The network for 'regulation of cardiac muscle cell contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of cardiac muscle cell contraction

Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.

NameDescriptionProbabilityFunc Analog Organism
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.992
JUPjunction plakoglobin0.988
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.982
DLG4discs, large homolog 4 (Drosophila)0.969
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.964
MPZL2myelin protein zero-like 20.952
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.945
CTNND1catenin (cadherin-associated protein), delta 10.941
KCNE1potassium voltage-gated channel, Isk-related family, member 10.928
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.921
ACTN2actinin, alpha 20.919
PSEN1presenilin 10.900
DSC2desmocollin 20.876
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.806
SCN5Asodium channel, voltage-gated, type V, alpha subunit0.786
DSG2desmoglein 20.773
MPZL3myelin protein zero-like 30.766
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.715
KRT14keratin 140.690
SNTG2syntrophin, gamma 20.622
LIN7Blin-7 homolog B (C. elegans)0.603
PKP3plakophilin 30.530
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.521
KCNIP2Kv channel interacting protein 20.499
MAPK12mitogen-activated protein kinase 120.325
CLCN3chloride channel 30.314
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.294
DTNAdystrobrevin, alpha0.235
PTPRJprotein tyrosine phosphatase, receptor type, J0.226
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.206
APCadenomatous polyposis coli0.197
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.183
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.179
PKP2plakophilin 20.178
TRIM29tripartite motif containing 290.144
CTNNBIP1catenin, beta interacting protein 10.143
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.140
ADAM11ADAM metallopeptidase domain 110.133
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.108
GLE1GLE1 RNA export mediator homolog (yeast)0.108
PKP4plakophilin 40.090
PSEN2presenilin 2 (Alzheimer disease 4)0.088
KCNIP1Kv channel interacting protein 10.081
EGFRepidermal growth factor receptor0.080
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.079
ERBB2IPerbb2 interacting protein0.075
DLGAP1discs, large (Drosophila) homolog-associated protein 10.069
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.067
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.058
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.058
LAD1ladinin 10.056
FRMD5FERM domain containing 50.054
MYOZ1myozenin 10.049
KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 10.048
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.046
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.042
CDH3cadherin 3, type 1, P-cadherin (placental)0.041
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.038
KRT5keratin 50.037
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.037
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.036
ZFYVE9zinc finger, FYVE domain containing 90.036
KRT8keratin 80.034
WDYHV1WDYHV motif containing 10.034
MARK3MAP/microtubule affinity-regulating kinase 30.032
FLNBfilamin B, beta0.031
RHAGRh-associated glycoprotein0.031
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.031
AKAP6A kinase (PRKA) anchor protein 60.030
COL17A1collagen, type XVII, alpha 10.029
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.028
CDH15cadherin 15, type 1, M-cadherin (myotubule)0.027
DPP6dipeptidyl-peptidase 60.027
GJB3gap junction protein, beta 3, 31kDa0.026
GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.025
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.024
HRH3histamine receptor H30.024
EHD1EH-domain containing 10.023
NLGN1neuroligin 10.023
KCNG3potassium voltage-gated channel, subfamily G, member 30.023
DSG1desmoglein 10.023
KCNB2potassium voltage-gated channel, Shab-related subfamily, member 20.023
TBX5T-box 50.022
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.021
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.021
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 50.020
ATP1B2ATPase, Na+/K+ transporting, beta 2 polypeptide0.020
OPRD1opioid receptor, delta 10.020
GLIS2GLIS family zinc finger 20.019
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.019
HAND2heart and neural crest derivatives expressed 20.018
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.018
NOS1nitric oxide synthase 1 (neuronal)0.018
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.573
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.273
cldnbclaudin b0.256
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.195
cmlc1cardiac myosin light chain-10.150
adrb2aadrenergic receptor, beta 2a0.148
mpzmyelin protein zero0.129
anxa11bannexin A11b0.114
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.094
krt8keratin 80.083
six2asine oculis-related homeobox 2a0.082
LOC100000433hypothetical LOC1000004330.077
tnnt2atroponin T2a, cardiac0.077
sdprbserum deprivation response b0.062
tnnc1atroponin C type 1a (slow)0.062
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.059
dsg2desmoglein 20.056
synpo2lbsynaptopodin 2-like b0.052
myl7myosin, light polypeptide 7, regulatory0.047
pvalb8parvalbumin 80.046
slc24a5solute carrier family 24, member 50.043
jupjunction plakoglobin0.042
perpPERP, TP53 apoptosis effector0.040
atp1a1a.3ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide0.040
slc38a3solute carrier family 38, member 30.039
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.038
scn4basodium channel, voltage-gated, type IV, beta a0.036
mgaMAX gene associated0.035
dnajaDnaJ (Hsp40) homolog, subfamily A member0.035
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.034
cldnhclaudin h0.034
igfbp3insulin-like growth factor binding protein 30.032
cfdlcomplement factor D (adipsin) like0.031
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.031
tspan7btetraspanin 7b0.030
anxa11aannexin A11a0.028
agr2anterior gradient homolog 2 (Xenopus laevis)0.028
scn12absodium channel, voltage gated, type XII, alpha b0.027
il8interleukin 80.027
matn1matrilin 10.027
cdh17cadherin 17, LI cadherin (liver-intestine)0.027
trpc1transient receptor potential cation channel, subfamily C, member 10.025
pmelapremelanosome protein a0.024
rbm24aRNA binding motif protein 24a0.024
foxi3aforkhead box I3a0.023
scn12aasodium channel, voltage gated, type XII, alpha a0.023
mybpc3myosin binding protein C, cardiac0.023
cox6a1cytochrome c oxidase subunit VIa polypeptide 10.023
kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.023
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.022
sparcsecreted acidic cysteine rich glycoprotein0.022
lin7clin-7 homolog C (C. elegans)0.022
ca2carbonic anhydrase II0.022
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.021
fhlafour and a half LIM domains a0.021
m17IL-6 subfamily cytokine M170.021
hnf1bbHNF1 homeobox Bb0.021
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.020
ripk4receptor-interacting serine-threonine kinase 40.020
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.020
rhcgbRhesus blood group, C glycoprotein b0.020
scn3bsodium channel, voltage-gated, type III, beta0.019
eporerythropoietin receptor0.019
aspnasporin (LRR class 1)0.018
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.018
tm9sf2transmembrane 9 superfamily member 20.018
scn2bsodium channel, voltage-gated, type II, beta0.018
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.018
tp53tumor protein p530.018
papss2b3'-phosphoadenosine 5'-phosphosulfate synthase 2b0.017
hdlbphigh density lipoprotein-binding protein (vigilin)0.017
rapsnreceptor-associated protein of the synapse, 43kD0.017
bcdo2lbeta-carotene 15, 15-dioxygenase 2, like0.016
ldb3aLIM-domain binding factor 3a0.016
gamtguanidinoacetate N-methyltransferase0.016
actn2actinin, alpha 20.016
dsc2ldesmocollin 2 like0.016
bidaBH3 interacting domain death agonist0.016
trpm7transient receptor potential cation channel, subfamily M, member 70.016
llgl2lethal giant larvae homolog 2 (Drosophila)0.016
actc1aactin, alpha, cardiac muscle 1a0.015
ypel1yippee-like 1 (Drosophila)0.015
zc4h2zinc finger, C4H2 domain containing0.015
rhoaaras homolog gene family, member Aa0.015
eya4eyes absent homolog 4 (Drosophila)0.015
flot1bflotillin 1b0.015
grifingalectin related inter-fiber protein0.015
hmgn3high mobility group nucleosomal binding domain 30.014
ftr82finTRIM family, member 820.014
ddtD-dopachrome tautomerase0.014
tnni1btroponin I, skeletal, slow b0.014
ppargperoxisome proliferator activated receptor gamma0.014
dspadesmoplakin a0.014
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Scn5asodium channel, voltage-gated, type V, alpha0.992
Ryr2ryanodine receptor 2, cardiac0.987
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.978
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.877
Tbx5T-box 50.808
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.474
Tbx3T-box 30.379
Gja1gap junction protein, alpha 10.248
Tjp1tight junction protein 10.218
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.177
Scn1asodium channel, voltage-gated, type I, alpha0.124
Ldb3LIM domain binding 30.120
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.108
Dsg2desmoglein 20.085
Dmddystrophin, muscular dystrophy0.082
Xirp1xin actin-binding repeat containing 10.077
Nos3nitric oxide synthase 3, endothelial cell0.067
Hand2heart and neural crest derivatives expressed transcript 20.064
Kcnk3potassium channel, subfamily K, member 30.063
Casq2calsequestrin 20.058
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.057
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.057
Rnf112ring finger protein 1120.055
Gata6GATA binding protein 60.052
Spna1spectrin alpha 10.044
Cacna2d2calcium channel, voltage-dependent, alpha 2/delta subunit 20.043
Ptpn11protein tyrosine phosphatase, non-receptor type 110.041
Cxadrcoxsackie virus and adenovirus receptor0.041
Vegfavascular endothelial growth factor A0.039
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.039
Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.039
Tnni2troponin I, skeletal, fast 20.037
Gata4GATA binding protein 40.035
Gjd3gap junction protein, delta 30.034
Itga7integrin alpha 70.033
Pygmmuscle glycogen phosphorylase0.032
Mybpc3myosin binding protein C, cardiac0.030
Hrchistidine rich calcium binding protein0.029
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.025
Cntn4contactin 40.025
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.024
Dsc1desmocollin 10.023
Pcdh12protocadherin 120.023
Ighmbp2immunoglobulin mu binding protein 20.022
Srrm4serine/arginine repetitive matrix 40.022
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.022
Myom2myomesin 20.020
Ckmt2creatine kinase, mitochondrial 20.020
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.020
Dmpkdystrophia myotonica-protein kinase0.020
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.020
Gjb2gap junction protein, beta 20.019
Gjb6gap junction protein, beta 60.019
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.019
Cdh4cadherin 40.018
Rbbp7retinoblastoma binding protein 70.018
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.018
Hif1ahypoxia inducible factor 1, alpha subunit0.018
Kcnd2potassium voltage-gated channel, Shal-related family, member 20.017
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.017
Fam164cfamily with sequence similarity 164, member C0.017
SpegSPEG complex locus0.016
Wnt11wingless-related MMTV integration site 110.016
Srpk3serine/arginine-rich protein specific kinase 30.016
Cdh13cadherin 130.016
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.016
Mmp15matrix metallopeptidase 150.016
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.016
Gja5gap junction protein, alpha 50.015
PerpPERP, TP53 apoptosis effector0.015
Sstr3somatostatin receptor 30.015
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.015
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.015
Cox8bcytochrome c oxidase, subunit VIIIb0.015
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.015
Hey2hairy/enhancer-of-split related with YRPW motif 20.015
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.014
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.014
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.014
Epas1endothelial PAS domain protein 10.014
Emp2epithelial membrane protein 20.014
Crhr2corticotropin releasing hormone receptor 20.013
Limch1LIM and calponin homology domains 10.013
Gad2glutamic acid decarboxylase 20.013
Gjb5gap junction protein, beta 50.013
Kcna7potassium voltage-gated channel, shaker-related subfamily, member 70.013
Usp13ubiquitin specific peptidase 13 (isopeptidase T-3)0.013
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.013
Myl3myosin, light polypeptide 30.013
Hsf4heat shock transcription factor 40.013
Fut2fucosyltransferase 20.012
Hbb-b1hemoglobin, beta adult major chain0.012
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.012
Coro6coronin 60.012
Spnb1spectrin beta 10.012
Wnk2WNK lysine deficient protein kinase 20.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.531
LOC100362824caveolin 2-like0.270
Fgf16fibroblast growth factor 160.201
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.156
Inhainhibin alpha0.132
Scn5asodium channel, voltage-gated, type V, alpha subunit0.122
Fgf14fibroblast growth factor 140.121
Appamyloid beta (A4) precursor protein0.098
Cav2caveolin 20.096
Strnstriatin, calmodulin binding protein0.088
Ppardperoxisome proliferator-activated receptor delta0.078
Gja3gap junction protein, alpha 30.076
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.075
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.062
Kcnk3potassium channel, subfamily K, member 30.060
Wipf3WAS/WASL interacting protein family, member 30.058
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.057
Casq2calsequestrin 2 (cardiac muscle)0.048
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.047
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.045
Prkcaprotein kinase C, alpha0.042
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.041
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.040
Grik3glutamate receptor, ionotropic, kainate 30.038
LOC680199hypothetical protein LOC6801990.036
Glra1glycine receptor, alpha 10.036
Chrm2cholinergic receptor, muscarinic 20.036
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.035
Batf3basic leucine zipper transcription factor, ATF-like 30.034
Nos3nitric oxide synthase 3, endothelial cell0.034
Ednraendothelin receptor type A0.034
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.033
Pla2g5phospholipase A2, group V0.030
Mchr1melanin-concentrating hormone receptor 10.029
Sptbn1spectrin, beta, non-erythrocytic 10.028
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.027
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.027
Rab20RAB20, member RAS oncogene family0.027
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.026
Tmem38atransmembrane protein 38a0.026
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.025
Sctrsecretin receptor0.025
Lrrc4bleucine rich repeat containing 4B0.024
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.024
A2bp1ataxin 2 binding protein 10.024
Hand2heart and neural crest derivatives expressed 20.024
RGD1564327similar to integrin alpha 80.023
Itpr1inositol 1,4,5-triphosphate receptor, type 10.023
Fgf7fibroblast growth factor 70.023
Phkg1phosphorylase kinase, gamma 10.023
Msx2msh homeobox 20.023
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.022
Slc14a2solute carrier family 14 (urea transporter), member 20.022
Gcm1glial cells missing homolog 1 (Drosophila)0.021
Cckarcholecystokinin A receptor0.021
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.020
Capn9calpain 90.020
Gad2glutamate decarboxylase 20.020
Kcnip2Kv channel-interacting protein 20.020
Gria1glutamate receptor, ionotropic, AMPA 10.020
Toretrispanning orphan0.020
Cryba1crystallin, beta A10.019
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.019
Wt1Wilms tumor 10.019
Dccdeleted in colorectal carcinoma0.019
Lim2lens intrinsic membrane protein 20.019
Galr1galanin receptor 10.018
Cav3caveolin 30.018
Myl7myosin, light chain 7, regulatory0.018
RGD1309036hypothetical LOC2928740.018
Tnni1troponin I type 1 (skeletal, slow)0.018
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.017
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.017
Trhrthyrotropin releasing hormone receptor0.017
Fitm1fat storage-inducing transmembrane protein 10.017
Fgf23fibroblast growth factor 230.017
Rab1bRAB1B, member RAS oncogene family0.017
Pgcprogastricsin (pepsinogen C)0.017
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.017
Nptxrneuronal pentraxin receptor0.017
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.017
Sh3bgrSH3 domain binding glutamic acid-rich protein0.017
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.017
Gzmkgranzyme K0.017
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.016
Aif1lallograft inflammatory factor 1-like0.016
Vom1r90vomeronasal 1 receptor 900.016
Prl8a2prolactin family 8, subfamily a, member 20.016
Hspb2heat shock protein beta 20.016
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.016
Arandrogen receptor0.016
Rims1regulating synaptic membrane exocytosis 10.015
Tnp1transition protein 10.015
Ros1c-ros oncogene 1 , receptor tyrosine kinase0.015
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.015
Syt8synaptotagmin VIII0.015
Mapk3mitogen activated protein kinase 30.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism