The network for 'membrane tubulation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

membrane tubulation

A modification in a plasma membrane resulting in formation of a tubular invagination.

NameDescriptionProbabilityFunc Analog Organism
SNX9sorting nexin 91.000
DNM2dynamin 21.000
DNM1dynamin 11.000
FASLGFas ligand (TNF superfamily, member 6)1.000
ITSN1intersectin 1 (SH3 domain protein)0.980
ADAM15ADAM metallopeptidase domain 150.976
WASLWiskott-Aldrich syndrome-like0.945
SYNJ1synaptojanin 10.874
SNX33sorting nexin 330.857
DAAM1dishevelled associated activator of morphogenesis 10.756
SH3GL2SH3-domain GRB2-like 20.677
SH3GL1SH3-domain GRB2-like 10.498
PACSIN2protein kinase C and casein kinase substrate in neurons 20.428
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.403
GRB2growth factor receptor-bound protein 20.339
FNBP1formin binding protein 10.292
SH3KBP1SH3-domain kinase binding protein 10.270
PACSIN1protein kinase C and casein kinase substrate in neurons 10.266
TNK2tyrosine kinase, non-receptor, 20.158
RIN3Ras and Rab interactor 30.132
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.127
PTPN18protein tyrosine phosphatase, non-receptor type 18 (brain-derived)0.114
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.087
ANKRD28ankyrin repeat domain 280.066
CASP10caspase 10, apoptosis-related cysteine peptidase0.066
SH3GL3SH3-domain GRB2-like 30.058
DPPA4developmental pluripotency associated 40.049
TRIP10thyroid hormone receptor interactor 100.044
DPYSL4dihydropyrimidinase-like 40.037
SPRY2sprouty homolog 2 (Drosophila)0.029
WIPF1WAS/WASL interacting protein family, member 10.029
MYO1Emyosin IE0.028
ATXN2ataxin 20.026
CASP8caspase 8, apoptosis-related cysteine peptidase0.024
ITKIL2-inducible T-cell kinase0.024
PACSIN3protein kinase C and casein kinase substrate in neurons 30.023
EHD1EH-domain containing 10.023
GAS7growth arrest-specific 70.021
CD2CD2 molecule0.021
SGK3serum/glucocorticoid regulated kinase family, member 30.021
PTPROprotein tyrosine phosphatase, receptor type, O0.021
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.020
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.020
NOSTRINnitric oxide synthase trafficker0.018
FASFas (TNF receptor superfamily, member 6)0.017
SEPT8septin 80.016
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.016
RHOAras homolog gene family, member A0.016
SOS1son of sevenless homolog 1 (Drosophila)0.015
REPS2RALBP1 associated Eps domain containing 20.013
HCKhemopoietic cell kinase0.011
PDCD6IPprogrammed cell death 6 interacting protein0.011
SH3PXD2ASH3 and PX domains 2A0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CaMKIICalcium/calmodulin-dependent protein kinase II0.185
ChcClathrin heavy chain0.170
Dap160Dynamin associated protein 1600.092
unc-104CG8566 gene product from transcript CG8566-RB0.077
Rab11Rab-protein 110.064
Sop2Suppressor of profilin 20.062
witwishful thinking0.049
Rab5Rab-protein 50.047
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.047
ifcinfertile crescent0.047
lqfliquid facets0.046
par-1CG8201 gene product from transcript CG8201-RA0.045
Cdc42CG12530 gene product from transcript CG12530-RA0.041
PP2A-B'CG7913 gene product from transcript CG7913-RK0.040
G-oalpha47AG protein oalpha 47A0.039
CspCysteine string protein0.038
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.037
Vrp1Verprolin 10.037
Cip4CG15015 gene product from transcript CG15015-RA0.032
par-6CG5884 gene product from transcript CG5884-RA0.031
Arp14DActin-related protein 14D0.028
WASpCG1520 gene product from transcript CG1520-RA0.028
AcslAcyl-CoA synthetase long-chain0.026
PknProtein kinase related to protein kinase N0.020
Pak3CG14895 gene product from transcript CG14895-RA0.020
nwknervous wreck0.018
pex1peroxin 10.017
fwdfour wheel drive0.017
CG32528CG32528 gene product from transcript CG32528-RA0.016
cpacapping protein alpha0.015
Ank2Ankyrin 20.015
Nrx-1Neurexin 10.014
Syt4Synaptotagmin 40.014
NFATNFAT homolog0.014
rheaCG6831 gene product from transcript CG6831-RA0.013
Fak56DFocal Adhesion Kinase0.013
Hip14Huntingtin-interacting protein 140.012
alpha-Specalpha Spectrin0.012
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.011
RalaRas-related protein0.011
CrebB-17ACyclic-AMP response element binding protein B at 17A0.011
Arp66BActin-related protein 66B0.011
Sra-1specifically Rac1-associated protein 10.011
l(1)G0232lethal (1) G02320.011
DadDaughters against dpp0.010
coroCG9446 gene product from transcript CG9446-RC0.010
Vap-33-1CG5014 gene product from transcript CG5014-RB0.010
Snap25Synapse protein 250.010
sqhspaghetti squash0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dnm1dynamin 10.594
Mta1metastasis associated 10.537
Abi1abl-interactor 10.512
WasWiskott-Aldrich syndrome homolog (human)0.466
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.419
Ptpn18protein tyrosine phosphatase, non-receptor type 180.409
Maptmicrotubule-associated protein tau0.401
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.233
Pde1bphosphodiesterase 1B, Ca2+-calmodulin dependent0.173
Ptpn12protein tyrosine phosphatase, non-receptor type 120.167
Dlg4discs, large homolog 4 (Drosophila)0.152
Abcb9ATP-binding cassette, sub-family B (MDR/TAP), member 90.145
Baiap2brain-specific angiogenesis inhibitor 1-associated protein 20.130
Grb2growth factor receptor bound protein 20.121
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.113
Rasgrp1RAS guanyl releasing protein 10.105
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.097
Sh3kbp1SH3-domain kinase binding protein 10.085
Rgs14regulator of G-protein signaling 140.081
Pcsk1nproprotein convertase subtilisin/kexin type 1 inhibitor0.069
Cyfip2cytoplasmic FMR1 interacting protein 20.064
Arpc2actin related protein 2/3 complex, subunit 20.059
Gna15guanine nucleotide binding protein, alpha 150.059
Atxn2ataxin 20.057
Ptk2PTK2 protein tyrosine kinase 20.057
Calm1calmodulin 10.056
Crmp1collapsin response mediator protein 10.055
D14Abb1eDNA segment, Chr 14, Abbott 1 expressed0.053
Matkmegakaryocyte-associated tyrosine kinase0.050
Rap1bRAS related protein 1b0.050
Pacsin1protein kinase C and casein kinase substrate in neurons 10.050
Nbeal1neurobeachin like 10.049
Fmnl1formin-like 10.049
Lcorligand dependent nuclear receptor corepressor0.047
Hecaheadcase homolog (Drosophila)0.046
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.046
Iqgap1IQ motif containing GTPase activating protein 10.045
Wasf2WAS protein family, member 20.045
Ppp1r12cprotein phosphatase 1, regulatory (inhibitor) subunit 12C0.044
Galnt6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 60.044
Arhgap9Rho GTPase activating protein 90.043
Trim46tripartite motif-containing 460.042
Gng3guanine nucleotide binding protein (G protein), gamma 30.041
Dtx1deltex 1 homolog (Drosophila)0.041
Hmha1histocompatibility (minor) HA-10.041
Frmd8FERM domain containing 80.040
Syt9synaptotagmin IX0.040
Kif5ckinesin family member 5C0.039
Actr2ARP2 actin-related protein 2 homolog (yeast)0.037
Sult4a1sulfotransferase family 4A, member 10.037
Hap1huntingtin-associated protein 10.036
Dnm2dynamin 20.035
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.035
Resp18regulated endocrine-specific protein 180.035
Actg1actin, gamma, cytoplasmic 10.034
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.034
Nefhneurofilament, heavy polypeptide0.034
Neflneurofilament, light polypeptide0.033
Ap2a1adaptor protein complex AP-2, alpha 1 subunit0.033
Tubb4tubulin, beta 40.033
Kif5akinesin family member 5A0.033
Ddx25DEAD (Asp-Glu-Ala-Asp) box polypeptide 250.033
Rasal1RAS protein activator like 1 (GAP1 like)0.033
Wdr1WD repeat domain 10.033
Erbb2ipErbb2 interacting protein0.032
Gnazguanine nucleotide binding protein, alpha z subunit0.031
Itsn1intersectin 1 (SH3 domain protein 1A)0.031
Rap2cRAP2C, member of RAS oncogene family0.031
Tjap1tight junction associated protein 10.030
Nrcamneuron-glia-CAM-related cell adhesion molecule0.030
Cant1calcium activated nucleotidase 10.030
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.030
Scg5secretogranin V0.030
Pnckpregnancy upregulated non-ubiquitously expressed CaM kinase0.029
Pim2proviral integration site 20.029
Nckap1lNCK associated protein 1 like0.029
Man2a1mannosidase 2, alpha 10.029
Kif1akinesin family member 1A0.029
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.028
Dtx2deltex 2 homolog (Drosophila)0.028
Fam49bfamily with sequence similarity 49, member B0.028
Sh3bp1SH3-domain binding protein 10.028
Mknk1MAP kinase-interacting serine/threonine kinase 10.028
Mtmr7myotubularin related protein 70.028
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.028
Padi2peptidyl arginine deiminase, type II0.027
Cltcclathrin, heavy polypeptide (Hc)0.027
Pdcd6ipprogrammed cell death 6 interacting protein0.027
Sorl1sortilin-related receptor, LDLR class A repeats-containing0.027
Arhgef2rho/rac guanine nucleotide exchange factor (GEF) 20.027
1110014N23RikRIKEN cDNA 1110014N23 gene0.027
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.026
Ugt8aUDP galactosyltransferase 8A0.026
Syn2synapsin II0.026
Tpm4tropomyosin 40.026
Ldoc1lleucine zipper, down-regulated in cancer 1-like0.026
Sema4dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fnbp1formin binding protein 10.046
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.039
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.034
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.029
Pkn2protein kinase N20.026
S1pr5sphingosine-1-phosphate receptor 50.020
Exoc4exocyst complex component 40.020
Ptprgprotein tyrosine phosphatase, receptor type, G0.020
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.018
Exoc7exocyst complex component 70.017
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.016
Synj1synaptojanin 10.016
Syn2synapsin II0.016
Coblcordon-bleu homolog (mouse)0.015
Myo1gmyosin IG0.014
Hmha1histocompatibility (minor) HA-10.014
Lphn3latrophilin 30.014
Sept1septin 10.014
Fmnl1formin-like 10.014
LOC363326hypothetical LOC3633260.014
Arhgap27Rho GTPase activating protein 270.014
Emp2epithelial membrane protein 20.013
Csnk1g3casein kinase 1, gamma 30.013
Dnm3dynamin 30.013
Mknk1MAP kinase-interacting serine/threonine kinase 10.013
Ptk2bPTK2B protein tyrosine kinase 2 beta0.012
Arhgap4Rho GTPase activating protein 40.012
Hcls1hematopoietic cell specific Lyn substrate 10.012
G3bp2GTPase activating protein (SH3 domain) binding protein 20.012
Taok1TAO kinase 10.012
Usf2upstream transcription factor 2, c-fos interacting0.011
Pcyt1aphosphate cytidylyltransferase 1, choline, alpha0.011
Picalmphosphatidylinositol binding clathrin assembly protein0.011
Lcp2lymphocyte cytosolic protein 20.011
Gosr1golgi SNAP receptor complex member 10.011
CamkvCaM kinase-like vesicle-associated0.011
Cpt1acarnitine palmitoyltransferase 1a, liver0.010
BspryB-box and SPRY domain containing0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism