The network for 'ventricular cardiac muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ventricular cardiac muscle cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.

NameDescriptionProbabilityFunc Analog Organism
MED25mediator complex subunit 250.977
CDK2cyclin-dependent kinase 20.877
TBX5T-box 50.726
BMPR1Abone morphogenetic protein receptor, type IA0.605
HDAC4histone deacetylase 40.583
CKS1BCDC28 protein kinase regulatory subunit 1B0.361
CDK1cyclin-dependent kinase 10.253
RXRAretinoid X receptor, alpha0.247
RARAretinoic acid receptor, alpha0.240
HNF4Ahepatocyte nuclear factor 4, alpha0.212
SPOPspeckle-type POZ protein0.204
FLNAfilamin A, alpha0.192
NCOA1nuclear receptor coactivator 10.183
CCNB2cyclin B20.141
CCNA2cyclin A20.132
CCNE1cyclin E10.121
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.119
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.088
HDAC9histone deacetylase 90.086
WDFY3WD repeat and FYVE domain containing 30.086
SRFserum response factor (c-fos serum response element-binding transcription factor)0.079
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.078
ITGA7integrin, alpha 70.077
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.075
CCNB1cyclin B10.073
ITGB4integrin, beta 40.071
CKS2CDC28 protein kinase regulatory subunit 20.068
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.067
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.064
KANK2KN motif and ankyrin repeat domains 20.061
GATA4GATA binding protein 40.055
FSTL1follistatin-like 10.049
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.044
FHL3four and a half LIM domains 30.043
MEF2Amyocyte enhancer factor 2A0.037
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.036
NCOA3nuclear receptor coactivator 30.036
FLNBfilamin B, beta0.033
PSEN2presenilin 2 (Alzheimer disease 4)0.032
ACTN4actinin, alpha 40.031
CDC27cell division cycle 27 homolog (S. cerevisiae)0.024
PBX1pre-B-cell leukemia homeobox 10.023
TUBB6tubulin, beta 60.022
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.022
ARandrogen receptor0.021
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.020
CD151CD151 molecule (Raph blood group)0.019
NR5A2nuclear receptor subfamily 5, group A, member 20.019
UBE2Kubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)0.018
CTBP2C-terminal binding protein 20.018
HIST2H3Chistone cluster 2, H3c0.018
SPTBN1spectrin, beta, non-erythrocytic 10.016
PRKD2protein kinase D20.016
TRPM7transient receptor potential cation channel, subfamily M, member 70.015
ZNF512Bzinc finger protein 512B0.014
TAGLN2transgelin 20.014
AHNAKAHNAK nucleoprotein0.014
EEF2Keukaryotic elongation factor-2 kinase0.014
ITGB1BP2integrin beta 1 binding protein (melusin) 20.014
USP25ubiquitin specific peptidase 250.014
TCF4transcription factor 40.014
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.013
PDLIM7PDZ and LIM domain 7 (enigma)0.013
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.013
ALOX12arachidonate 12-lipoxygenase0.013
CREBBPCREB binding protein0.013
INCENPinner centromere protein antigens 135/155kDa0.013
RXRGretinoid X receptor, gamma0.012
ZFYVE9zinc finger, FYVE domain containing 90.012
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.012
VTA1Vps20-associated 1 homolog (S. cerevisiae)0.012
TP53BP1tumor protein p53 binding protein 10.012
TOP2Atopoisomerase (DNA) II alpha 170kDa0.012
PBKPDZ binding kinase0.012
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.012
ECHDC1enoyl CoA hydratase domain containing 10.011
HRhairless homolog (mouse)0.011
FOXC1forkhead box C10.011
ACACAacetyl-CoA carboxylase alpha0.010
BMPR1Bbone morphogenetic protein receptor, type IB0.010
PTK6PTK6 protein tyrosine kinase 60.010
ATF3activating transcription factor 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.997
bmp4bone morphogenetic protein 40.994
ttnatitin a0.946
nkx2.5NK2 transcription factor related 50.930
vmhcventricular myosin heavy chain0.881
hey2hairy/enhancer-of-split related with YRPW motif 20.617
actc1bactin, alpha, cardiac muscle 1b0.556
desmadesmin a0.553
myl1myosin, light chain 1, alkali; skeletal, fast0.475
myl7myosin, light polypeptide 7, regulatory0.409
tnnc2troponin C type 2 (fast)0.357
mylz2myosin, light polypeptide 2, skeletal muscle0.336
atp2a2aATPase, Ca++ transporting, cardiac muscle, slow twitch 2a0.258
actc1aactin, alpha, cardiac muscle 1a0.256
gpr126G protein-coupled receptor 1260.225
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.224
mef2camyocyte enhancer factor 2ca0.194
sema3aasemaphorin 3aa0.183
fgf8afibroblast growth factor 8 a0.182
ttnbtitin b0.178
tnnc1btroponin C type 1b (slow)0.175
rarabretinoic acid receptor, alpha b0.147
tbx5aT-box 5a0.136
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.115
casq2calsequestrin 20.098
smyd1bSET and MYND domain containing 1b0.098
fgf3fibroblast growth factor 30.090
tbx20T-box 200.088
wnt11rwingless-type MMTV integration site family, member 11, related0.088
ldb3bLIM domain binding 3b0.086
tnnc1atroponin C type 1a (slow)0.082
nexnnexilin (F actin binding protein)0.072
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.066
rxrgaretinoid x receptor, gamma a0.065
myod1myogenic differentiation 10.062
cx43connexin 430.056
aldh1a2aldehyde dehydrogenase 1 family, member A20.052
tmem38atransmembrane protein 38A0.051
aldoabaldolase a, fructose-bisphosphate, b0.051
cmlc1cardiac myosin light chain-10.047
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.047
tnni1btroponin I, skeletal, slow b0.047
tbx1T-box 10.044
synpo2lbsynaptopodin 2-like b0.041
mylz3myosin, light polypeptide 3, skeletal muscle0.041
brd2abromodomain-containing 2a0.040
egr1early growth response 10.038
dlx2adistal-less homeobox gene 2a0.037
tnni2a.4troponin I, skeletal, fast 2a.40.037
pvalb2parvalbumin 20.036
tbx18T-box 180.033
pcdh10bprotocadherin 10b0.033
gata6GATA-binding protein 60.031
ckmbcreatine kinase, muscle b0.030
alcamaactivated leukocyte cell adhesion molecule a0.030
tnnt3btroponin T3b, skeletal, fast0.030
pvalb4parvalbumin 40.030
ckmacreatine kinase, muscle a0.030
tnnt2atroponin T2a, cardiac0.029
foxh1forkhead box H10.029
actn3bactinin alpha 3b0.028
egr2bearly growth response 2b0.025
tbx5bT-box 5b0.024
hand2heart and neural crest derivatives expressed transcript 20.023
nanos3nanos homolog 30.022
tpm2tropomyosin 2 (beta)0.022
tbx2aT-box gene 2a0.021
ogg18-oxoguanine DNA glycosylase0.020
efnb2aephrin B2a0.019
scn4basodium channel, voltage-gated, type IV, beta a0.019
aldh1a3aldehyde dehydrogenase 1 family, member A30.019
lama4laminin, alpha 40.019
smyhc1slow myosin heavy chain 10.018
scn12absodium channel, voltage gated, type XII, alpha b0.018
vdravitamin D receptor a0.017
fstafollistatin a0.017
cpoxcoproporphyrinogen oxidase0.017
hhexhematopoietically expressed homeobox0.017
klf4Kruppel-like factor 40.017
etv5bets variant 5b0.016
cav3caveolin 30.015
bmp2abone morphogenetic protein 2a0.014
vmhclventricular myosin heavy chain-like0.014
jph2junctophilin 20.014
ccna2cyclin A20.014
mef2dmyocyte enhancer factor 2d0.014
atp1b3bATPase, Na+/K+ transporting, beta 3b polypeptide0.014
acta1bactin, alpha 1b, skeletal muscle0.013
hsp90a.1heat shock protein 90-alpha 10.013
raraaretinoic acid receptor, alpha a0.013
tmem2transmembrane protein 20.012
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.012
cmybtranscription factor cmyb0.012
hspb7heat shock protein family, alpha-crystallin-related, b70.012
hspd1heat shock 60kD protein 1 (chaperonin)0.012
fgf18afibroblast growth factor 18a0.012
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hand2heart and neural crest derivatives expressed transcript 21.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Hand1heart and neural crest derivatives expressed transcript 10.999
Fgf8fibroblast growth factor 80.998
Shhsonic hedgehog0.998
Gata4GATA binding protein 40.995
Bmp7bone morphogenetic protein 70.993
Tbx1T-box 10.992
Rargretinoic acid receptor, gamma0.990
Bmp4bone morphogenetic protein 40.984
Foxc1forkhead box C10.983
Sox9SRY-box containing gene 90.982
Tgfb2transforming growth factor, beta 20.980
Fgfr2fibroblast growth factor receptor 20.980
Pitx2paired-like homeodomain transcription factor 20.963
Isl1ISL1 transcription factor, LIM/homeodomain0.959
Foxc2forkhead box C20.957
Rxraretinoid X receptor alpha0.951
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.949
Ednraendothelin receptor type A0.924
Fgfr3fibroblast growth factor receptor 30.900
Tcfap2atranscription factor AP-2, alpha0.896
Prrx1paired related homeobox 10.877
Msx1homeobox, msh-like 10.806
Fgfr1fibroblast growth factor receptor 10.782
Ptpn11protein tyrosine phosphatase, non-receptor type 110.760
Ece1endothelin converting enzyme 10.716
Acvr1activin A receptor, type 10.702
Smosmoothened homolog (Drosophila)0.683
Hoxa1homeobox A10.657
Vegfavascular endothelial growth factor A0.638
Ntf3neurotrophin 30.633
Pax2paired box gene 20.572
Nr2f2nuclear receptor subfamily 2, group F, member 20.560
Mesp1mesoderm posterior 10.528
Gata6GATA binding protein 60.513
Eya1eyes absent 1 homolog (Drosophila)0.499
Rspo2R-spondin 2 homolog (Xenopus laevis)0.473
Hey2hairy/enhancer-of-split related with YRPW motif 20.465
Ror2receptor tyrosine kinase-like orphan receptor 20.424
Gata5GATA binding protein 50.419
Rarbretinoic acid receptor, beta0.413
Tbx3T-box 30.361
Gli3GLI-Kruppel family member GLI30.342
Jag1jagged 10.301
Zfpm2zinc finger protein, multitype 20.300
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.279
Tbx5T-box 50.252
Gscgoosecoid homeobox0.248
Pax8paired box gene 80.236
Gli2GLI-Kruppel family member GLI20.234
Otx2orthodenticle homolog 2 (Drosophila)0.211
Runx2runt related transcription factor 20.205
Dlx5distal-less homeobox 50.201
Birc5baculoviral IAP repeat-containing 50.190
Alx4aristaless-like homeobox 40.187
Pax3paired box gene 30.181
Nrp1neuropilin 10.180
Msx2homeobox, msh-like 20.180
Hdac4histone deacetylase 40.180
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.162
Thrbthyroid hormone receptor beta0.140
Ltbp1latent transforming growth factor beta binding protein 10.137
Tgfbr2transforming growth factor, beta receptor II0.136
Thrathyroid hormone receptor alpha0.136
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.130
Itgb1integrin beta 1 (fibronectin receptor beta)0.125
Nkx6-1NK6 homeobox 10.122
Hdac5histone deacetylase 50.121
Gja1gap junction protein, alpha 10.118
Efnb2ephrin B20.108
Pdx1pancreatic and duodenal homeobox 10.107
Foxh1forkhead box H10.106
Fgfrl1fibroblast growth factor receptor-like 10.105
Pbx1pre B-cell leukemia transcription factor 10.096
Hoxd13homeobox D130.096
Fgf15fibroblast growth factor 150.095
DbpD site albumin promoter binding protein0.094
Foxe1forkhead box E10.094
Chd7chromodomain helicase DNA binding protein 70.093
Pthlhparathyroid hormone-like peptide0.092
Tcf21transcription factor 210.090
Gdf6growth differentiation factor 60.089
Mef2dmyocyte enhancer factor 2D0.088
Gja5gap junction protein, alpha 50.088
Rararetinoic acid receptor, alpha0.085
Prrx2paired related homeobox 20.081
Myl3myosin, light polypeptide 30.079
Nr2f1nuclear receptor subfamily 2, group F, member 10.078
Alx3aristaless-like homeobox 30.078
Hey1hairy/enhancer-of-split related with YRPW motif 10.077
Ccna2cyclin A20.075
Bmpr1abone morphogenetic protein receptor, type 1A0.074
Chrm2cholinergic receptor, muscarinic 2, cardiac0.073
Cdk1cyclin-dependent kinase 10.071
Prc1protein regulator of cytokinesis 10.070
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.068
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.068
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pttg1pituitary tumor-transforming 10.185
Traf4af1TRAF4 associated factor 10.142
Cdk1cyclin-dependent kinase 10.138
Top2atopoisomerase (DNA) II alpha0.123
Cdkn3cyclin-dependent kinase inhibitor 30.082
Ube2cubiquitin-conjugating enzyme E2C0.057
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.043
Ns5atp9NS5A (hepatitis C virus) transactivated protein 90.037
Cdca3cell division cycle associated 30.028
Rrm2ribonucleotide reductase M20.026
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.021
Cks2CDC28 protein kinase regulatory subunit 20.019
Nusap1nucleolar and spindle associated protein 10.018
Cox8bcytochrome c oxidase, subunit VIIIb0.015
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.015
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.014
Depdc1DEP domain containing 10.014
Hmmrhyaluronan mediated motility receptor (RHAMM)0.012
LOC689399hypothetical protein LOC6893990.012
Actc1actin, alpha, cardiac muscle 10.012
Epn1Epsin 10.012
Hand2heart and neural crest derivatives expressed 20.011
Myom1myomesin 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism