The network for 'g protein coupled receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

g protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
ARRB1arrestin, beta 11.000
CCR5chemokine (C-C motif) receptor 50.999
CAV1caveolin 1, caveolae protein, 22kDa0.997
ADRBK1adrenergic, beta, receptor kinase 10.997
DRD2dopamine receptor D20.996
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.995
IL8interleukin 80.992
ALBalbumin0.992
MAPTmicrotubule-associated protein tau0.989
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.988
CCL4chemokine (C-C motif) ligand 40.987
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.987
CXCL2chemokine (C-X-C motif) ligand 20.986
PTPN1protein tyrosine phosphatase, non-receptor type 10.986
HTR45-hydroxytryptamine (serotonin) receptor 40.979
PRKCGprotein kinase C, gamma0.979
NCF2neutrophil cytosolic factor 20.977
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.974
CXCL9chemokine (C-X-C motif) ligand 90.967
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.960
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.959
IFNGinterferon, gamma0.951
CCL5chemokine (C-C motif) ligand 50.947
IL10interleukin 100.945
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.942
CXCL10chemokine (C-X-C motif) ligand 100.941
IL1Binterleukin 1, beta0.937
CCL8chemokine (C-C motif) ligand 80.935
GPRASP1G protein-coupled receptor associated sorting protein 10.926
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.923
CALM1calmodulin 1 (phosphorylase kinase, delta)0.918
CCR7chemokine (C-C motif) receptor 70.914
CCL22chemokine (C-C motif) ligand 220.914
CXCL3chemokine (C-X-C motif) ligand 30.912
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.902
ARRB2arrestin, beta 20.902
FGAfibrinogen alpha chain0.899
GFAPglial fibrillary acidic protein0.897
CHRNA4cholinergic receptor, nicotinic, alpha 40.897
RGS1regulator of G-protein signaling 10.892
CCL2chemokine (C-C motif) ligand 20.871
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.870
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.868
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.865
GHRHRgrowth hormone releasing hormone receptor0.856
CCL19chemokine (C-C motif) ligand 190.855
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.854
PSEN1presenilin 10.852
IGF1Rinsulin-like growth factor 1 receptor0.849
CXCL5chemokine (C-X-C motif) ligand 50.844
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.842
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.833
CCR1chemokine (C-C motif) receptor 10.825
NPYneuropeptide Y0.823
HRH3histamine receptor H30.822
CYTIPcytohesin 1 interacting protein0.821
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.815
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.809
CRHR2corticotropin releasing hormone receptor 20.803
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.801
CCR4chemokine (C-C motif) receptor 40.800
OPRK1opioid receptor, kappa 10.799
RHOAras homolog gene family, member A0.796
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.791
NTRK3neurotrophic tyrosine kinase, receptor, type 30.779
GRIA1glutamate receptor, ionotropic, AMPA 10.779
KCNJ9potassium inwardly-rectifying channel, subfamily J, member 90.772
CXCL11chemokine (C-X-C motif) ligand 110.758
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.752
MAP3K5mitogen-activated protein kinase kinase kinase 50.745
ADRA1Dadrenergic, alpha-1D-, receptor0.745
CRPC-reactive protein, pentraxin-related0.743
CCKcholecystokinin0.742
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.740
LATlinker for activation of T cells0.735
CCKBRcholecystokinin B receptor0.734
CCL11chemokine (C-C motif) ligand 110.723
CDSNcorneodesmosin0.714
PTGER3prostaglandin E receptor 3 (subtype EP3)0.696
HMOX2heme oxygenase (decycling) 20.696
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.695
CALCAcalcitonin-related polypeptide alpha0.695
AQP9aquaporin 90.692
IL2RBinterleukin 2 receptor, beta0.687
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.682
IRS1insulin receptor substrate 10.682
TBR1T-box, brain, 10.681
IRF4interferon regulatory factor 40.673
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.673
CXCR5chemokine (C-X-C motif) receptor 50.668
PRKCAprotein kinase C, alpha0.665
CCL7chemokine (C-C motif) ligand 70.664
MEOX2mesenchyme homeobox 20.658
MLNmotilin0.658
SOCS3suppressor of cytokine signaling 30.656
GRM1glutamate receptor, metabotropic 10.653
CCL20chemokine (C-C motif) ligand 200.652
GPR65G protein-coupled receptor 650.649
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.645
ZBED1zinc finger, BED-type containing 10.640
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pkg-1Protein PKG-10.949
pde-4Protein PDE-40.762
pdfr-1Protein PDFR-10.727
odr-3Protein ODR-30.724
itr-1Protein ITR-10.710
goa-1Protein GOA-10.616
eat-4Protein EAT-40.594
madd-4Protein MADD-40.474
ser-7Protein SER-70.467
mod-1Protein MOD-10.395
unc-43Protein UNC-430.368
CELE_R13H7.2Protein R13H7.20.350
F52A8.1Protein F52A8.10.328
npr-4Protein NPR-40.322
kcc-1Protein KCC-10.313
gpb-1Protein GPB-10.310
eat-6Protein EAT-60.289
cal-4Protein CAL-40.285
egl-36Protein EGL-360.280
best-18Protein BEST-180.278
ser-3Protein SER-30.257
CELE_H04M03.12Protein H04M03.120.223
ser-2Protein SER-20.219
egl-30Protein EGL-300.217
nep-11Protein NEP-110.213
cmd-1Protein CMD-10.197
M01A8.2Protein M01A8.20.194
nlp-15Protein NLP-150.182
Y37D8A.2Protein Y37D8A.20.178
C30B5.7Protein C30B5.70.174
flp-7Protein FLP-70.170
unc-25Protein UNC-250.168
rskn-2Protein RSKN-20.160
ida-1Protein IDA-10.159
frm-1Protein FRM-10.155
ist-1Protein IST-10.155
lgc-46Protein LGC-460.153
unc-2Protein UNC-20.153
arrd-26Protein ARRD-260.151
aat-5Protein AAT-50.149
glb-33Protein GLB-330.149
crp-1Protein CRP-10.144
myo-6Protein MYO-60.143
twk-40Protein TWK-400.141
saeg-1Protein SAEG-10.137
stim-1Protein STIM-10.126
arrd-13Protein ARRD-130.124
nlg-1Protein NLG-10.123
sgca-1Protein SGCA-10.115
cho-1Protein CHO-10.114
Y56A3A.6Protein Y56A3A.60.113
F28F5.4Protein F28F5.40.113
ser-4Protein SER-40.113
kin-20Protein KIN-200.113
lite-1Protein LITE-10.110
unc-73Protein UNC-730.108
rsbp-1Protein RSBP-10.108
xbx-3Protein XBX-30.108
twk-30Protein TWK-300.104
ogt-1Protein OGT-10.103
CELE_C29F4.3Protein C29F4.30.102
cdh-4Protein CDH-40.102
dop-1Protein DOP-10.102
unc-80Protein UNC-800.101
unc-17Protein UNC-170.100
CELE_Y53F4B.5Protein Y53F4B.50.098
arrd-15Protein ARRD-150.097
lrp-1Protein LRP-10.097
unc-9Protein UNC-90.097
R13A5.9Protein R13A5.90.096
slo-2Protein SLO-20.095
pdf-1Protein PDF-10.095
npr-12Protein NPR-120.094
W01A11.7Protein W01A11.70.092
CELE_Y69H2.1Protein Y69H2.10.091
glr-4Protein GLR-40.087
npr-6Protein NPR-60.087
unc-13Protein UNC-130.086
sol-1Protein SOL-10.085
unc-103Protein UNC-1030.084
daf-12Protein DAF-120.081
DH11.5Protein DH11.50.079
pes-7Protein PES-70.079
gcy-28Protein GCY-280.079
abts-3Protein ABTS-30.079
twk-17Protein TWK-170.079
C39B10.1Protein C39B10.10.078
srr-3Protein SRR-30.078
ncr-1Protein NCR-10.077
F32B4.5Protein F32B4.50.077
dmsr-8Protein DMSR-80.076
aex-3Protein AEX-30.075
gpa-14Protein GPA-140.075
F54G2.1Protein F54G2.10.073
M03F8.6Protein M03F8.60.073
C25E10.12Protein C25E10.120.073
C17B7.8Protein C17B7.80.073
hot-7Protein HOT-70.073
npr-27Protein NPR-270.072
ima-3Protein IMA-30.072
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
si:dkey-228g21.4si:dkey-228g21.40.901
plcg1phospholipase C, gamma 10.883
chatcholine acetyltransferase0.845
hrh1histamine receptor H10.812
LOC100003330melanocortin-2 receptor accessory protein 2-like0.740
drd2bdopamine receptor D2b0.720
npy8brneuropeptide Y receptor Y8b0.706
oprk1opioid receptor, kappa 10.698
adra2badrenergic, alpha-2B-, receptor0.685
LOC569642hypothetical protein LOC5696420.681
opn4lopsin 4, like0.680
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.680
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.676
rhorhodopsin0.645
mchr1bmelanin-concentrating hormone receptor 1b0.611
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.606
opn4aopsin 4a (melanopsin)0.593
kiss1KiSS-1 metastasis-suppressor0.593
mc4rmelanocortin 4 receptor0.591
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.588
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.587
oprm1opioid receptor, mu 10.576
ulk2unc-51-like kinase 2 (C. elegans)0.533
maomonoamine oxidase0.524
pink1PTEN induced putative kinase 10.465
cadm2bcell adhesion molecule 2b0.448
mtnr1bamelatonin receptor type 1B a0.442
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.441
si:ch211-124k10.1si:ch211-124k10.10.438
gnrhr3gonadotropin releasing hormone receptor 30.436
trpc1transient receptor potential cation channel, subfamily C, member 10.431
avplarginine vasopressin-like0.419
lin7alin-7 homolog A (C. elegans)0.418
dbhdopamine beta hydroxylase0.399
tbx1T-box 10.391
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.391
tac1tachykinin 10.388
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.386
esr2aestrogen receptor 2a0.371
vangl2vang-like 2 (van gogh, Drosophila)0.364
gcm2glial cells missing homolog 2 (Drosophila)0.359
ptprcprotein tyrosine phosphatase, receptor type, C0.358
drd2adopamine receptor D2a0.355
adra2cadrenergic, alpha-2C-, receptor0.352
LOC100331502melanopsin-B-like0.349
kcnn1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 10.344
gnrhr4gonadotropin releasing hormone receptor 40.336
ntf7neurotrophin 70.333
osr1odd-skipped related 1 (Drosophila)0.330
lhx8aLIM homeobox 8a0.321
gucy2fguanylate cyclase 2F, retinal0.311
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.310
mc1rmelanocortin 1 receptor0.310
pmchpro-melanin concentrating hormone0.293
nbl1neuroblastoma, suppression of tumorigenicity 10.289
kiss2kisspeptin 20.282
adra2aadrenergic, alpha-2A-, receptor0.275
LOC555482tachykinin receptor 3-like0.271
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.266
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.256
ildr1bimmunoglobulin-like domain containing receptor 1b0.256
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.251
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.248
gc2guanylyl cyclase 20.238
mchr1amelanin-concentrating hormone receptor 1a0.229
gna14guanine nucleotide binding protein (G protein), alpha 140.229
arr3aarrestin 3a, retinal (X-arrestin)0.225
hdchistidine decarboxylase0.219
c1qtnf4C1q and tumor necrosis factor related protein 40.218
LOC793448protein-glutamine gamma-glutamyltransferase K-like0.215
oxtloxytocin-like0.215
cnga5cyclic nucleotide gated channel alpha 50.213
pou1f1POU domain, class 1, transcription factor 10.212
tshbthyroid stimulating hormone, beta subunit0.212
scn1labsodium channel, voltage-gated, type I like, alpha b0.211
nlgn1neuroligin 10.206
gnaqguanine nucleotide binding protein (G protein), q polypeptide0.206
adra2dbadrenergic, alpha-2D-, receptor b0.204
gnai3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.203
itgb1aintegrin, beta 1a0.202
gnai2lguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like0.199
pdcaphosducin a0.198
vdravitamin D receptor a0.198
opn4x1opsin 4x10.196
camk2g2calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 20.192
crb2bcrumbs homolog 2b0.186
gnrh3gonadotropin-releasing hormone 30.183
gnav1guanine nucleotide binding protein (G protein) alpha v10.183
paqr7bprogestin and adipoQ receptor family member VII, b0.181
LOC568691opsin-3-like0.179
pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.176
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.173
insrainsulin receptor a0.173
arf1ADP-ribosylation factor 10.167
tas2r202taste receptor, type 2, member 2020.166
ctsl1acathepsin L, 1 a0.165
slc18a3bsolute carrier family 18 (vesicular acetylcholine), member 3b0.164
wu:fc57f07wu:fc57f070.163
fam84bfamily with sequence similarity 84, member B0.162
irbpinterphotoreceptor retinoid-binding protein0.161
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
norpAno receptor potential A1.000
trptransient receptor potential1.000
Arr2Arrestin 20.985
inaDinactivation no afterpotential D0.981
rdgCretinal degeneration C0.979
Galpha49BG protein alpha49B0.976
ninaEneither inactivation nor afterpotential E0.969
G-oalpha47AG protein oalpha 47A0.958
NrgNeuroglian0.955
trpltrp-like0.952
Nrx-1Neurexin 10.947
CG42629CG42629 gene product from transcript CG42629-RB0.945
inaCinactivation no afterpotential C0.925
rdgBretinal degeneration B0.916
Octbeta2RCG33976 gene product from transcript CG33976-RA0.903
beta-Specbeta Spectrin0.895
oa2octopamine receptor 20.892
TrhTryptophan hydroxylase0.890
CkIalphaCasein kinase Ialpha0.882
Rac2CG8556 gene product from transcript CG8556-RA0.879
foxoforkhead box, sub-group O0.876
CngCyclic-nucleotide-gated ion channel protein0.870
TbhTyramine beta hydroxylase0.855
rprreaper0.850
painpainless0.830
Akt1CG4006 gene product from transcript CG4006-RA0.801
Snap25Synapse protein 250.787
inx2innexin 20.779
ttan0.779
mttmangetout0.763
Ilp2Insulin-like peptide 20.738
Arr1Arrestin 10.725
sNPFshort neuropeptide F precursor0.706
dncdunce0.700
ninaAneither inactivation nor afterpotential A0.698
AdarAdenosine deaminase acting on RNA0.694
rdgAretinal degeneration A0.693
Rh5Rhodopsin 50.683
CG31619CG31619 gene product from transcript CG31619-RC0.672
Plc21CPhospholipase C at 21C0.662
LanB1CG7123 gene product from transcript CG7123-RA0.632
Rh3Rhodopsin 30.628
CG13253CG13253 gene product from transcript CG13253-RB0.597
CG16778CG16778 gene product from transcript CG16778-RA0.594
Ced-12CG5336 gene product from transcript CG5336-RA0.585
sNPF-Rshort neuropeptide F receptor0.583
Rh6Rhodopsin 60.576
drkdownstream of receptor kinase0.572
DabDisabled0.570
GABA-B-R3metabotropic GABA-B receptor subtype 30.565
sloslowpoke0.563
CG7191CG7191 gene product from transcript CG7191-RA0.563
CG31221CG31221 gene product from transcript CG31221-RA0.561
G-ialpha65AG protein alphai subunit 65A0.559
CG13792CG13792 gene product from transcript CG13792-RA0.545
enaenabled0.538
nwknervous wreck0.537
sdaslamdance0.535
NetBNetrin-B0.520
Pde8Phosphodiesterase 80.505
shishibire0.500
npfneuropeptide F0.496
Rac1CG2248 gene product from transcript CG2248-RA0.488
SNF4AgammaSNF4/AMP-activated protein kinase gamma subunit0.484
5-HT1ASerotonin receptor 1A0.476
Gyc-89DbGuanylyl cyclase at 89Db0.468
rutrutabaga0.449
NLazNeural Lazarillo0.423
p120ctnAdherens junction protein p1200.419
GABA-B-R2metabotropic GABA-B receptor subtype 20.408
scbscab0.404
Atf-2Activating transcription factor-20.394
GluRIIAGlutamate receptor IIA0.389
Ilp5Insulin-like peptide 50.383
ia2CG31795 gene product from transcript CG31795-RD0.378
CG34400CG34400 gene product from transcript CG34400-RD0.378
chpchaoptic0.377
Ast-CAllatostatin C0.372
staistathmin0.368
NPFR1neuropeptide F receptor0.366
Tre1trapped in endoderm-10.364
CG34354CG34354 gene product from transcript CG34354-RA0.360
Ank2Ankyrin 20.357
CG31191CG31191 gene product from transcript CG31191-RA0.354
5-HT7Serotonin receptor 70.354
pHClCG33989 gene product from transcript CG33989-RD0.348
ClkClock0.346
inaEinactivation no afterpotential E0.341
Ggamma1G protein gamma 10.330
rawCG12437 gene product from transcript CG12437-RB0.327
Smg1CG32743 gene product from transcript CG32743-RA0.326
moodyCG4322 gene product from transcript CG4322-RD0.324
amnamnesiac0.314
ninaCneither inactivation nor afterpotential C0.309
jebjelly belly0.305
RdlResistant to dieldrin0.304
dsfdissatisfaction0.302
CG5890CG5890 gene product from transcript CG5890-RB0.299
CG13565CG13565 gene product from transcript CG13565-RA0.294
Gbeta76CG protein beta-subunit 76C0.293
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.999
Pgrprogesterone receptor0.994
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.985
Drd2dopamine receptor D20.982
Ren1renin 1 structural0.976
Vegfavascular endothelial growth factor A0.967
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.959
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.955
Cnr1cannabinoid receptor 1 (brain)0.954
Npy1rneuropeptide Y receptor Y10.951
Grm1glutamate receptor, metabotropic 10.950
Oprk1opioid receptor, kappa 10.949
Kcnk3potassium channel, subfamily K, member 30.947
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.946
Ptpn11protein tyrosine phosphatase, non-receptor type 110.946
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.941
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.941
Esr1estrogen receptor 1 (alpha)0.928
Cckbrcholecystokinin B receptor0.926
Ednrbendothelin receptor type B0.915
Thrbthyroid hormone receptor beta0.910
Rasgrf2RAS protein-specific guanine nucleotide-releasing factor 20.904
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.903
Tgfbr2transforming growth factor, beta receptor II0.891
Lepleptin0.889
Clockcircadian locomotor output cycles kaput0.888
Nos3nitric oxide synthase 3, endothelial cell0.884
Klklotho0.880
Lhcgrluteinizing hormone/choriogonadotropin receptor0.873
Sstr1somatostatin receptor 10.872
Nxph1neurexophilin 10.868
Uts2rurotensin 2 receptor0.866
Adrb1adrenergic receptor, beta 10.864
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.853
Selpselectin, platelet0.852
Dio2deiodinase, iodothyronine, type II0.842
Oprm1opioid receptor, mu 10.837
Tyrtyrosinase0.828
Npy2rneuropeptide Y receptor Y20.825
Lhx3LIM homeobox protein 30.824
Gabrb2gamma-aminobutyric acid (GABA) A receptor, subunit beta 20.822
Mmp16matrix metallopeptidase 160.821
Rgs9regulator of G-protein signaling 90.818
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.817
Gnrhrgonadotropin releasing hormone receptor0.815
Kcns2K+ voltage-gated channel, subfamily S, 20.808
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.808
Vav3vav 3 oncogene0.806
Bglapbone gamma carboxyglutamate protein0.803
Cx3cr1chemokine (C-X3-C) receptor 10.781
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.779
Flt1FMS-like tyrosine kinase 10.775
Mc3rmelanocortin 3 receptor0.773
Plxnd1plexin D10.771
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.769
Smad3MAD homolog 3 (Drosophila)0.764
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.764
Ptk2PTK2 protein tyrosine kinase 20.760
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.743
Htr75-hydroxytryptamine (serotonin) receptor 70.740
Rfpl4ret finger protein-like 40.739
Crhr1corticotropin releasing hormone receptor 10.735
Kiss1rKISS1 receptor0.733
Neurog2neurogenin 20.729
Rgs4regulator of G-protein signaling 40.728
Itgaxintegrin alpha X0.725
Nos1nitric oxide synthase 1, neuronal0.722
Syt1synaptotagmin I0.722
Arrb1arrestin, beta 10.721
Msx1homeobox, msh-like 10.719
Syn2synapsin II0.719
Slc12a5solute carrier family 12, member 50.718
Arrb2arrestin, beta 20.712
Ctnnb1catenin (cadherin associated protein), beta 10.712
Grid1glutamate receptor, ionotropic, delta 10.710
Cd247CD247 antigen0.708
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.704
Gad2glutamic acid decarboxylase 20.698
Ncf1neutrophil cytosolic factor 10.693
Olfr70olfactory receptor 700.693
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.685
Gpr132G protein-coupled receptor 1320.685
Adora2aadenosine A2a receptor0.683
Fgf14fibroblast growth factor 140.683
Acvrl1activin A receptor, type II-like 10.683
Htr45 hydroxytryptamine (serotonin) receptor 40.678
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.675
Npy6rneuropeptide Y receptor Y60.673
Mkl2MKL/myocardin-like 20.670
Kcnh1potassium voltage-gated channel, subfamily H (eag-related), member 10.664
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.654
Gdnfglial cell line derived neurotrophic factor0.654
Htr3a5-hydroxytryptamine (serotonin) receptor 3A0.648
Tgfb2transforming growth factor, beta 20.644
Prrt1proline-rich transmembrane protein 10.638
Drd3dopamine receptor D30.635
Ccr5chemokine (C-C motif) receptor 50.633
Homer1homer homolog 1 (Drosophila)0.629
Plxnb1plexin B10.628
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.622
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Chrna7cholinergic receptor, nicotinic, alpha 70.902
Cd4Cd4 molecule0.828
Sstr3somatostatin receptor 30.824
Mc5rmelanocortin 5 receptor0.810
Olr1361olfactory receptor 13610.789
Adora2aadenosine A2a receptor0.771
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.741
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.718
Hpcahippocalcin0.708
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.704
Ptger2prostaglandin E receptor 2 (subtype EP2)0.679
Atp7bATPase, Cu++ transporting, beta polypeptide0.679
Crisp1cysteine-rich secretory protein 10.661
Lim2lens intrinsic membrane protein 20.652
Csf3colony stimulating factor 3 (granulocyte)0.648
Gfra2GDNF family receptor alpha 20.644
Drd1adopamine receptor D1A0.644
Chrna6cholinergic receptor, nicotinic, alpha 60.644
Trhrthyrotropin releasing hormone receptor0.629
Cckarcholecystokinin A receptor0.628
Fgf17fibroblast growth factor 170.615
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.611
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.608
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.594
Olr1641olfactory receptor 16410.586
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.584
Prkcgprotein kinase C, gamma0.562
Phkg1phosphorylase kinase, gamma 10.561
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.560
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.545
Chrm2cholinergic receptor, muscarinic 20.545
Rgs4regulator of G-protein signaling 40.537
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.534
Htr75-hydroxytryptamine (serotonin) receptor 70.532
Fgf14fibroblast growth factor 140.529
Adcy10adenylate cyclase 10 (soluble)0.527
Apoa5apolipoprotein A-V0.524
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.520
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.519
Sgp158proline-rich glycoprotein (sgp158)0.518
Grpgastrin releasing peptide0.512
Crhbpcorticotropin releasing hormone binding protein0.504
Arpp21cAMP-regulated phosphoprotein 210.498
Myt1lmyelin transcription factor 1-like0.494
Avparginine vasopressin0.493
Fgbfibrinogen beta chain0.488
Pthparathyroid hormone0.484
Il9rinterleukin 9 receptor0.469
Kcnv1potassium channel, subfamily V, member 10.467
Pde1bphosphodiesterase 1B, calmodulin-dependent0.466
Vipvasoactive intestinal peptide0.461
Il2rainterleukin 2 receptor, alpha0.460
Chrngcholinergic receptor, nicotinic, gamma0.460
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.455
Rgs9regulator of G-protein signaling 90.453
Sstr1somatostatin receptor 10.450
Gng7guanine nucleotide binding protein (G protein), gamma 70.446
Arandrogen receptor0.422
Col10a1collagen, type X, alpha 10.418
Cpne9copine family member IX0.417
Ccr3chemokine (C-C motif) receptor 30.417
Scn8asodium channel, voltage gated, type VIII, alpha subunit0.413
Gucy1b3guanylate cyclase 1, soluble, beta 30.409
Rup2urinary protein 20.409
Mchr1melanin-concentrating hormone receptor 10.409
Akr1c18aldo-keto reductase family 1, member C180.406
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.403
Giprgastric inhibitory polypeptide receptor0.380
Grm6glutamate receptor, metabotropic 60.378
Cntn4contactin 40.374
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.372
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.370
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.369
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.369
Mobpmyelin-associated oligodendrocyte basic protein0.367
Amphamphiphysin0.367
Cd38CD38 molecule0.364
Trhr2thyrotropin releasing hormone receptor 20.362
Slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.362
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.358
Nfascneurofascin0.357
Fgf2fibroblast growth factor 20.356
Cnga3cyclic nucleotide gated channel alpha 30.355
Sirpasignal-regulatory protein alpha0.354
Il12binterleukin 12B0.354
Esr2estrogen receptor 2 (ER beta)0.350
Semg1semenogelin I0.342
Prlhprolactin releasing hormone0.340
Figfc-fos induced growth factor0.339
Crhr1corticotropin releasing hormone receptor 10.337
Hcrtr1hypocretin (orexin) receptor 10.336
Ctrb1chymotrypsinogen B10.332
Adora1adenosine A1 receptor0.332
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.332
Ccr5chemokine (C-C motif) receptor 50.329
Reg3gregenerating islet-derived 3 gamma0.329
Nrcamneuronal cell adhesion molecule0.328
Mas1MAS1 oncogene0.325
Hcrtr2hypocretin (orexin) receptor 20.312
Cps1carbamoyl-phosphate synthetase 10.312
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
STE4Ste4p0.981
FUS3Fus3p0.941
STE5Ste5p0.906
FAR1Far1p0.900
STE7Ste7p0.871
CDC24Cdc24p0.867
SSK2Ssk2p0.654
MKK1Mkk1p0.638
PBS2Pbs2p0.544
STE11Ste11p0.542
STE2Ste2p0.526
BCK1Bck1p0.480
SSK1Ssk1p0.479
MSG5Msg5p0.471
PPZ1Ppz1p0.429
KDX1Kdx1p0.403
AGA2Aga2p0.361
NBP2Nbp2p0.335
BEM1Bem1p0.328
KSS1Kss1p0.306
MF(ALPHA)2Mf(alpha)2p0.266
STE12Ste12p0.234
MF(ALPHA)1Mf(alpha)1p0.218
HKR1Hkr1p0.191
RLM1Rlm1p0.191
ROM2Rom2p0.174
CLA4Cla4p0.165
MATALPHA1Matalpha1p0.165
SST2Sst2p0.148
STE18Ste18p0.132
SLT2Slt2p0.130
STE3Ste3p0.121
PTP2Ptp2p0.116
STE20Ste20p0.110
FYV8Fyv8p0.092
IRA1Ira1p0.084
GPA1Gpa1p0.079
YPT35Ypt35p0.070
RHO5Rho5p0.066
GIC2Gic2p0.061
DBF2Dbf2p0.060
BEM3Bem3p0.059
VPS15Vps15p0.058
BAR1Bar1p0.056
SKM1Skm1p0.052
FIR1Fir1p0.052
RHO1Rho1p0.051
BEM2Bem2p0.051
GDS1Gds1p0.051
SSK22Ssk22p0.045
GIP4Gip4p0.043
CAB3Cab3p0.042
EBS1Ebs1p0.041
FMP48Fmp48p0.041
VHS3Vhs3p0.041
SDP1Sdp1p0.041
FET4Fet4p0.040
YPL088Whypothetical protein0.040
NAT1Nat1p0.040
KNH1Knh1p0.039
OSH7Osh7p0.039
TPK2Tpk2p0.039
UBP5Ubp5p0.038
KIC1Kic1p0.037
CLN3Cln3p0.037
OPY1Opy1p0.036
TFB1Tfb1p0.036
BCK2Bck2p0.036
MSB3Msb3p0.036
CDC55Cdc55p0.036
UBP11Ubp11p0.036
YOR338Whypothetical protein0.035
GPB2Gpb2p0.035
SDS22Sds22p0.035
FUS2Fus2p0.035
PKC1Pkc1p0.034
RIM13Rim13p0.034
CRG1Crg1p0.034
PEP5Pep5p0.033
DIG1Dig1p0.032
GIC1Gic1p0.032
RAS2Ras2p0.032
YLR264C-Ahypothetical protein0.032
SRD1Srd1p0.032
MATALPHA2Matalpha2p0.031
AGA1Aga1p0.030
MKK2Mkk2p0.030
BFR1Bfr1p0.030
YLR162Whypothetical protein0.030
DSE4Dse4p0.029
ACK1Ack1p0.029
NGL3Ngl3p0.028
TKL2Tkl2p0.028
MER1Mer1p0.028
ELP6Elp6p0.027
YOL038C-Ahypothetical protein0.027
AKR1Akr1p0.027
YNL234Whypothetical protein0.027
YJL163Chypothetical protein0.027
HXT11Hxt11p0.026