The network for 'chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

chromatin silencing

Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.

NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 11.000
HDAC2histone deacetylase 20.996
DNMT1DNA (cytosine-5-)-methyltransferase 10.995
RB1retinoblastoma 10.984
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.970
SIN3ASIN3 homolog A, transcription regulator (yeast)0.950
UHRF1ubiquitin-like with PHD and ring finger domains 10.916
TP53tumor protein p530.844
EEDembryonic ectoderm development0.822
PARP1poly (ADP-ribose) polymerase 10.786
RBBP4retinoblastoma binding protein 40.773
MCM7minichromosome maintenance complex component 70.756
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.665
WDR5WD repeat domain 50.619
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.549
BMI1BMI1 polycomb ring finger oncogene0.542
H2AFXH2A histone family, member X0.514
ACTL6Aactin-like 6A0.498
PCNAproliferating cell nuclear antigen0.497
MCM5minichromosome maintenance complex component 50.488
ESR1estrogen receptor 10.486
CBX5chromobox homolog 50.483
EP300E1A binding protein p3000.475
HIST1H3Bhistone cluster 1, H3b0.469
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.446
HCFC1host cell factor C1 (VP16-accessory protein)0.414
CHD4chromodomain helicase DNA binding protein 40.410
SIRT1sirtuin 10.408
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.380
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.380
BRCA1breast cancer 1, early onset0.360
CREBBPCREB binding protein0.354
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.353
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.338
CHAF1Achromatin assembly factor 1, subunit A (p150)0.317
SP1Sp1 transcription factor0.300
RUVBL1RuvB-like 1 (E. coli)0.298
MCM2minichromosome maintenance complex component 20.262
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.242
NBNnibrin0.216
MCM6minichromosome maintenance complex component 60.201
MCM3minichromosome maintenance complex component 30.194
TMPOthymopoietin0.191
DAXXdeath-domain associated protein0.186
CDC6cell division cycle 6 homolog (S. cerevisiae)0.176
WHSC1Wolf-Hirschhorn syndrome candidate 10.164
HIST1H3Dhistone cluster 1, H3d0.156
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.155
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.152
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.145
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.132
THOC4THO complex 40.132
HIST1H2BGhistone cluster 1, H2bg0.131
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.128
HDAC3histone deacetylase 30.125
HIST1H2AEhistone cluster 1, H2ae0.123
KDM1Alysine (K)-specific demethylase 1A0.117
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.113
BCORBCL6 corepressor0.107
TRIM28tripartite motif containing 280.105
SSRP1structure specific recognition protein 10.096
MDM2Mdm2 p53 binding protein homolog (mouse)0.093
MRFAP1Morf4 family associated protein 10.090
MTA1metastasis associated 10.089
MSH6mutS homolog 6 (E. coli)0.087
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.083
CSNK2A1casein kinase 2, alpha 1 polypeptide0.070
SAP30Sin3A-associated protein, 30kDa0.069
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.068
HIST2H3Chistone cluster 2, H3c0.068
NCOR2nuclear receptor corepressor 20.067
HIST1H2AMhistone cluster 1, H2am0.066
EZH2enhancer of zeste homolog 2 (Drosophila)0.063
TOP2Btopoisomerase (DNA) II beta 180kDa0.056
MYST1MYST histone acetyltransferase 10.054
HIST1H3Ahistone cluster 1, H3a0.054
USP11ubiquitin specific peptidase 110.053
HIST1H4Hhistone cluster 1, H4h0.049
HIST1H2AIhistone cluster 1, H2ai0.049
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.047
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.047
HIST1H4Bhistone cluster 1, H4b0.046
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.046
DICER1dicer 1, ribonuclease type III0.044
E2F3E2F transcription factor 30.043
NCAPHnon-SMC condensin I complex, subunit H0.043
HIST1H4Dhistone cluster 1, H4d0.043
NCOR1nuclear receptor corepressor 10.041
HDGFhepatoma-derived growth factor0.041
MEN1multiple endocrine neoplasia I0.040
CBX8chromobox homolog 80.040
TFDP1transcription factor Dp-10.039
SUZ12suppressor of zeste 12 homolog (Drosophila)0.038
ORC3origin recognition complex, subunit 30.038
SMAD3SMAD family member 30.037
SETD7SET domain containing (lysine methyltransferase) 70.037
GATAD2AGATA zinc finger domain containing 2A0.037
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.037
HIST1H2ALhistone cluster 1, H2al0.036
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.036
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CTCFCG8591 gene product from transcript CG8591-RA1.000
His2AvHistone H2A variant0.999
E(var)3-9Enhancer of variegation 3-90.998
Su(var)3-7Suppressor of variegation 3-70.997
eggeggless0.995
Su(var)205Suppressor of variegation 2050.995
ash1absent, small, or homeotic discs 10.994
Sir2CG5216 gene product from transcript CG5216-RA0.992
PcPolycomb0.991
pr-set7CG3307 gene product from transcript CG3307-RC0.990
gppgrappa0.988
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.988
ScmSex comb on midleg0.986
Pp1-87BProtein phosphatase 1 at 87B0.979
D1D1 chromosomal protein0.972
Snr1Snf5-related 10.970
Acf1ATP-dependent chromatin assembly factor large subunit0.967
Dp1Dodeca-satellite-binding protein 10.956
escextra sexcombs0.937
Rpd3CG7471 gene product from transcript CG7471-RA0.935
IswiImitation SWI0.933
trxtrithorax0.912
BRWD3CG31132 gene product from transcript CG31132-RA0.907
BEAF-32Boundary element-associated factor of 32kD0.901
crmcramped0.900
Jarid2CG3654 gene product from transcript CG3654-RD0.884
r2d2CG7138 gene product from transcript CG7138-RB0.878
E(z)Enhancer of zeste0.878
mod(mdg4)modifier of mdg40.876
XNPCG4548 gene product from transcript CG4548-RA0.816
HmgDHigh mobility group protein D0.815
G9aCG2995 gene product from transcript CG2995-RA0.812
SMC1CG6057 gene product from transcript CG6057-RA0.790
SuURSuppressor of Under-Replication0.780
RecQ4CG7487 gene product from transcript CG7487-RA0.773
e(y)3enhancer of yellow 30.765
cgcombgap0.724
PclPolycomblike0.692
lidlittle imaginal discs0.670
ParpPoly-(ADP-ribose) polymerase0.616
SMC2CG10212 gene product from transcript CG10212-RA0.597
RgaRegena0.581
Hel25EHelicase at 25E0.579
JIL-1CG6297 gene product from transcript CG6297-RA0.576
trrtrithorax-related0.568
PliPellino0.544
Rac1CG2248 gene product from transcript CG2248-RA0.543
Su(var)2-10Suppressor of variegation 2-100.524
sxcsuper sex combs0.516
MRG15CG6363 gene product from transcript CG6363-RA0.471
mus209mutagen-sensitive 2090.467
p53CG33336 gene product from transcript CG33336-RB0.464
notnon-stop0.451
PscPosterior sex combs0.441
CG8165CG8165 gene product from transcript CG8165-RA0.434
Mt2Methyltransferase 20.414
barrbarren0.380
mofmales absent on the first0.366
effeffete0.347
vasvasa0.344
HP4Heterochromatin protein 40.326
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.320
rinrasputin0.315
ph-ppolyhomeotic proximal0.300
CG3363CG3363 gene product from transcript CG3363-RB0.297
smt3CG4494 gene product from transcript CG4494-RA0.289
staustaufen0.284
MoeMoesin0.274
chmchameau0.274
TrnTransportin0.260
mormoira0.255
Suv4-20CG13363 gene product from transcript CG13363-RA0.246
Chd1Chromodomain-helicase-DNA-binding protein 10.235
CG5899CG5899 gene product from transcript CG5899-RA0.234
phopleiohomeotic0.232
ChroChromator0.232
waplwings apart-like0.230
TrlTrithorax-like0.228
Rho1CG8416 gene product from transcript CG8416-RB0.211
glugluon0.211
lolallola like0.209
B52CG10851 gene product from transcript CG10851-RB0.208
CG5720CG5720 gene product from transcript CG5720-RA0.206
msl-2male-specific lethal 20.198
howheld out wings0.197
Mi-2CG8103 gene product from transcript CG8103-RA0.196
MBD-likeCG8208 gene product from transcript CG8208-RA0.196
ari-2ariadne 20.191
RavusCG15889 gene product from transcript CG15889-RA0.190
dltdiscs lost0.187
Su(var)3-3Suppressor of variegation 3-30.183
CG3078CG3078 gene product from transcript CG3078-RA0.181
eastenhanced adult sensory threshold0.179
Sep2Septin-20.178
lwrlesswright0.176
wwhite0.174
pashapartner of drosha0.172
crpcropped0.168
AlhAlhambra0.165
CG10630CG10630 gene product from transcript CG10630-RA0.162
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.999
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.992
Hdac1histone deacetylase 10.983
Ezh2enhancer of zeste homolog 2 (Drosophila)0.979
Pou5f1POU domain, class 5, transcription factor 10.961
NanogNanog homeobox0.941
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.924
Arid1bAT rich interactive domain 1B (SWI-like)0.903
RybpRING1 and YY1 binding protein0.896
CtcfCCCTC-binding factor0.852
Hdac2histone deacetylase 20.791
Dnmt3aDNA methyltransferase 3A0.764
Wdr5WD repeat domain 50.747
Suz12suppressor of zeste 12 homolog (Drosophila)0.701
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.681
Dnmt3bDNA methyltransferase 3B0.632
Pcgf2polycomb group ring finger 20.629
Trp53transformation related protein 530.613
H3f3aH3 histone, family 3A0.553
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.547
Rbbp4retinoblastoma binding protein 40.478
Bmi1Bmi1 polycomb ring finger oncogene0.462
Dnmt1DNA methyltransferase (cytosine-5) 10.443
Mta2metastasis-associated gene family, member 20.400
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.380
Cdkn1bcyclin-dependent kinase inhibitor 1B0.349
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.336
Kdm2blysine (K)-specific demethylase 2B0.330
NipblNipped-B homolog (Drosophila)0.322
Trim28tripartite motif-containing 280.322
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.320
Chd4chromodomain helicase DNA binding protein 40.318
Ep400E1A binding protein p4000.312
Ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.297
Smc1astructural maintenance of chromosomes 1A0.275
CrebbpCREB binding protein0.266
Mta1metastasis associated 10.258
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.252
Ep300E1A binding protein p3000.238
Phc2polyhomeotic-like 2 (Drosophila)0.231
Brca1breast cancer 10.227
Mecp2methyl CpG binding protein 20.219
Rb1retinoblastoma 10.216
Brca2breast cancer 20.210
Smc3structural maintenace of chromosomes 30.209
Sin3atranscriptional regulator, SIN3A (yeast)0.202
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.200
E2f1E2F transcription factor 10.198
Sall4sal-like 4 (Drosophila)0.198
Bptfbromodomain PHD finger transcription factor0.195
Matr3matrin 30.188
Hist1h3ghistone cluster 1, H3g0.176
Arid1aAT rich interactive domain 1A (SWI-like)0.171
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.162
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.158
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.154
Lmnb1lamin B10.144
Rbbp7retinoblastoma binding protein 70.133
Hmgb1high mobility group box 10.129
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.127
Sp1trans-acting transcription factor 10.125
Stag1stromal antigen 10.122
Sp4trans-acting transcription factor 40.122
Trim24tripartite motif-containing 240.106
Rbl2retinoblastoma-like 20.105
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.105
Tcfcp2l1transcription factor CP2-like 10.100
Parp1poly (ADP-ribose) polymerase family, member 10.099
Dnmt3lDNA (cytosine-5-)-methyltransferase 3-like0.095
MgaMAX gene associated0.094
Cdk4cyclin-dependent kinase 40.091
L3mbtl2l(3)mbt-like 2 (Drosophila)0.090
Brd4bromodomain containing 40.088
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.084
Men1multiple endocrine neoplasia 10.081
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.079
Scaf11SR-related CTD-associated factor 110.076
Nup85nucleoporin 850.073
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.070
Mbtd1mbt domain containing 10.069
Nucks1nuclear casein kinase and cyclin-dependent kinase substrate 10.067
Usp9xubiquitin specific peptidase 9, X chromosome0.065
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.064
Rfc5replication factor C (activator 1) 50.063
Erbb2ipErbb2 interacting protein0.062
Csnk1a1casein kinase 1, alpha 10.061
Mdm4transformed mouse 3T3 cell double minute 40.061
Msh2mutS homolog 2 (E. coli)0.060
Tcf3transcription factor 30.059
RanRAN, member RAS oncogene family0.058
Zmym5zinc finger, MYM-type 50.058
Rpa2replication protein A20.057
Ccna2cyclin A20.057
Zfp292zinc finger protein 2920.056
Eedembryonic ectoderm development0.056
Jarid2jumonji, AT rich interactive domain 20.052
Hellshelicase, lymphoid specific0.051
Rcc2regulator of chromosome condensation 20.050
Cdk2cyclin-dependent kinase 20.049
Rrm1ribonucleotide reductase M10.049
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
HHT1Hht1p0.999
SIR2Sir2p0.998
SIN3Sin3p0.996
RPD3Rpd3p0.996
SIR4Sir4p0.993
RLF2Rlf2p0.990
HHF1Hhf1p0.987
SET1Set1p0.972
ORC2Orc2p0.970
RXT2Rxt2p0.961
RCO1Rco1p0.951
MMS22Mms22p0.939
RAP1Rap1p0.926
HDA1Hda1p0.926
SET3Set3p0.910
ORC5Orc5p0.900
SAS2Sas2p0.894
HAT1Hat1p0.883
SDS3Sds3p0.875
SNT1Snt1p0.872
ORC1Orc1p0.839
SPT10Spt10p0.832
BDF1Bdf1p0.830
HMO1Hmo1p0.829
SWD3Swd3p0.819
SIR3Sir3p0.804
CTI6Cti6p0.787
SET2Set2p0.777
HOS4Hos4p0.772
NET1Net1p0.768
ARP4Arp4p0.750
SDC1Sdc1p0.750
ORC6Orc6p0.733
CHL1Chl1p0.720
HHO1Hho1p0.714
NUP133Nup133p0.709
YTA7Yta7p0.702
FKH1Fkh1p0.673
FOB1Fob1p0.668
CHD1Chd1p0.667
UME1Ume1p0.659
RIF1Rif1p0.658
ISW1Isw1p0.621
SUM1Sum1p0.618
CDC6Cdc6p0.606
STH1Sth1p0.591
UBP8Ubp8p0.590
RSC2Rsc2p0.589
RTT106Rtt106p0.584
DEF1Def1p0.583
MCM3Mcm3p0.559
IFH1Ifh1p0.557
CTF18Ctf18p0.551
TAF14Taf14p0.550
FHL1Fhl1p0.543
ASF1Asf1p0.540
ORC3Orc3p0.527
ITC1Itc1p0.524
HOS2Hos2p0.522
ISW2Isw2p0.522
BRE1Bre1p0.486
PHO23Pho23p0.484
BRE2Bre2p0.474
NUP120Nup120p0.473
HHT2Hht2p0.463
SAS5Sas5p0.460
HST1Hst1p0.458
SPP1Spp1p0.453
SAS4Sas4p0.441
HST3Hst3p0.438
SIC1Sic1p0.437
FUN30Fun30p0.435
ZDS1Zds1p0.420
CPR1Cpr1p0.419
GCN5Gcn5p0.419
HDA3Hda3p0.416
SPT21Spt21p0.415
SWD1Swd1p0.405
MIG2Mig2p0.387
RAD9Rad9p0.385
GLC7Glc7p0.382
CKA1Cka1p0.381
CTK1Ctk1p0.381
SAP30Sap30p0.376
VPS27Vps27p0.373
ORC4Orc4p0.372
HAT2Hat2p0.361
PAP2Pap2p0.354
RSC8Rsc8p0.352
RAD17Rad17p0.344
NGG1Ngg1p0.343
NTO1Nto1p0.341
RFM1Rfm1p0.340
RVB2Rvb2p0.335
MIG3Mig3p0.330
MCM6Mcm6p0.329
LYS5Lys5p0.317
HOS3Hos3p0.309
MRS6Mrs6p0.300
SGF29Sgf29p0.291