009340.214
tlr9toll-like receptor 90.206
trim25tripartite motif-containing 250.167
irak4interleukin-1 receptor-associated kinase 40.162
c1qccomplement component 1, q subcomponent, C chain0.160
defbl3defensin, beta-like 30.136
si:ch211-195h23.3si:ch211-195h23.30.135
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.109
gfergrowth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)0.109
ef1aelongation factor 1-alpha0.104
c3ccomplement component c3c0.102
itln1intelectin 10.101
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.095
foxp3aforkhead box P3a0.094
tlr21toll-like receptor 210.092
rif1RAP1 interacting factor homolog (yeast)0.091
stat6signal transducer and activator of transcription 6, interleukin-4 induced0.090
zgc:63831zgc:638310.086
c1qbcomplement component 1, q subcomponent, B chain0.083
cd40lgCD40 ligand0.080
ugt5c2UDP glucuronosyltransferase 5 family, polypeptide C20.077
LOC795096hypothetical protein LOC7950960.076
il10interleukin 100.076
zgc:113293zgc:1132930.076
illr1immune-related, lectin-like receptor 10.075
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.073
tlr22toll-like receptor 220.073
slc12a10.1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.10.071
nitr13novel immune-type receptor 130.070
il12bbinterleukin 12B, b0.069
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.068
pygbphosphorylase, glycogen; brain0.067
card9caspase recruitment domain family, member 90.067
ezh2enhancer of zeste homolog 2 (Drosophila)0.066
pcsk7proprotein convertase subtilisin/kexin type 70.066
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.065
tnfrsf18tumor necrosis factor receptor superfamily, member 180.064
illr3immune-related, lectin-like receptor 30.064
cd247lCD247 antigen like0.063
tbx21T-box 210.063
tufmTu translation elongation factor, mitochondrial0.063
zgc:110775zgc:1107750.061
zgc:162329zgc:1623290.057
LOC794786interferon-induced protein with tetratricopeptide repeats 1-like0.057
nitr8novel immune-type receptor 80.055
cd209CD209 molecule0.055
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.055
atp2b4ATPase, Ca++ transporting, plasma membrane 40.055
itln3intelectin 30.054
lrmplymphoid-restricted membrane protein0.053
c1qacomplement component 1, q subcomponent, A chain0.053
psmb9aproteasome (prosome, macropain) subunit, beta type, 9a0.050
stc1lstanniocalcin 1, like0.049
grnagranulin a0.049
zgc:64161zgc:641610.048
LOC567504interferon-induced protein with tetratricopeptide repeats 5-like0.048
nitr4anovel immune-type receptor 4a0.048
g6pdglucose-6-phosphate dehydrogenase0.048
adrb2aadrenergic receptor, beta 2a0.048
ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.047
ifnphi1interferon phi 10.047
wu:fk76c08wu:fk76c080.047
pth1aparathyroid hormone 1a0.047
npy7rneuropeptide Y receptor Y70.047
nitr12novel immune-type receptor 120.046
zgc:123282zgc:1232820.045
nos2anitric oxide synthase 2a, inducible0.045
pycardPYD and CARD domain containing0.045
b2mbeta-2-microglobulin0.045
si:ch211-140f21.1si:ch211-140f21.10.043
prdm9PR domain containing 90.043
gsk3bglycogen synthase kinase 3 beta0.042
crfb7cytokine receptor family member b70.042
ugt5a2UDP glucuronosyltransferase 5 family, polypeptide A20.041
LOC567441interferon-induced protein with tetratricopeptide repeats 5-like0.041
crfa31.2IL-4RA-like protein 20.041
LOC100534776toll-like receptor 7-like0.041
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.041
ca15acarbonic anhydrase XV a0.041
phbprohibitin0.041
LOC793458peptide Y-like0.041
dlg2discs, large (Drosophila) homolog 20.041
cd40CD40 antigen0.040
tbpTATA box binding protein0.040
insrainsulin receptor a0.039
vtg6vitellogenin 60.039
LOC100001239interferon-induced protein with tetratricopeptide repeats 5-like0.039
card14caspase recruitment domain family, member 140.039
suv39h1bsuppressor of variegation 3-9 homolog 1b0.039
ifng1-2interferon, gamma 1-20.039
angptl1angiopoietin-like 10.038
amhanti-Mullerian hormone0.038
zgc:101598zgc:1015980.037
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.037
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cd40CD40 antigen0.995
Icosinducible T-cell co-stimulator0.991
Tnftumor necrosis factor0.990
Ighimmunoglobulin heavy chain complex0.983
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.942
Cd28CD28 antigen0.929
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.918
FasFas (TNF receptor superfamily member 6)0.898
Klrk1killer cell lectin-like receptor subfamily K, member 10.886
Il4interleukin 40.879
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.849
Klrg1killer cell lectin-like receptor subfamily G, member 10.841
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.836
H2-K1histocompatibility 2, K1, K region0.824
Il2interleukin 20.803
H2-D1histocompatibility 2, D region locus 10.794
Map3k14mitogen-activated protein kinase kinase kinase 140.790
B2mbeta-2 microglobulin0.780
Ccr1chemokine (C-C motif) receptor 10.770
Ltalymphotoxin A0.749
Prf1perforin 1 (pore forming protein)0.746
Ccl2chemokine (C-C motif) ligand 20.714
FaslFas ligand (TNF superfamily, member 6)0.701
Clec4dC-type lectin domain family 4, member d0.699
Slamf1signaling lymphocytic activation molecule family member 10.678
Clec4nC-type lectin domain family 4, member n0.667
Cd19CD19 antigen0.640
Klra9killer cell lectin-like receptor subfamily A, member 90.634
Gzmkgranzyme K0.615
Gzmagranzyme A0.552
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.533
Xcl1chemokine (C motif) ligand 10.515
Il6interleukin 60.505
Ncr1natural cytotoxicity triggering receptor 10.503
TapbpTAP binding protein0.499
Foxp3forkhead box P30.488
Pax5paired box gene 50.480
Il2rbinterleukin 2 receptor, beta chain0.461
Il1binterleukin 1 beta0.437
Ikzf1IKAROS family zinc finger 10.435
MefvMediterranean fever0.418
ItkIL2-inducible T-cell kinase0.415
Ifnginterferon gamma0.414
Il4rainterleukin 4 receptor, alpha0.405
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.404
Cd44CD44 antigen0.397
H2-Q7histocompatibility 2, Q region locus 70.395
Cxcl9chemokine (C-X-C motif) ligand 90.394
Ccl8chemokine (C-C motif) ligand 80.384
Il12binterleukin 12b0.371
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.353
Pdcd1programmed cell death 10.344
Socs1suppressor of cytokine signaling 10.339
Il10interleukin 100.332
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.331
Map3k7mitogen-activated protein kinase kinase kinase 70.325
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.324
Clec4eC-type lectin domain family 4, member e0.299
Il18rapinterleukin 18 receptor accessory protein0.298
Pnp2purine-nucleoside phosphorylase 20.295
Klrd1killer cell lectin-like receptor, subfamily D, member 10.290
Cd8b1CD8 antigen, beta chain 10.274
Stat5asignal transducer and activator of transcription 5A0.265
Ciitaclass II transactivator0.258
Pdcd1lg2programmed cell death 1 ligand 20.256
Mmp12matrix metallopeptidase 120.254
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.245
Apoeapolipoprotein E0.242
Stat5bsignal transducer and activator of transcription 5B0.240
Msr1macrophage scavenger receptor 10.236
C3complement component 30.231
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.228
Tnfaip3tumor necrosis factor, alpha-induced protein 30.221
Ccl9chemokine (C-C motif) ligand 90.221
TcraT-cell receptor alpha chain0.221
Irg1immunoresponsive gene 10.217
Batfbasic leucine zipper transcription factor, ATF-like0.215
Cd7CD7 antigen0.208
Cd96CD96 antigen0.197
Cd5CD5 antigen0.195
Gzmbgranzyme B0.187
Ubdubiquitin D0.185
Klrc1killer cell lectin-like receptor subfamily C, member 10.184
Traf2TNF receptor-associated factor 20.183
Hcsthematopoietic cell signal transducer0.182
Lyz2lysozyme 20.181
Ikbkbinhibitor of kappaB kinase beta0.179
Ccr7chemokine (C-C motif) receptor 70.177
Trem3triggering receptor expressed on myeloid cells 30.177
Ccl7chemokine (C-C motif) ligand 70.168
Aoahacyloxyacyl hydrolase0.164
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.161
Cxcr5chemokine (C-X-C motif) receptor 50.161
Ccl22chemokine (C-C motif) ligand 220.160
Stat3signal transducer and activator of transcription 30.157
Cd209dCD209d antigen0.156
Clec7aC-type lectin domain family 7, member a0.155
Il7interleukin 70.152
Fcgr3Fc receptor, IgG, low affinity III0.151
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.150
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.414
RT1-EC2RT1 class Ib, locus EC20.247
Hsph1heat shock 105/110 protein 10.167
Stip1stress-induced phosphoprotein 10.051
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.050
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.043
RT1-CE12RT1 class I, locus CE120.040
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.034
Apol3apolipoprotein L, 30.025
Gbp2guanylate binding protein 20.020
Hspb1heat shock protein 10.018
Klrd1killer cell lectin-like receptor, subfamily D, member 10.018
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.018
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.017
Casp1caspase 10.017
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.015
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.014
Dnaja4DnaJ (Hsp40) homolog, subfamily A, member 40.013
Gzmbgranzyme B0.012
Cd247Cd247 molecule0.012
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.012
Ccl5chemokine (C-C motif) ligand 50.010
Cxcr4chemokine (C-X-C motif) receptor 40.010
Fth1ferritin, heavy polypeptide 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism