The network for 'negative regulation of response to dna damage stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of response to dna damage stimulus

Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.

NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 10.986
TP53tumor protein p530.674
BCL2B-cell CLL/lymphoma 20.447
EP300E1A binding protein p3000.344
THOC4THO complex 40.333
BCL2L11BCL2-like 11 (apoptosis facilitator)0.331
BAXBCL2-associated X protein0.317
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.174
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.137
CDK2cyclin-dependent kinase 20.112
UBR1ubiquitin protein ligase E3 component n-recognin 10.105
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.104
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.104
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.100
JMJD6jumonji domain containing 60.094
SETD8SET domain containing (lysine methyltransferase) 80.093
RB1retinoblastoma 10.091
LAPTM5lysosomal protein transmembrane 50.088
CREBBPCREB binding protein0.087
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.080
RUNX1runt-related transcription factor 10.076
ESR1estrogen receptor 10.074
H2AFXH2A histone family, member X0.073
HIPK2homeodomain interacting protein kinase 20.072
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.065
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.065
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.064
CHEK2CHK2 checkpoint homolog (S. pombe)0.062
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.056
BADBCL2-associated agonist of cell death0.053
BAK1BCL2-antagonist/killer 10.053
KAT2BK(lysine) acetyltransferase 2B0.050
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.048
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.048
SF3B2splicing factor 3b, subunit 2, 145kDa0.045
E2F1E2F transcription factor 10.045
CHEK1CHK1 checkpoint homolog (S. pombe)0.042
PAIP2poly(A) binding protein interacting protein 20.041
ATMataxia telangiectasia mutated0.040
THOC2THO complex 20.040
PRMT6protein arginine methyltransferase 60.039
WRNWerner syndrome, RecQ helicase-like0.039
THOC5THO complex 50.038
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.038
TP53BP2tumor protein p53 binding protein, 20.038
EGR1early growth response 10.038
ZRANB1zinc finger, RAN-binding domain containing 10.037
LIN28Blin-28 homolog B (C. elegans)0.037
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.037
RIN1Ras and Rab interactor 10.035
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.035
SF3B1splicing factor 3b, subunit 1, 155kDa0.035
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.033
MDM4Mdm4 p53 binding protein homolog (mouse)0.033
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.031
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.031
SARNPSAP domain containing ribonucleoprotein0.029
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.029
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.028
UHRF2ubiquitin-like with PHD and ring finger domains 20.028
ATRataxia telangiectasia and Rad3 related0.028
CXCR4chemokine (C-X-C motif) receptor 40.027
CCNT1cyclin T10.027
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.027
SPRR2Asmall proline-rich protein 2A0.026
USP42ubiquitin specific peptidase 420.026
JUBjub, ajuba homolog (Xenopus laevis)0.025
RHOAras homolog gene family, member A0.025
YAP1Yes-associated protein 10.025
PSEN2presenilin 2 (Alzheimer disease 4)0.024
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.023
BRCA1breast cancer 1, early onset0.023
SETD7SET domain containing (lysine methyltransferase) 70.023
RBBP8retinoblastoma binding protein 80.023
MDM2Mdm2 p53 binding protein homolog (mouse)0.022
TK1thymidine kinase 1, soluble0.022
DCAF7DDB1 and CUL4 associated factor 70.021
CUX1cut-like homeobox 10.021
ADRM1adhesion regulating molecule 10.021
UBXN1UBX domain protein 10.020
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.020
HNRNPMheterogeneous nuclear ribonucleoprotein M0.020
SNRPD3small nuclear ribonucleoprotein D3 polypeptide 18kDa0.020
THOC1THO complex 10.019
STRN4striatin, calmodulin binding protein 40.019
GATA2GATA binding protein 20.019
DBN1drebrin 10.019
BTBD2BTB (POZ) domain containing 20.019
U2AF1U2 small nuclear RNA auxiliary factor 10.019
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.019
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.019
CLNS1Achloride channel, nucleotide-sensitive, 1A0.019
HDAC1histone deacetylase 10.019
FANCD2Fanconi anemia, complementation group D20.019
CDK4cyclin-dependent kinase 40.019
SF3A1splicing factor 3a, subunit 1, 120kDa0.018
FBXW11F-box and WD repeat domain containing 110.018
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.018
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
scav-1Protein SCAV-10.030
C26B9.5Protein C26B9.50.026
F39G3.5Protein F39G3.50.025
mrp-1Protein MRP-10.025
nlt-1Protein NLT-10.024
pgrn-1Protein PGRN-10.023
R01B10.3Protein R01B10.30.021
C16B8.3Protein C16B8.30.021
R10H10.3Protein R10H10.30.020
H36L18.2Protein H36L18.20.019
haf-4Protein HAF-40.018
lat-1Protein LAT-10.017
npp-4Protein NPP-40.017
CELE_R02D3.8Protein R02D3.80.016
gas-1Protein GAS-10.016
nep-22Protein NEP-220.016
C10B5.1Protein C10B5.10.016
pir-1Protein PIR-10.016
kin-4Protein KIN-40.016
acl-3Protein ACL-30.015
kbp-3Protein KBP-30.014
vha-10Protein VHA-100.014
egl-3Protein EGL-30.014
T12B3.3Protein T12B3.30.014
R08D7.5Protein R08D7.50.014
lron-7Protein LRON-70.013
sbt-1Protein SBT-10.013
F40E10.6Protein F40E10.60.013
C14B1.8Protein C14B1.80.013
vab-9Protein VAB-90.013
CELE_T20G5.10Protein T20G5.100.013
T25B9.8Protein T25B9.80.013
F14D2.11Protein F14D2.110.013
F13E6.1Protein F13E6.10.012
acly-2Protein ACLY-20.012
C48E7.2Protein C48E7.20.011
prx-3Protein PRX-30.011
CELE_Y39G10AR.15Protein Y39G10AR.150.011
B0304.4Protein B0304.40.011
bmy-1Protein BMY-10.011
B0393.8Protein B0393.80.011
cdk-1Protein CDK-10.011
F23F1.4Protein F23F1.40.011
F40F11.3Protein F40F11.30.011
CELE_Y106G6H.1Protein Y106G6H.10.011
F39B2.7Protein F39B2.70.011
T14B4.3Protein T14B4.30.011
drr-1Protein DRR-10.011
C27B7.2Protein C27B7.20.011
F35H10.5Protein F35H10.50.011
ost-1Protein OST-10.011
oac-59Protein OAC-590.010
ape-1Protein APE-10.010
ZK1127.12Protein ZK1127.120.010
kbp-5Protein KBP-50.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cxcr4bchemokine (C-X-C motif), receptor 4b0.111
thoc3THO complex 30.063
znf703zinc finger protein 7030.052
nutf2lnuclear transport factor 2, like0.044
lmo4aLIM domain only 4a0.042
crabp2bcellular retinoic acid binding protein 2, b0.039
eny2enhancer of yellow 2 homolog (Drosophila)0.036
rargaretinoic acid receptor gamma a0.035
thoc7THO complex 70.034
tgfbitransforming growth factor, beta-induced0.033
btg2B-cell translocation gene 20.032
tbx6T-box gene 60.026
glulbglutamate-ammonia ligase (glutamine synthase) b0.026
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.026
ncor1nuclear receptor co-repressor 10.025
dhrs3adehydrogenase/reductase (SDR family) member 3a0.024
cahzcarbonic anhydrase0.024
snrpb2small nuclear ribonucleoprotein polypeptide B20.024
gins2GINS complex subunit 20.023
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.023
baxabcl2-associated X protein, a0.023
plxnb2aplexin b2a0.023
g3bp1GTPase activating protein (SH3 domain) binding protein 10.023
orc6origin recognition complex, subunit 60.021
tipintimeless interacting protein0.021
akt2v-akt murine thymoma viral oncogene homolog 20.020
mmp2matrix metalloproteinase 20.019
fzd2frizzled homolog 20.019
eif4heukaryotic translation initiation factor 4h0.018
prim1primase polypeptide 10.018
sf3b5splicing factor 3b, subunit 50.018
nrarpanotch-regulated ankyrin repeat protein a0.017
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.017
gdf6agrowth differentiation factor 6a0.017
bcl2l10BCL2-like 10 (apoptosis facilitator)0.017
pax8paired box gene 80.017
zfand5azinc finger, AN1-type domain 5a0.016
mcl1bmyeloid cell leukemia sequence 1b0.016
ccng1cyclin G10.016
rarabretinoic acid receptor, alpha b0.015
jag1bjagged 1b0.015
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.015
casp8caspase 8, apoptosis-related cysteine peptidase0.015
aldh1a2aldehyde dehydrogenase 1 family, member A20.015
rbm17RNA binding motif protein 170.015
fzd7bfrizzled homolog 7b0.014
rangap1Ran GTPase activating protein 10.014
ruvbl1RuvB-like 1 (E. coli)0.014
pcdh8protocadherin 80.014
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.014
psmd11aproteasome (prosome, macropain) 216S subunit, non-ATPase, 11a0.014
glmnaglomulin, FKBP associated protein a0.014
prickle1bprickle homolog 1 (Drosophila) b0.014
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.014
rpa3replication protein A30.014
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.014
mmp13amatrix metalloproteinase 13a0.014
cnn3acalponin 3, acidic a0.013
slbpstem-loop binding protein0.013
cse1lchromosome segregation 1-like (S. cerevisiae)0.013
hsp47heat shock protein 470.013
eaf2ELL associated factor 20.013
mcl1amyeloid cell leukemia sequence 1a0.013
cxcr4achemokine (C-X-C motif) receptor 4a0.013
ctskcathepsin K0.013
ftsj1FtsJ homolog 1 (E. coli)0.013
ppp4caprotein phosphatase 4 (formerly X), catalytic subunit a0.013
ddx39aaDEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa0.013
sae1SUMO1 activating enzyme subunit 10.012
ctsbacathepsin B, a0.012
wnt11rwingless-type MMTV integration site family, member 11, related0.012
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.012
zzef1zinc finger, ZZ-type with EF hand domain 10.012
sod1superoxide dismutase 1, soluble0.012
ppil2peptidylprolyl isomerase (cyclophilin)-like 20.012
lsm1LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.012
tmem48transmembrane protein 480.012
nola1nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)0.012
acvr1bactivin A receptor, type IB0.012
krt18keratin 180.012
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.012
her1hairy-related 10.012
ppiapeptidylprolyl isomerase A (cyclophilin A)0.012
gtf2e2general transcription factor IIE, polypeptide 2, beta0.012
ube2g2ubiquitin-conjugating enzyme E2G 20.012
mapre1lmicrotubule-associated protein, RP/EB family, member 1, like0.012
dcun1d5DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)0.011
id1inhibitor of DNA binding 10.011
eef1geukaryotic translation elongation factor 1 gamma0.011
rbb4lretinoblastoma binding protein 4, like0.011
LOC555279hypothetical LOC5552790.011
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.742
Cdk4cyclin-dependent kinase 40.685
Cdkn1bcyclin-dependent kinase inhibitor 1B0.482
H2-Aahistocompatibility 2, class II antigen A, alpha0.482
Mdm2transformed mouse 3T3 cell double minute 20.307
Mdm4transformed mouse 3T3 cell double minute 40.178
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.153
Rb1retinoblastoma 10.148
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.119
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.068
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.045
Senp2SUMO/sentrin specific peptidase 20.045
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.045
Prnpprion protein0.044
Qrich1glutamine-rich 10.037
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.032
Pum1pumilio 1 (Drosophila)0.032
Ccnd1cyclin D10.026
Hdac1histone deacetylase 10.025
Mmp9matrix metallopeptidase 90.022
Kdm2blysine (K)-specific demethylase 2B0.022
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.020
Ceacam16carcinoembryonic antigen-related cell adhesion molecule 160.019
Ewsr1Ewing sarcoma breakpoint region 10.019
Clk4CDC like kinase 40.019
Eif2c1eukaryotic translation initiation factor 2C, 10.018
Ccne1cyclin E10.018
Smn1survival motor neuron 10.018
Trip12thyroid hormone receptor interactor 120.018
Bptfbromodomain PHD finger transcription factor0.017
Ccnb1cyclin B10.017
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.017
Commd6COMM domain containing 60.017
Il1r1interleukin 1 receptor, type I0.017
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.017
Srsf4serine/arginine-rich splicing factor 40.016
2500003M10RikRIKEN cDNA 2500003M10 gene0.015
Asxl1additional sex combs like 1 (Drosophila)0.015
Wdr26WD repeat domain 260.015
Smu1smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)0.015
Tab2TGF-beta activated kinase 1/MAP3K7 binding protein 20.015
Rpa2replication protein A20.015
Thbs1thrombospondin 10.015
Mark3MAP/microtubule affinity-regulating kinase 30.014
Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a0.014
Ranbp9RAN binding protein 90.014
Gtf2bgeneral transcription factor IIB0.014
En1engrailed 10.014
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.013
Trraptransformation/transcription domain-associated protein0.013
Nod2nucleotide-binding oligomerization domain containing 20.013
Cxcr4chemokine (C-X-C motif) receptor 40.012
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.012
Gm3258predicted gene 32580.012
Naa35N(alpha)-acetyltransferase 35, NatC auxiliary subunit0.012
Adam17a disintegrin and metallopeptidase domain 170.012
Criptcysteine-rich PDZ-binding protein0.012
Arid1aAT rich interactive domain 1A (SWI-like)0.011
2610027L16RikRIKEN cDNA 2610027L16 gene0.011
CrebbpCREB binding protein0.011
Gabpb1GA repeat binding protein, beta 10.011
Prmt1protein arginine N-methyltransferase 10.010
Rbm22RNA binding motif protein 220.010
Banf1barrier to autointegration factor 10.010
Refbp2RNA and export factor binding protein 20.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism