The network for 'protein demethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein demethylation

The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.

NameDescriptionProbabilityFunc Analog Organism
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.823
BCORBCL6 corepressor0.542
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.436
ZCCHC17zinc finger, CCHC domain containing 170.212
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.196
BRD4bromodomain containing 40.187
USP9Yubiquitin specific peptidase 9, Y-linked0.179
U2AF1U2 small nuclear RNA auxiliary factor 10.152
ZFXzinc finger protein, X-linked0.102
ZNF217zinc finger protein 2170.099
NCOA6nuclear receptor coactivator 60.092
DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.087
ZNF512Bzinc finger protein 512B0.069
EIF1AYeukaryotic translation initiation factor 1A, Y-linked0.068
KDM5Dlysine (K)-specific demethylase 5D0.066
CCNL1cyclin L10.055
KDM5Blysine (K)-specific demethylase 5B0.048
HBP1HMG-box transcription factor 10.046
ZFYzinc finger protein, Y-linked0.045
KIAA0182KIAA01820.040
UBXN7UBX domain protein 70.040
BRD1bromodomain containing 10.038
RIOK3RIO kinase 3 (yeast)0.037
RLFrearranged L-myc fusion0.034
WDR26WD repeat domain 260.033
CYorf15Achromosome Y open reading frame 15A0.032
UTYubiquitously transcribed tetratricopeptide repeat gene, Y-linked0.031
GPBP1L1GC-rich promoter binding protein 1-like 10.031
CCNG2cyclin G20.030
RCOR1REST corepressor 10.030
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.026
PUM1pumilio homolog 1 (Drosophila)0.026
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.025
UBR1ubiquitin protein ligase E3 component n-recognin 10.024
JARID2jumonji, AT rich interactive domain 20.024
USP9Xubiquitin specific peptidase 9, X-linked0.022
KDM3Alysine (K)-specific demethylase 3A0.022
MXI1MAX interactor 10.021
RPS4Y1ribosomal protein S4, Y-linked 10.020
MKRN1makorin ring finger protein 10.019
KLHL24kelch-like 24 (Drosophila)0.019
NCOR1nuclear receptor corepressor 10.018
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.018
SPENspen homolog, transcriptional regulator (Drosophila)0.018
PHF21APHD finger protein 21A0.018
CHD4chromodomain helicase DNA binding protein 40.017
PRRC2Cproline-rich coiled-coil 2C0.017
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.016
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.016
CUX1cut-like homeobox 10.015
ATAD2BATPase family, AAA domain containing 2B0.015
PPP2R2Dprotein phosphatase 2, regulatory subunit B, delta0.015
RNF38ring finger protein 380.015
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.015
C20orf111chromosome 20 open reading frame 1110.014
ELLelongation factor RNA polymerase II0.013
PCGF1polycomb group ring finger 10.013
KDM5Clysine (K)-specific demethylase 5C0.013
SERTAD2SERTA domain containing 20.013
MTF1metal-regulatory transcription factor 10.012
RYBPRING1 and YY1 binding protein0.012
HIST1H3Bhistone cluster 1, H3b0.012
TBC1D15TBC1 domain family, member 150.012
HELZhelicase with zinc finger0.012
BRD2bromodomain containing 20.012
BAZ2Abromodomain adjacent to zinc finger domain, 2A0.012
PHF1PHD finger protein 10.012
MKNK2MAP kinase interacting serine/threonine kinase 20.012
GOLGB1golgin B10.011
GATAD2BGATA zinc finger domain containing 2B0.011
ARID1AAT rich interactive domain 1A (SWI-like)0.011
MLL3myeloid/lymphoid or mixed-lineage leukemia 30.011
MSL2male-specific lethal 2 homolog (Drosophila)0.011
CNOT8CCR4-NOT transcription complex, subunit 80.010
RBBP5retinoblastoma binding protein 50.010
MTA1metastasis associated 10.010
PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)0.010
YPEL5yippee-like 5 (Drosophila)0.010
CEP350centrosomal protein 350kDa0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wu:fi04c06wu:fi04c060.463
kdm4blysine (K)-specific demethylase 4B0.458
ash1lash1 (absent, small, or homeotic)-like (Drosophila)0.375
ankrd12ankyrin repeat domain 120.239
si:dkey-21n12.1si:dkey-21n12.10.210
phf2PHD finger protein 20.204
btg1B-cell translocation gene 10.176
gpatch8G patch domain containing 80.121
supt6hsuppressor of Ty 6 homolog0.116
si:ch211-57k11.10si:ch211-57k11.100.104
npeppsaminopeptidase puromycin sensitive0.104
zgc:162740zgc:1627400.090
LOC100536021spectrin beta chain, brain 1-like0.090
zgc:77407zgc:774070.083
mapk3mitogen-activated protein kinase 30.078
phrf1PHD and ring finger domains 10.077
zgc:113421zgc:1134210.073
lmbrd2bLMBR1 domain containing 2b0.064
myef2myelin expression factor 20.061
midnmidnolin0.059
nova2neuro-oncological ventral antigen 20.056
skianuclear oncoprotein skia0.056
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.053
mbnl2muscleblind-like 2 (Drosophila)0.053
im:7163548im:71635480.051
ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.050
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.049
LOC100148274hypothetical protein LOC1001482740.048
tcf12transcription factor 120.047
brd3bbromodomain containing 3b0.045
brapBRCA1 associated protein0.044
thoc2THO complex 20.044
ptenaphosphatase and tensin homolog A0.044
fbxl5F-box and leucine-rich repeat protein 50.044
nktrnatural killer-tumor recognition sequence0.044
nvlnuclear VCP-like0.043
pcdh10bprotocadherin 10b0.043
kdm1alysine (K)-specific demethylase 1a0.043
arid4aAT rich interactive domain 4A (RBP1-like)0.042
fxr2fragile X mental retardation, autosomal homolog 20.037
si:dkeyp-89d7.1si:dkeyp-89d7.10.035
pcdh18aprotocadherin 18a0.033
elf2aE74-like factor 2a (ets domain transcription factor)0.033
tnrc6btrinucleotide repeat containing 6B0.033
trim8tripartite motif-containing 80.033
tecpr2tectonin beta-propeller repeat containing 20.032
syne2bspectrin repeat containing, nuclear envelope 2b0.031
fbln4fibulin 40.031
mll4bmyeloid/lymphoid or mixed-lineage leukemia 4b0.030
sall1asal-like 1a (Drosophila)0.030
wu:fa07b03wu:fa07b030.029
fcho2FCH domain only 20.028
foxp2forkhead box P20.028
ikbkaplinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein like0.027
actr8ARP8 actin-related protein 8 homolog (yeast)0.027
ints1integrator complex subunit 10.026
nt5dc25'-nucleotidase domain containing 20.026
tiprlTIP41, TOR signaling pathway regulator-like (S. cerevisiae)0.026
zgc:101761zgc:1017610.026
strn3striatin, calmodulin binding protein 30.025
atp2b4ATPase, Ca++ transporting, plasma membrane 40.025
caskcalcium/calmodulin-dependent serine protein kinase0.025
si:ch211-81a5.7si:ch211-81a5.70.025
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.024
peli1bpellino homolog 1b (Drosophila)0.024
rc3rabconnectin 30.024
faf1Fas associated factor 10.023
wu:fc48e01wu:fc48e010.022
nfianuclear factor I/A0.022
cd99l2CD99 antigen-like 20.022
rnf41ring finger protein 410.022
abca5ATP-binding cassette, sub-family A (ABC1), member 50.022
ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.022
im:7139293im:71392930.022
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.022
senp6aSUMO1/sentrin specific peptidase 6a0.021
c1orf109c1orf109 homolog (H. sapiens)0.021
ep300bE1A binding protein p300 b0.021
kif5bbkinesin family member 5B, b0.020
wu:fb54a03wu:fb54a030.020
usp25ubiquitin specific protease 250.020
otud5aOTU domain containing 5a0.020
LOC563749hypothetical protein LOC5637490.019
ppp3ccaprotein phosphatase 3, catalytic subunit, gamma isozyme, a0.019
smc1alstructural maintenance of chromosomes 1A, like0.019
exoc7exocyst complex component 70.019
si:dkey-181m9.9si:dkey-181m9.90.018
oxsr1aoxidative-stress responsive 1a0.018
znf148zinc finger protein 1480.018
rpap2RNA polymerase II associated protein 20.018
cadm3cell adhesion molecule 30.018
si:dkey-175m17.8si:dkey-175m17.80.018
mical3flavoprotein oxidoreductase MICAL30.018
ranbp9RAN binding protein 90.018
si:dkeyp-38g8.5si:dkeyp-38g8.50.017
osgepl1O-sialoglycoprotein endopeptidase-like 10.017
ggnbp2gametogenetin binding protein 20.017
celf4CUGBP, Elav-like family member 40.016
clstn1calsyntenin 10.016
zgc:163008zgc:1630080.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rnf2ring finger protein 20.994
Kdm1alysine (K)-specific demethylase 1A0.673
Sin3atranscriptional regulator, SIN3A (yeast)0.307
BcorBCL6 interacting corepressor0.301
Kdm2blysine (K)-specific demethylase 2B0.263
Cbx8chromobox homolog 8 (Drosophila Pc class)0.218
Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.178
Csnk2a1casein kinase 2, alpha 1 polypeptide0.145
Ctbp1C-terminal binding protein 10.072
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.065
Csnk2a2casein kinase 2, alpha prime polypeptide0.050
Eif2s3yeukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked0.049
Ccng2cyclin G20.048
Zfp292zinc finger protein 2920.043
Cbx3chromobox homolog 3 (Drosophila HP1 gamma)0.043
Bmi1Bmi1 polycomb ring finger oncogene0.040
Cul9cullin 90.039
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.035
Arid1bAT rich interactive domain 1B (SWI-like)0.034
Clk3CDC-like kinase 30.032
Skp1aS-phase kinase-associated protein 1A0.027
Morf4l1mortality factor 4 like 10.025
Lin28alin-28 homolog A (C. elegans)0.025
Yaf2YY1 associated factor 20.024
Utyubiquitously transcribed tetratricopeptide repeat gene, Y chromosome0.024
Pum1pumilio 1 (Drosophila)0.023
Kdm5dlysine (K)-specific demethylase 5D0.022
Men1multiple endocrine neoplasia 10.022
Lin28blin-28 homolog B (C. elegans)0.022
Phrf1PHD and ring finger domains 10.019
MgaMAX gene associated0.019
Rlfrearranged L-myc fusion sequence0.019
Xrn15'-3' exoribonuclease 10.017
Ctbp2C-terminal binding protein 20.017
A930001N09RikRIKEN cDNA A930001N09 gene0.015
Clk1CDC-like kinase 10.014
Maml1mastermind like 1 (Drosophila)0.013
Klhl24kelch-like 24 (Drosophila)0.013
Kdm5blysine (K)-specific demethylase 5B0.013
Cbx7chromobox homolog 70.013
Fbxo38F-box protein 380.013
Jarid2jumonji, AT rich interactive domain 20.012
Dbx1developing brain homeobox 10.012
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.011
Zfand5zinc finger, AN1-type domain 50.011
Sp4trans-acting transcription factor 40.011
Esr1estrogen receptor 1 (alpha)0.011
Fam103a1family with sequence similarity 103, member A10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism