The network for 'response to estradiol' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to estradiol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
EGFRepidermal growth factor receptor0.995
ARandrogen receptor0.984
CREBBPCREB binding protein0.979
PTPN1protein tyrosine phosphatase, non-receptor type 10.966
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.956
CAV1caveolin 1, caveolae protein, 22kDa0.923
CASP3caspase 3, apoptosis-related cysteine peptidase0.867
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.812
JAK2Janus kinase 20.734
IL8interleukin 80.720
EPORerythropoietin receptor0.673
INSRinsulin receptor0.599
IL4Rinterleukin 4 receptor0.595
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.589
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.524
MDM2Mdm2 p53 binding protein homolog (mouse)0.504
NCOA2nuclear receptor coactivator 20.501
CXCL2chemokine (C-X-C motif) ligand 20.501
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.463
FGFR2fibroblast growth factor receptor 20.443
TP53tumor protein p530.439
NCOA1nuclear receptor coactivator 10.421
SOCS1suppressor of cytokine signaling 10.421
THBS1thrombospondin 10.418
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.377
GH1growth hormone 10.366
FADDFas (TNFRSF6)-associated via death domain0.345
NOSTRINnitric oxide synthase trafficker0.338
TBX5T-box 50.333
CXCL3chemokine (C-X-C motif) ligand 30.328
UHRF1ubiquitin-like with PHD and ring finger domains 10.323
APAF1apoptotic peptidase activating factor 10.297
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.295
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.289
PTPN6protein tyrosine phosphatase, non-receptor type 60.289
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.287
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.272
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.235
SRFserum response factor (c-fos serum response element-binding transcription factor)0.232
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.222
GHRgrowth hormone receptor0.215
POU5F1POU class 5 homeobox 10.213
RUNX1runt-related transcription factor 10.203
NCOA6nuclear receptor coactivator 60.196
CRYAAcrystallin, alpha A0.189
SORBS3sorbin and SH3 domain containing 30.183
SOCS3suppressor of cytokine signaling 30.182
NRIP1nuclear receptor interacting protein 10.175
CASP9caspase 9, apoptosis-related cysteine peptidase0.172
RARAretinoic acid receptor, alpha0.161
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.148
RXRAretinoid X receptor, alpha0.142
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.138
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.136
NRP1neuropilin 10.133
CCNB1cyclin B10.132
FASFas (TNF receptor superfamily, member 6)0.124
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.124
CSH2chorionic somatomammotropin hormone 20.122
CDK6cyclin-dependent kinase 60.115
PTPRJprotein tyrosine phosphatase, receptor type, J0.108
SOCS2suppressor of cytokine signaling 20.107
NCOA3nuclear receptor coactivator 30.104
PTPRBprotein tyrosine phosphatase, receptor type, B0.103
DAXXdeath-domain associated protein0.103
CCND3cyclin D30.101
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.100
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.097
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.096
CCL20chemokine (C-C motif) ligand 200.095
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.095
EP300E1A binding protein p3000.088
HSPB8heat shock 22kDa protein 80.087
PPARAperoxisome proliferator-activated receptor alpha0.087
APPamyloid beta (A4) precursor protein0.077
IL12RB2interleukin 12 receptor, beta 20.077
PDIA3protein disulfide isomerase family A, member 30.076
NCOR2nuclear receptor corepressor 20.076
BRCA1breast cancer 1, early onset0.072
SIRT1sirtuin 10.069
PLCG1phospholipase C, gamma 10.067
ALDH1A1aldehyde dehydrogenase 1 family, member A10.066
BCL2A1BCL2-related protein A10.065
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.064
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.063
FGF1fibroblast growth factor 1 (acidic)0.063
IL2RBinterleukin 2 receptor, beta0.062
PGRprogesterone receptor0.061
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.059
IL1Binterleukin 1, beta0.058
IL6interleukin 6 (interferon, beta 2)0.058
GH2growth hormone 20.058
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.057
IFNAR2interferon (alpha, beta and omega) receptor 20.056
GATA4GATA binding protein 40.054
NR0B2nuclear receptor subfamily 0, group B, member 20.053
PPP5Cprotein phosphatase 5, catalytic subunit0.051
PCGF2polycomb group ring finger 20.050
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.049
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
socs3asuppressor of cytokine signaling 3a0.250
esr1estrogen receptor 10.237
igf1insulin-like growth factor 10.196
nrg2aneuregulin 2a0.154
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.142
col1a2collagen, type I, alpha 20.113
twist1atwist1a0.107
vtg3vitellogenin 3, phosvitinless0.106
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.086
mcoln1mucolipin 10.080
ripk2receptor-interacting serine-threonine kinase 20.078
ca2carbonic anhydrase II0.078
fgf8afibroblast growth factor 8 a0.075
col5a1procollagen, type V, alpha 10.072
shhasonic hedgehog a0.070
dkk1bdickkopf 1b0.066
cpla2cytosolic phospholipase a20.063
myod1myogenic differentiation 10.063
ghragrowth hormone receptor a0.059
igf2ainsulin-like growth factor 2a0.054
arandrogen receptor0.054
apoebapolipoprotein Eb0.053
ghrbgrowth hormone receptor b0.043
stat3signal transduction and activation of transcription 30.043
epas1bendothelial PAS domain protein 1b0.042
esr2aestrogen receptor 2a0.040
sox9aSRY-box containing gene 9a0.038
gdf11growth differentiation factor 110.037
atf3activating transcription factor 30.036
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.034
fabp11afatty acid binding protein 11a0.034
fosl2fos-like antigen 20.030
mycamyelocytomatosis oncogene a0.029
ptgs1prostaglandin-endoperoxide synthase 10.029
esr2bestrogen receptor 2b0.029
lppLIM domain containing preferred translocation partner in lipoma0.028
prox1prospero-related homeobox gene 10.027
zgc:153997zgc:1539970.027
inhbaainhibin, beta Aa0.025
wnt10awingless-type MMTV integration site family, member 10a0.023
npntnephronectin0.022
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.020
foxa3forkhead box A30.020
gap43growth associated protein 430.019
wnt3awingless-type MMTV integration site family, member 3A0.018
esrrbestrogen-related receptor beta0.018
anxa1bannexin A1b0.017
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.017
wt1awilms tumor 1a0.017
lama5laminin, alpha 50.016
th2tyrosine hydroxylase 20.016
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.016
crabp1bcellular retinoic acid binding protein 1b0.016
col12a1collagen, type XII, alpha 10.016
junbljun B proto-oncogene, like0.016
pcnaproliferating cell nuclear antigen0.016
rfngradical fringe homolog (Drosophila)0.016
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.015
tgfbitransforming growth factor, beta-induced0.015
irx2airoquois homeobox protein 2, a0.014
lpar1lysophosphatidic acid receptor 10.014
mstnamyostatin a0.014
myogmyogenin0.013
igf2binsulin-like growth factor 2b0.013
anxa1cannexin A1c0.013
prom1bprominin 1 b0.013
junbjun B proto-oncogene0.012
pacsin3protein kinase C and casein kinase substrate in neurons 30.012
nog1noggin 10.012
mstnbmyostatin b0.012
nav3neuron navigator 30.012
tbpl2TATA box binding protein like 20.012
pax7apaired box gene 7a0.012
ncam1bneural cell adhesion molecule 1b0.012
si:rp71-39b20.7si:rp71-39b20.70.011
meis1myeloid ecotropic viral integration 10.011
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.011
ca8carbonic anhydrase VIII0.011
slit3slit (Drosophila) homolog 30.011
LOC799612prolactin 20.011
copebcore promoter element binding protein0.011
insrainsulin receptor a0.011
aplnraapelin receptor a0.011
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.011
vtg2vitellogenin 20.011
LOC555504novel protocadherin protein0.011
gsdfgonadal somatic cell derived factor0.010
raraaretinoic acid receptor, alpha a0.010
foxa2forkhead box A20.010
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.010
aldh2aaldehyde dehydrogenase 2 family (mitochondrial)a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.947
Trp53transformation related protein 530.827
Ptpn11protein tyrosine phosphatase, non-receptor type 110.490
Nos3nitric oxide synthase 3, endothelial cell0.425
Esr1estrogen receptor 1 (alpha)0.405
Fgfr2fibroblast growth factor receptor 20.384
Col1a1collagen, type I, alpha 10.265
Apoeapolipoprotein E0.262
Vegfavascular endothelial growth factor A0.246
Cdkn1bcyclin-dependent kinase inhibitor 1B0.235
Lepleptin0.231
Esr2estrogen receptor 2 (beta)0.220
Stat5asignal transducer and activator of transcription 5A0.216
Nos1nitric oxide synthase 1, neuronal0.192
Cav1caveolin 1, caveolae protein0.182
Arandrogen receptor0.179
Csf1colony stimulating factor 1 (macrophage)0.156
Stat3signal transducer and activator of transcription 30.127
Cdk4cyclin-dependent kinase 40.124
Ccl2chemokine (C-C motif) ligand 20.114
Cdk2cyclin-dependent kinase 20.106
Ptenphosphatase and tensin homolog0.103
Ctnnb1catenin (cadherin associated protein), beta 10.101
Itgb1integrin beta 1 (fibronectin receptor beta)0.097
Sox9SRY-box containing gene 90.093
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.088
Ptgs2prostaglandin-endoperoxide synthase 20.088
Nos2nitric oxide synthase 2, inducible0.084
Foxa2forkhead box A20.082
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.078
Prlrprolactin receptor0.077
Ghrgrowth hormone receptor0.072
Foxc2forkhead box C20.069
Tnftumor necrosis factor0.065
Apcadenomatosis polyposis coli0.061
Cd44CD44 antigen0.061
Smad3MAD homolog 3 (Drosophila)0.058
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.056
Pgrprogesterone receptor0.052
Shhsonic hedgehog0.051
Cdk6cyclin-dependent kinase 60.049
Zeb1zinc finger E-box binding homeobox 10.049
Egfrepidermal growth factor receptor0.047
Fgfr1fibroblast growth factor receptor 10.045
Il10interleukin 100.044
Grb10growth factor receptor bound protein 100.044
Fshrfollicle stimulating hormone receptor0.043
Ppargperoxisome proliferator activated receptor gamma0.042
Rxraretinoid X receptor alpha0.040
Pax3paired box gene 30.037
Il6stinterleukin 6 signal transducer0.037
Tbx1T-box 10.036
Fgfr3fibroblast growth factor receptor 30.035
Kiss1KiSS-1 metastasis-suppressor0.033
Tgfbr2transforming growth factor, beta receptor II0.031
Tgfb1transforming growth factor, beta 10.030
Jak2Janus kinase 20.028
Igf1rinsulin-like growth factor I receptor0.027
Pitx2paired-like homeodomain transcription factor 20.027
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.027
Ece1endothelin converting enzyme 10.027
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.026
Prrx2paired related homeobox 20.025
Vhlvon Hippel-Lindau tumor suppressor0.024
Insrinsulin receptor0.024
Ccnd1cyclin D10.023
Pthlhparathyroid hormone-like peptide0.023
Vdrvitamin D receptor0.023
Prrx1paired related homeobox 10.023
Bmp4bone morphogenetic protein 40.023
Kitkit oncogene0.023
Loxlysyl oxidase0.023
Psen1presenilin 10.021
Tlr4toll-like receptor 40.020
Ezh2enhancer of zeste homolog 2 (Drosophila)0.020
Mmp9matrix metallopeptidase 90.020
Sfrp2secreted frizzled-related protein 20.020
Ptprcprotein tyrosine phosphatase, receptor type, C0.020
Lmnalamin A0.020
Hdac1histone deacetylase 10.019
Hand2heart and neural crest derivatives expressed transcript 20.019
Timp3tissue inhibitor of metalloproteinase 30.019
Ednraendothelin receptor type A0.019
Igf1insulin-like growth factor 10.019
Klklotho0.018
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.018
Sim1single-minded homolog 1 (Drosophila)0.017
Isl1ISL1 transcription factor, LIM/homeodomain0.017
Tgfb2transforming growth factor, beta 20.017
Pomcpro-opiomelanocortin-alpha0.016
Pax7paired box gene 70.016
Slc12a1solute carrier family 12, member 10.016
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.016
Dmap1DNA methyltransferase 1-associated protein 10.016
Notch2Notch gene homolog 2 (Drosophila)0.015
Sox4SRY-box containing gene 40.015
Nr3c1nuclear receptor subfamily 3, group C, member 10.014
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.014
Drd2dopamine receptor D20.014
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.848
Ahsgalpha-2-HS-glycoprotein0.829
Bcl2B-cell CLL/lymphoma 20.805
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.788
Agtr1aangiotensin II receptor, type 1a0.748
Fgfr2fibroblast growth factor receptor 20.663
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.654
Mmp10matrix metallopeptidase 100.642
Nr5a2nuclear receptor subfamily 5, group A, member 20.631
Prlhrprolactin releasing hormone receptor0.625
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.624
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.622
Fn1fibronectin 10.611
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.602
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.599
Plauplasminogen activator, urokinase0.588
Mpeg1macrophage expressed 10.585
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.568
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.553
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.552
Trhrthyrotropin releasing hormone receptor0.538
Mmp3matrix metallopeptidase 30.535
Cxcl2chemokine (C-X-C motif) ligand 20.530
Chrna7cholinergic receptor, nicotinic, alpha 70.517
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.513
Flt1FMS-related tyrosine kinase 10.511
Hbe2hemoglobin, epsilon 20.502
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.494
Reg3gregenerating islet-derived 3 gamma0.488
Dab2disabled homolog 2 (Drosophila)0.487
Prlprolactin0.485
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.475
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.472
Anxa1annexin A10.469
Bcanbrevican0.467
Tgfbr2transforming growth factor, beta receptor II0.467
S1pr2sphingosine-1-phosphate receptor 20.464
Clstn3calsyntenin 30.464
Slc22a6solute carrier family 22 (organic anion transporter), member 60.460
Slco2a1solute carrier organic anion transporter family, member 2a10.457
Csf1colony stimulating factor 1 (macrophage)0.454
Synposynaptopodin0.444
Ednrbendothelin receptor type B0.436
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.426
Ednraendothelin receptor type A0.419
Il1rninterleukin 1 receptor antagonist0.419
Col3a1collagen, type III, alpha 10.417
Jak2Janus kinase 20.414
Nrg1neuregulin 10.414
Col1a2collagen, type I, alpha 20.406
Il12binterleukin 12B0.404
Prrx1paired related homeobox 10.404
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.399
Insrrinsulin receptor-related receptor0.393
Leprleptin receptor0.391
Aebp1AE binding protein 10.387
Col10a1collagen, type X, alpha 10.386
Casp12caspase 120.382
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.382
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.382
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.368
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.366
Glp2rglucagon-like peptide 2 receptor0.363
Il1r1interleukin 1 receptor, type I0.362
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.359
Pcolceprocollagen C-endopeptidase enhancer0.349
Tff1trefoil factor 10.348
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.344
Nefmneurofilament, medium polypeptide0.338
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.337
Irs1insulin receptor substrate 10.333
Pzppregnancy-zone protein0.331
Aqp9aquaporin 90.331
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.330
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.326
Fosl2fos-like antigen 20.323
Halhistidine ammonia lyase0.320
Adra2aadrenergic, alpha-2A-, receptor0.320
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.319
Marcksmyristoylated alanine rich protein kinase C substrate0.317
Pdia4protein disulfide isomerase family A, member 40.317
Hist1h1ahistone cluster 1, H1a0.316
Cd4Cd4 molecule0.315
Ccl2chemokine (C-C motif) ligand 20.315
Tshbthyroid stimulating hormone, beta0.313
RGD1564327similar to integrin alpha 80.311
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.311
RGD1564664similar to LOC387763 protein0.310
RradRas-related associated with diabetes0.307
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.306
Foxj1forkhead box J10.305
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.304
Vcsa1variable coding sequence A10.304
Nos1nitric oxide synthase 1, neuronal0.304
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.303
Mamdc4MAM domain containing 40.303
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.302
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.302
Socs3suppressor of cytokine signaling 30.301
Nfascneurofascin0.299
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism