The network for 'regulation of type i interferon mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of type i interferon mediated signaling pathway

Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.

NameDescriptionProbabilityFunc Analog Organism
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.994
GHRgrowth hormone receptor0.946
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.776
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.673
PIAS4protein inhibitor of activated STAT, 40.307
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.283
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.257
PTPRBprotein tyrosine phosphatase, receptor type, B0.137
CASP8caspase 8, apoptosis-related cysteine peptidase0.098
IRAK1interleukin-1 receptor-associated kinase 10.085
RIPK2receptor-interacting serine-threonine kinase 20.072
MYD88myeloid differentiation primary response gene (88)0.062
CDC37cell division cycle 37 homolog (S. cerevisiae)0.061
TMEM173transmembrane protein 1730.046
FASFas (TNF receptor superfamily, member 6)0.043
FZD1frizzled homolog 1 (Drosophila)0.035
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.035
TBK1TANK-binding kinase 10.033
FKBP4FK506 binding protein 4, 59kDa0.031
GRB10growth factor receptor-bound protein 100.031
PTPN3protein tyrosine phosphatase, non-receptor type 30.031
CAV2caveolin 20.029
IRAK2interleukin-1 receptor-associated kinase 20.028
IRF9interferon regulatory factor 90.025
IRF3interferon regulatory factor 30.024
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.024
INSRinsulin receptor0.023
CASP10caspase 10, apoptosis-related cysteine peptidase0.021
TRAF2TNF receptor-associated factor 20.021
PPP5Cprotein phosphatase 5, catalytic subunit0.018
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.018
IRF7interferon regulatory factor 70.017
BIDBH3 interacting domain death agonist0.017
FASLGFas ligand (TNF superfamily, member 6)0.014
BCAR1breast cancer anti-estrogen resistance 10.014
NCOA6nuclear receptor coactivator 60.013
MAP3K14mitogen-activated protein kinase kinase kinase 140.013
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.013
TRAF6TNF receptor-associated factor 60.013
B2Mbeta-2-microglobulin0.011
ITGA1integrin, alpha 10.011
TRIM27tripartite motif containing 270.011
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.011
FTSJD2FtsJ methyltransferase domain containing 20.011
KIAA1274KIAA12740.011
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.011
STK11serine/threonine kinase 110.011
PLCG1phospholipase C, gamma 10.010
ANGangiogenin, ribonuclease, RNase A family, 50.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat1signal transducer and activator of transcription 10.917
Stat2signal transducer and activator of transcription 20.817
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.724
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.579
Irf9interferon regulatory factor 90.573
Uba7ubiquitin-like modifier activating enzyme 70.552
Usp18ubiquitin specific peptidase 180.531
Igtpinterferon gamma induced GTPase0.472
Irgm2immunity-related GTPase family M member 20.464
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.447
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.434
TapbpTAP binding protein0.422
Irgm1immunity-related GTPase family M member 10.408
Parp14poly (ADP-ribose) polymerase family, member 140.380
Trim21tripartite motif-containing 210.372
Stat3signal transducer and activator of transcription 30.351
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.284
Irf1interferon regulatory factor 10.274
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.258
Ifi35interferon-induced protein 350.245
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.230
Myd88myeloid differentiation primary response gene 880.218
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.176
Oasl22'-5' oligoadenylate synthetase-like 20.171
Parp9poly (ADP-ribose) polymerase family, member 90.159
Gbp7guanylate binding protein 70.140
Parp10poly (ADP-ribose) polymerase family, member 100.136
Irf7interferon regulatory factor 70.134
Gbp2guanylate binding protein 20.133
Rtp4receptor transporter protein 40.123
Ptrfpolymerase I and transcript release factor0.118
Leprleptin receptor0.112
Tgtp2T-cell specific GTPase 20.109
Isg15ISG15 ubiquitin-like modifier0.105
Trim30atripartite motif-containing 30A0.104
Psmb10proteasome (prosome, macropain) subunit, beta type 100.100
Unc93b1unc-93 homolog B1 (C. elegans)0.090
Ifi47interferon gamma inducible protein 470.090
Bcl3B-cell leukemia/lymphoma 30.089
Ifit1interferon-induced protein with tetratricopeptide repeats 10.083
Traf3TNF receptor-associated factor 30.079
Rsad2radical S-adenosyl methionine domain containing 20.073
Gbp3guanylate binding protein 30.067
BC006779cDNA sequence BC0067790.067
Tor3atorsin family 3, member A0.062
Ppargperoxisome proliferator activated receptor gamma0.054
FasFas (TNF receptor superfamily member 6)0.054
Casp8caspase 80.053
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.049
Oas1a2'-5' oligoadenylate synthetase 1A0.049
Ifit3interferon-induced protein with tetratricopeptide repeats 30.045
Batfbasic leucine zipper transcription factor, ATF-like0.043
Sfpi1SFFV proviral integration 10.043
Stat6signal transducer and activator of transcription 60.042
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.041
Map3k8mitogen-activated protein kinase kinase kinase 80.041
Bst2bone marrow stromal cell antigen 20.038
Mx1myxovirus (influenza virus) resistance 10.036
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.033
Znfx1zinc finger, NFX1-type containing 10.032
1810019J16RikRIKEN cDNA 1810019J16 gene0.031
H2-K1histocompatibility 2, K1, K region0.031
Socs3suppressor of cytokine signaling 30.030
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.030
Ikbkeinhibitor of kappaB kinase epsilon0.029
Ifnar2interferon (alpha and beta) receptor 20.029
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.029
Parp12poly (ADP-ribose) polymerase family, member 120.029
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.028
Mx2myxovirus (influenza virus) resistance 20.028
NmiN-myc (and STAT) interactor0.027
Sp100nuclear antigen Sp1000.027
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.026
Ifih1interferon induced with helicase C domain 10.026
Ly6elymphocyte antigen 6 complex, locus E0.026
Ifi27l2ainterferon, alpha-inducible protein 27 like 2A0.025
DaxxFas death domain-associated protein0.025
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.024
Ifnar1interferon (alpha and beta) receptor 10.024
Ifi44interferon-induced protein 440.024
Trim25tripartite motif-containing 250.023
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.023
TapbplTAP binding protein-like0.022
Lepleptin0.022
Pmlpromyelocytic leukemia0.022
Tnfaip3tumor necrosis factor, alpha-induced protein 30.022
Lgals9lectin, galactose binding, soluble 90.022
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.020
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.020
Cxcl10chemokine (C-X-C motif) ligand 100.020
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.020
Oasl12'-5' oligoadenylate synthetase-like 10.019
AW112010expressed sequence AW1120100.019
Csf1colony stimulating factor 1 (macrophage)0.019
Iigp1interferon inducible GTPase 10.019
Samhd1SAM domain and HD domain, 10.019
Oas22'-5' oligoadenylate synthetase 20.019
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.018
Zbp1Z-DNA binding protein 10.018
H2-M3histocompatibility 2, M region locus 30.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism