The network for 'negative regulation of cellular amine metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular amine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
PTPN1protein tyrosine phosphatase, non-receptor type 10.996
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.994
ESR1estrogen receptor 10.979
FYNFYN oncogene related to SRC, FGR, YES0.978
BTKBruton agammaglobulinemia tyrosine kinase0.978
SMAD3SMAD family member 30.977
GHRgrowth hormone receptor0.974
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.859
LCKlymphocyte-specific protein tyrosine kinase0.858
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.847
NCK1NCK adaptor protein 10.821
FEM1Bfem-1 homolog b (C. elegans)0.791
PRKCBprotein kinase C, beta0.768
SHC1SHC (Src homology 2 domain containing) transforming protein 10.763
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.762
KLF4Kruppel-like factor 4 (gut)0.759
SMURF2SMAD specific E3 ubiquitin protein ligase 20.755
EGFRepidermal growth factor receptor0.753
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.731
CTBP1C-terminal binding protein 10.708
NOXA1NADPH oxidase activator 10.697
CAV1caveolin 1, caveolae protein, 22kDa0.691
PRKCZprotein kinase C, zeta0.687
SPRY2sprouty homolog 2 (Drosophila)0.684
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.664
SCHIP1schwannomin interacting protein 10.648
VAV1vav 1 guanine nucleotide exchange factor0.639
BAK1BCL2-antagonist/killer 10.638
PLCG1phospholipase C, gamma 10.633
SIN3ASIN3 homolog A, transcription regulator (yeast)0.629
GRB2growth factor receptor-bound protein 20.625
SH2D1ASH2 domain containing 1A0.622
MAPK12mitogen-activated protein kinase 120.615
KLF6Kruppel-like factor 60.613
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.602
SMAD7SMAD family member 70.570
PTPN6protein tyrosine phosphatase, non-receptor type 60.557
TBC1D10ATBC1 domain family, member 10A0.542
SOCS2suppressor of cytokine signaling 20.542
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.523
ITKIL2-inducible T-cell kinase0.513
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.511
ZNF496zinc finger protein 4960.510
PROX1prospero homeobox 10.503
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.477
BCL2L1BCL2-like 10.475
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.471
DTNAdystrobrevin, alpha0.461
NRIP1nuclear receptor interacting protein 10.452
HIPK2homeodomain interacting protein kinase 20.435
SOCS1suppressor of cytokine signaling 10.434
EPORerythropoietin receptor0.426
SMAD1SMAD family member 10.402
SCN5Asodium channel, voltage-gated, type V, alpha subunit0.400
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.393
MED28mediator complex subunit 280.392
SYKspleen tyrosine kinase0.390
CD2APCD2-associated protein0.376
SMAD5SMAD family member 50.375
METmet proto-oncogene (hepatocyte growth factor receptor)0.374
TESK1testis-specific kinase 10.370
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.370
CLCN3chloride channel 30.370
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.369
HCKhemopoietic cell kinase0.369
SETD8SET domain containing (lysine methyltransferase) 80.355
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.355
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.354
UHRF2ubiquitin-like with PHD and ring finger domains 20.354
SPRR2Asmall proline-rich protein 2A0.352
FLNBfilamin B, beta0.337
PTENphosphatase and tensin homolog0.336
ARHGAP5Rho GTPase activating protein 50.334
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.334
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.329
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.327
RASA1RAS p21 protein activator (GTPase activating protein) 10.322
BLNKB-cell linker0.321
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.319
PTPRBprotein tyrosine phosphatase, receptor type, B0.316
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.308
TGIF1TGFB-induced factor homeobox 10.306
TSC22D1TSC22 domain family, member 10.298
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.298
SH3KBP1SH3-domain kinase binding protein 10.291
SMURF1SMAD specific E3 ubiquitin protein ligase 10.291
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.283
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.282
GAB1GRB2-associated binding protein 10.277
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.277
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.275
BADBCL2-associated agonist of cell death0.272
TFF1trefoil factor 10.266
HCFC1host cell factor C1 (VP16-accessory protein)0.261
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.253
SPTBN1spectrin, beta, non-erythrocytic 10.242
SKIv-ski sarcoma viral oncogene homolog (avian)0.241
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
FynFyn proto-oncogene0.999
Ptenphosphatase and tensin homolog0.999
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.998
Trp53transformation related protein 530.995
Egfrepidermal growth factor receptor0.991
Smad3MAD homolog 3 (Drosophila)0.990
Leprleptin receptor0.989
Axin1axin 10.982
Bcl2B-cell leukemia/lymphoma 20.964
Grb2growth factor receptor bound protein 20.957
Shc1src homology 2 domain-containing transforming protein C10.947
Slamf1signaling lymphocytic activation molecule family member 10.940
Notch1Notch gene homolog 1 (Drosophila)0.935
Arrb2arrestin, beta 20.934
Smad1MAD homolog 1 (Drosophila)0.931
Atg12autophagy-related 12 (yeast)0.926
Apcadenomatosis polyposis coli0.926
Zeb1zinc finger E-box binding homeobox 10.921
Ptpn11protein tyrosine phosphatase, non-receptor type 110.918
Eporerythropoietin receptor0.912
Ighimmunoglobulin heavy chain complex0.907
Sfrp2secreted frizzled-related protein 20.905
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.899
Ascl1achaete-scute complex homolog 1 (Drosophila)0.894
En1engrailed 10.851
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.843
Vegfavascular endothelial growth factor A0.842
Gsk3bglycogen synthase kinase 3 beta0.840
Vhlvon Hippel-Lindau tumor suppressor0.840
Neurod1neurogenic differentiation 10.835
Vaspvasodilator-stimulated phosphoprotein0.825
Shhsonic hedgehog0.823
Mcl1myeloid cell leukemia sequence 10.817
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.813
Cd28CD28 antigen0.812
Foxp1forkhead box P10.809
Ikzf1IKAROS family zinc finger 10.777
TcrbT-cell receptor beta chain0.771
Spry4sprouty homolog 4 (Drosophila)0.766
Jak2Janus kinase 20.760
Pax6paired box gene 60.756
Arrb1arrestin, beta 10.753
Vangl2vang-like 2 (van gogh, Drosophila)0.731
Notch2Notch gene homolog 2 (Drosophila)0.717
Gli2GLI-Kruppel family member GLI20.717
Smad7MAD homolog 7 (Drosophila)0.716
Msx1homeobox, msh-like 10.716
Smad4MAD homolog 4 (Drosophila)0.701
Gab1growth factor receptor bound protein 2-associated protein 10.675
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.657
Icosinducible T-cell co-stimulator0.649
TcrdT-cell receptor delta chain0.643
BrafBraf transforming gene0.634
Cd44CD44 antigen0.628
Cdkn1bcyclin-dependent kinase inhibitor 1B0.626
Mdm2transformed mouse 3T3 cell double minute 20.610
Neurod4neurogenic differentiation 40.607
Smurf1SMAD specific E3 ubiquitin protein ligase 10.601
Vav2vav 2 oncogene0.593
Sos1son of sevenless homolog 1 (Drosophila)0.590
Cxcr4chemokine (C-X-C motif) receptor 40.580
Kitkit oncogene0.574
Map3k7mitogen-activated protein kinase kinase kinase 70.571
Ldb3LIM domain binding 30.562
Dusp1dual specificity phosphatase 10.561
Nos3nitric oxide synthase 3, endothelial cell0.558
Irf8interferon regulatory factor 80.557
Gata4GATA binding protein 40.551
Cishcytokine inducible SH2-containing protein0.539
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.522
Prkczprotein kinase C, zeta0.520
Stat3signal transducer and activator of transcription 30.519
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.517
Ppargperoxisome proliferator activated receptor gamma0.502
Akt1thymoma viral proto-oncogene 10.498
MecomMDS1 and EVI1 complex locus0.490
Rnf111ring finger 1110.482
Otx2orthodenticle homolog 2 (Drosophila)0.482
Mdm4transformed mouse 3T3 cell double minute 40.480
Drd2dopamine receptor D20.461
Chukconserved helix-loop-helix ubiquitous kinase0.458
Gab2growth factor receptor bound protein 2-associated protein 20.458
Sp1trans-acting transcription factor 10.451
Socs2suppressor of cytokine signaling 20.450
Spna1spectrin alpha 10.447
Edn3endothelin 30.446
BtkBruton agammaglobulinemia tyrosine kinase0.441
Gna13guanine nucleotide binding protein, alpha 130.440
Bdkrb2bradykinin receptor, beta 20.429
Ptf1apancreas specific transcription factor, 1a0.421
Nptx1neuronal pentraxin 10.414
Rag1recombination activating gene 10.412
Ezh2enhancer of zeste homolog 2 (Drosophila)0.411
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.411
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.410
Ncoa3nuclear receptor coactivator 30.402
Ank1ankyrin 1, erythroid0.402
Bach1BTB and CNC homology 10.402
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.018
Klf9Kruppel-like factor 90.017
Slfn2schlafen 20.016
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.016
Isg15ISG15 ubiquitin-like modifier0.016
Hckhemopoietic cell kinase0.016
Lyz2lysozyme 20.015
Creb1cAMP responsive element binding protein 10.015
Sgk1serum/glucocorticoid regulated kinase 10.015
Tgfbr2transforming growth factor, beta receptor II0.015
RT1-S3RT1 class Ib, locus S30.015
RT1-EC2RT1 class Ib, locus EC20.015
Tsc22d3TSC22 domain family, member 30.014
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.014
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.014
Ptpn6protein tyrosine phosphatase, non-receptor type 60.014
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.014
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.014
Dtx3ldeltex 3-like (Drosophila)0.014
Gbp2guanylate binding protein 20.014
Mx1myxovirus (influenza virus) resistance 10.014
Lgals9lectin, galactoside-binding, soluble, 90.013
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.013
Ddx39DEAD (Asp-Glu-Ala-Asp) box polypeptide 390.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.013
Rsad2radical S-adenosyl methionine domain containing 20.013
Stat6signal transducer and activator of transcription 60.013
TapbpTAP binding protein0.013
Car5acarbonic anhydrase 5a, mitochondrial0.013
Aif1allograft inflammatory factor 10.013
Ripk3receptor-interacting serine-threonine kinase 30.012
Usp18ubiquitin specific peptidase 180.012
Dusp1dual specificity phosphatase 10.012
Fgd4FYVE, RhoGEF and PH domain containing 40.012
Nek9NIMA (never in mitosis gene a)- related kinase 90.012
Vav1vav 1 guanine nucleotide exchange factor0.012
Rps8ribosomal protein S80.012
Ddit4DNA-damage-inducible transcript 40.012
Litaflipopolysaccharide-induced TNF factor0.012
Foxa3forkhead box A30.012
Rpl4ribosomal protein L40.012
Masp1mannan-binding lectin serine peptidase 10.012
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.012
Cd37CD37 molecule0.012
Dctn1dynactin 10.012
Arnt2aryl hydrocarbon receptor nuclear translocator 20.012
LOC688549hypothetical protein LOC6885490.012
Lgals5lectin, galactose binding, soluble 50.012
Icam1intercellular adhesion molecule 10.012
Oas1a2'-5' oligoadenylate synthetase 1A0.012
Zfp36zinc finger protein 360.012
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.012
Efnb1ephrin B10.012
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.012
Gna11guanine nucleotide binding protein, alpha 110.012
Cd53Cd53 molecule0.012
Pink1PTEN induced putative kinase 10.012
Fgfr4fibroblast growth factor receptor 40.012
Clcn5chloride channel 50.012
Apol3apolipoprotein L, 30.011
Arrb1arrestin, beta 10.011
RGD1359529similar to chromosome 1 open reading frame 630.011
Cd44Cd44 molecule0.011
Gja5gap junction protein, alpha 50.011
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.011
St3gal3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.011
Parp9poly (ADP-ribose) polymerase family, member 90.011
Csnk1g2casein kinase 1, gamma 20.011
Klk1b3kallikrein 1-related peptidase b30.011
Adhfe1alcohol dehydrogenase, iron containing, 10.011
Arhgap9Rho GTPase activating protein 90.011
Tinagl1tubulointerstitial nephritis antigen-like 10.011
RT1-Db1RT1 class II, locus Db10.011
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.011
Nr1i2nuclear receptor subfamily 1, group I, member 20.011
Gmfgglia maturation factor, gamma0.011
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.011
Rab3aRAB3A, member RAS oncogene family0.011
Hnf4ahepatocyte nuclear factor 4, alpha0.011
Ass1argininosuccinate synthetase 10.011
Usf2upstream transcription factor 2, c-fos interacting0.011
Map3k8mitogen-activated protein kinase kinase kinase 80.011
Klf2Kruppel-like factor 2 (lung)0.011
Egfrepidermal growth factor receptor0.011
Spp2secreted phosphoprotein 20.011
Lcp2lymphocyte cytosolic protein 20.011
Fgfr2fibroblast growth factor receptor 20.011
MGC112830similar to transcription factor0.011
Rabac1Rab acceptor 1 (prenylated)0.011
Mug1murinoglobulin 10.011
Sox17SRY (sex determining region Y)-box 170.011
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.011
Ifngr1interferon gamma receptor 10.011
Purbpurine rich element binding protein B0.011
Notch1Notch homolog 1, translocation-associated (Drosophila)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism