The network for 'melanin metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

melanin metabolic process

The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.

NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.999
MAPK8mitogen-activated protein kinase 80.965
BCL2L1BCL2-like 10.942
ARHGAP1Rho GTPase activating protein 10.861
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.852
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.736
CASP8caspase 8, apoptosis-related cysteine peptidase0.712
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.655
EGFRepidermal growth factor receptor0.599
JUNjun proto-oncogene0.558
MAP2K4mitogen-activated protein kinase kinase 40.547
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.516
SHC1SHC (Src homology 2 domain containing) transforming protein 10.454
SH3BP2SH3-domain binding protein 20.391
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.341
NLRC4NLR family, CARD domain containing 40.337
JUPjunction plakoglobin0.328
ZNF746zinc finger protein 7460.323
GRB7growth factor receptor-bound protein 70.267
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.257
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.257
MAPRE3microtubule-associated protein, RP/EB family, member 30.256
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.255
DSG2desmoglein 20.252
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.247
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.221
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.203
CASP4caspase 4, apoptosis-related cysteine peptidase0.173
LMO2LIM domain only 2 (rhombotin-like 1)0.165
CASP10caspase 10, apoptosis-related cysteine peptidase0.160
RHOAras homolog gene family, member A0.155
CTNND1catenin (cadherin-associated protein), delta 10.152
CASP9caspase 9, apoptosis-related cysteine peptidase0.151
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.151
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.150
FASFas (TNF receptor superfamily, member 6)0.135
LRDDleucine-rich repeats and death domain containing0.134
ATF3activating transcription factor 30.109
ATP8ATP synthase F0 subunit 80.106
GRB10growth factor receptor-bound protein 100.106
LY6G6Flymphocyte antigen 6 complex, locus G6F0.105
SERPINB1serpin peptidase inhibitor, clade B (ovalbumin), member 10.096
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.095
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.091
MAPRE2microtubule-associated protein, RP/EB family, member 20.091
CFLARCASP8 and FADD-like apoptosis regulator0.090
MAP3K1mitogen-activated protein kinase kinase kinase 10.088
GAS7growth arrest-specific 70.086
AMBRA1autophagy/beclin-1 regulator 10.083
NCF4neutrophil cytosolic factor 4, 40kDa0.081
MAP2K7mitogen-activated protein kinase kinase 70.080
PLCG1phospholipase C, gamma 10.073
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.072
IFI16interferon, gamma-inducible protein 160.072
ITKIL2-inducible T-cell kinase0.072
TOM1L1target of myb1 (chicken)-like 10.069
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.069
ARRB1arrestin, beta 10.069
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.067
CDH3cadherin 3, type 1, P-cadherin (placental)0.061
SPRY4sprouty homolog 4 (Drosophila)0.060
LATlinker for activation of T cells0.060
PPP5Cprotein phosphatase 5, catalytic subunit0.058
PTPN11protein tyrosine phosphatase, non-receptor type 110.056
COL7A1collagen, type VII, alpha 10.056
BCAMbasal cell adhesion molecule (Lutheran blood group)0.054
UBE2R2ubiquitin-conjugating enzyme E2R 20.052
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.052
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.052
ATF2activating transcription factor 20.051
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.050
TGFAtransforming growth factor, alpha0.050
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.049
VAV2vav 2 guanine nucleotide exchange factor0.049
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.049
MTA2metastasis associated 1 family, member 20.049
EPHA3EPH receptor A30.049
DOK4docking protein 40.048
APC2adenomatosis polyposis coli 20.048
PRKCAprotein kinase C, alpha0.047
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.046
DSG1desmoglein 10.046
CDH5cadherin 5, type 2 (vascular endothelium)0.045
RFWD2ring finger and WD repeat domain 20.045
RAP1ARAP1A, member of RAS oncogene family0.044
MTHFD1Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like0.044
FNBP1formin binding protein 10.044
DEF6differentially expressed in FDCP 6 homolog (mouse)0.043
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.043
MAPK8IP3mitogen-activated protein kinase 8 interacting protein 30.043
LAMB3laminin, beta 30.042
XPO7exportin 70.042
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.042
WDR1WD repeat domain 10.042
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mitfamicrophthalmia-associated transcription factor a0.534
grem2gremlin 2, cysteine knot superfamily0.489
pmelapremelanosome protein a0.397
kitakit receptor a0.362
slc24a5solute carrier family 24, member 50.249
efnb3bephrin B3b0.244
tnfrsfatumor necrosis factor receptor superfamily, member a0.230
dctdopachrome tautomerase0.207
nrarpbnotch-regulated ankyrin repeat protein b0.125
il1binterleukin 1, beta and interleukin 1, beta0.124
stc1lstanniocalcin 1, like0.115
tyrp1btyrosinase-related protein 1b0.114
ednrb1endothelin receptor B0.107
fzd5frizzled homolog 50.107
syngr1asynaptogyrin 1a0.106
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.106
tyrp1tyrosinase-related protein 10.105
rpe65aretinal pigment epithelium-specific protein 65a0.094
dkk1bdickkopf 1b0.093
atp1a3bATPase, Na+/K+ transporting, alpha 3b polypeptide0.092
lfnglunatic fringe homolog0.088
slc2a15bsolute carrier family 2 (facilitated glucose transporter), member 15b0.080
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.074
pcsk5aproprotein convertase subtilisin/kexin type 5a0.074
pax3apaired box gene 3a0.073
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.071
ighzimmunoglobulin heavy constant zeta0.068
mc5ramelanocortin 5a receptor0.065
aox3aldehyde oxidase 30.064
chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.063
myo6bmyosin VIb0.062
hmgb1bhigh-mobility group box 1b0.062
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.061
map2k4bmitogen-activated protein kinase kinase 4b0.061
fgfr4fibroblast growth factor receptor 40.060
slit3slit (Drosophila) homolog 30.060
foxn4forkhead box N40.060
inhbbinhibin, beta B0.059
slc45a2solute carrier family 45, member 20.058
hoxa1ahomeo box A1a0.058
ptprkprotein tyrosine phosphatase, receptor type, K0.057
ptp4a1protein tyrosine phosphatase type IVA, member 10.054
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.054
cx39.9connexin 39.90.053
yap1Yes-associated protein 10.052
gna12guanine nucleotide binding protein (G protein) alpha 120.052
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.052
rgrbretinal G protein coupled receptor b0.052
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.051
wnt4bwingless-type MMTV integration site family, member 4b0.050
fbxl14bF-box and leucine-rich repeat protein 14b0.049
ints6integrator complex subunit 60.048
msnamoesin a0.048
LOC100000934hypothetical protein LOC1000009340.047
thsd7athrombospondin, type I, domain containing 7A0.046
six4.3sine oculis homeobox homolog 4.30.046
syt9asynaptotagmin IXa0.046
cdkl1cyclin-dependent kinase-like 1 (CDC2-related kinase)0.044
tob1atransducer of ERBB2, 1a0.043
furinbfurin (paired basic amino acid cleaving enzyme) b0.043
hmx2H6 family homeobox 20.042
myo10l1myosin X-like 10.040
chd7chromodomain helicase DNA binding protein 70.040
olfm1bolfactomedin 1b0.040
cyt1type I cytokeratin, enveloping layer0.040
col9a1collagen, type IX, alpha 10.040
ctsl1bcathepsin L, 1 b0.040
pknox1.2pbx/knotted 1 homeobox 1.20.039
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.038
notch3notch homolog 30.038
prox2prospero homeobox 20.038
runx3runt-related transcription factor 30.038
fmr1fragile X mental retardation 10.037
grhl2bgrainyhead-like 2b (Drosophila)0.037
tnfsf18tumor necrosis factor (ligand) superfamily, member 180.036
faddFas (tnfrsf6)-associated via death domain0.035
spon2aspondin 2a, extracellular matrix protein0.035
wnt10awingless-type MMTV integration site family, member 10a0.034
ptrfbpolymerase I and transcript release factor b0.034
cenphcentromere protein H0.034
mapk6mitogen-activated protein kinase 60.034
dynlt3dynein, light chain, Tctex-type 30.034
arpc2actin related protein 2/3 complex, subunit 20.033
znf536zinc finger protein 5360.033
lamb4laminin, beta 40.033
cap1Cap1 CAP, adenylate cyclase-associated protein 10.033
nt5e5'-nucleotidase, ecto (CD73)0.033
dag1dystroglycan 10.033
perpPERP, TP53 apoptosis effector0.032
mlphbmelanophilin b0.032
foxn1forkhead box N10.032
ctsdcathepsin D0.032
arf6ADP-ribosylation factor 60.031
clint1clathrin interactor 10.030
numblnumb homolog (Drosophila)-like0.030
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC1.000
proPO-A1prophenol oxidase A10.998
Rac2CG8556 gene product from transcript CG8556-RA0.966
Spn27ASerpin 27A0.958
Flo-2flotillin 20.936
Rac1CG2248 gene product from transcript CG2248-RA0.933
Lsp1alphaLarval serum protein 1 alpha0.905
Sp7Serine protease 70.878
PGRP-SDCG7496 gene product from transcript CG7496-RA0.866
Lsp1betaLarval serum protein 1 beta0.857
Rho1CG8416 gene product from transcript CG8416-RB0.821
PGRP-SAPeptidoglycan recognition protein SA0.796
EphrinCG1862 gene product from transcript CG1862-RA0.778
Cdc42CG12530 gene product from transcript CG12530-RA0.615
alpha-Man-IIbCG4606 gene product from transcript CG4606-RA0.540
grassGram-positive Specific Serine protease0.534
SPESpatzle-Processing Enzyme0.523
vavCG7893 gene product from transcript CG7893-RB0.452
p38bCG7393 gene product from transcript CG7393-RA0.450
Spn28DSerpin 28D0.429
Ras85DRas oncogene at 85D0.421
MP1Melanization Protease 10.364
imdimmune deficiency0.353
Eb1CG3265 gene product from transcript CG3265-RF0.321
alpha-Man-Ialpha Mannosidase I0.309
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.278
CG42377CG42377 gene product from transcript CG42377-RA0.264
PvrPDGF- and VEGF-receptor related0.243
CG8193CG8193 gene product from transcript CG8193-RA0.208
JraJun-related antigen0.202
Myd88CG2078 gene product from transcript CG2078-RA0.201
CG13144CG13144 gene product from transcript CG13144-RA0.180
Obp99bOdorant-binding protein 99b0.176
Fbp1Fat body protein 10.173
Spn1Serine protease inhibitor 10.169
Mekk1CG7717 gene product from transcript CG7717-RB0.150
Atg1Autophagy-specific gene 10.142
Nipped-ACG33554 gene product from transcript CG33554-RE0.137
Gs1Glutamine synthetase 10.135
CG18594CG18594 gene product from transcript CG18594-RA0.134
IrcImmune-regulated catalase0.134
alpha-Man-IIalpha Mannosidase II0.134
EphEph receptor tyrosine kinase0.131
CG13568CG13568 gene product from transcript CG13568-RG0.130
pirkpoor Imd response upon knock-in0.130
GpdhGlycerol 3 phosphate dehydrogenase0.129
Lsp2Larval serum protein 20.127
Vrp1Verprolin 10.122
CG6361CG6361 gene product from transcript CG6361-RA0.122
Or67dOdorant receptor 67d0.120
tbcetubulin-specific chaperone E0.120
Spn77BaSerpin 77Ba0.118
PGRP-LFPeptidoglycan recognition protein LF0.115
NcNedd2-like caspase0.112
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.109
ari-2ariadne 20.105
upd2unpaired 20.102
betaInt-nubeta[nu] integrin0.100
bip2CG2009 gene product from transcript CG2009-RA0.097
CG11376CG11376 gene product from transcript CG11376-RA0.088
Lsp1gammaLarval serum protein 1 gamma0.084
ppk25pickpocket 250.084
CG9184CG9184 gene product from transcript CG9184-RB0.083
GNBP1Gram-negative bacteria binding protein 10.073
CG12766CG12766 gene product from transcript CG12766-RA0.072
Fbp2Fat body protein 20.068
CG15917CG15917 gene product from transcript CG15917-RA0.068
Gr39aGustatory receptor 39a0.067
rempAreduced mechanoreceptor potential A0.067
Sgs1Salivary gland secretion 10.067
l(3)mbnlethal (3) malignant blood neoplasm0.067
DlicDynein light intermediate chain0.066
piepineapple eye0.066
Dhc64CDynein heavy chain 64C0.065
DNaseIIDeoxyribonuclease II0.064
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lystlysosomal trafficking regulator0.995
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.982
Mitfmicrophthalmia-associated transcription factor0.977
Kitkit oncogene0.707
Tyrp1tyrosinase-related protein 10.630
Bcl2B-cell leukemia/lymphoma 20.619
Map3k14mitogen-activated protein kinase kinase kinase 140.613
Ephb2Eph receptor B20.471
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.456
Rac1RAS-related C3 botulinum substrate 10.445
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.410
Ctnnb1catenin (cadherin associated protein), beta 10.313
PycardPYD and CARD domain containing0.242
Ltblymphotoxin B0.236
BaxBCL2-associated X protein0.197
Oca2oculocutaneous albinism II0.196
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.180
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.178
Trp53transformation related protein 530.172
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.162
Bak1BCL2-antagonist/killer 10.158
Tlr4toll-like receptor 40.146
Cd19CD19 antigen0.136
Grb2growth factor receptor bound protein 20.131
Ikzf1IKAROS family zinc finger 10.099
Casp4caspase 4, apoptosis-related cysteine peptidase0.092
Socs1suppressor of cytokine signaling 10.084
Tnftumor necrosis factor0.080
Il7interleukin 70.077
Cxcl13chemokine (C-X-C motif) ligand 130.076
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.075
Gbp5guanylate binding protein 50.075
Il1binterleukin 1 beta0.074
Arhgap1Rho GTPase activating protein 10.072
SrcRous sarcoma oncogene0.071
Efnb2ephrin B20.069
Slc26a4solute carrier family 26, member 40.058
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.053
Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.049
Efna3ephrin A30.048
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.045
Adam10a disintegrin and metallopeptidase domain 100.044
Epha4Eph receptor A40.042
Pmelpremelanosome protein0.041
Ifnginterferon gamma0.040
Pou2af1POU domain, class 2, associating factor 10.039
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.039
Toxthymocyte selection-associated high mobility group box0.038
Ptprcprotein tyrosine phosphatase, receptor type, C0.034
Rab38RAB38, member of RAS oncogene family0.034
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.032
Atp7aATPase, Cu++ transporting, alpha polypeptide0.032
Rnd3Rho family GTPase 30.031
Efnb1ephrin B10.031
Casp1caspase 10.030
Myo5amyosin VA0.029
Icosinducible T-cell co-stimulator0.028
Wdr1WD repeat domain 10.027
Mapk10mitogen-activated protein kinase 100.026
Iqgap1IQ motif containing GTPase activating protein 10.026
Ccdc88acoiled coil domain containing 88A0.026
Arpc4actin related protein 2/3 complex, subunit 40.025
Slc24a5solute carrier family 24, member 50.024
Il4interleukin 40.023
Cxcr5chemokine (C-X-C motif) receptor 50.023
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.022
Mapk8mitogen-activated protein kinase 80.022
Il18interleukin 180.021
Slc45a2solute carrier family 45, member 20.021
Klc1kinesin light chain 10.021
Plcg1phospholipase C, gamma 10.021
Nf1neurofibromatosis 10.020
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.020
Krt2keratin 20.020
Gdnfglial cell line derived neurotrophic factor0.019
Ltbrlymphotoxin B receptor0.019
Mc1rmelanocortin 1 receptor0.019
Krt33bkeratin 33B0.018
Prkceprotein kinase C, epsilon0.018
Crb2crumbs homolog 2 (Drosophila)0.017
Ephb3Eph receptor B30.017
Gata6GATA binding protein 60.016
Drd4dopamine receptor D40.015
Ednrbendothelin receptor type B0.015
Ptpn12protein tyrosine phosphatase, non-receptor type 120.015
Gata4GATA binding protein 40.015
Id2inhibitor of DNA binding 20.015
Ikzf3IKAROS family zinc finger 30.014
Ncf1neutrophil cytosolic factor 10.014
Plxna4plexin A40.014
Sav1salvador homolog 1 (Drosophila)0.013
Hif1ahypoxia inducible factor 1, alpha subunit0.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism