The network for 'negative regulation of mrna splicing via spliceosome' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mrna splicing via spliceosome

Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.

NameDescriptionProbabilityFunc Analog Organism
RNPS1RNA binding protein S1, serine-rich domain0.999
SRSF1serine/arginine-rich splicing factor 10.990
HNRNPKheterogeneous nuclear ribonucleoprotein K0.959
SF3A2splicing factor 3a, subunit 2, 66kDa0.935
SRSF2serine/arginine-rich splicing factor 20.911
TRA2Btransformer 2 beta homolog (Drosophila)0.893
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.813
RBM39RNA binding motif protein 390.770
U2AF2U2 small nuclear RNA auxiliary factor 20.764
HNRNPA1heterogeneous nuclear ribonucleoprotein A10.680
EIF4A3eukaryotic translation initiation factor 4A30.624
SRSF3serine/arginine-rich splicing factor 30.607
MAGOHmago-nashi homolog, proliferation-associated (Drosophila)0.520
SRSF6serine/arginine-rich splicing factor 60.483
PTBP1polypyrimidine tract binding protein 10.466
SRPK2SRSF protein kinase 20.427
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.422
U2AF1U2 small nuclear RNA auxiliary factor 10.366
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.313
SRRM1serine/arginine repetitive matrix 10.270
SRPK1SRSF protein kinase 10.227
SRSF4serine/arginine-rich splicing factor 40.224
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.207
HNRPDLheterogeneous nuclear ribonucleoprotein D-like0.189
PCBP1poly(rC) binding protein 10.140
SF3B4splicing factor 3b, subunit 4, 49kDa0.081
ARGLU1arginine and glutamate rich 10.080
SF1splicing factor 10.069
SUGP1SURP and G patch domain containing 10.068
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.068
PNNpinin, desmosome associated protein0.056
PRPF38APRP38 pre-mRNA processing factor 38 (yeast) domain containing A0.055
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.050
TARDBPTAR DNA binding protein0.050
DHX15DEAH (Asp-Glu-Ala-His) box polypeptide 150.050
SYNCRIPsynaptotagmin binding, cytoplasmic RNA interacting protein0.050
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.043
SRSF9serine/arginine-rich splicing factor 90.041
HNRNPFheterogeneous nuclear ribonucleoprotein F0.035
RBMXRNA binding motif protein, X-linked0.034
SRRTserrate RNA effector molecule homolog (Arabidopsis)0.033
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.031
HNRNPRheterogeneous nuclear ribonucleoprotein R0.031
EEDembryonic ectoderm development0.028
SRSF10serine/arginine-rich splicing factor 100.027
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.026
SREK1splicing regulatory glutamine/lysine-rich protein 10.026
MAT2Amethionine adenosyltransferase II, alpha0.025
PTBP2polypyrimidine tract binding protein 20.025
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.023
CHERPcalcium homeostasis endoplasmic reticulum protein0.021
ILF3interleukin enhancer binding factor 3, 90kDa0.021
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.021
RALYRNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse))0.020
CARM1coactivator-associated arginine methyltransferase 10.018
CLK2CDC-like kinase 20.016
CIRBPcold inducible RNA binding protein0.016
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.016
CELF1CUGBP, Elav-like family member 10.015
USP22ubiquitin specific peptidase 220.014
CUL1cullin 10.013
PABPN1poly(A) binding protein, nuclear 10.013
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.012
PRCCpapillary renal cell carcinoma (translocation-associated)0.012
ABCF3ATP-binding cassette, sub-family F (GCN20), member 30.011
SRSF7serine/arginine-rich splicing factor 70.010
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.010
C19orf43chromosome 19 open reading frame 430.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.439
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.392
cx43.4connexin 43.40.309
ssbSjogren syndrome antigen B (autoantigen La)0.281
hmga1ahigh mobility group AT-hook 1a0.118
sf3b4splicing factor 3b, subunit 40.049
snrnp70small nuclear ribonucleoprotein 70 (U1)0.045
wu:fb58e05wu:fb58e050.042
nova2neuro-oncological ventral antigen 20.041
marcksamyristoylated alanine rich protein kinase C substrate a0.039
si:dkey-261h17.1si:dkey-261h17.10.038
anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.037
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.033
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.033
srsf6aserine/arginine-rich splicing factor 6a0.031
zgc:86598zgc:865980.030
fzd7bfrizzled homolog 7b0.030
ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39b0.028
anp32aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A0.027
npm1nucleophosmin 10.027
brd3abromodomain containing 3a0.025
tgif1TGFB-induced factor homeobox 10.025
prpf39PRP39 pre-mRNA processing factor 39 homolog (yeast)0.024
pcdh2acprotocadherin 2 alpha c0.023
si:dkey-250d21.1si:dkey-250d21.10.023
lrmplymphoid-restricted membrane protein0.023
arid4aAT rich interactive domain 4A (RBP1-like)0.022
erfEts2 repressor factor0.022
slc30a4solute carrier family 30 (zinc transporter), member 40.021
nr2f6anuclear receptor subfamily 2, group F, member 6a0.021
nrxn1aneurexin 1a0.021
zgc:64040zgc:640400.021
si:dkey-181m9.9si:dkey-181m9.90.020
acsl1acyl-CoA synthetase long-chain family member 10.020
arpc5aactin related protein 2/3 complex, subunit 5A0.020
ranbp1RAN binding protein 10.019
nhp2NHP2 ribonucleoprotein homolog (yeast)0.019
npm4nucleophosmin/nucleoplasmin, 40.019
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.019
sf1splicing factor 10.019
ilf2interleukin enhancer binding factor 20.019
psen1presenilin 10.019
pomt2protein-O-mannosyltransferase 20.018
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.018
nrxn3aneurexin 3a0.018
ybx1Y box binding protein 10.018
h2afvlH2A histone family, member V, like0.017
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.017
setbSET translocation (myeloid leukemia-associated) B0.017
ftsjFtsJ homolog 3 (E. coli)0.016
zgc:66100zgc:661000.016
rfc2replication factor C (activator 1) 20.016
nucks1anuclear casein kinase and cyclin-dependent kinase substrate 1a0.015
cpsf2cleavage and polyadenylation specific factor 20.015
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.015
zgc:56304zgc:563040.015
ube2v2ubiquitin-conjugating enzyme E2 variant 20.015
ctpsCTP synthase0.015
drap1DR1-associated protein 1 (negative cofactor 2 alpha)0.015
caprin1acell cycle associated protein 1a0.015
ddx39aaDEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa0.015
sf3a2splicing factor 3a, subunit 20.015
wu:fi04f09wu:fi04f090.014
smu1smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)0.014
yap1Yes-associated protein 10.014
si:dkey-67c22.2si:dkey-67c22.20.014
ahcyS-adenosylhomocysteine hydrolase0.014
si:dkey-236e20.6si:dkey-236e20.60.014
paf1paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.014
srsf5aserine/arginine-rich splicing factor 5a0.014
ctbp1C-terminal binding protein 10.014
fktnfukutin0.014
hnrplheterogeneous nuclear ribonucleoprotein L0.014
acvr1lactivin A receptor, type I like0.014
cherpcalcium homeostasis endoplasmic reticulum protein0.014
eif1beukaryotic translation initiation factor 1B0.014
zgc:112425zgc:1124250.013
ifrd2interferon-related developmental regulator 20.013
eftud2elongation factor Tu GTP binding domain containing 20.013
lsm14abLSM14 homolog Ab (SCD6, S. cerevisiae)0.013
rqcd1RCD1 required for cell differentiation1 homolog (S. pombe)0.013
slc43a1asolute carrier family 43, member 1a0.013
etf1eukaryotic translation termination factor 10.013
actn4actinin, alpha 40.013
ctnnacatenin (cadherin-associated protein), alpha0.013
zgc:112982zgc:1129820.013
rbm4.2RNA binding motif protein 4.20.012
fam3cfamily with sequence similarity 3, member C0.012
slitrk5SLIT and NTRK-like family, member 50.012
xrn25'-3' exoribonuclease 20.012
ctnnb1catenin (cadherin-associated protein), beta 10.012
pa2g4aproliferation-associated 2G4, a0.012
zgc:77155zgc:771550.012
mll4bmyeloid/lymphoid or mixed-lineage leukemia 4b0.012
eif3s10eukaryotic translation initiation factor 3, subunit 10 (theta)0.012
nmd3NMD3 homolog (S. cerevisiae)0.011
snrpcsmall nuclear ribonucleoprotein polypeptide C0.011
rfc4replication factor C (activator 1) 40.011
srsf2serine/arginine-rich splicing factor 20.011
ck2bcasein kinase 2 beta0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Df31Decondensation factor 310.014
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.874
Hnrnpa3heterogeneous nuclear ribonucleoprotein A30.534
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.523
Hnrnpa2b1heterogeneous nuclear ribonucleoprotein A2/B10.489
Srsf1serine/arginine-rich splicing factor 10.459
TardbpTAR DNA binding protein0.390
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.344
Trim28tripartite motif-containing 280.326
Srsf2serine/arginine-rich splicing factor 20.273
Srsf11serine/arginine-rich splicing factor 110.244
Srsf6serine/arginine-rich splicing factor 60.243
Srsf7serine/arginine-rich splicing factor 70.224
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.216
Pnnpinin0.155
Tra2btransformer 2 beta homolog (Drosophila)0.143
Prpf38bPRP38 pre-mRNA processing factor 38 (yeast) domain containing B0.141
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.117
Ctbp1C-terminal binding protein 10.100
Srsf3serine/arginine-rich splicing factor 30.095
Ptges3prostaglandin E synthase 3 (cytosolic)0.093
Hnrnpmheterogeneous nuclear ribonucleoprotein M0.092
Pabpn1poly(A) binding protein, nuclear 10.088
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.084
Ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.074
Eedembryonic ectoderm development0.058
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.055
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.052
Raver2ribonucleoprotein, PTB-binding 20.050
Hnrnph2heterogeneous nuclear ribonucleoprotein H20.046
Hmgb1high mobility group box 10.044
Tra2atransformer 2 alpha homolog (Drosophila)0.043
Fusfusion, derived from t(12;16) malignant liposarcoma (human)0.041
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.034
Dhx9DEAH (Asp-Glu-Ala-His) box polypeptide 90.034
Akr1c12aldo-keto reductase family 1, member C120.033
Akr1c13aldo-keto reductase family 1, member C130.033
Ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.032
CtcfCCCTC-binding factor0.030
Prpf4bPRP4 pre-mRNA processing factor 4 homolog B (yeast)0.028
Gcfc1GC-rich sequence DNA-binding factor 10.028
SetSET nuclear oncogene0.027
Ewsr1Ewing sarcoma breakpoint region 10.025
2500003M10RikRIKEN cDNA 2500003M10 gene0.025
Hmgn1high mobility group nucleosomal binding domain 10.025
H3f3bH3 histone, family 3B0.024
Anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.023
Fubp1far upstream element (FUSE) binding protein 10.023
Rbm25RNA binding motif protein 250.023
Impdh2inosine 5'-phosphate dehydrogenase 20.023
U2af1U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 10.023
Ptmaprothymosin alpha0.022
Nxf1nuclear RNA export factor 1 homolog (S. cerevisiae)0.021
Zfp207zinc finger protein 2070.020
Hnrnpa0heterogeneous nuclear ribonucleoprotein A00.020
Sf3b1splicing factor 3b, subunit 10.020
Wsb1WD repeat and SOCS box-containing 10.019
Ythdf2YTH domain family 20.019
Rbbp7retinoblastoma binding protein 70.019
2310036O22RikRIKEN cDNA 2310036O22 gene0.018
Safb2scaffold attachment factor B20.018
Safbscaffold attachment factor B0.018
Nononon-POU-domain-containing, octamer binding protein0.018
Matr3matrin 30.018
Tubgcp3tubulin, gamma complex associated protein 30.017
Lbrlamin B receptor0.017
Prpf39PRP39 pre-mRNA processing factor 39 homolog (yeast)0.017
Rbm8aRNA binding motif protein 8a0.017
Usp7ubiquitin specific peptidase 70.016
Raver1ribonucleoprotein, PTB-binding 10.016
Atad3aATPase family, AAA domain containing 3A0.015
Luc7l2LUC7-like 2 (S. cerevisiae)0.014
Mat2amethionine adenosyltransferase II, alpha0.014
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.014
Luc7l3LUC7-like 3 (S. cerevisiae)0.014
Tial1Tia1 cytotoxic granule-associated RNA binding protein-like 10.014
Fam76bfamily with sequence similarity 76, member B0.014
Akap8A kinase (PRKA) anchor protein 80.014
Rnps1ribonucleic acid binding protein S10.013
Rbm14RNA binding motif protein 140.013
Nclnucleolin0.013
Hcfc1host cell factor C10.012
Hnrnph3heterogeneous nuclear ribonucleoprotein H30.012
Taf1dTATA box binding protein (Tbp)-associated factor, RNA polymerase I, D0.012
SonSon DNA binding protein0.012
Srsf9serine/arginine-rich splicing factor 90.012
Nap1l1nucleosome assembly protein 1-like 10.011
Srek1splicing regulatory glutamine/lysine-rich protein 10.011
Ivns1abpinfluenza virus NS1A binding protein0.011
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.011
Rbm39RNA binding motif protein 390.011
Tia1cytotoxic granule-associated RNA binding protein 10.011
Hnrpllheterogeneous nuclear ribonucleoprotein L-like0.011
Mrpl3mitochondrial ribosomal protein L30.010
Vps72vacuolar protein sorting 72 (yeast)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sfrs2splicing factor, arginine/serine-rich 20.190
Sfrs1splicing factor, arginine/serine-rich 10.142
Hnrph1heterogeneous nuclear ribonucleoprotein H10.058
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.047
Hnrnpa0heterogeneous nuclear ribonucleoprotein A00.045
Ptmaprothymosin alpha0.042
Hnrnpa3heterogeneous nuclear ribonucleoprotein A30.040
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.038
Trim28tripartite motif-containing 280.031
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.030
TardbpTAR DNA binding protein0.029
Nolc1nucleolar and coiled-body phosphoprotein 10.028
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.026
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.025
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.025
Arf6ADP-ribosylation factor 60.024
Ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.024
Uba2ubiquitin-like modifier activating enzyme 20.022
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.020
Tra2atransformer 2 alpha homolog (Drosophila)0.020
Tra2btransformer 2 beta homolog (Drosophila)0.018
Eif4heukaryotic translation initiation factor 4H0.017
Hnrnprheterogeneous nuclear ribonucleoprotein R0.016
Hnrpdheterogeneous nuclear ribonucleoprotein D0.014
LOC686980similar to arsenate resistance protein 20.013
Mcrs1microspherule protein 10.013
Cnot6CCR4-NOT transcription complex, subunit 60.013
C1galt1core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 10.013
Rnps1ribonucleic acid binding protein S10.013
Hdac1histone deacetylase 10.012
Sf3a3splicing factor 3a, subunit 30.012
Sfrs5splicing factor, arginine/serine-rich 50.011
Smarce1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.011
Fusfusion (involved in t(12;16) in malignant liposarcoma) (human)0.011
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.011
Hnrpmheterogeneous nuclear ribonucleoprotein M0.010
Ewsr1Ewing sarcoma breakpoint region 10.010
Puf60poly-U binding splicing factor 600.010
Axin1axin 10.010
Dhx15DEAH (Asp-Glu-Ala-His) box polypeptide 150.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
UBI4Ubi4p0.023
PWP2Pwp2p0.022
SHE4She4p0.021
UTP15Utp15p0.018
DBP9Dbp9p0.016
ELP3Elp3p0.015
FBP26Fbp26p0.014
YLR345Whypothetical protein0.013
RPA34Rpa34p0.013
KRR1Krr1p0.013
ELP2Elp2p0.012
PRB1Prb1p0.012
DIS3Dis3p0.012
UTP6Utp6p0.011
YAK1Yak1p0.011
TMA17Tma17p0.011
HSP42Hsp42p0.010
KRE33Kre33p0.010