The network for 'srebp signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

srebp signaling pathway

A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.

NameDescriptionProbabilityFunc Analog Organism
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.158
SC4MOLsterol-C4-methyl oxidase-like0.049
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.045
IDI1isopentenyl-diphosphate delta isomerase 10.035
CUL1cullin 10.033
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.030
SQLEsqualene epoxidase0.027
CCDC6coiled-coil domain containing 60.017
FDFT1farnesyl-diphosphate farnesyltransferase 10.015
SREBF2sterol regulatory element binding transcription factor 20.013
DHCR77-dehydrocholesterol reductase0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
imdimmune deficiency0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.708
Ptenphosphatase and tensin homolog0.504
Lmnb2lamin B20.289
Lmnb1lamin B10.276
Itgb1integrin beta 1 (fibronectin receptor beta)0.187
Gja1gap junction protein, alpha 10.120
Fgfr3fibroblast growth factor receptor 30.114
Col1a1collagen, type I, alpha 10.112
Ptpn11protein tyrosine phosphatase, non-receptor type 110.100
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.088
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.086
Sh3pxd2bSH3 and PX domains 2B0.080
Smad4MAD homolog 4 (Drosophila)0.075
Egfrepidermal growth factor receptor0.071
Ptk2PTK2 protein tyrosine kinase 20.064
Vegfavascular endothelial growth factor A0.057
Ppargperoxisome proliferator activated receptor gamma0.056
Fbn1fibrillin 10.054
Smn1survival motor neuron 10.052
Gtf2ird1general transcription factor II I repeat domain-containing 10.040
Akt1thymoma viral proto-oncogene 10.030
2310046A06RikRIKEN cDNA 2310046A06 gene0.029
Plk1polo-like kinase 1 (Drosophila)0.028
Fgfr2fibroblast growth factor receptor 20.028
Nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.024
Scd1stearoyl-Coenzyme A desaturase 10.021
E2f1E2F transcription factor 10.021
Vhlvon Hippel-Lindau tumor suppressor0.021
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.019
Ankprogressive ankylosis0.018
Bscl2Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)0.017
Cav1caveolin 1, caveolae protein0.017
Dmddystrophin, muscular dystrophy0.017
Hif1ahypoxia inducible factor 1, alpha subunit0.016
Myh9myosin, heavy polypeptide 9, non-muscle0.016
Ldlrlow density lipoprotein receptor0.015
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.014
Mapk8mitogen-activated protein kinase 80.014
Rb1retinoblastoma 10.013
Notch2Notch gene homolog 2 (Drosophila)0.013
Prkceprotein kinase C, epsilon0.013
Brca1breast cancer 10.013
Apoeapolipoprotein E0.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Chaf1bchromatin assembly factor 1, subunit B (p60)0.013
Ptch1patched homolog 10.013
Mfn2mitofusin 20.012
Ptgs2prostaglandin-endoperoxide synthase 20.012
Ighmbp2immunoglobulin mu binding protein 20.012
Rbl1retinoblastoma-like 1 (p107)0.012
Iduaiduronidase, alpha-L-0.012
Ahraryl-hydrocarbon receptor0.011
Pola1polymerase (DNA directed), alpha 10.011
Tcof1Treacher Collins Franceschetti syndrome 1, homolog0.011
Tagln2transgelin 20.011
Sox9SRY-box containing gene 90.011
Slc25a16solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 160.011
Supv3l1suppressor of var1, 3-like 1 (S. cerevisiae)0.011
Cyp51cytochrome P450, family 510.010
Ube2cubiquitin-conjugating enzyme E2C0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism