The network for 'negative regulation of protein ubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.

NameDescriptionProbabilityFunc Analog Organism
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.865
SMAD7SMAD family member 70.849
TP53tumor protein p530.662
SMURF2SMAD specific E3 ubiquitin protein ligase 20.517
DAXXdeath-domain associated protein0.517
UBCubiquitin C0.424
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.419
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.384
SMAD4SMAD family member 40.374
HSPA1Bheat shock 70kDa protein 1B0.367
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.347
TRAF6TNF receptor-associated factor 60.334
HUWE1HECT, UBA and WWE domain containing 10.321
DTX3Ldeltex 3-like (Drosophila)0.314
RNF11ring finger protein 110.266
MAP3K7mitogen-activated protein kinase kinase kinase 70.246
SMAD1SMAD family member 10.200
HSPA1Aheat shock 70kDa protein 1A0.200
SMAD5SMAD family member 50.173
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.156
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.145
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.134
MBD1methyl-CpG binding domain protein 10.128
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.118
BIRC2baculoviral IAP repeat containing 20.117
TRIM21tripartite motif containing 210.116
CAV1caveolin 1, caveolae protein, 22kDa0.114
BAG3BCL2-associated athanogene 30.114
NOXA1NADPH oxidase activator 10.114
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.111
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.110
SP110SP110 nuclear body protein0.107
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.105
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.103
PARP9poly (ADP-ribose) polymerase family, member 90.103
PARP14poly (ADP-ribose) polymerase family, member 140.102
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.101
POU3F2POU class 3 homeobox 20.099
ZRANB1zinc finger, RAN-binding domain containing 10.095
ZNF496zinc finger protein 4960.091
UHRF2ubiquitin-like with PHD and ring finger domains 20.089
CDC27cell division cycle 27 homolog (S. cerevisiae)0.087
GSK3Bglycogen synthase kinase 3 beta0.085
HSPA4heat shock 70kDa protein 40.084
SMAD3SMAD family member 30.079
MED15mediator complex subunit 150.079
POU5F1POU class 5 homeobox 10.078
FBXW11F-box and WD repeat domain containing 110.076
SPRY4sprouty homolog 4 (Drosophila)0.075
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.066
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.065
PTENphosphatase and tensin homolog0.065
ZNF263zinc finger protein 2630.065
HIPK2homeodomain interacting protein kinase 20.064
RNF111ring finger protein 1110.062
WWP2WW domain containing E3 ubiquitin protein ligase 20.061
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.060
ARIH2ariadne homolog 2 (Drosophila)0.060
CCNB1cyclin B10.059
IRAK2interleukin-1 receptor-associated kinase 20.055
PAX3paired box 30.055
HSPA8heat shock 70kDa protein 80.054
PRKCZprotein kinase C, zeta0.054
SMAD2SMAD family member 20.051
HERC2hect domain and RLD 20.051
PMLpromyelocytic leukemia0.050
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.049
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.049
ARRB1arrestin, beta 10.049
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.048
TRIM5tripartite motif containing 50.046
CHORDC1cysteine and histidine-rich domain (CHORD) containing 10.045
IRAK1interleukin-1 receptor-associated kinase 10.045
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.044
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.044
NEDD4neural precursor cell expressed, developmentally down-regulated 40.044
SKP2S-phase kinase-associated protein 2 (p45)0.044
SIAH1seven in absentia homolog 1 (Drosophila)0.043
SETDB1SET domain, bifurcated 10.042
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.041
PRKCBprotein kinase C, beta0.041
PRKCAprotein kinase C, alpha0.041
NCOA3nuclear receptor coactivator 30.041
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.040
EGFRepidermal growth factor receptor0.040
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.040
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.040
FLNBfilamin B, beta0.039
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.039
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.039
SLC39A7solute carrier family 39 (zinc transporter), member 70.038
ELK1ELK1, member of ETS oncogene family0.038
HSPH1heat shock 105kDa/110kDa protein 10.038
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.038
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.037
CFL1cofilin 1 (non-muscle)0.037
CDCP1CUB domain containing protein 10.037
NCLnucleolin0.036
IRF7interferon regulatory factor 70.035
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Per2period homolog 2 (Drosophila)0.901
Cry2cryptochrome 2 (photolyase-like)0.810
Arntlaryl hydrocarbon receptor nuclear translocator-like0.523
Psen1presenilin 10.369
Clockcircadian locomotor output cycles kaput0.251
Iigp1interferon inducible GTPase 10.192
Shhsonic hedgehog0.129
Ncoa3nuclear receptor coactivator 30.121
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.116
Aim2absent in melanoma 20.107
Usp18ubiquitin specific peptidase 180.099
Wnt3awingless-related MMTV integration site 3A0.089
Arrb1arrestin, beta 10.080
Notch1Notch gene homolog 1 (Drosophila)0.079
Trp53transformation related protein 530.079
Gbp3guanylate binding protein 30.066
Ifih1interferon induced with helicase C domain 10.065
Rpgrip1lRpgrip1-like0.063
Oasl22'-5' oligoadenylate synthetase-like 20.063
Kdm2blysine (K)-specific demethylase 2B0.062
Irf9interferon regulatory factor 90.062
Lrrk2leucine-rich repeat kinase 20.059
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.048
Arrb2arrestin, beta 20.044
Ptrfpolymerase I and transcript release factor0.042
Gclmglutamate-cysteine ligase, modifier subunit0.042
Rargretinoic acid receptor, gamma0.042
Irgm2immunity-related GTPase family M member 20.038
Casp4caspase 4, apoptosis-related cysteine peptidase0.036
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.036
Igtpinterferon gamma induced GTPase0.036
Per1period homolog 1 (Drosophila)0.035
Ifit1interferon-induced protein with tetratricopeptide repeats 10.033
Wnt4wingless-related MMTV integration site 40.033
Gli3GLI-Kruppel family member GLI30.032
Pax2paired box gene 20.031
Axin1axin 10.030
Wnt10bwingless related MMTV integration site 10b0.030
Sgol2shugoshin-like 2 (S. pombe)0.030
Fgf8fibroblast growth factor 80.029
Smad6MAD homolog 6 (Drosophila)0.029
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.028
Use1unconventional SNARE in the ER 1 homolog (S. cerevisiae)0.028
Hspa8heat shock protein 80.027
Gdnfglial cell line derived neurotrophic factor0.027
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.027
Csnk1ecasein kinase 1, epsilon0.027
Dkk1dickkopf homolog 1 (Xenopus laevis)0.026
Ncstnnicastrin0.026
Usp2ubiquitin specific peptidase 20.024
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.024
ND6NADH dehydrogenase subunit 60.024
Casp1caspase 10.024
Pou3f1POU domain, class 3, transcription factor 10.024
Cdx1caudal type homeobox 10.024
Rtp4receptor transporter protein 40.023
Irgm1immunity-related GTPase family M member 10.023
Kpna1karyopherin (importin) alpha 10.023
Pthlhparathyroid hormone-like peptide0.022
Ror2receptor tyrosine kinase-like orphan receptor 20.022
Irf7interferon regulatory factor 70.022
Sap18Sin3-associated polypeptide 180.021
Ifit3interferon-induced protein with tetratricopeptide repeats 30.021
Amhr2anti-Mullerian hormone type 2 receptor0.021
Lhx1LIM homeobox protein 10.020
Stat1signal transducer and activator of transcription 10.020
Ptch1patched homolog 10.020
Klklotho0.019
Tgtp2T-cell specific GTPase 20.019
Cacybpcalcyclin binding protein0.019
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.018
Sh3bp1SH3-domain binding protein 10.017
Ccne1cyclin E10.017
Cdk5r2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.017
Ikbkapinhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein0.017
Fbxl3F-box and leucine-rich repeat protein 30.017
Foxm1forkhead box M10.017
Ccna2cyclin A20.017
Rnf19aring finger protein 19A0.017
Psmb10proteasome (prosome, macropain) subunit, beta type 100.017
Tbrachyury0.016
Ccne2cyclin E20.016
Chmp2achromatin modifying protein 2A0.016
Setdb1SET domain, bifurcated 10.016
En1engrailed 10.016
Wnt9awingless-type MMTV integration site 9A0.016
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.016
Notch2Notch gene homolog 2 (Drosophila)0.016
SkilSKI-like0.016
Atg12autophagy-related 12 (yeast)0.016
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.015
SrcRous sarcoma oncogene0.015
H2-Q7histocompatibility 2, Q region locus 70.015
Per3period homolog 3 (Drosophila)0.015
Cdk2cyclin-dependent kinase 20.015
Rnf2ring finger protein 20.015
Ctnnb1catenin (cadherin associated protein), beta 10.015
Iqcb1IQ calmodulin-binding motif containing 10.014
Parp14poly (ADP-ribose) polymerase family, member 140.014
Bmp4bone morphogenetic protein 40.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism