The network for 'tube development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

NameDescriptionProbabilityFunc Analog Organism
RB1retinoblastoma 11.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
EGFRepidermal growth factor receptor1.000
ESR1estrogen receptor 10.999
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.999
TP53tumor protein p530.996
VEGFAvascular endothelial growth factor A0.995
FLNAfilamin A, alpha0.995
CAV1caveolin 1, caveolae protein, 22kDa0.993
YAP1Yes-associated protein 10.992
CREBBPCREB binding protein0.986
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.986
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.984
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.984
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.983
SP1Sp1 transcription factor0.983
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.980
MYH9myosin, heavy chain 9, non-muscle0.979
RXRAretinoid X receptor, alpha0.979
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.978
NRP1neuropilin 10.974
SMURF1SMAD specific E3 ubiquitin protein ligase 10.974
SMAD2SMAD family member 20.970
MDM2Mdm2 p53 binding protein homolog (mouse)0.970
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.969
THBS1thrombospondin 10.966
PTPN1protein tyrosine phosphatase, non-receptor type 10.964
SMAD3SMAD family member 30.962
GSK3Bglycogen synthase kinase 3 beta0.962
NR4A1nuclear receptor subfamily 4, group A, member 10.961
FN1fibronectin 10.957
ZNF512Bzinc finger protein 512B0.955
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.947
JAG1jagged 10.946
PRKCZprotein kinase C, zeta0.938
BCL2B-cell CLL/lymphoma 20.936
MAPK8mitogen-activated protein kinase 80.936
FGFR1fibroblast growth factor receptor 10.924
NCOR2nuclear receptor corepressor 20.923
PAX3paired box 30.920
SHC1SHC (Src homology 2 domain containing) transforming protein 10.914
COL1A1collagen, type I, alpha 10.910
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.905
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.904
SIN3ASIN3 homolog A, transcription regulator (yeast)0.902
RUNX1runt-related transcription factor 10.902
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.892
RARAretinoic acid receptor, alpha0.887
SMAD7SMAD family member 70.887
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.880
SOX2SRY (sex determining region Y)-box 20.875
FGFR2fibroblast growth factor receptor 20.870
FOXA2forkhead box A20.864
AKT1v-akt murine thymoma viral oncogene homolog 10.863
BECN1beclin 1, autophagy related0.859
FHL2four and a half LIM domains 20.855
FGF1fibroblast growth factor 1 (acidic)0.854
PLECplectin0.851
APCadenomatous polyposis coli0.848
EP300E1A binding protein p3000.847
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.843
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.840
METmet proto-oncogene (hepatocyte growth factor receptor)0.839
YY1YY1 transcription factor0.832
COL2A1collagen, type II, alpha 10.819
IQGAP1IQ motif containing GTPase activating protein 10.818
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.817
PKM2pyruvate kinase, muscle0.815
STK3serine/threonine kinase 30.814
DVL3dishevelled, dsh homolog 3 (Drosophila)0.814
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.811
COL6A1collagen, type VI, alpha 10.799
NCOA1nuclear receptor coactivator 10.796
KRT8keratin 80.782
EGR1early growth response 10.764
ACTN1actinin, alpha 10.749
PXNpaxillin0.743
MAPK14mitogen-activated protein kinase 140.743
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.733
COL4A1collagen, type IV, alpha 10.721
ATF2activating transcription factor 20.717
NCOA3nuclear receptor coactivator 30.712
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.704
COL5A1collagen, type V, alpha 10.700
NCOR1nuclear receptor corepressor 10.698
MYOD1myogenic differentiation 10.698
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.696
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.693
RASA1RAS p21 protein activator (GTPase activating protein) 10.691
TNCtenascin C0.682
CDC37cell division cycle 37 homolog (S. cerevisiae)0.680
SOX1SRY (sex determining region Y)-box 10.676
RAD21RAD21 homolog (S. pombe)0.674
FOXF1forkhead box F10.673
TBX2T-box 20.669
AXIN1axin 10.666
NOTCH3notch 30.664
INSRinsulin receptor0.662
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.651
COL3A1collagen, type III, alpha 10.650
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.999
his-31Protein HIS-310.989
his-45Protein HIS-450.984
his-5Protein HIS-50.974
his-48Protein HIS-480.951
his-64Protein HIS-640.950
egl-18Protein EGL-180.913
his-61Protein HIS-610.909
hlh-1Protein HLH-10.904
elt-6Protein ELT-60.886
his-62Protein HIS-620.865
his-47Protein HIS-470.863
his-1Protein HIS-10.861
his-46Protein HIS-460.828
his-30Protein HIS-300.816
atn-1Protein ATN-10.815
his-59Protein HIS-590.801
his-29Protein HIS-290.795
his-16Protein HIS-160.775
egl-46Protein EGL-460.768
zip-7Protein ZIP-70.766
his-9Protein HIS-90.763
his-42Protein HIS-420.761
his-2Protein HIS-20.752
cam-1Protein CAM-10.749
hlh-2Protein HLH-20.740
his-52Protein HIS-520.717
bar-1Protein BAR-10.671
act-4Protein ACT-40.634
his-50Protein HIS-500.634
hnd-1Protein HND-10.624
fkh-2Protein FKH-20.613
mig-5Protein MIG-50.579
his-4Protein HIS-40.497
soc-2Protein SOC-20.484
his-32Protein HIS-320.483
his-39Protein HIS-390.465
hda-1Protein HDA-10.463
lag-1Protein LAG-10.456
F36D4.5Protein F36D4.50.456
pal-1Protein PAL-10.451
sax-3Protein SAX-30.444
pop-1Protein POP-10.419
his-38Protein HIS-380.416
his-14Protein HIS-140.400
his-3Protein HIS-30.399
crt-1Protein CRT-10.398
egl-27Protein EGL-270.398
unc-62Protein UNC-620.398
sma-6Protein SMA-60.391
unc-98Protein UNC-980.390
che-13Protein CHE-130.385
his-63Protein HIS-630.378
nhr-67Protein NHR-670.375
mls-2Protein MLS-20.372
sem-4Protein SEM-40.370
mab-5Protein MAB-50.361
mep-1Protein MEP-10.360
unc-5Protein UNC-50.354
hmg-1.2Protein HMG-1.20.353
unc-42Protein UNC-420.347
syg-2Protein SYG-20.343
lin-12Protein LIN-120.333
Y44E3A.6Protein Y44E3A.60.327
nhr-25Protein NHR-250.319
deb-1Protein DEB-10.313
irx-1Protein IRX-10.301
flh-2Protein FLH-20.300
emb-9Protein EMB-90.290
nrde-2Protein NRDE-20.287
tbx-9Protein TBX-90.276
rig-6Protein RIG-60.270
sem-5Protein SEM-50.270
ldb-1Protein LDB-10.266
C35D10.7Protein C35D10.70.263
pes-1Protein PES-10.261
unc-37Protein UNC-370.256
his-6Protein HIS-60.250
patr-1Protein PATR-10.246
CELE_F54D5.5Protein F54D5.50.242
hbl-1Protein HBL-10.240
his-49Protein HIS-490.233
vab-3Protein VAB-30.233
R10E12.2Protein R10E12.20.228
ncam-1Protein NCAM-10.228
ncx-3Protein NCX-30.220
vab-1Protein VAB-10.217
zyg-8Protein ZYG-80.217
ceh-20Protein CEH-200.213
his-43Protein HIS-430.213
osm-5Protein OSM-50.212
rsp-1Protein RSP-10.206
epi-1Protein EPI-10.203
pry-1Protein PRY-10.203
lin-3Protein LIN-30.203
ifb-2Protein IFB-20.200
xpo-1Protein XPO-10.198
syd-2Protein SYD-20.195
wrm-1Protein WRM-10.193
osm-3Protein OSM-30.193
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
armarmadillo1.000
EgfrEpidermal growth factor receptor1.000
shnschnurri0.999
tkvthickveins0.999
cicubitus interruptus0.998
MadMothers against dpp0.998
brkbrinker0.997
emcextra macrochaetae0.997
atoatonal0.997
Rac1CG2248 gene product from transcript CG2248-RA0.996
stumpsCG31317 gene product from transcript CG31317-RC0.993
mewmultiple edematous wings0.992
mysmyospheroid0.992
l(2)gllethal (2) giant larvae0.990
LanB1CG7123 gene product from transcript CG7123-RA0.990
edechinoid0.989
snasnail0.989
ttvtout-velu0.988
zfh1Zn finger homeodomain 10.988
Ras85DRas oncogene at 85D0.987
msnmisshapen0.987
Akt1CG4006 gene product from transcript CG4006-RA0.986
pucpuckered0.986
crbcrumbs0.986
pntpointed0.985
tgotango0.985
slp1sloppy paired 10.984
LanB2Laminin B20.982
EcREcdysone receptor0.981
retnretained0.981
NNotch0.980
ribribbon0.980
wgwingless0.977
Pi3K92ECG4141 gene product from transcript CG4141-RB0.976
wbwing blister0.976
G-oalpha47AG protein oalpha 47A0.974
srpserpent0.973
shgshotgun0.972
htlheartless0.971
twitwist0.971
dadaughterless0.969
btlbreathless0.969
ftz-f1ftz transcription factor 10.966
fz2frizzled 20.964
argosCG4531 gene product from transcript CG4531-RA0.960
Doc2Dorsocross20.960
coracoracle0.959
kniknirps0.959
hephemipterous0.956
CycACyclin A0.954
linlines0.952
E(spl)Enhancer of split0.952
CtBPC-terminal Binding Protein0.952
nejnejire0.951
Src42ASrc oncogene at 42A0.950
MrtfMyocardin-related transcription factor0.950
slmbsupernumerary limbs0.950
frcfringe connection0.947
Gap1GTPase-activating protein 10.946
ifinflated0.945
tintinman0.944
rlrolled0.942
hkbhuckebein0.941
bazbazooka0.941
rawCG12437 gene product from transcript CG12437-RB0.936
drkdownstream of receptor kinase0.932
drprdraper0.929
LanALaminin A0.928
snssticks and stones0.923
scbscab0.922
panpangolin0.916
fasfaint sausage0.915
vvlventral veins lacking0.914
eyaeyes absent0.906
ushu-shaped0.905
Six4CG3871 gene product from transcript CG3871-RA0.897
mammastermind0.888
PknProtein kinase related to protein kinase N0.886
roboroundabout0.879
rolsrolling pebbles0.876
gbbglass bottom boat0.875
rapretina aberrant in pattern0.872
lolalongitudinals lacking0.867
TSG101tumor suppressor protein 1010.867
ftzfushi tarazu0.863
opaodd paired0.860
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.853
jingCG9397 gene product from transcript CG9397-RI0.852
midmidline0.849
TBPHCG10327 gene product from transcript CG10327-RC0.847
howheld out wings0.844
pyrpyramus0.838
lunaCG33473 gene product from transcript CG33473-RB0.838
Syx1ASyntaxin 1A0.837
zipzipper0.835
bibbig brain0.834
ptcpatched0.826
KhcKinesin heavy chain0.826
HLHmdeltaE(spl) region transcript mdelta0.822
cswcorkscrew0.820
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fkbp1aFK506 binding protein 1a0.565
Fgfr1Fibroblast growth factor receptor 10.463
Ednraendothelin receptor type A0.458
Pdclphosducin-like0.392
Cmklr1chemokine-like receptor 10.392
Ascl1achaete-scute complex homolog 1 (Drosophila)0.365
Fstl1follistatin-like 10.340
Jak1Janus kinase 10.320
Atf3activating transcription factor 30.311
Tgfbr2transforming growth factor, beta receptor II0.307
Col12a1collagen, type XII, alpha 10.306
Rararetinoic acid receptor, alpha0.294
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.293
Unc5bunc-5 homolog B (C. elegans)0.291
Loxl1lysyl oxidase-like 10.282
Postnperiostin, osteoblast specific factor0.279
Slit3slit homolog 3 (Drosophila)0.257
Ncr1natural cytotoxicity triggering receptor 10.217
Smcpsperm mitochondria-associated cysteine-rich protein0.213
Lgals7lectin, galactoside-binding, soluble, 70.208
Col1a1collagen, type I, alpha 10.206
Bgnbiglycan0.201
Cyp51cytochrome P450, family 510.195
Foxd3forkhead box D30.194
Hand2heart and neural crest derivatives expressed 20.193
Dchs1dachsous 1 (Drosophila)0.190
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.186
JunJun oncogene0.184
Phox2apaired-like homeobox 2a0.182
Sc4molsterol-C4-methyl oxidase-like0.182
Prrx1paired related homeobox 10.179
Smad7SMAD family member 70.177
Oxtroxytocin receptor0.177
Casp2caspase 20.177
Ube2d4ubiquitin-conjugating enzyme E2D 40.175
Hoxb7homeo box B70.172
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.171
Nfianuclear factor I/A0.168
Id1inhibitor of DNA binding 10.168
Ier2immediate early response 20.167
Plagl1pleiomorphic adenoma gene-like 10.163
Sox17SRY (sex determining region Y)-box 170.162
Pipprolactin induced protein0.162
Gja5gap junction protein, alpha 50.162
Pfn1profilin 10.157
Rhoaras homolog gene family, member A0.156
Maneamannosidase, endo-alpha0.156
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.154
Foxe1forkhead box E1 (thyroid transcription factor 2)0.151
Vcanversican0.149
Stxbp2syntaxin binding protein 20.148
Klf2Kruppel-like factor 2 (lung)0.146
Csn1s2acasein alpha s2-like A0.145
Leprleptin receptor0.144
Col8a1collagen, type VIII, alpha 10.144
Arntaryl hydrocarbon receptor nuclear translocator0.144
Efnb1ephrin B10.141
Sirpasignal-regulatory protein alpha0.137
Cux1cut-like homeobox 10.136
Ephx1epoxide hydrolase 1, microsomal0.135
Sval1seminal vesicle antigen-like 10.134
Adam17ADAM metallopeptidase domain 170.134
Kcns1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 10.133
Acta2smooth muscle alpha-actin0.133
Il1r1interleukin 1 receptor, type I0.133
Igfbp5insulin-like growth factor binding protein 50.133
Sqlesqualene epoxidase0.132
Akt2v-akt murine thymoma viral oncogene homolog 20.132
Bcl2B-cell CLL/lymphoma 20.130
Agtr1aangiotensin II receptor, type 1a0.127
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.125
Il8rbinterleukin 8 receptor, beta0.124
Ptger4prostaglandin E receptor 4 (subtype EP4)0.122
Ctsjcathepsin J0.121
Anxa4annexin A40.121
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.121
Twist2twist homolog 2 (Drosophila)0.120
Casp1caspase 10.119
Fgfr2fibroblast growth factor receptor 20.117
Dusp1dual specificity phosphatase 10.116
Idi1isopentenyl-diphosphate delta isomerase 10.115
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.115
Nr1d2nuclear receptor subfamily 1, group D, member 20.112
KlKlotho0.110
Fdft1farnesyl diphosphate farnesyl transferase 10.109
Tcfe2atranscription factor E2a0.109
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.108
Sdc3syndecan 30.108
Agtr1bangiotensin II receptor, type 1b0.107
Gdf10growth differentiation factor 100.107
Nr1h4nuclear receptor subfamily 1, group H, member 40.106
Svs1seminal vesicle secretory protein 10.104
Dab2disabled homolog 2 (Drosophila)0.104
Bmp3bone morphogenetic protein 30.104
Foxm1forkhead box M10.103
Hoxc4homeo box C40.103
Pax8paired box 80.103
Selenbp1selenium binding protein 10.102
Rps6ka1ribosomal protein S6 kinase polypeptide 10.102
Obp2bodorant binding protein 2B0.101
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism