The network for 'non canonical wnt signaling pathway via mapk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

non canonical wnt signaling pathway via mapk cascade

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade.

NameDescriptionProbabilityFunc Analog Organism
DVL1dishevelled, dsh homolog 1 (Drosophila)1.000
BBS10Bardet-Biedl syndrome 100.997
ZNF512Bzinc finger protein 512B0.992
CEP164centrosomal protein 164kDa0.967
CSNK1Ecasein kinase 1, epsilon0.938
WNT3Awingless-type MMTV integration site family, member 3A0.915
WT1Wilms tumor 10.911
FZD1frizzled homolog 1 (Drosophila)0.910
LRRK2leucine-rich repeat kinase 20.900
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.873
ELF5E74-like factor 5 (ets domain transcription factor)0.778
SFRP1secreted frizzled-related protein 10.753
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.721
FGF18fibroblast growth factor 180.712
WNT5Awingless-type MMTV integration site family, member 5A0.699
NDPNorrie disease (pseudoglioma)0.489
LRP6low density lipoprotein receptor-related protein 60.447
GDF10growth differentiation factor 100.280
WNT1wingless-type MMTV integration site family, member 10.274
WIF1WNT inhibitory factor 10.265
BMP4bone morphogenetic protein 40.264
MMP11matrix metallopeptidase 11 (stromelysin 3)0.251
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.232
CILPcartilage intermediate layer protein, nucleotide pyrophosphohydrolase0.230
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.224
PTGISprostaglandin I2 (prostacyclin) synthase0.194
AXIN1axin 10.187
IHHIndian hedgehog0.186
WNT11wingless-type MMTV integration site family, member 110.183
FOXF2forkhead box F20.150
KLHL12kelch-like 12 (Drosophila)0.145
MXRA5matrix-remodelling associated 50.144
WNT3wingless-type MMTV integration site family, member 30.119
CXCL14chemokine (C-X-C motif) ligand 140.118
EHFets homologous factor0.113
BMP7bone morphogenetic protein 70.112
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 50.093
MFAP5microfibrillar associated protein 50.092
GPR124G protein-coupled receptor 1240.090
FZD8frizzled homolog 8 (Drosophila)0.089
FBLN1fibulin 10.089
FZD10frizzled homolog 10 (Drosophila)0.083
BAHD1bromo adjacent homology domain containing 10.079
PITX1paired-like homeodomain 10.078
ROR2receptor tyrosine kinase-like orphan receptor 20.078
SOX21SRY (sex determining region Y)-box 210.078
ROBO2roundabout, axon guidance receptor, homolog 2 (Drosophila)0.077
FGF4fibroblast growth factor 40.076
C7orf36chromosome 7 open reading frame 360.076
PRELPproline/arginine-rich end leucine-rich repeat protein0.076
MYST2MYST histone acetyltransferase 20.072
SMAD1SMAD family member 10.064
CSNK1Dcasein kinase 1, delta0.064
EPHB3EPH receptor B30.062
CCDC92coiled-coil domain containing 920.061
WNT7Awingless-type MMTV integration site family, member 7A0.061
ITIH5inter-alpha (globulin) inhibitor H50.060
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.060
TNFAIP8L1tumor necrosis factor, alpha-induced protein 8-like 10.060
NKAPNFKB activating protein0.058
THBS2thrombospondin 20.057
PLXDC1plexin domain containing 10.056
PRRX2paired related homeobox 20.055
WNT10Awingless-type MMTV integration site family, member 10A0.055
FOXF1forkhead box F10.055
EPHB2EPH receptor B20.054
SFRP4secreted frizzled-related protein 40.054
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.054
FZD7frizzled homolog 7 (Drosophila)0.054
MAP2K6mitogen-activated protein kinase kinase 60.054
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.053
GRPgastrin-releasing peptide0.052
AQP5aquaporin 50.052
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.052
LRRC17leucine rich repeat containing 170.051
WNT6wingless-type MMTV integration site family, member 60.050
LBX1ladybird homeobox 10.047
HMX1H6 family homeobox 10.047
HOXD11homeobox D110.046
TCF7L1transcription factor 7-like 1 (T-cell specific, HMG-box)0.045
AXIN2axin 20.045
OLFML1olfactomedin-like 10.045
ITGA8integrin, alpha 80.045
WNT5Bwingless-type MMTV integration site family, member 5B0.045
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.044
JAG1jagged 10.044
GPC4glypican 40.043
INHBBinhibin, beta B0.043
KCNK9potassium channel, subfamily K, member 90.043
HSD11B2hydroxysteroid (11-beta) dehydrogenase 20.042
USH1GUsher syndrome 1G (autosomal recessive)0.042
GUCA2Aguanylate cyclase activator 2A (guanylin)0.042
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.041
ITGBL1integrin, beta-like 1 (with EGF-like repeat domains)0.041
PDGFCplatelet derived growth factor C0.041
OCA2oculocutaneous albinism II0.041
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dvl2dishevelled 2, dsh homolog (Drosophila)1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Dvl3dishevelled 3, dsh homolog (Drosophila)1.000
Vangl1vang-like 1 (van gogh, Drosophila)1.000
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.995
Smurf2SMAD specific E3 ubiquitin protein ligase 20.829
Ptk7PTK7 protein tyrosine kinase 70.825
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.814
Wnt3awingless-related MMTV integration site 3A0.793
Pax2paired box gene 20.671
Fgf8fibroblast growth factor 80.593
Ror2receptor tyrosine kinase-like orphan receptor 20.521
Pcsk5proprotein convertase subtilisin/kexin type 50.510
Efna4ephrin A40.445
Lhx1LIM homeobox protein 10.435
Tbx2T-box 20.396
Gdnfglial cell line derived neurotrophic factor0.339
Pvrl1poliovirus receptor-related 10.323
Wnt10bwingless related MMTV integration site 10b0.300
Pax8paired box gene 80.288
Fgf18fibroblast growth factor 180.258
Wnt4wingless-related MMTV integration site 40.258
Vax1ventral anterior homeobox containing gene 10.254
Dact3dapper homolog 3, antagonist of beta-catenin (xenopus)0.251
Lmx1aLIM homeobox transcription factor 1 alpha0.210
Pax1paired box gene 10.200
Dkk1dickkopf homolog 1 (Xenopus laevis)0.198
Nkd1naked cuticle 1 homolog (Drosophila)0.197
Retret proto-oncogene0.183
Amhanti-Mullerian hormone0.178
Amhr2anti-Mullerian hormone type 2 receptor0.157
Bmp7bone morphogenetic protein 70.155
Fzd8frizzled homolog 8 (Drosophila)0.153
Pou3f3POU domain, class 3, transcription factor 30.138
Gli1GLI-Kruppel family member GLI10.132
Rargretinoic acid receptor, gamma0.129
Hoxa13homeobox A130.128
Wnt6wingless-related MMTV integration site 60.116
Foxf1aforkhead box F1a0.116
Npas1neuronal PAS domain protein 10.115
Hoxc9homeobox C90.114
Clic3chloride intracellular channel 30.113
Grin2dglutamate receptor, ionotropic, NMDA2D (epsilon 4)0.113
Wnt1wingless-related MMTV integration site 10.104
Rspo1R-spondin homolog (Xenopus laevis)0.103
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.102
Tead3TEA domain family member 30.100
Ntn3netrin 30.099
Fgfr4fibroblast growth factor receptor 40.097
Wnt7awingless-related MMTV integration site 7A0.095
Fzd1frizzled homolog 1 (Drosophila)0.094
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.092
Barx2BarH-like homeobox 20.092
Smad3MAD homolog 3 (Drosophila)0.092
Tctex1d4Tctex1 domain containing 40.089
Wnt9awingless-type MMTV integration site 9A0.087
Sult5a1sulfotransferase family 5A, member 10.085
Barx1BarH-like homeobox 10.085
Col13a1collagen, type XIII, alpha 10.085
Emid2EMI domain containing 20.083
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.082
Sim2single-minded homolog 2 (Drosophila)0.081
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.080
Fzd10frizzled homolog 10 (Drosophila)0.080
Krt15keratin 150.080
BikBCL2-interacting killer0.079
Zbtb7czinc finger and BTB domain containing 7C0.077
Jph2junctophilin 20.073
Mesp1mesoderm posterior 10.073
Fgf10fibroblast growth factor 100.072
Tbx3T-box 30.070
Foxd2forkhead box D20.069
Axin1axin 10.069
Hoxd11homeobox D110.069
Nkd2naked cuticle 2 homolog (Drosophila)0.068
Scube1signal peptide, CUB domain, EGF-like 10.068
Hoxa2homeobox A20.065
Epha1Eph receptor A10.065
Gja5gap junction protein, alpha 50.065
Gpr50G-protein-coupled receptor 500.065
Hoxb1homeobox B10.064
Nr5a1nuclear receptor subfamily 5, group A, member 10.063
Dlx4distal-less homeobox 40.062
Porcnporcupine homolog (Drosophila)0.062
En1engrailed 10.061
Efna2ephrin A20.060
Slc34a2solute carrier family 34 (sodium phosphate), member 20.059
Irx4Iroquois related homeobox 4 (Drosophila)0.057
Fgf15fibroblast growth factor 150.057
Cdx1caudal type homeobox 10.057
Zfp651zinc finger protein 6510.056
Ror1receptor tyrosine kinase-like orphan receptor 10.056
Gata6GATA binding protein 60.055
Rbpjlrecombination signal binding protein for immunoglobulin kappa J region-like0.055
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.055
Zfp771zinc finger protein 7710.055
BC024139cDNA sequence BC0241390.054
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism