The network for 'methylation dependent chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

methylation dependent chromatin silencing

Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.

NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 11.000
DNMT1DNA (cytosine-5-)-methyltransferase 11.000
UHRF1ubiquitin-like with PHD and ring finger domains 11.000
HDAC2histone deacetylase 21.000
MTA1metastasis associated 10.998
CHD4chromodomain helicase DNA binding protein 40.998
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.996
EZH2enhancer of zeste homolog 2 (Drosophila)0.995
EEDembryonic ectoderm development0.994
SIN3ASIN3 homolog A, transcription regulator (yeast)0.987
SP1Sp1 transcription factor0.985
RBBP4retinoblastoma binding protein 40.979
KDM1Alysine (K)-specific demethylase 1A0.973
MTA3metastasis associated 1 family, member 30.962
ESR1estrogen receptor 10.955
MTA2metastasis associated 1 family, member 20.915
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.901
FOXD3forkhead box D30.893
GATAD2AGATA zinc finger domain containing 2A0.879
PAX3paired box 30.837
SOX10SRY (sex determining region Y)-box 100.830
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.822
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.816
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.639
E2F3E2F transcription factor 30.570
GATAD2BGATA zinc finger domain containing 2B0.546
SOX2SRY (sex determining region Y)-box 20.509
SUZ12suppressor of zeste 12 homolog (Drosophila)0.502
HCFC1host cell factor C1 (VP16-accessory protein)0.461
WWP2WW domain containing E3 ubiquitin protein ligase 20.457
NRIP1nuclear receptor interacting protein 10.422
CBX5chromobox homolog 50.383
RB1retinoblastoma 10.370
MBD2methyl-CpG binding domain protein 20.310
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.306
CHD3chromodomain helicase DNA binding protein 30.297
TRIM28tripartite motif containing 280.273
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.202
RCOR1REST corepressor 10.187
RBBP7retinoblastoma binding protein 70.163
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.151
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.143
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.126
BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)0.122
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.118
POGZpogo transposable element with ZNF domain0.105
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.087
DAXXdeath-domain associated protein0.083
HTThuntingtin0.083
CTBP1C-terminal binding protein 10.075
SAP30Sin3A-associated protein, 30kDa0.070
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.065
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.064
CDK2AP1cyclin-dependent kinase 2 associated protein 10.061
PELP1proline, glutamate and leucine rich protein 10.061
MBD1methyl-CpG binding domain protein 10.060
KIAA0101KIAA01010.052
PBRM1polybromo 10.049
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 20.049
KHSRPKH-type splicing regulatory protein0.048
NCOR2nuclear receptor corepressor 20.046
CSNK1G2casein kinase 1, gamma 20.046
MEOX2mesenchyme homeobox 20.043
HMGA1high mobility group AT-hook 10.041
ARID1AAT rich interactive domain 1A (SWI-like)0.041
EHMT2euchromatic histone-lysine N-methyltransferase 20.038
SOX11SRY (sex determining region Y)-box 110.037
ARID1BAT rich interactive domain 1B (SWI1-like)0.035
C14orf43chromosome 14 open reading frame 430.033
SOX1SRY (sex determining region Y)-box 10.031
CARM1coactivator-associated arginine methyltransferase 10.030
H3F3BH3 histone, family 3B (H3.3B)0.029
BAZ1Bbromodomain adjacent to zinc finger domain, 1B0.028
ZBTB17zinc finger and BTB domain containing 170.027
ESR2estrogen receptor 2 (ER beta)0.027
POU4F1POU class 4 homeobox 10.027
NR2E3nuclear receptor subfamily 2, group E, member 30.026
MYOD1myogenic differentiation 10.025
EP300E1A binding protein p3000.025
HOXD12homeobox D120.024
NR0B1nuclear receptor subfamily 0, group B, member 10.024
NOVA2neuro-oncological ventral antigen 20.024
SOX21SRY (sex determining region Y)-box 210.023
FANCCFanconi anemia, complementation group C0.023
GRIP1glutamate receptor interacting protein 10.022
POU3F2POU class 3 homeobox 20.021
YY1YY1 transcription factor0.021
CENPBcentromere protein B, 80kDa0.020
FOXE1forkhead box E1 (thyroid transcription factor 2)0.020
CDCA7cell division cycle associated 70.020
BCL6B-cell CLL/lymphoma 60.019
ASCL1achaete-scute complex homolog 1 (Drosophila)0.019
CEP152centrosomal protein 152kDa0.019
LHX1LIM homeobox 10.019
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.019
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.019
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.019
SMAD7SMAD family member 70.018
NKX2-1NK2 homeobox 10.018
C16orf87chromosome 16 open reading frame 870.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dnmt3bDNA methyltransferase 3B0.951
Sall4sal-like 4 (Drosophila)0.825
NanogNanog homeobox0.636
Pou5f1POU domain, class 5, transcription factor 10.624
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.606
Dnmt3lDNA (cytosine-5-)-methyltransferase 3-like0.563
Tcfcp2l1transcription factor CP2-like 10.338
Dnmt3aDNA methyltransferase 3A0.280
Arid1bAT rich interactive domain 1B (SWI-like)0.105
Sall1sal-like 1 (Drosophila)0.078
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.056
Esrrbestrogen related receptor, beta0.055
Mta1metastasis associated 10.051
Nr0b1nuclear receptor subfamily 0, group B, member 10.040
Arid1aAT rich interactive domain 1A (SWI-like)0.038
Chd4chromodomain helicase DNA binding protein 40.028
Sox2SRY-box containing gene 20.027
Mta2metastasis-associated gene family, member 20.024
Smarcc2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.019
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.013
Smarcb1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.013
L3mbtl2l(3)mbt-like 2 (Drosophila)0.013
Rnf2ring finger protein 20.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism