The network for 'positive regulation of superoxide anion generation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of superoxide anion generation

Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.

NameDescriptionProbabilityFunc Analog Organism
IL8interleukin 80.947
CXCL3chemokine (C-X-C motif) ligand 30.847
CXCL2chemokine (C-X-C motif) ligand 20.828
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.705
PRDX1peroxiredoxin 10.598
IL1Binterleukin 1, beta0.446
NOXA1NADPH oxidase activator 10.356
PRKCZprotein kinase C, zeta0.344
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.313
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.287
NCF1neutrophil cytosolic factor 10.284
CAV1caveolin 1, caveolae protein, 22kDa0.239
ENGendoglin0.173
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.149
CCL20chemokine (C-C motif) ligand 200.146
IL6interleukin 6 (interferon, beta 2)0.144
NUMBnumb homolog (Drosophila)0.143
PDPK13-phosphoinositide dependent protein kinase-10.137
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.119
ZNF71zinc finger protein 710.115
CDCP1CUB domain containing protein 10.110
DCTN1dynactin 10.087
CCDC115coiled-coil domain containing 1150.086
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.085
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.074
CARD11caspase recruitment domain family, member 110.071
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.066
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.059
IER3immediate early response 30.056
RARAretinoic acid receptor, alpha0.053
PRKCBprotein kinase C, beta0.052
CXCL5chemokine (C-X-C motif) ligand 50.051
PPP2R4protein phosphatase 2A activator, regulatory subunit 40.050
PICK1protein interacting with PRKCA 10.047
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.046
SH3RF1SH3 domain containing ring finger 10.046
MAPTmicrotubule-associated protein tau0.044
CYBAcytochrome b-245, alpha polypeptide0.041
MTORmechanistic target of rapamycin (serine/threonine kinase)0.040
TGFB3transforming growth factor, beta 30.039
PARK7Parkinson disease (autosomal recessive, early onset) 70.037
CASP3caspase 3, apoptosis-related cysteine peptidase0.037
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.035
TGFBR1transforming growth factor, beta receptor 10.034
AKT1v-akt murine thymoma viral oncogene homolog 10.033
APPamyloid beta (A4) precursor protein0.032
NMT2N-myristoyltransferase 20.029
ARRB1arrestin, beta 10.028
TSC22D1TSC22 domain family, member 10.028
THBS1thrombospondin 10.028
TRIM9tripartite motif containing 90.027
ASXL1additional sex combs like 1 (Drosophila)0.027
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.027
PLAURplasminogen activator, urokinase receptor0.026
CD2CD2 molecule0.025
BCL10B-cell CLL/lymphoma 100.024
LCKlymphocyte-specific protein tyrosine kinase0.024
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.024
STK4serine/threonine kinase 40.024
INADLInaD-like (Drosophila)0.024
TNFAIP6tumor necrosis factor, alpha-induced protein 60.024
BADBCL2-associated agonist of cell death0.024
VHLvon Hippel-Lindau tumor suppressor0.023
CCL14chemokine (C-C motif) ligand 140.023
PTENphosphatase and tensin homolog0.022
ACTBactin, beta0.021
MAP3K5mitogen-activated protein kinase kinase kinase 50.021
MBD1methyl-CpG binding domain protein 10.021
SQSTM1sequestosome 10.020
FKBP1AFK506 binding protein 1A, 12kDa0.019
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.019
GFAPglial fibrillary acidic protein0.019
COX6Ccytochrome c oxidase subunit VIc0.019
SOD2superoxide dismutase 2, mitochondrial0.019
PRKCAprotein kinase C, alpha0.018
PEBP4phosphatidylethanolamine-binding protein 40.018
SMG1SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)0.018
ZC3H12Azinc finger CCCH-type containing 12A0.018
CCL2chemokine (C-C motif) ligand 20.018
CCHCR1coiled-coil alpha-helical rod protein 10.018
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.016
PRDX6peroxiredoxin 60.016
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.016
FAM129Afamily with sequence similarity 129, member A0.016
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.015
PAWRPRKC, apoptosis, WT1, regulator0.015
THEM4thioesterase superfamily member 40.015
DPP4dipeptidyl-peptidase 40.015
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.015
LRRK2leucine-rich repeat kinase 20.015
SH2D1ASH2 domain containing 1A0.014
PTK2BPTK2B protein tyrosine kinase 2 beta0.014
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.014
AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.014
PPP1R10protein phosphatase 1, regulatory (inhibitor) subunit 100.014
INHBAinhibin, beta A0.014
FABP4fatty acid binding protein 4, adipocyte0.014
FYNFYN oncogene related to SRC, FGR, YES0.014
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.014
MED25mediator complex subunit 250.014
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.069
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.062
Ren1renin 1 structural0.030
Ptgs2prostaglandin-endoperoxide synthase 20.018
Il1rninterleukin 1 receptor antagonist0.014
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.013
Apoeapolipoprotein E0.013
Vdrvitamin D receptor0.012
Vegfavascular endothelial growth factor A0.011
Ccl7chemokine (C-C motif) ligand 70.010
Csf1colony stimulating factor 1 (macrophage)0.010
Trp53transformation related protein 530.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism