The network for 'muscle hypertrophy' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle hypertrophy

The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.

NameDescriptionProbabilityFunc Analog Organism
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.772
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.362
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.354
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.229
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.174
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.166
ITGB1BP3integrin beta 1 binding protein 30.149
BMPR1Bbone morphogenetic protein receptor, type IB0.138
TRIM63tripartite motif containing 630.109
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.106
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.092
C3orf15chromosome 3 open reading frame 150.079
HDAC4histone deacetylase 40.077
TRPC3transient receptor potential cation channel, subfamily C, member 30.060
MAPK1mitogen-activated protein kinase 10.058
CAPN3calpain 3, (p94)0.054
MAPK8mitogen-activated protein kinase 80.053
MAPK14mitogen-activated protein kinase 140.053
NCOA1nuclear receptor coactivator 10.049
MAPK9mitogen-activated protein kinase 90.045
TCAPtitin-cap (telethonin)0.045
MAP3K1mitogen-activated protein kinase kinase kinase 10.044
BAG3BCL2-associated athanogene 30.037
MYOZ2myozenin 20.034
IGF2Rinsulin-like growth factor 2 receptor0.032
DLG2discs, large homolog 2 (Drosophila)0.032
CALCAcalcitonin-related polypeptide alpha0.031
MYCBPc-myc binding protein0.027
MYOZ1myozenin 10.026
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.026
PKD2polycystic kidney disease 2 (autosomal dominant)0.025
PRKCQprotein kinase C, theta0.025
MAPK6mitogen-activated protein kinase 60.023
KLF13Kruppel-like factor 130.023
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.023
CYLDcylindromatosis (turban tumor syndrome)0.021
AKAP6A kinase (PRKA) anchor protein 60.021
OSGEPO-sialoglycoprotein endopeptidase0.021
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.020
FAF1Fas (TNFRSF6) associated factor 10.019
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.019
HDAC9histone deacetylase 90.018
ACTN1actinin, alpha 10.018
CIAPIN1cytokine induced apoptosis inhibitor 10.018
ITPR3inositol 1,4,5-trisphosphate receptor, type 30.017
MYOD1myogenic differentiation 10.016
HIST1H4Fhistone cluster 1, H4f0.016
MBNL1muscleblind-like (Drosophila)0.015
HSPB8heat shock 22kDa protein 80.015
ATP2B1ATPase, Ca++ transporting, plasma membrane 10.014
OBSL1obscurin-like 10.014
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.014
HIST1H3Bhistone cluster 1, H3b0.013
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.013
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.012
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.012
HSPB2heat shock 27kDa protein 20.011
CRYBB2crystallin, beta B20.011
PDPK13-phosphoinositide dependent protein kinase-10.011
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.010
FRZBfrizzled-related protein0.010
ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mef2camyocyte enhancer factor 2ca0.086
nrxn2aneurexin 2a0.085
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.069
fabp11afatty acid binding protein 11a0.058
cx45.6connexin 45.60.051
tmem59ltransmembrane protein 59-like and transmembrane protein 59-like0.044
hspb12heat shock protein, alpha-crystallin-related, b120.044
ppargperoxisome proliferator activated receptor gamma0.043
hspb9heat shock protein, alpha-crystallin-related, 90.042
nkx2.5NK2 transcription factor related 50.041
vtg1vitellogenin 10.039
hspb8heat shock protein, alpha-crystallin-related, b80.035
arpc3actin related protein 2/3 complex, subunit 30.032
gata5GATA-binding protein 50.031
blmBloom syndrome0.030
grin1aglutamate receptor, ionotropic, N-methyl D-aspartate 1a0.030
tbx20T-box 200.030
slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.029
hspb7heat shock protein family, alpha-crystallin-related, b70.029
adrb2aadrenergic receptor, beta 2a0.029
xirp1xin actin-binding repeat containing 10.028
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.028
nr2e3nuclear receptor subfamily 2, group E, member 30.028
hspb11heat shock protein, alpha-crystallin-related, b110.028
recql5RecQ protein-like 50.027
smyd1bSET and MYND domain containing 1b0.026
scn1basodium channel, voltage-gated, type I, beta a0.025
ctsl1acathepsin L, 1 a0.023
arpc5bactin related protein 2/3 complex, subunit 5B0.023
gpiaglucose phosphate isomerase a0.023
cpa4carboxypeptidase A40.022
slc30a2solute carrier family 30 (zinc transporter), member 20.021
mycamyelocytomatosis oncogene a0.021
lifrbleukemia inhibitory factor receptor alpha b0.021
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.020
fabp7afatty acid binding protein 7, brain, a0.020
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.019
slc6a4asolute carrier family 6 (neurotransmitter transporter, serotonin), member 4A0.019
hsp90a.1heat shock protein 90-alpha 10.019
gfapglial fibrillary acidic protein0.019
desmadesmin a0.019
psenenpresenilin enhancer 2 homolog0.019
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.019
ccng1cyclin G10.018
tnnt2atroponin T2a, cardiac0.018
itga7integrin, alpha 70.018
LOC798872deiodinase 30.018
nexnnexilin (F actin binding protein)0.018
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.018
cntn1acontactin 1a0.018
tpm4tropomyosin 40.018
ube2l3aubiquitin-conjugating enzyme E2L 3a0.018
sncbsynuclein, beta0.017
wnt10awingless-type MMTV integration site family, member 10a0.017
rbm24aRNA binding motif protein 24a0.017
ndrg4N-myc downstream regulated gene 40.016
cmybtranscription factor cmyb0.016
smyd2bSET and MYND domain containing 2b0.016
tnnt1troponin T1, skeletal, slow0.016
brd4bromodomain containing 40.015
alcambactivated leukocyte cell adhesion molecule b0.015
cryaacrystallin, alpha A0.015
slc16a10solute carrier family 16, member 10 (aromatic amino acid transporter)0.015
hsp70heat shock cognate 70-kd protein0.015
ptch1patched 10.015
cx43connexin 430.015
copebcore promoter element binding protein0.014
unc45bunc-45 homolog B (C. elegans)0.014
hhexhematopoietically expressed homeobox0.014
glra1glycine receptor, alpha 10.014
fasFas (TNF receptor superfamily, member 6)0.014
sncgasynuclein, gamma a0.014
rhouaras homolog gene family, member Ua0.014
hspb6heat shock protein, alpha-crystallin-related, b60.014
gata6GATA-binding protein 60.014
tpm3tropomyosin 30.014
lppLIM domain containing preferred translocation partner in lipoma0.014
cdc42cell division cycle 420.014
m17IL-6 subfamily cytokine M170.014
jam2ajunctional adhesion molecule 2a0.014
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.014
vamp1vesicle-associated membrane protein 10.014
rab3cRAB3C, member RAS oncogene family0.014
myf6myogenic factor 60.014
cacna1abcalcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b0.013
pawrlPRKC, apoptosis, WT1, regulator like0.013
mef2cbmyocyte enhancer factor 2cb0.013
aldocbaldolase C, fructose-bisphosphate, b0.013
pabpc4poly(A) binding protein, cytoplasmic 4 (inducible form)0.013
mta3metastasis associated family, member 30.013
fabp3fatty acid binding protein 3, muscle and heart0.013
onecut1one cut domain, family member 10.013
timm17atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.013
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gata4GATA binding protein 40.989
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.924
Hand2heart and neural crest derivatives expressed transcript 20.742
Adrb1adrenergic receptor, beta 10.568
Zfpm2zinc finger protein, multitype 20.480
Jag1jagged 10.475
Prrx1paired related homeobox 10.442
Arandrogen receptor0.350
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.306
Hand1heart and neural crest derivatives expressed transcript 10.287
Nos3nitric oxide synthase 3, endothelial cell0.285
Epas1endothelial PAS domain protein 10.268
Bmp4bone morphogenetic protein 40.217
Rxraretinoid X receptor alpha0.216
Tgfb2transforming growth factor, beta 20.187
Gata6GATA binding protein 60.168
Ush1gUsher syndrome 1G homolog (human)0.155
Ptpn11protein tyrosine phosphatase, non-receptor type 110.151
Klf4Kruppel-like factor 4 (gut)0.150
Gata5GATA binding protein 50.149
Nr4a1nuclear receptor subfamily 4, group A, member 10.146
Hey2hairy/enhancer-of-split related with YRPW motif 20.143
Ednraendothelin receptor type A0.143
Vegfavascular endothelial growth factor A0.138
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.133
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.130
Pnpla2patatin-like phospholipase domain containing 20.129
Mef2cmyocyte enhancer factor 2C0.128
Pax8paired box gene 80.124
Hdac4histone deacetylase 40.115
Inhbainhibin beta-A0.113
Ppargperoxisome proliferator activated receptor gamma0.111
Hivep2human immunodeficiency virus type I enhancer binding protein 20.107
Dusp1dual specificity phosphatase 10.106
Kcns2K+ voltage-gated channel, subfamily S, 20.098
Nos1nitric oxide synthase 1, neuronal0.096
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.095
Pthlhparathyroid hormone-like peptide0.095
Dmddystrophin, muscular dystrophy0.094
Rhobras homolog gene family, member B0.091
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.091
Fgf8fibroblast growth factor 80.089
Tac2tachykinin 20.085
Tnxbtenascin XB0.085
Klf6Kruppel-like factor 60.082
Klf2Kruppel-like factor 2 (lung)0.082
Oprm1opioid receptor, mu 10.077
Nppanatriuretic peptide type A0.077
Smad6MAD homolog 6 (Drosophila)0.074
Epha3Eph receptor A30.073
Sstr4somatostatin receptor 40.071
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.070
Klf3Kruppel-like factor 3 (basic)0.067
Arid1bAT rich interactive domain 1B (SWI-like)0.067
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.060
Scn5asodium channel, voltage-gated, type V, alpha0.058
FosFBJ osteosarcoma oncogene0.056
Pdlim3PDZ and LIM domain 30.055
Gdf9growth differentiation factor 90.054
Slc22a6solute carrier family 22 (organic anion transporter), member 60.053
JunJun oncogene0.053
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.052
Kifc2kinesin family member C20.052
Zeb2zinc finger E-box binding homeobox 20.051
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.051
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.051
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.050
Mef2dmyocyte enhancer factor 2D0.048
Kcnk2potassium channel, subfamily K, member 20.048
Edn3endothelin 30.047
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.047
Mesp1mesoderm posterior 10.046
Capza2capping protein (actin filament) muscle Z-line, alpha 20.045
Msx1homeobox, msh-like 10.045
Scn7asodium channel, voltage-gated, type VII, alpha0.044
Spnb2spectrin beta 20.043
Zfr2zinc finger RNA binding protein 20.042
Foxh1forkhead box H10.042
Ppp1r1bprotein phosphatase 1, regulatory (inhibitor) subunit 1B0.041
FosbFBJ osteosarcoma oncogene B0.040
Lama2laminin, alpha 20.040
Casq2calsequestrin 20.040
Abcc9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.040
Drd2dopamine receptor D20.040
Edn1endothelin 10.039
Hoxb1homeobox B10.039
Zswim6zinc finger, SWIM domain containing 60.039
Ptpn14protein tyrosine phosphatase, non-receptor type 140.039
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.038
Hrh1histamine receptor H10.038
Foxc2forkhead box C20.038
Apoeapolipoprotein E0.038
Gucy1b3guanylate cyclase 1, soluble, beta 30.037
Wt1Wilms tumor 1 homolog0.037
Agtr1aangiotensin II receptor, type 1a0.036
AxlAXL receptor tyrosine kinase0.036
Eporerythropoietin receptor0.035
Hbegfheparin-binding EGF-like growth factor0.035
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism