The network for 'cardiac muscle cell contraction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell contraction

The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.

NameDescriptionProbabilityFunc Analog Organism
DLG4discs, large homolog 4 (Drosophila)1.000
CDH1cadherin 1, type 1, E-cadherin (epithelial)1.000
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.999
MPZL2myelin protein zero-like 20.999
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.997
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.997
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.997
KCNE1potassium voltage-gated channel, Isk-related family, member 10.997
DSC2desmocollin 20.997
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.996
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.995
ACTN2actinin, alpha 20.995
JUPjunction plakoglobin0.994
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.992
MPZL3myelin protein zero-like 30.989
DSG2desmoglein 20.987
PKP3plakophilin 30.985
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.984
KCNIP2Kv channel interacting protein 20.980
PSEN1presenilin 10.971
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.961
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.957
LIN7Blin-7 homolog B (C. elegans)0.951
KRT14keratin 140.916
APCadenomatous polyposis coli0.912
CDH3cadherin 3, type 1, P-cadherin (placental)0.908
MAPK12mitogen-activated protein kinase 120.901
CTNND1catenin (cadherin-associated protein), delta 10.887
SPTBspectrin, beta, erythrocytic0.841
CLCN3chloride channel 30.755
DTNAdystrobrevin, alpha0.753
CTNNBIP1catenin, beta interacting protein 10.739
KRT5keratin 50.736
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.735
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.727
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.694
PKP2plakophilin 20.682
LAD1ladinin 10.652
PDCD6programmed cell death 60.640
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.622
MYOZ1myozenin 10.620
TRIM29tripartite motif containing 290.620
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.573
PTPRJprotein tyrosine phosphatase, receptor type, J0.560
CALM1calmodulin 1 (phosphorylase kinase, delta)0.539
RHAGRh-associated glycoprotein0.476
ADAM11ADAM metallopeptidase domain 110.446
DSC3desmocollin 30.437
ZFYVE9zinc finger, FYVE domain containing 90.401
DSG3desmoglein 30.386
DSG1desmoglein 10.380
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.375
GLE1GLE1 RNA export mediator homolog (yeast)0.374
FLNBfilamin B, beta0.359
FRMD5FERM domain containing 50.358
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.339
KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 10.338
CAPN2calpain 2, (m/II) large subunit0.329
PSEN2presenilin 2 (Alzheimer disease 4)0.327
AKAP6A kinase (PRKA) anchor protein 60.324
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 50.320
KRT16keratin 160.316
PKP4plakophilin 40.310
KRT18keratin 180.310
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.309
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.296
MARK3MAP/microtubule affinity-regulating kinase 30.295
ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome0.291
GJB3gap junction protein, beta 3, 31kDa0.287
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.286
DSC1desmocollin 10.286
KRT6Bkeratin 6B0.279
KCNG3potassium voltage-gated channel, subfamily G, member 30.270
ERBB2IPerbb2 interacting protein0.267
COL17A1collagen, type XVII, alpha 10.264
DLGAP1discs, large (Drosophila) homolog-associated protein 10.243
CDH15cadherin 15, type 1, M-cadherin (myotubule)0.234
GLIS2GLIS family zinc finger 20.226
TCF4transcription factor 40.224
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.217
KRT6Akeratin 6A0.211
KCNA2potassium voltage-gated channel, shaker-related subfamily, member 20.207
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.203
BSNbassoon (presynaptic cytomatrix protein)0.203
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.202
ACTR1AARP1 actin-related protein 1 homolog A, centractin alpha (yeast)0.195
BAI1brain-specific angiogenesis inhibitor 10.191
HRH3histamine receptor H30.190
KLK10kallikrein-related peptidase 100.188
PDZK1PDZ domain containing 10.186
GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.181
VEGFAvascular endothelial growth factor A0.181
PRKCGprotein kinase C, gamma0.178
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.178
OPRD1opioid receptor, delta 10.178
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.178
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.650
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.441
ldb3aLIM-domain binding factor 3a0.390
cmlc1cardiac myosin light chain-10.242
atp1a1a.3ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide0.221
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.158
tnnt2atroponin T2a, cardiac0.142
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.118
mybpc3myosin binding protein C, cardiac0.106
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.100
myl7myosin, light polypeptide 7, regulatory0.086
cldnhclaudin h0.079
tnnc1atroponin C type 1a (slow)0.071
rbm24aRNA binding motif protein 24a0.071
adrb2aadrenergic receptor, beta 2a0.068
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.067
cldnbclaudin b0.065
rassf7bRas association (RalGDS/AF-6) domain family (N-terminal) member 7b0.065
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.059
xirp1xin actin-binding repeat containing 10.056
sdprbserum deprivation response b0.055
synpo2lbsynaptopodin 2-like b0.055
anxa11bannexin A11b0.048
crb2acrumbs homolog 2a0.047
perpPERP, TP53 apoptosis effector0.043
jupjunction plakoglobin0.040
fhlafour and a half LIM domains a0.040
actn2actinin, alpha 20.038
ftr82finTRIM family, member 820.038
LOC100000433hypothetical LOC1000004330.037
pmelapremelanosome protein a0.037
arpc5aactin related protein 2/3 complex, subunit 5A0.034
agr2anterior gradient homolog 2 (Xenopus laevis)0.034
tnnc1btroponin C type 1b (slow)0.033
krt8keratin 80.031
syngr2asynaptogyrin 2a0.031
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.031
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.030
kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.029
scn12aasodium channel, voltage gated, type XII, alpha a0.029
dsg2desmoglein 20.029
tnni1btroponin I, skeletal, slow b0.028
dsc2ldesmocollin 2 like0.028
cabp1calcium binding protein 10.027
eya4eyes absent homolog 4 (Drosophila)0.027
lamc1laminin, gamma 10.027
anxa6annexin A60.026
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.026
vmhclventricular myosin heavy chain-like0.026
ddx18DEAD (Asp-Glu-Ala-Asp) box polypeptide 180.025
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.024
actc1aactin, alpha, cardiac muscle 1a0.024
scn4basodium channel, voltage-gated, type IV, beta a0.023
tbx18T-box 180.023
cfdlcomplement factor D (adipsin) like0.023
vmhcventricular myosin heavy chain0.022
pvalb8parvalbumin 80.022
papss2b3'-phosphoadenosine 5'-phosphosulfate synthase 2b0.021
rhcgbRhesus blood group, C glycoprotein b0.021
flot1bflotillin 1b0.021
bcl2l1bcl2-like 10.021
trpc1transient receptor potential cation channel, subfamily C, member 10.020
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.020
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.020
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.020
slc2a11bsolute carrier family 2 (facilitated glucose transporter), member 11b0.020
ing4inhibitor of growth family, member 40.019
rtn1breticulon 1b0.019
ndrg4N-myc downstream regulated gene 40.019
hist1h4lhistone 1, H4, like0.019
slc12a10.2solute carrier family 12 (sodium/potassium/chloride transporters), member 10.20.018
ucp3uncoupling protein 30.018
sept2septin 20.018
mlphbmelanophilin b0.018
ppargperoxisome proliferator activated receptor gamma0.018
LOC567131calcitonin gene-related peptide type 1 receptor-like0.018
il8interleukin 80.017
ccdc80coiled-coil domain containing 800.017
aspnasporin (LRR class 1)0.017
foxi3aforkhead box I3a0.016
adrb2badrenergic receptor, beta 2b0.016
plekha7pleckstrin homology domain containing, family A member 70.016
cotl1coactosin-like 1 (Dictyostelium)0.016
cdh17cadherin 17, LI cadherin (liver-intestine)0.016
trpm7transient receptor potential cation channel, subfamily M, member 70.016
six2asine oculis-related homeobox 2a0.016
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.016
slc24a5solute carrier family 24, member 50.015
scn12absodium channel, voltage gated, type XII, alpha b0.015
fabp11afatty acid binding protein 11a0.015
fxr1fragile X mental retardation, autosomal homolog 10.015
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Ryr2ryanodine receptor 2, cardiac0.999
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.998
Tbx5T-box 50.997
Scn5asodium channel, voltage-gated, type V, alpha0.996
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.973
Gja1gap junction protein, alpha 10.938
Tbx3T-box 30.920
Gja5gap junction protein, alpha 50.803
Scn1asodium channel, voltage-gated, type I, alpha0.779
Tjp1tight junction protein 10.743
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.709
Xirp1xin actin-binding repeat containing 10.614
Casq2calsequestrin 20.570
Kcnk3potassium channel, subfamily K, member 30.561
Dtnadystrobrevin alpha0.538
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.517
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.499
Ldb3LIM domain binding 30.492
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.452
Cxadrcoxsackie virus and adenovirus receptor0.408
Nos3nitric oxide synthase 3, endothelial cell0.399
Spnb1spectrin beta 10.390
Cacna2d2calcium channel, voltage-dependent, alpha 2/delta subunit 20.377
Gata6GATA binding protein 60.371
Dmddystrophin, muscular dystrophy0.371
Hbb-b1hemoglobin, beta adult major chain0.351
Dsg2desmoglein 20.345
Gjb6gap junction protein, beta 60.335
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.311
Rnf112ring finger protein 1120.289
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.286
Itga7integrin alpha 70.270
Mybpc3myosin binding protein C, cardiac0.267
Hand2heart and neural crest derivatives expressed transcript 20.251
Vegfavascular endothelial growth factor A0.248
Hrchistidine rich calcium binding protein0.237
Gata4GATA binding protein 40.216
Ighmbp2immunoglobulin mu binding protein 20.198
Ptpn11protein tyrosine phosphatase, non-receptor type 110.197
Epas1endothelial PAS domain protein 10.196
Dbx1developing brain homeobox 10.191
Pygmmuscle glycogen phosphorylase0.189
Tnni2troponin I, skeletal, fast 20.172
Dsc1desmocollin 10.165
Aplnrapelin receptor0.164
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.163
Hif1ahypoxia inducible factor 1, alpha subunit0.163
Flt1FMS-like tyrosine kinase 10.159
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.157
Snap25synaptosomal-associated protein 250.156
Myom2myomesin 20.155
Dmpkdystrophia myotonica-protein kinase0.151
Kcnd2potassium voltage-gated channel, Shal-related family, member 20.147
Dsc2desmocollin 20.146
Jag1jagged 10.145
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.137
Pcdh12protocadherin 120.136
Hey2hairy/enhancer-of-split related with YRPW motif 20.134
Gjb2gap junction protein, beta 20.133
Serpinb5serine (or cysteine) peptidase inhibitor, clade B, member 50.130
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.128
Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.128
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.126
Lama2laminin, alpha 20.124
Sstr3somatostatin receptor 30.122
SpegSPEG complex locus0.122
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.120
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.118
Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.116
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.115
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.114
Ntf3neurotrophin 30.111
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.108
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.106
PerpPERP, TP53 apoptosis effector0.106
Irx3Iroquois related homeobox 3 (Drosophila)0.105
Mmp15matrix metallopeptidase 150.103
Rbfox1RNA binding protein, fox-1 homolog (C. elegans) 10.101
Hspb7heat shock protein family, member 7 (cardiovascular)0.101
Adam17a disintegrin and metallopeptidase domain 170.100
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.098
Raf1v-raf-leukemia viral oncogene 10.098
Mpzmyelin protein zero0.097
Srpk3serine/arginine-rich protein specific kinase 30.096
Esrrgestrogen-related receptor gamma0.095
Rgs6regulator of G-protein signaling 60.094
Coro6coronin 60.093
Myl3myosin, light polypeptide 30.092
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.091
Cdh13cadherin 130.091
Atmataxia telangiectasia mutated homolog (human)0.090
Gpr37G protein-coupled receptor 370.090
Ckmt2creatine kinase, mitochondrial 20.088
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.085
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.085
Nppbnatriuretic peptide type B0.084
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.084
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.788
LOC100362824caveolin 2-like0.676
Scn5asodium channel, voltage-gated, type V, alpha subunit0.528
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.493
Lrrc4bleucine rich repeat containing 4B0.375
Fgf14fibroblast growth factor 140.325
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.316
Dlg4discs, large homolog 4 (Drosophila)0.237
Fgf16fibroblast growth factor 160.225
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.195
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.187
Gja3gap junction protein, alpha 30.181
Prdm2PR domain containing 2, with ZNF domain0.156
Gria1glutamate receptor, ionotropic, AMPA 10.152
Itpr1inositol 1,4,5-triphosphate receptor, type 10.147
Lim2lens intrinsic membrane protein 20.144
Kcng2potassium voltage-gated channel, subfamily G, member 20.142
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.136
Wipf3WAS/WASL interacting protein family, member 30.136
Hand2heart and neural crest derivatives expressed 20.132
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.130
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.112
Arandrogen receptor0.110
Pla2g5phospholipase A2, group V0.109
Aif1lallograft inflammatory factor 1-like0.105
Ppardperoxisome proliferator-activated receptor delta0.104
Prkcgprotein kinase C, gamma0.098
Tmem38atransmembrane protein 38a0.097
A2bp1ataxin 2 binding protein 10.096
Gad2glutamate decarboxylase 20.094
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.091
Cd46CD46 molecule, complement regulatory protein0.088
Aqp4aquaporin 40.086
Fitm1fat storage-inducing transmembrane protein 10.085
Wt1Wilms tumor 10.080
Inhainhibin alpha0.079
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.078
Prkcaprotein kinase C, alpha0.078
Gcm1glial cells missing homolog 1 (Drosophila)0.077
Nos3nitric oxide synthase 3, endothelial cell0.077
RGD1562344similar to Gm566 protein0.075
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.072
Trpc4transient receptor potential cation channel, subfamily C, member 40.072
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.070
Chp2calcineurin B homologous protein 20.069
Vom2r27vomeronasal 2 receptor, 270.069
Lrrc14bleucine rich repeat containing 14B0.069
Freqfrequenin homolog (Drosophila)0.068
Strnstriatin, calmodulin binding protein0.067
Dlx5distal-less homeobox 50.065
Slc14a2solute carrier family 14 (urea transporter), member 20.065
Mchr1melanin-concentrating hormone receptor 10.065
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.065
Appamyloid beta (A4) precursor protein0.065
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.064
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.064
RGD1305627hypothetical LOC3144670.063
Ptgfrprostaglandin F receptor0.063
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.062
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.061
Grik3glutamate receptor, ionotropic, kainate 30.060
Tbx19T-box 190.060
Gja1gap junction protein, alpha 10.059
Gnrh1gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)0.059
Olr416olfactory receptor 4160.058
Ryr2ryanodine receptor 2, cardiac0.057
Rimbp2RIMS binding protein 20.057
Inpp5jinositol polyphosphate-5-phosphatase J0.057
Rab20RAB20, member RAS oncogene family0.055
BokBCL2-related ovarian killer0.055
Hapln1hyaluronan and proteoglycan link protein 10.054
Casq2calsequestrin 2 (cardiac muscle)0.054
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.054
Tpsb2tryptase beta 20.053
Map1amicrotubule-associated protein 1A0.053
Ank2ankyrin 2, neuronal0.053
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.053
Cpne9copine family member IX0.053
Il9rinterleukin 9 receptor0.052
Tns1tensin 10.052
Syn1synapsin I0.052
Nptxrneuronal pentraxin receptor0.052
RGD1309036hypothetical LOC2928740.051
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.051
Pygmphosphorylase, glycogen, muscle0.051
RGD1308165similar to hypothetical protein MGC173370.050
Cdh17cadherin 170.050
Folh1folate hydrolase 10.050
Ros1c-ros oncogene 1 , receptor tyrosine kinase0.050
Dlgap1discs, large (Drosophila) homolog-associated protein 10.048
Ugt2b7UDP glucuronosyltransferase 2 family, polypeptide B70.047
Msx2msh homeobox 20.046
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.046
Rims1regulating synaptic membrane exocytosis 10.046
Rph3alrabphilin 3A-like (without C2 domains)0.046
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.045
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism