The network for 'regulation of protein tyrosine kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein tyrosine kinase activity

Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.992
GRB2growth factor receptor-bound protein 20.989
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.986
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.962
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.956
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.946
SHC1SHC (Src homology 2 domain containing) transforming protein 10.807
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.774
NCK1NCK adaptor protein 10.710
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.601
VEGFAvascular endothelial growth factor A0.569
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.467
MPDZmultiple PDZ domain protein0.464
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.450
PDCD6IPprogrammed cell death 6 interacting protein0.424
CCR5chemokine (C-C motif) receptor 50.409
BTKBruton agammaglobulinemia tyrosine kinase0.346
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.330
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.280
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.276
SOCS1suppressor of cytokine signaling 10.235
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.215
EPORerythropoietin receptor0.196
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.186
PLCG1phospholipase C, gamma 10.185
SPRR2Asmall proline-rich protein 2A0.185
SH3KBP1SH3-domain kinase binding protein 10.181
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.175
CCL4chemokine (C-C motif) ligand 40.155
NRP1neuropilin 10.149
XAB2XPA binding protein 20.143
GAB1GRB2-associated binding protein 10.143
FYNFYN oncogene related to SRC, FGR, YES0.133
ABI2abl-interactor 20.132
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.130
AXLAXL receptor tyrosine kinase0.126
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.121
PTK2PTK2 protein tyrosine kinase 20.114
BLNKB-cell linker0.114
SOCS3suppressor of cytokine signaling 30.113
HCKhemopoietic cell kinase0.113
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.108
ZNF496zinc finger protein 4960.105
SH3GL2SH3-domain GRB2-like 20.102
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.092
SHC2SHC (Src homology 2 domain containing) transforming protein 20.092
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.089
BADBCL2-associated agonist of cell death0.086
BCAR1breast cancer anti-estrogen resistance 10.083
CD28CD28 molecule0.083
NCKAP1NCK-associated protein 10.078
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.074
PTPN1protein tyrosine phosphatase, non-receptor type 10.073
JAK2Janus kinase 20.072
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.071
CCL5chemokine (C-C motif) ligand 50.070
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.070
PGFplacental growth factor0.069
PTPN23protein tyrosine phosphatase, non-receptor type 230.066
CXCL9chemokine (C-X-C motif) ligand 90.066
TNS4tensin 40.064
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.063
MUC1mucin 1, cell surface associated0.062
SNX9sorting nexin 90.060
CCL2chemokine (C-C motif) ligand 20.059
CCL8chemokine (C-C motif) ligand 80.058
PTK6PTK6 protein tyrosine kinase 60.057
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.056
LRRK2leucine-rich repeat kinase 20.051
ARRB1arrestin, beta 10.050
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.050
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.048
SHC3SHC (Src homology 2 domain containing) transforming protein 30.046
HSPA13heat shock protein 70kDa family, member 130.046
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.045
RNF11ring finger protein 110.043
SOCS2suppressor of cytokine signaling 20.041
EGFepidermal growth factor0.041
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.041
IDEinsulin-degrading enzyme0.039
SNX33sorting nexin 330.038
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.038
PTK2BPTK2B protein tyrosine kinase 2 beta0.038
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.038
SORBS3sorbin and SH3 domain containing 30.035
GRB7growth factor receptor-bound protein 70.034
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.034
MED28mediator complex subunit 280.034
APPamyloid beta (A4) precursor protein0.033
MAPTmicrotubule-associated protein tau0.032
DLG1discs, large homolog 1 (Drosophila)0.032
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.032
RASA1RAS p21 protein activator (GTPase activating protein) 10.031
CCL3chemokine (C-C motif) ligand 30.031
PRKCAprotein kinase C, alpha0.031
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.030
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.030
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
RalaRas-related protein0.720
Socs36ESuppressor of cytokine signaling at 36E0.497
CblCG7037 gene product from transcript CG7037-RB0.297
argosCG4531 gene product from transcript CG4531-RA0.127
RpL3Ribosomal protein L30.085
dec-1defective chorion 10.082
Pvf1PDGF- and VEGF-related factor 10.078
aopanterior open0.070
Su(H)Suppressor of Hairless0.052
SaraSmad anchor for receptor activation0.051
cv-2crossveinless 20.041
sogshort gastrulation0.038
Act5CActin 5C0.033
rdgBretinal degeneration B0.032
RpL17Ribosomal protein L170.026
witwishful thinking0.021
CG11727CG11727 gene product from transcript CG11727-RD0.021
CG1021CG1021 gene product from transcript CG1021-RE0.020
CG3194CG3194 gene product from transcript CG3194-RB0.020
ninaEneither inactivation nor afterpotential E0.019
CG13349CG13349 gene product from transcript CG13349-RA0.019
Kr-h1Kruppel homolog 10.017
GgaCG3002 gene product from transcript CG3002-RB0.017
Tm1Tropomyosin 10.017
par-1CG8201 gene product from transcript CG8201-RA0.016
slboslow border cells0.016
drkdownstream of receptor kinase0.015
CG32372CG32372 gene product from transcript CG32372-RA0.015
ShcSHC-adaptor protein0.014
orboo18 RNA-binding protein0.012
rolsrolling pebbles0.012
CG13830CG13830 gene product from transcript CG13830-RD0.012
Tip60CG6121 gene product from transcript CG6121-RA0.011
Ras64BRas oncogene at 64B0.010
CG9867CG9867 gene product from transcript CG9867-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dab1disabled homolog 1 (Drosophila)0.999
Prnpprion protein0.981
Egfrepidermal growth factor receptor0.972
Appamyloid beta (A4) precursor protein0.971
Vangl1vang-like 1 (van gogh, Drosophila)0.943
Grb2growth factor receptor bound protein 20.899
Dvl2dishevelled 2, dsh homolog (Drosophila)0.863
Ptpn11protein tyrosine phosphatase, non-receptor type 110.807
Retret proto-oncogene0.806
SrcRous sarcoma oncogene0.793
Psen1presenilin 10.712
Arrb1arrestin, beta 10.659
Apoeapolipoprotein E0.604
Wnt3awingless-related MMTV integration site 3A0.550
Vangl2vang-like 2 (van gogh, Drosophila)0.525
Tgfatransforming growth factor alpha0.466
Arrb2arrestin, beta 20.456
CblCasitas B-lineage lymphoma0.438
Lrp8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor0.405
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.340
Myd88myeloid differentiation primary response gene 880.330
Shc1src homology 2 domain-containing transforming protein C10.318
Pax8paired box gene 80.306
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.300
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.298
Hif1ahypoxia inducible factor 1, alpha subunit0.293
Wnt4wingless-related MMTV integration site 40.285
Sox10SRY-box containing gene 100.281
Flt1FMS-like tyrosine kinase 10.268
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.261
Stat3signal transducer and activator of transcription 30.244
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.241
Rpl8ribosomal protein L80.232
Lhx1LIM homeobox protein 10.212
Nos3nitric oxide synthase 3, endothelial cell0.212
Ptpn12protein tyrosine phosphatase, non-receptor type 120.210
Ntf3neurotrophin 30.208
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.201
Clstn1calsyntenin 10.198
Cpeb3cytoplasmic polyadenylation element binding protein 30.190
Csf1colony stimulating factor 1 (macrophage)0.181
Bdnfbrain derived neurotrophic factor0.179
Dkk1dickkopf homolog 1 (Xenopus laevis)0.172
Nr3c1nuclear receptor subfamily 3, group C, member 10.171
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.169
Gab2growth factor receptor bound protein 2-associated protein 20.168
Dvl3dishevelled 3, dsh homolog (Drosophila)0.167
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.158
Aplp2amyloid beta (A4) precursor-like protein 20.154
Pax2paired box gene 20.153
Adra2aadrenergic receptor, alpha 2a0.145
Kcnh3potassium voltage-gated channel, subfamily H (eag-related), member 30.144
Phox2apaired-like homeobox 2a0.138
Notch2Notch gene homolog 2 (Drosophila)0.128
Gdnfglial cell line derived neurotrophic factor0.123
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.119
Tlr4toll-like receptor 40.118
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.116
Wnt9awingless-type MMTV integration site 9A0.111
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.107
Phox2bpaired-like homeobox 2b0.106
Ctnnb1catenin (cadherin associated protein), beta 10.102
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.100
Emx1empty spiracles homolog 1 (Drosophila)0.096
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.096
FynFyn proto-oncogene0.094
Nr2e1nuclear receptor subfamily 2, group E, member 10.091
Tgfb1transforming growth factor, beta 10.088
Numbnumb gene homolog (Drosophila)0.088
Vldlrvery low density lipoprotein receptor0.087
Sept7septin 70.085
Dnm1dynamin 10.085
Trp73transformation related protein 730.085
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.084
Fgf10fibroblast growth factor 100.081
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.079
Cd44CD44 antigen0.079
Jak2Janus kinase 20.077
Chmp1bchromatin modifying protein 1B0.070
Rps6ka3ribosomal protein S6 kinase polypeptide 30.068
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.066
Sos1son of sevenless homolog 1 (Drosophila)0.065
Actr3ARP3 actin-related protein 3 homolog (yeast)0.063
Hbegfheparin-binding EGF-like growth factor0.063
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.062
Agtr1aangiotensin II receptor, type 1a0.059
Porcnporcupine homolog (Drosophila)0.058
Vti1avesicle transport through interaction with t-SNAREs homolog 1A (yeast)0.057
Vav2vav 2 oncogene0.056
Ptk2PTK2 protein tyrosine kinase 20.056
Capza2capping protein (actin filament) muscle Z-line, alpha 20.055
BikBCL2-interacting killer0.054
Wnt7awingless-related MMTV integration site 7A0.052
Nptx1neuronal pentraxin 10.050
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.050
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism