The network for 'mitotic spindle checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic spindle checkpoint

A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.691
ANAPC4anaphase promoting complex subunit 40.500
CDC20cell division cycle 20 homolog (S. cerevisiae)0.415
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.366
CDC27cell division cycle 27 homolog (S. cerevisiae)0.361
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.271
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.256
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.168
CDK2cyclin-dependent kinase 20.145
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.141
CCT8chaperonin containing TCP1, subunit 8 (theta)0.122
CCNA2cyclin A20.094
AURKBaurora kinase B0.089
CCNB1cyclin B10.084
ANAPC5anaphase promoting complex subunit 50.074
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.071
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.069
CASC5cancer susceptibility candidate 50.066
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.065
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.060
TP53BP1tumor protein p53 binding protein 10.055
CSNK2Bcasein kinase 2, beta polypeptide0.054
MDC1mediator of DNA-damage checkpoint 10.049
CKS2CDC28 protein kinase regulatory subunit 20.047
BRCA2breast cancer 2, early onset0.045
CENPJcentromere protein J0.045
FXR2fragile X mental retardation, autosomal homolog 20.045
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.044
PLK4polo-like kinase 40.039
SASS6spindle assembly 6 homolog (C. elegans)0.039
TINF2TERF1 (TRF1)-interacting nuclear factor 20.039
SKA2spindle and kinetochore associated complex subunit 20.038
CDC23cell division cycle 23 homolog (S. cerevisiae)0.034
H2AFXH2A histone family, member X0.034
SKA3spindle and kinetochore associated complex subunit 30.034
ATMINATM interactor0.031
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.029
PTTG1pituitary tumor-transforming 10.028
FANCD2Fanconi anemia, complementation group D20.027
TOP2Atopoisomerase (DNA) II alpha 170kDa0.027
CEP135centrosomal protein 135kDa0.026
SMC4structural maintenance of chromosomes 40.026
MAPRE1microtubule-associated protein, RP/EB family, member 10.026
CBX5chromobox homolog 50.025
C13orf34chromosome 13 open reading frame 340.025
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.025
PRC1protein regulator of cytokinesis 10.024
LMNAlamin A/C0.024
ZWINTZW10 interactor0.024
SKA1spindle and kinetochore associated complex subunit 10.023
HMMRhyaluronan-mediated motility receptor (RHAMM)0.023
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.023
KIF11kinesin family member 110.022
CENPFcentromere protein F, 350/400kDa (mitosin)0.021
TTKTTK protein kinase0.020
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.019
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.019
FBXO5F-box protein 50.019
PPME1protein phosphatase methylesterase 10.019
HNRNPMheterogeneous nuclear ribonucleoprotein M0.019
CENPEcentromere protein E, 312kDa0.018
CKS1BCDC28 protein kinase regulatory subunit 1B0.018
TERF2IPtelomeric repeat binding factor 2, interacting protein0.018
ANAPC11anaphase promoting complex subunit 110.017
SGOL1shugoshin-like 1 (S. pombe)0.017
CDKN3cyclin-dependent kinase inhibitor 30.017
PARP3poly (ADP-ribose) polymerase family, member 30.017
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.016
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.016
AKT1v-akt murine thymoma viral oncogene homolog 10.016
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.016
SMC6structural maintenance of chromosomes 60.015
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.015
PRNPprion protein0.015
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.015
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.015
HIST1H4Ahistone cluster 1, H4a0.015
RAD52RAD52 homolog (S. cerevisiae)0.015
ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)0.014
TRIP13thyroid hormone receptor interactor 130.014
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.014
PAXIP1PAX interacting (with transcription-activation domain) protein 10.014
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.014
SMC3structural maintenance of chromosomes 30.014
KIF18Akinesin family member 18A0.014
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.014
KIF14kinesin family member 140.013
KIF5Bkinesin family member 5B0.013
CDK1cyclin-dependent kinase 10.013
MAD2L1BPMAD2L1 binding protein0.012
SFNstratifin0.012
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.012
SGOL2shugoshin-like 2 (S. pombe)0.012
KDM4Alysine (K)-specific demethylase 4A0.012
OR5AR1olfactory receptor, family 5, subfamily AR, member 10.012
DLGAP5discs, large (Drosophila) homolog-associated protein 50.011
HIST1H3Ahistone cluster 1, H3a0.011
HIST1H1Ehistone cluster 1, H1e0.011
MYST1MYST histone acetyltransferase 10.011
CREBBPCREB binding protein0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cdl-1Protein CDL-10.018
bmk-1Protein BMK-10.018
mcm-2Protein MCM-20.018
gpr-2Protein GPR-20.018
C49H3.9Protein C49H3.90.017
ZK507.6Protein ZK507.60.017
his-6Protein HIS-60.015
rnr-1Protein RNR-10.014
air-2Protein AIR-20.014
pcn-1Protein PCN-10.013
htz-1Protein HTZ-10.012
air-1Protein AIR-10.012
fzy-1Protein FZY-10.012
cec-5Protein CEC-50.011
gpr-1Protein GPR-10.011
mex-5Protein MEX-50.010
pri-2Protein PRI-20.010
cyb-1Protein CYB-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ncdnon-claret disjunctional0.289
aslasterless0.241
CycBCyclin B0.233
BubR1Bub1-related kinase0.158
flflfalafel0.141
Pp2A-29BProtein phosphatase 2A at 29B0.119
CycB3Cyclin B30.098
Pp1-87BProtein phosphatase 1 at 87B0.097
enokenoki mushroom0.056
Mcm7Minichromosome maintenance 70.055
nbsCG6754 gene product from transcript CG6754-RC0.050
ruxroughex0.048
Cap-GCG34438 gene product from transcript CG34438-RF0.047
cnncentrosomin0.040
thrthree rows0.039
Klp10ACG1453 gene product from transcript CG1453-RA0.034
Cks30ACyclin-dependent kinase subunit 30A0.033
Mcm10Sensitized chromosome inheritance modifier 190.031
CG10722CG10722 gene product from transcript CG10722-RA0.029
Cdc37CG12019 gene product from transcript CG12019-RA0.029
nodno distributive disjunction0.027
IncenpInner centromere protein0.026
CG9776CG9776 gene product from transcript CG9776-RA0.025
dupdouble parked0.024
mus312mutagen-sensitive 3120.022
SMC2CG10212 gene product from transcript CG10212-RA0.021
Fs(2)KetFemale sterile (2) Ketel0.021
CG14213CG14213 gene product from transcript CG14213-RB0.021
gwlgreatwall0.020
mus304mutagen-sensitive 3040.018
Klp3AKinesin-like protein at 3A0.018
Grip75CG6176 gene product from transcript CG6176-RA0.018
pluplutonium0.017
msb1lCG10364 gene product from transcript CG10364-RA0.017
gishgilgamesh0.017
ogreoptic ganglion reduced0.016
Usp7ubiquitin-specific protease 70.016
I-2Inhibitor-20.016
RpS20Ribosomal protein S200.016
Xe7CG2179 gene product from transcript CG2179-RA0.016
KP78bCG17216 gene product from transcript CG17216-RB0.016
Klp61FKinesin-like protein at 61F0.016
Nup153Nucleoporin 1530.015
mad2CG17498 gene product from transcript CG17498-RA0.015
TfIISRNA polymerase II elongation factor0.015
CG1240CG1240 gene product from transcript CG1240-RA0.014
cdc2cCG10498 gene product from transcript CG10498-RC0.013
betaTub56Dbeta-Tubulin at 56D0.013
NiPp1Nuclear inhibitor of Protein phosphatase 10.013
borrborealin-related0.013
aspabnormal spindle0.012
Sep2Septin-20.012
SAKSak kinase0.012
Mcm5Minichromosome maintenance 50.012
prodproliferation disrupter0.012
CG2617CG2617 gene product from transcript CG2617-RA0.012
Rsf1Repressor splicing factor 10.012
ldslodestar0.012
PepProtein on ecdysone puffs0.011
mei-9meiotic 90.011
KrnKeren0.011
CycACyclin A0.011
CG3542CG3542 gene product from transcript CG3542-RA0.010
pngpan gu0.010
CG15141CG15141 gene product from transcript CG15141-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.986
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.864
Trp53transformation related protein 530.769
Rpgrip1lRpgrip1-like0.726
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.625
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.416
Brca2breast cancer 20.390
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.345
Cdk1cyclin-dependent kinase 10.279
Rnf2ring finger protein 20.245
Ccnb2cyclin B20.197
Prc1protein regulator of cytokinesis 10.164
Sgol2shugoshin-like 2 (S. pombe)0.163
Cenpecentromere protein E0.158
Kdm2blysine (K)-specific demethylase 2B0.155
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.125
Lrrk2leucine-rich repeat kinase 20.122
Cdca8cell division cycle associated 80.115
Ccnb1cyclin B10.103
Kif20akinesin family member 20A0.103
Spag5sperm associated antigen 50.102
Hmmrhyaluronan mediated motility receptor (RHAMM)0.094
Ccna2cyclin A20.082
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.072
Skp1aS-phase kinase-associated protein 1A0.064
Cdc25ccell division cycle 25 homolog C (S. pombe)0.061
Dlgap5discs, large (Drosophila) homolog-associated protein 50.057
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.057
Ube2cubiquitin-conjugating enzyme E2C0.056
Pot1aprotection of telomeres 1A0.052
Ooepoocyte expressed protein homolog (dog)0.050
Nlrp5NLR family, pyrin domain containing 50.046
Birc5baculoviral IAP repeat-containing 50.040
Kif4kinesin family member 40.036
Cenpkcentromere protein K0.036
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.036
Kif2ckinesin family member 2C0.035
Trp63transformation related protein 630.033
Depdc1aDEP domain containing 1a0.032
Kif22kinesin family member 220.031
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.030
SetSET nuclear oncogene0.030
Mdm4transformed mouse 3T3 cell double minute 40.028
Mki67antigen identified by monoclonal antibody Ki 670.025
Melkmaternal embryonic leucine zipper kinase0.025
Sgol1shugoshin-like 1 (S. pombe)0.024
Eno1enolase 1, alpha non-neuron0.024
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.024
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.023
C330027C09RikRIKEN cDNA C330027C09 gene0.021
Gsk3bglycogen synthase kinase 3 beta0.021
Ccnfcyclin F0.020
Kif23kinesin family member 230.020
Plk1polo-like kinase 1 (Drosophila)0.019
Mis18bp1MIS18 binding protein 10.019
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.019
Aurkaaurora kinase A0.019
Cdkn3cyclin-dependent kinase inhibitor 30.019
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.019
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.018
Brca1breast cancer 10.018
Hoxa13homeobox A130.017
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.016
6720463M24RikRIKEN cDNA 6720463M24 gene0.016
Acdadrenocortical dysplasia0.016
Ckap2cytoskeleton associated protein 20.016
Lig4ligase IV, DNA, ATP-dependent0.016
Fbxo5F-box protein 50.015
Cenpncentromere protein N0.015
CblCasitas B-lineage lymphoma0.014
Ncapgnon-SMC condensin I complex, subunit G0.014
Cdk2cyclin-dependent kinase 20.014
Kdm1alysine (K)-specific demethylase 1A0.013
Hspa8heat shock protein 80.013
E2f8E2F transcription factor 80.013
Mdm2transformed mouse 3T3 cell double minute 20.013
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.013
Scaf4SR-related CTD-associated factor 40.013
Cenpfcentromere protein F0.012
Suv39h2suppressor of variegation 3-9 homolog 2 (Drosophila)0.012
Fignl1fidgetin-like 10.012
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.012
Mns1meiosis-specific nuclear structural protein 10.012
Hist1h2bmhistone cluster 1, H2bm0.012
Trp73transformation related protein 730.012
Purbpurine rich element binding protein B0.012
Dppa3developmental pluripotency-associated 30.012
Irf6interferon regulatory factor 60.011
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.011
Csnk2a1casein kinase 2, alpha 1 polypeptide0.011
Msh2mutS homolog 2 (E. coli)0.011
Mastlmicrotubule associated serine/threonine kinase-like0.011
BlmBloom syndrome, RecQ helicase-like0.011
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.011
Cbx8chromobox homolog 8 (Drosophila Pc class)0.011
Hist2h2abhistone cluster 2, H2ab0.011
Rbbp4retinoblastoma binding protein 40.011
Hist2h4histone cluster 2, H40.010
Hist1h2aahistone cluster 1, H2aa0.010
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PPH21Pph21p0.932
KEL1Kel1p0.884
CDC28Cdc28p0.826
PPH22Pph22p0.816
GLC7Glc7p0.771
SLK19Slk19p0.753
CDC20Cdc20p0.735
BUB3Bub3p0.677
BFA1Bfa1p0.631
BUB1Bub1p0.617
MAD2Mad2p0.580
CLB4Clb4p0.574
GIC1Gic1p0.564
NUD1Nud1p0.548
RTS1Rts1p0.540
MAD3Mad3p0.500
MCM21Mcm21p0.498
CDC5Cdc5p0.388
CDC55Cdc55p0.387
FMP48Fmp48p0.365
SLI15Sli15p0.358
HHT1Hht1p0.344
PPZ1Ppz1p0.302
HHF2Hhf2p0.292
IML3Iml3p0.266
MPS1Mps1p0.264
CTF13Ctf13p0.254
ELM1Elm1p0.239
CAB3Cab3p0.217
KIP1Kip1p0.208
PIG2Pig2p0.208
BUB2Bub2p0.206
YPI1Ypi1p0.203
BMH1Bmh1p0.196
REG1Reg1p0.195
PCL10Pcl10p0.182
CKA1Cka1p0.181
CLB3Clb3p0.172
CDC14Cdc14p0.160
CTF3Ctf3p0.148
GIP2Gip2p0.145
CLB1Clb1p0.140
KIC1Kic1p0.138
SIC1Sic1p0.137
SFI1Sfi1p0.135
SGO1Sgo1p0.125
SPC24Spc24p0.121
ASE1Ase1p0.120
BMH2Bmh2p0.118
SKP2Skp2p0.117
TOF2Tof2p0.110
DMA2Dma2p0.108
KCS1Kcs1p0.107
TPD3Tpd3p0.105
FAR1Far1p0.101
BIM1Bim1p0.100
ORC3Orc3p0.098
DMA1Dma1p0.094
CLB6Clb6p0.093
MAD1Mad1p0.091
SDS22Sds22p0.090
GAC1Gac1p0.084
BUD8Bud8p0.083
VIK1Vik1p0.083
NBL1Nbl1p0.080
AME1Ame1p0.074
TGL2Tgl2p0.070
CDH1Cdh1p0.069
KEL2Kel2p0.068
STE23Ste23p0.068
CBF1Cbf1p0.063
CIN1Cin1p0.063
CIN8Cin8p0.062
NDD1Ndd1p0.062
KIN1Kin1p0.060
SKM1Skm1p0.060
CDC123Cdc123p0.059
MSA2Msa2p0.057
ESP1Esp1p0.056
LTE1Lte1p0.054
HST3Hst3p0.053
ZDS1Zds1p0.052
SPC29Spc29p0.045
ECO1Eco1p0.043
YIL151Chypothetical protein0.043
NTO1Nto1p0.042
DAM1Dam1p0.042
FRK1Frk1p0.042
STE4Ste4p0.041
SOL1Sol1p0.041
RAD53Rad53p0.041
CHL4Chl4p0.040
GLG1Glg1p0.039
SPC110Spc110p0.039
SRD1Srd1p0.039
FIN1Fin1p0.038
CKB1Ckb1p0.038
CAR1Car1p0.037
DSN1Dsn1p0.036
PSY4Psy4p0.036