The network for 'response to amino acid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to amino acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.948
UBR1ubiquitin protein ligase E3 component n-recognin 10.925
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.787
DLG4discs, large homolog 4 (Drosophila)0.787
TOB1transducer of ERBB2, 10.764
RRAGCRas-related GTP binding C0.709
COL1A1collagen, type I, alpha 10.627
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.562
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.552
CAV1caveolin 1, caveolae protein, 22kDa0.536
GARSglycyl-tRNA synthetase0.477
COL3A1collagen, type III, alpha 10.418
IARSisoleucyl-tRNA synthetase0.414
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.401
UHRF1ubiquitin-like with PHD and ring finger domains 10.387
GSTM2glutathione S-transferase mu 2 (muscle)0.295
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.255
ACTG1actin, gamma 10.236
BCL2L1BCL2-like 10.213
COL1A2collagen, type I, alpha 20.195
ASNSasparagine synthetase (glutamine-hydrolyzing)0.187
GSK3Bglycogen synthase kinase 3 beta0.184
MTORmechanistic target of rapamycin (serine/threonine kinase)0.184
NOSTRINnitric oxide synthase trafficker0.181
LAMTOR2late endosomal/lysosomal adaptor, MAPK and MTOR activator 20.124
NCF1neutrophil cytosolic factor 10.119
ESRRGestrogen-related receptor gamma0.110
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.108
DNMT1DNA (cytosine-5-)-methyltransferase 10.094
NRP1neuropilin 10.092
EIF4Eeukaryotic translation initiation factor 4E0.089
COL4A1collagen, type IV, alpha 10.081
RRAGDRas-related GTP binding D0.080
MDM2Mdm2 p53 binding protein homolog (mouse)0.079
MARSmethionyl-tRNA synthetase0.077
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.071
MAPTmicrotubule-associated protein tau0.070
COL5A1collagen, type V, alpha 10.069
PDGFAplatelet-derived growth factor alpha polypeptide0.063
BECN1beclin 1, autophagy related0.060
AARSalanyl-tRNA synthetase0.059
LAMTOR3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.057
EEDembryonic ectoderm development0.057
GSTM4glutathione S-transferase mu 40.057
BCL2B-cell CLL/lymphoma 20.054
CCR5chemokine (C-C motif) receptor 50.051
AGXT2alanine--glyoxylate aminotransferase 20.044
THBS1thrombospondin 10.043
BBS1Bardet-Biedl syndrome 10.042
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.042
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.041
AGTR2angiotensin II receptor, type 20.040
SARSseryl-tRNA synthetase0.040
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.039
PPARGperoxisome proliferator-activated receptor gamma0.037
CASP8caspase 8, apoptosis-related cysteine peptidase0.036
CYR61cysteine-rich, angiogenic inducer, 610.035
CASP7caspase 7, apoptosis-related cysteine peptidase0.035
FADDFas (TNFRSF6)-associated via death domain0.034
FBN1fibrillin 10.034
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.033
LRRK2leucine-rich repeat kinase 20.032
PRDX1peroxiredoxin 10.031
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.031
EPRSglutamyl-prolyl-tRNA synthetase0.028
CASP10caspase 10, apoptosis-related cysteine peptidase0.027
CAPNS1calpain, small subunit 10.026
AKT1v-akt murine thymoma viral oncogene homolog 10.026
YARStyrosyl-tRNA synthetase0.025
CARScysteinyl-tRNA synthetase0.025
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.022
TFRCtransferrin receptor (p90, CD71)0.021
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.021
COL4A2collagen, type IV, alpha 20.021
FERMT2fermitin family member 20.021
C7orf59chromosome 7 open reading frame 590.020
GSTM3glutathione S-transferase mu 3 (brain)0.020
SHMT2serine hydroxymethyltransferase 2 (mitochondrial)0.019
AKT1S1AKT1 substrate 1 (proline-rich)0.019
COL5A2collagen, type V, alpha 20.019
HBXIPhepatitis B virus x interacting protein0.018
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.018
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.017
FASLGFas ligand (TNF superfamily, member 6)0.017
FN1fibronectin 10.017
JAK2Janus kinase 20.017
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.017
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.016
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.016
CFL2cofilin 2 (muscle)0.016
CTNND1catenin (cadherin-associated protein), delta 10.015
PTENphosphatase and tensin homolog0.015
XIAPX-linked inhibitor of apoptosis0.015
HSPG2heparan sulfate proteoglycan 20.015
LOXlysyl oxidase0.015
CDCP1CUB domain containing protein 10.014
COL16A1collagen, type XVI, alpha 10.014
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.013
DEPTORDEP domain containing MTOR-interacting protein0.013
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
emb-9Protein EMB-90.024
ifg-1Protein IFG-10.018
pqn-59Protein PQN-590.016
sax-7Protein SAX-70.014
F48A11.4Protein F48A11.40.014
mig-6Protein MIG-60.013
F21C10.7Protein F21C10.70.013
chd-1Protein CHD-10.012
M02E1.1Protein M02E1.10.012
plc-3Protein PLC-30.011
lgc-39Protein LGC-390.011
npp-11Protein NPP-110.010
npp-13Protein NPP-130.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
col1a1acollagen, type I, alpha 1a0.999
col1a2collagen, type I, alpha 20.979
col12a1collagen, type XII, alpha 10.906
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.860
col5a1procollagen, type V, alpha 10.814
gad2glutamate decarboxylase 20.776
postnperiostin, osteoblast specific factor0.761
ca15bcarbonic anhydrase XV b0.651
sparcsecreted acidic cysteine rich glycoprotein0.596
stat3signal transduction and activation of transcription 30.583
socs3asuppressor of cytokine signaling 3a0.579
rab11fip4aRAB11 family interacting protein 4 (class II) a0.539
fgfrl1afibroblast growth factor receptor-like 1a0.513
col5a2lcollagen, type V, alpha 2-like0.457
col1a1bcollagen, type I, alpha 1b0.444
mmp9matrix metalloproteinase 90.390
mmp2matrix metalloproteinase 20.377
ehd2EH-domain containing 20.363
apoebapolipoprotein Eb0.299
pcnaproliferating cell nuclear antigen0.294
stc1lstanniocalcin 1, like0.289
ctskcathepsin K0.269
dnmt8DNA (cytosine-5-)-methyltransferase 80.267
dnmt4DNA (cytosine-5-)-methyltransferase 40.263
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.255
aldh1a3aldehyde dehydrogenase 1 family, member A30.247
chsy1chondroitin sulfate synthase 10.237
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.235
olfml3bolfactomedin-like 3b0.233
il8interleukin 80.223
dnmt7DNA (cytosine-5-)-methyltransferase 70.219
chrna4cholinergic receptor, nicotinic, alpha 40.207
krt8keratin 80.196
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.191
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.190
col6a3collagen, type VI, alpha 30.183
piwil1piwi-like 1 (Drosophila)0.176
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.174
mmp14bmatrix metalloproteinase 14b (membrane-inserted)0.166
dnmt1DNA (cytosine-5-)-methyltransferase 10.165
matn4matrilin 40.148
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.146
il1binterleukin 1, beta and interleukin 1, beta0.143
sat1aspermidine/spermine N1-acetyltransferase 1a0.140
anxa2aannexin A2a0.140
tgfbitransforming growth factor, beta-induced0.139
igfbp5ainsulin-like growth factor binding protein 5a0.137
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.132
sst3somatostatin 30.129
mpzmyelin protein zero0.128
fynaFYN oncogene related to SRC, FGR, YES a0.127
mcm3MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)0.123
slc15a1bsolute carrier family 15 (oligopeptide transporter), member 1b0.122
nanos3nanos homolog 30.121
nlgn2bneuroligin 2b0.121
LOC799612prolactin 20.118
pdlim3aPDZ and LIM domain 3a0.117
krt15keratin 150.116
gcm2glial cells missing homolog 2 (Drosophila)0.115
vldlrvery low density lipoprotein receptor0.112
tpm3tropomyosin 30.111
farsbphenylalanyl-tRNA synthetase, beta subunit0.109
prickle2prickle-like 2 (Drosophila)0.107
slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.107
kiss1KiSS-1 metastasis-suppressor0.107
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.106
sybusyntabulin (syntaxin-interacting)0.106
thbs4bthrombospondin 4b0.103
prickle1bprickle homolog 1 (Drosophila) b0.103
sp2sp2 transcription factor0.103
acvr1bactivin A receptor, type IB0.101
capza1bcapping protein (actin filament) muscle Z-line, alpha 1b0.097
pou4f2POU domain, class 4, transcription factor 20.096
morc3bMORC family CW-type zinc finger 3b0.096
mycamyelocytomatosis oncogene a0.096
fasFas (TNF receptor superfamily, member 6)0.095
anxa11bannexin A11b0.093
slc1a3bsolute carrier family 1 (glial high affinity glutamate transporter), member 3b0.092
thbs1thrombospondin 10.090
dnmt6DNA (cytosine-5-)-methyltransferase 60.090
ikzf1IKAROS family zinc finger 1 (Ikaros)0.089
h1mlinker histone H1M0.089
junbljun B proto-oncogene, like0.087
shisa2shisa homolog 2 (Xenopus laevis)0.086
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.085
pth2rparathyroid hormone 2 receptor0.085
lsrlipolysis stimulated lipoprotein receptor0.083
cbsbcystathionine-beta-synthase b0.082
pdgfrlplatelet-derived growth factor receptor-like0.079
junjun proto-oncogene0.079
vasavasa homolog0.079
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Akt1CG4006 gene product from transcript CG4006-RA0.061
Octbeta2RCG33976 gene product from transcript CG33976-RA0.032
CG13253CG13253 gene product from transcript CG13253-RB0.028
Bet5CG1359 gene product from transcript CG1359-RA0.020
CG8372CG8372 gene product from transcript CG8372-RA0.018
CG5110CG5110 gene product from transcript CG5110-RA0.016
CG14837CG14837 gene product from transcript CG14837-RC0.013
RagACG11968 gene product from transcript CG11968-RA0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.999
Leprleptin receptor0.995
Ighimmunoglobulin heavy chain complex0.984
Trp53transformation related protein 530.983
Col6a1collagen, type VI, alpha 10.978
Stat3signal transducer and activator of transcription 30.959
Ptenphosphatase and tensin homolog0.942
Col4a1collagen, type IV, alpha 10.919
Col1a2collagen, type I, alpha 20.917
Dnmt3bDNA methyltransferase 3B0.877
Tnftumor necrosis factor0.873
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.871
Col3a1collagen, type III, alpha 10.863
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.849
Tgfb1transforming growth factor, beta 10.847
Col4a2collagen, type IV, alpha 20.822
Col5a2collagen, type V, alpha 20.820
Ccl2chemokine (C-C motif) ligand 20.810
Ifnginterferon gamma0.803
Lrp1low density lipoprotein receptor-related protein 10.797
Col6a2collagen, type VI, alpha 20.764
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.750
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.737
Apoeapolipoprotein E0.727
Mtormechanistic target of rapamycin (serine/threonine kinase)0.672
Dnmt3aDNA methyltransferase 3A0.657
Mmp9matrix metallopeptidase 90.630
Vegfavascular endothelial growth factor A0.630
Nos3nitric oxide synthase 3, endothelial cell0.630
Csf1colony stimulating factor 1 (macrophage)0.614
Ldlrlow density lipoprotein receptor0.574
Lama5laminin, alpha 50.567
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.565
Jak2Janus kinase 20.544
Hspg2perlecan (heparan sulfate proteoglycan 2)0.537
Col4a3collagen, type IV, alpha 30.535
Fbn1fibrillin 10.531
Neurl1aneuralized homolog 1A (Drosophila)0.522
Il6stinterleukin 6 signal transducer0.517
Cpeb3cytoplasmic polyadenylation element binding protein 30.515
Zeb1zinc finger E-box binding homeobox 10.500
Ltbp2latent transforming growth factor beta binding protein 20.489
Col6a3collagen, type VI, alpha 30.486
Ctskcathepsin K0.485
Ezh2enhancer of zeste homolog 2 (Drosophila)0.455
Smad3MAD homolog 3 (Drosophila)0.453
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.452
FasFas (TNF receptor superfamily member 6)0.451
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.442
Cd44CD44 antigen0.434
Lyz2lysozyme 20.433
Ptpn11protein tyrosine phosphatase, non-receptor type 110.389
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.378
Irs1insulin receptor substrate 10.376
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.373
Nr1h4nuclear receptor subfamily 1, group H, member 40.363
Nos1nitric oxide synthase 1, neuronal0.361
RoraRAR-related orphan receptor alpha0.353
Col4a5collagen, type IV, alpha 50.352
Ltbp3latent transforming growth factor beta binding protein 30.341
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.333
Tnctenascin C0.329
Runx2runt related transcription factor 20.317
Bak1BCL2-antagonist/killer 10.317
Lmnalamin A0.317
Bcl2B-cell leukemia/lymphoma 20.308
Bglapbone gamma carboxyglutamate protein0.308
Ptgs2prostaglandin-endoperoxide synthase 20.307
Mmp2matrix metallopeptidase 20.302
Ncoa3nuclear receptor coactivator 30.283
Lama4laminin, alpha 40.281
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.279
Il4interleukin 40.278
Il6interleukin 60.278
BaxBCL2-associated X protein0.274
Itgb1integrin beta 1 (fibronectin receptor beta)0.264
Vdrvitamin D receptor0.262
Tubb5tubulin, beta 50.237
Il10interleukin 100.231
Ppargperoxisome proliferator activated receptor gamma0.221
Egfrepidermal growth factor receptor0.218
Col11a1collagen, type XI, alpha 10.216
Tnfaip3tumor necrosis factor, alpha-induced protein 30.215
Ltalymphotoxin A0.214
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.213
Cd19CD19 antigen0.212
Tbx3T-box 30.207
Fgfr2fibroblast growth factor receptor 20.207
Col4a6collagen, type IV, alpha 60.207
Nfibnuclear factor I/B0.207
Ikzf1IKAROS family zinc finger 10.201
Postnperiostin, osteoblast specific factor0.200
Pthlhparathyroid hormone-like peptide0.200
Wt1Wilms tumor 1 homolog0.198
Plcg1phospholipase C, gamma 10.197
Tspan12tetraspanin 120.196
Klf15Kruppel-like factor 150.194
Fstl1follistatin-like 10.190
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gstm1glutathione S-transferase mu 10.947
Ccl2chemokine (C-C motif) ligand 20.904
Cd14CD14 molecule0.780
Ephx1epoxide hydrolase 1, microsomal0.753
Fn1fibronectin 10.646
Il1binterleukin 1 beta0.622
Icam1intercellular adhesion molecule 10.564
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.482
Gstm2glutathione S-transferase mu 20.476
Col3a1collagen, type III, alpha 10.472
Mmp3matrix metallopeptidase 30.441
Cdk4cyclin-dependent kinase 40.424
Mgst2microsomal glutathione S-transferase 20.419
Ccl4chemokine (C-C motif) ligand 40.402
BokBCL2-related ovarian killer0.352
Gsta3glutathione S-transferase A30.348
Prdx2peroxiredoxin 20.313
Casp1caspase 10.307
Mgst1microsomal glutathione S-transferase 10.304
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.298
Cxcl10chemokine (C-X-C motif) ligand 100.282
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.271
Anxa5annexin A50.262
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.259
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.254
G6pdglucose-6-phosphate dehydrogenase0.245
Mgpmatrix Gla protein0.232
Tgfb1transforming growth factor, beta 10.221
Jak1Janus kinase 10.219
Ccl20chemokine (C-C motif) ligand 200.210
Loxlysyl oxidase0.209
Coro1bcoronin, actin-binding protein, 1B0.192
Cyp51cytochrome P450, family 510.191
Vipvasoactive intestinal peptide0.190
Mmp12matrix metallopeptidase 120.189
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.186
Il6interleukin 60.180
PawrPRKC, apoptosis, WT1, regulator0.179
Reg3gregenerating islet-derived 3 gamma0.177
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.173
Tnftumor necrosis factor (TNF superfamily, member 2)0.164
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.163
Ntf4neurotrophin 40.157
Gpx1glutathione peroxidase 10.156
Fkbp1aFK506 binding protein 1a0.151
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.150
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.148
Cyb5acytochrome b5 type A (microsomal)0.147
Timp1TIMP metallopeptidase inhibitor 10.141
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.138
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.135
Eif4ebp1eukaryotic translation initiation factor 4E binding protein 10.133
Ifnginterferon gamma0.132
Pfn1profilin 10.132
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.131
Col5a2collagen, type V, alpha 20.127
Aebp1AE binding protein 10.126
Mmp2matrix metallopeptidase 20.125
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.125
Il2rbinterleukin 2 receptor, beta0.122
Postnperiostin, osteoblast specific factor0.122
Pkm2pyruvate kinase, muscle0.121
Cdh17cadherin 170.120
Lgals3lectin, galactoside-binding, soluble, 30.119
Hmox1heme oxygenase (decycling) 10.116
Anxa2annexin A20.115
Stat6signal transducer and activator of transcription 60.109
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.108
Col12a1collagen, type XII, alpha 10.108
Timp2TIMP metallopeptidase inhibitor 20.107
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.107
Capn8calpain 80.106
Hist1h1ahistone cluster 1, H1a0.106
Cacnb3calcium channel, voltage-dependent, beta 3 subunit0.102
Myo1bmyosin Ib0.100
Cd36CD36 molecule (thrombospondin receptor)0.100
Casp7caspase 70.097
Fapfibroblast activation protein, alpha0.097
Ces1ccarboxylesterase 1C0.094
Stat4signal transducer and activator of transcription 40.094
Klk8kallikrein related-peptidase 80.093
F2rl1coagulation factor II (thrombin) receptor-like 10.092
Expiextracellular proteinase inhibitor0.092
Pcolceprocollagen C-endopeptidase enhancer0.092
Gstt1glutathione S-transferase theta 10.090
Starsteroidogenic acute regulatory protein0.090
Gsta4glutathione S-transferase alpha 40.090
TcrbT-cell receptor beta chain0.090
Dhfrdihydrofolate reductase0.089
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.088
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.088
Pla1aphospholipase A1 member A0.087
Aqp8aquaporin 80.087
Cela1chymotrypsin-like elastase family, member 10.086
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism