The network for 'negative regulation of synaptic transmission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

NameDescriptionProbabilityFunc Analog Organism
C1QAcomplement component 1, q subcomponent, A chain0.999
CFLARCASP8 and FADD-like apoptosis regulator0.979
ADORA2Aadenosine A2a receptor0.852
C1QCcomplement component 1, q subcomponent, C chain0.758
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.687
PICK1protein interacting with PRKCA 10.680
FASFas (TNF receptor superfamily, member 6)0.634
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.630
C1QBcomplement component 1, q subcomponent, B chain0.502
VAC14Vac14 homolog (S. cerevisiae)0.500
APPamyloid beta (A4) precursor protein0.489
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.467
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.450
LRRK2leucine-rich repeat kinase 20.420
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.358
MYOGmyogenin (myogenic factor 4)0.311
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.285
NCOA3nuclear receptor coactivator 30.273
PRKCEprotein kinase C, epsilon0.263
MKL1megakaryoblastic leukemia (translocation) 10.245
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.244
DLG4discs, large homolog 4 (Drosophila)0.243
CASP8caspase 8, apoptosis-related cysteine peptidase0.216
TAC1tachykinin, precursor 10.189
NTRK3neurotrophic tyrosine kinase, receptor, type 30.182
ACCN2amiloride-sensitive cation channel 2, neuronal0.176
PACSIN1protein kinase C and casein kinase substrate in neurons 10.151
DRD2dopamine receptor D20.139
SNCAIPsynuclein, alpha interacting protein0.135
PRKCGprotein kinase C, gamma0.135
PRLHRprolactin releasing hormone receptor0.134
WBP11WW domain binding protein 110.130
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.126
KSR1kinase suppressor of ras 10.112
MAP2K1mitogen-activated protein kinase kinase 10.111
DLGAP1discs, large (Drosophila) homolog-associated protein 10.109
MYOD1myogenic differentiation 10.108
SH3GL3SH3-domain GRB2-like 30.106
CYTH2cytohesin 20.105
NLKnemo-like kinase0.101
RHEBRas homolog enriched in brain0.101
GRIA2glutamate receptor, ionotropic, AMPA 20.098
PUM2pumilio homolog 2 (Drosophila)0.098
MAPTmicrotubule-associated protein tau0.095
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.092
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.091
SH3RF1SH3 domain containing ring finger 10.084
SYN1synapsin I0.082
RABAC1Rab acceptor 1 (prenylated)0.078
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.075
CCL14chemokine (C-C motif) ligand 140.075
DLGAP2discs, large (Drosophila) homolog-associated protein 20.074
PEBP4phosphatidylethanolamine-binding protein 40.073
IL8interleukin 80.070
PRKCZprotein kinase C, zeta0.069
CASP10caspase 10, apoptosis-related cysteine peptidase0.069
FABP4fatty acid binding protein 4, adipocyte0.068
KALRNkalirin, RhoGEF kinase0.068
MED31mediator complex subunit 310.066
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.064
PACSIN3protein kinase C and casein kinase substrate in neurons 30.063
DNM1dynamin 10.061
PACSIN2protein kinase C and casein kinase substrate in neurons 20.061
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.060
KRASv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.060
RASSF5Ras association (RalGDS/AF-6) domain family member 50.059
PCDHA4protocadherin alpha 40.059
SRGAP2SLIT-ROBO Rho GTPase activating protein 20.057
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.056
BAG1BCL2-associated athanogene0.056
SPRR2Asmall proline-rich protein 2A0.055
MKL2MKL/myocardin-like 20.055
HIST1H3Bhistone cluster 1, H3b0.054
C4orf14chromosome 4 open reading frame 140.054
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.053
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.053
RALGDSral guanine nucleotide dissociation stimulator0.052
ADAM11ADAM metallopeptidase domain 110.052
USP38ubiquitin specific peptidase 380.052
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.051
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.050
CAV2caveolin 20.050
ATP1B2ATPase, Na+/K+ transporting, beta 2 polypeptide0.050
NELL1NEL-like 1 (chicken)0.050
BMI1BMI1 polycomb ring finger oncogene0.050
ATXN7L3ataxin 7-like 30.049
COPG2coatomer protein complex, subunit gamma 20.048
SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.047
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.047
DLG2discs, large homolog 2 (Drosophila)0.047
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.046
CACNB4calcium channel, voltage-dependent, beta 4 subunit0.046
TAOK1TAO kinase 10.046
MAP3K1mitogen-activated protein kinase kinase kinase 10.045
FNBP1formin binding protein 10.045
TUBtubby homolog (mouse)0.045
DRD1dopamine receptor D10.045
KCND2potassium voltage-gated channel, Shal-related subfamily, member 20.042
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
jebjelly belly0.188
CG42629CG42629 gene product from transcript CG42629-RB0.165
nwknervous wreck0.160
AlkCG8250 gene product from transcript CG8250-RA0.109
CG13253CG13253 gene product from transcript CG13253-RB0.098
Ras85DRas oncogene at 85D0.067
imdimmune deficiency0.055
BG4CG12297 gene product from transcript CG12297-RA0.036
CakiCalcium/calmodulin-dependent protein kinase0.027
CrebB-17ACyclic-AMP response element binding protein B at 17A0.025
Nrx-1Neurexin 10.023
RanBPMRan-binding protein M0.023
MESK2Misexpression suppressor of KSR 20.022
Snap25Synapse protein 250.022
oa2octopamine receptor 20.020
tipEtemperature-induced paralytic E0.019
RdlResistant to dieldrin0.019
TbhTyramine beta hydroxylase0.019
ShabShaker cognate b0.017
Ank2Ankyrin 20.015
Octbeta2RCG33976 gene product from transcript CG33976-RA0.014
nAcRalpha-30Dnicotinic Acetylcholine Receptor alpha 30D0.013
nAcRbeta-96Anicotinic Acetylcholine Receptor beta 96A0.013
Nmdar1NMDA receptor 10.013
Gycalpha99BGuanylyl cyclase alpha-subunit at 99B0.012
CG34400CG34400 gene product from transcript CG34400-RD0.011
CCKLR-17D1CCK-like receptor at 17D10.011
PIP5K59BCG3682 gene product from transcript CG3682-RE0.011
CaMKIICalcium/calmodulin-dependent protein kinase II0.010
Pde8Phosphodiesterase 80.010
Trim9CG31721 gene product from transcript CG31721-RB0.010
5-HT1BSerotonin receptor 1B0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gria2glutamate receptor, ionotropic, AMPA 20.143
Grm7glutamate receptor, metabotropic 70.085
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.064
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.063
Serp1stress-associated endoplasmic reticulum protein 10.063
Trpm1transient receptor potential cation channel, subfamily M, member 10.056
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.056
Magmyelin-associated glycoprotein0.056
Gria1glutamate receptor, ionotropic, AMPA 10.053
Pou3f1POU class 3 homeobox 10.045
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.044
Olr226olfactory receptor 2260.040
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.038
Adora1adenosine A1 receptor0.037
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.035
Nr4a3nuclear receptor subfamily 4, group A, member 30.034
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.033
Gria3glutamate receptor, ionotrophic, AMPA 30.033
Dlgap1discs, large (Drosophila) homolog-associated protein 10.032
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.031
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.031
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.031
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.029
Eef2eukaryotic translation elongation factor 20.029
Sept3septin 30.028
Smad3SMAD family member 30.028
Cyth1cytohesin 10.028
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.027
Gng7guanine nucleotide binding protein (G protein), gamma 70.027
Ptafrplatelet-activating factor receptor0.027
Npy5rneuropeptide Y receptor Y50.026
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.025
Gpr6G protein-coupled receptor 60.024
Calcrcalcitonin receptor0.024
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.024
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.024
Drd2dopamine receptor D20.024
Adora2aadenosine A2a receptor0.023
Grip2glutamate receptor interacting protein 20.023
Gzmkgranzyme K0.023
Pmfbp1polyamine modulated factor 1 binding protein 10.023
Sdcbpsyndecan binding protein0.023
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.022
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.022
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.022
Nmbrneuromedin B receptor0.022
Grk4G protein-coupled receptor kinase 40.021
Reg1aregenerating islet-derived 1 alpha0.021
Lphn1latrophilin 10.021
Fzd4frizzled homolog 4 (Drosophila)0.021
Cntn3contactin 3 (plasmacytoma associated)0.021
Prkcgprotein kinase C, gamma0.020
Pip5k1cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.020
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.019
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.019
Il13interleukin 130.019
Cnksr2connector enhancer of kinase suppressor of Ras 20.019
Folh1folate hydrolase 10.019
Gabra5gamma-aminobutyric acid (GABA) A receptor, alpha 50.019
Cxcr5chemokine (C-X-C motif) receptor 50.019
Cntn5contactin 50.019
Gpr83G protein-coupled receptor 830.019
Trhr2thyrotropin releasing hormone receptor 20.018
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.018
Sstr2somatostatin receptor 20.018
Fam83ffamily with sequence similarity 83, member F0.018
Gabra2gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 20.018
Neurod2neurogenic differentiation 20.018
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.018
Cnr1cannabinoid receptor 1 (brain)0.018
Vamp2vesicle-associated membrane protein 20.018
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.018
Gucy2dguanylate cyclase 2d0.018
Atp4aATPase, H+/K+ exchanging, alpha polypeptide0.018
Hpcal4hippocalcin-like 40.018
Gad2glutamate decarboxylase 20.018
Sv2csynaptic vesicle glycoprotein 2c0.017
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.017
Kalrnkalirin, RhoGEF kinase0.017
Mmp13matrix metallopeptidase 130.017
Slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.017
FevFEV (ETS oncogene family)0.017
Galgalanin prepropeptide0.017
Fgf14fibroblast growth factor 140.017
Aqp4aquaporin 40.017
Oprd1opioid receptor, delta 10.017
Gria4glutamate receptor, ionotrophic, AMPA 40.017
Tacr2tachykinin receptor 20.017
Fgfr2fibroblast growth factor receptor 20.016
Homer3homer homolog 3 (Drosophila)0.016
Syt4synaptotagmin IV0.016
Pfn1profilin 10.016
Cckarcholecystokinin A receptor0.016
Gpr12G protein-coupled receptor 120.016
Ifrd1interferon-related developmental regulator 10.016
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.016
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.016
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism