The network for 'tube closure' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tube closure

Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold.

NameDescriptionProbabilityFunc Analog Organism
TSC2tuberous sclerosis 20.820
LRRK2leucine-rich repeat kinase 20.796
CASP9caspase 9, apoptosis-related cysteine peptidase0.742
BCORBCL6 corepressor0.678
TRRAPtransformation/transcription domain-associated protein0.649
DVL3dishevelled, dsh homolog 3 (Drosophila)0.628
MEOX2mesenchyme homeobox 20.548
SOX10SRY (sex determining region Y)-box 100.454
PPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16A0.446
BBS1Bardet-Biedl syndrome 10.421
APCadenomatous polyposis coli0.417
MED25mediator complex subunit 250.361
EP300E1A binding protein p3000.344
USP9Xubiquitin specific peptidase 9, X-linked0.337
CNKSR2connector enhancer of kinase suppressor of Ras 20.333
SMAD3SMAD family member 30.324
AXIN1axin 10.317
SEC24DSEC24 family, member D (S. cerevisiae)0.286
CASP3caspase 3, apoptosis-related cysteine peptidase0.277
SEC23ASec23 homolog A (S. cerevisiae)0.273
CSNK1Ecasein kinase 1, epsilon0.250
AKAP11A kinase (PRKA) anchor protein 110.250
RXRAretinoid X receptor, alpha0.244
DVL1dishevelled, dsh homolog 1 (Drosophila)0.242
SETD8SET domain containing (lysine methyltransferase) 80.234
WASF2WAS protein family, member 20.215
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.211
C9orf89chromosome 9 open reading frame 890.205
FAT1FAT tumor suppressor homolog 1 (Drosophila)0.198
TSC1tuberous sclerosis 10.191
MBD2methyl-CpG binding domain protein 20.190
ARID1BAT rich interactive domain 1B (SWI1-like)0.182
MED29mediator complex subunit 290.159
ZFXzinc finger protein, X-linked0.146
LDB1LIM domain binding 10.145
USP22ubiquitin specific peptidase 220.141
ABI1abl-interactor 10.135
PUM1pumilio homolog 1 (Drosophila)0.133
LIN28Blin-28 homolog B (C. elegans)0.131
PCM1pericentriolar material 10.128
ZRANB1zinc finger, RAN-binding domain containing 10.117
ZFYVE9zinc finger, FYVE domain containing 90.116
XIAPX-linked inhibitor of apoptosis0.111
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.111
CLASP2cytoplasmic linker associated protein 20.110
WNT3Awingless-type MMTV integration site family, member 3A0.109
CARD11caspase recruitment domain family, member 110.109
PEX26peroxisomal biogenesis factor 260.109
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.109
BBS2Bardet-Biedl syndrome 20.107
CRMP1collapsin response mediator protein 10.102
MED24mediator complex subunit 240.101
SMAD4SMAD family member 40.099
VASPvasodilator-stimulated phosphoprotein0.096
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.096
CTBP2C-terminal binding protein 20.089
SORBS3sorbin and SH3 domain containing 30.088
PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 20.084
DLG5discs, large homolog 5 (Drosophila)0.082
EPAS1endothelial PAS domain protein 10.080
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.079
TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.077
BMP7bone morphogenetic protein 70.077
DKK1dickkopf homolog 1 (Xenopus laevis)0.076
GLI1GLI family zinc finger 10.075
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.075
AKIP1A kinase (PRKA) interacting protein 10.074
TRIP6thyroid hormone receptor interactor 60.074
WT1Wilms tumor 10.070
CDC37cell division cycle 37 homolog (S. cerevisiae)0.069
PKP4plakophilin 40.069
CSNK1Dcasein kinase 1, delta0.068
WNT5Awingless-type MMTV integration site family, member 5A0.068
ATXN7ataxin 70.068
ANKRD28ankyrin repeat domain 280.067
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.066
BMP2bone morphogenetic protein 20.065
SEC24ASEC24 family, member A (S. cerevisiae)0.065
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.064
MID1IP1MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))0.064
WASF1WAS protein family, member 10.064
PRKAR2Bprotein kinase, cAMP-dependent, regulatory, type II, beta0.064
GSK3Bglycogen synthase kinase 3 beta0.062
STK36serine/threonine kinase 360.061
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.061
TADA2Atranscriptional adaptor 2A0.060
AARSD1alanyl-tRNA synthetase domain containing 10.060
KCTD1potassium channel tetramerisation domain containing 10.059
FZD1frizzled homolog 1 (Drosophila)0.058
MED16mediator complex subunit 160.058
SMURF2SMAD specific E3 ubiquitin protein ligase 20.058
ZMYND11zinc finger, MYND-type containing 110.058
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.057
PFN1profilin 10.057
MTMR4myotubularin related protein 40.057
SMAD1SMAD family member 10.054
RYR2ryanodine receptor 2 (cardiac)0.054
SIN3ASIN3 homolog A, transcription regulator (yeast)0.054
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt5bwingless-type MMTV integration site family, member 5b0.633
fgf3fibroblast growth factor 30.600
ift88intraflagellar transport 88 homolog0.578
gpc4glypican 40.483
tbx2bT-box 2b0.436
bocbrother of CDO0.426
sp5lSp5 transcription factor-like0.423
tbx1T-box 10.410
tll1tolloid-like 10.406
bmp2bbone morphogenetic protein 2b0.404
foxd3forkhead box D30.385
wnt11wingless-type MMTV integration site family, member 110.358
gli2aGLI-Kruppel family member GLI2a0.289
flhfloating head0.283
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.280
lrrc6leucine rich repeat containing 60.278
gyltl1bglycosyltransferase-like 1b0.273
foxi1forkhead box I10.252
pkd2polycystic kidney disease 20.236
arl13bADP-ribosylation factor-like 13b0.230
ext1aexostoses (multiple) 1a0.206
gli1GLI-Kruppel family member 10.181
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.179
cdoncell adhesion molecule-related/down-regulated by oncogenes0.178
lamb1alaminin, beta 1a0.159
alcambactivated leukocyte cell adhesion molecule b0.158
fgf8afibroblast growth factor 8 a0.156
smosmoothened homolog (Drosophila)0.156
nkd1naked cuticle homolog 1 (Drosophila)0.151
kif17kinesin family member 170.146
eya1eyes absent homolog 10.142
sox3SRY-box containing gene 30.141
dzip1DAZ interacting protein 10.136
dync1h1dynein, cytoplasmic 1, heavy chain 10.134
spns2spinster homolog 2 (Drosophila)0.132
rargaretinoic acid receptor gamma a0.132
hoxb1bhomeo box B1b0.131
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.131
gpr98G protein-coupled receptor 980.127
plxnb2aplexin b2a0.127
mab21l2mab-21-like 20.127
wnt4awingless-type MMTV integration site family, member 4a0.126
efnb3bephrin B3b0.125
ift57intraflagellar transport protein 570.116
myh10myosin, heavy polypeptide 10, non-muscle and myosin, heavy chain 10, non-muscle0.115
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.113
spry2sprouty homolog 20.113
cc2d2acoiled-coil and C2 domain containing 2A0.112
six2asine oculis-related homeobox 2a0.108
prdm14PR domain containing 140.107
epb41l5erythrocyte membrane protein band 4.1 like 50.106
disp1dispatched homolog 1 (Drosophila)0.105
fgf24fibroblast growth factor 240.101
fzd7afrizzled homolog 7a0.099
rereaarginine-glutamic acid dipeptide (RE) repeats a0.099
zeb1zinc finger E-box binding homeobox 10.097
pcdh19protocadherin 190.096
otx1borthodenticle homolog 1b0.094
fzd10frizzled homolog 100.094
fgfr2fibroblast growth factor receptor 20.090
bmpr1abbone morphogenetic protein receptor, type 1ab0.090
shhasonic hedgehog a0.089
tpbgltrophoblast glycoprotein-like0.088
crtapcartilage associated protein0.087
raraaretinoic acid receptor, alpha a0.086
ier2immediate early response 20.085
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.085
mbtps1membrane-bound transcription factor protease, site 10.085
fn1fibronectin 10.084
vangl2vang-like 2 (van gogh, Drosophila)0.083
axin1axin 10.081
irx1airoquois homeobox protein 1, a0.080
efhc1EF-hand domain (C-terminal) containing 10.080
zic5zic family member 5 (odd-paired homolog, Drosophila)0.078
rykreceptor-like tyrosine kinase0.076
rarabretinoic acid receptor, alpha b0.074
dixdc1aDIX domain containing 1a0.074
sema6dlsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like0.073
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.073
kif3bkinesin family member 3B0.072
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.072
efnb2aephrin B2a0.072
zeb2azinc finger E-box binding homeobox 2a0.071
dctn1adynactin 1a0.071
ctbp2C-terminal binding protein 20.071
wnt2bbwingless-type MMTV integration site family, member 2Bb0.070
derl1Der1-like domain family, member 10.070
lrmplymphoid-restricted membrane protein0.069
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.067
lama5laminin, alpha 50.067
loxl2blysyl oxidase-like 2b0.067
ier5limmediate early response 5-like0.067
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.067
ccdc40coiled-coil domain containing 400.066
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Pax3paired box gene 31.000
Shhsonic hedgehog1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Otx2orthodenticle homolog 2 (Drosophila)0.998
Pitx2paired-like homeodomain transcription factor 20.997
Fgfr2fibroblast growth factor receptor 20.995
Tbx3T-box 30.993
Pax6paired box gene 60.991
Dvl2dishevelled 2, dsh homolog (Drosophila)0.989
Pbx1pre B-cell leukemia transcription factor 10.986
Pax2paired box gene 20.984
Smosmoothened homolog (Drosophila)0.981
Gli2GLI-Kruppel family member GLI20.976
Tcfap2atranscription factor AP-2, alpha0.975
Rargretinoic acid receptor, gamma0.972
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.972
Msx1homeobox, msh-like 10.967
Fgf10fibroblast growth factor 100.963
Dvl3dishevelled 3, dsh homolog (Drosophila)0.961
Wt1Wilms tumor 1 homolog0.955
Sox2SRY-box containing gene 20.947
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.942
Sall4sal-like 4 (Drosophila)0.939
Rarbretinoic acid receptor, beta0.922
Lhx1LIM homeobox protein 10.906
Foxc1forkhead box C10.905
Hoxa13homeobox A130.901
Eya1eyes absent 1 homolog (Drosophila)0.901
Hoxa11homeobox A110.891
Zic3zinc finger protein of the cerebellum 30.891
Alx4aristaless-like homeobox 40.886
Fgf8fibroblast growth factor 80.885
Pitx1paired-like homeodomain transcription factor 10.876
Prrx1paired related homeobox 10.868
Hoxa1homeobox A10.866
Lhx3LIM homeobox protein 30.856
Msx2homeobox, msh-like 20.849
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.841
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.817
Ascl1achaete-scute complex homolog 1 (Drosophila)0.810
Hoxd13homeobox D130.808
Ror2receptor tyrosine kinase-like orphan receptor 20.806
Apcadenomatosis polyposis coli0.805
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.776
Sox11SRY-box containing gene 110.766
Tcf15transcription factor 150.760
Hoxd11homeobox D110.753
Pax8paired box gene 80.746
Hoxa2homeobox A20.738
Efna2ephrin A20.725
Hoxa9homeobox A90.718
Bmp4bone morphogenetic protein 40.700
Bmp7bone morphogenetic protein 70.695
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.678
Neurog2neurogenin 20.676
Pou5f1POU domain, class 5, transcription factor 10.671
Hes5hairy and enhancer of split 5 (Drosophila)0.668
Rnf2ring finger protein 20.654
Wnt3awingless-related MMTV integration site 3A0.643
Hoxb4homeobox B40.640
Tbx2T-box 20.637
Dkk1dickkopf homolog 1 (Xenopus laevis)0.637
Shox2short stature homeobox 20.619
Pax7paired box gene 70.606
Fgfr1fibroblast growth factor receptor 10.606
Zic2zinc finger protein of the cerebellum 20.604
Foxc2forkhead box C20.599
Emx2empty spiracles homolog 2 (Drosophila)0.596
Fzd1frizzled homolog 1 (Drosophila)0.588
Ptf1apancreas specific transcription factor, 1a0.585
Nr5a1nuclear receptor subfamily 5, group A, member 10.580
Ptk7PTK7 protein tyrosine kinase 70.568
Lmx1aLIM homeobox transcription factor 1 alpha0.555
Dlx5distal-less homeobox 50.552
Wnt5awingless-related MMTV integration site 5A0.542
Insm1insulinoma-associated 10.530
Wnt6wingless-related MMTV integration site 60.527
Gbx2gastrulation brain homeobox 20.525
Hoxd9homeobox D90.525
Nhlh1nescient helix loop helix 10.521
Tsc2tuberous sclerosis 20.518
Foxg1forkhead box G10.510
Tcfap2ctranscription factor AP-2, gamma0.504
Gscgoosecoid homeobox0.499
Hoxa5homeobox A50.497
Alx3aristaless-like homeobox 30.497
Pax9paired box gene 90.490
Smad1MAD homolog 1 (Drosophila)0.479
Meox2mesenchyme homeobox 20.473
Foxf1aforkhead box F1a0.468
Hand2heart and neural crest derivatives expressed transcript 20.467
Pou3f3POU domain, class 3, transcription factor 30.457
Ptch1patched homolog 10.454
Neurod1neurogenic differentiation 10.451
Hoxa3homeobox A30.449
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism