The network for 'protein localization to vacuole' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein localization to vacuole

A process in which a protein is transported to, or maintained at, a location in a vacuole.

NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 20.842
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.766
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.360
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.259
RABEP1rabaptin, RAB GTPase binding effector protein 10.191
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.180
GABARAPL2GABA(A) receptor-associated protein-like 20.137
SORT1sortilin 10.094
SLC2A3solute carrier family 2 (facilitated glucose transporter), member 30.093
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.083
GABARAPGABA(A) receptor-associated protein0.082
ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)0.079
EEA1early endosome antigen 10.066
DNM2dynamin 20.062
PDCD6IPprogrammed cell death 6 interacting protein0.061
ANKRD13Aankyrin repeat domain 13A0.056
WWP1WW domain containing E3 ubiquitin protein ligase 10.051
LRRK2leucine-rich repeat kinase 20.049
SQSTM1sequestosome 10.048
LAMTOR2late endosomal/lysosomal adaptor, MAPK and MTOR activator 20.046
SYNRGsynergin, gamma0.044
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.043
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.038
CHMP4Bchromatin modifying protein 4B0.034
ELLelongation factor RNA polymerase II0.032
ZFYVE9zinc finger, FYVE domain containing 90.031
WWP2WW domain containing E3 ubiquitin protein ligase 20.029
SMURF1SMAD specific E3 ubiquitin protein ligase 10.025
IGF2Rinsulin-like growth factor 2 receptor0.025
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.025
COG7component of oligomeric golgi complex 70.022
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.020
FBXL15F-box and leucine-rich repeat protein 150.020
RAB22ARAB22A, member RAS oncogene family0.020
ROCK1Rho-associated, coiled-coil containing protein kinase 10.019
NBR1neighbor of BRCA1 gene 10.019
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.018
SORL1sortilin-related receptor, L(DLR class) A repeats containing0.016
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.015
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.015
TMED2transmembrane emp24 domain trafficking protein 20.015
RAB1ARAB1A, member RAS oncogene family0.015
OCRLoculocerebrorenal syndrome of Lowe0.015
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.015
SMAD4SMAD family member 40.014
RHOAras homolog gene family, member A0.013
CALCOCO2calcium binding and coiled-coil domain 20.013
ATG10ATG10 autophagy related 10 homolog (S. cerevisiae)0.013
SH3GL2SH3-domain GRB2-like 20.012
SEPT2septin 20.012
ATG4BATG4 autophagy related 4 homolog B (S. cerevisiae)0.012
CIZ1CDKN1A interacting zinc finger protein 10.012
SCFD1sec1 family domain containing 10.011
CANXcalnexin0.011
RABIFRAB interacting factor0.011
COG1component of oligomeric golgi complex 10.011
CAPRIN2caprin family member 20.011
SNX9sorting nexin 90.011
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.011
CTTNcortactin0.010
RAB6ARAB6A, member RAS oncogene family0.010
ZRANB1zinc finger, RAN-binding domain containing 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
paqr8progestin and adipoQ receptor family member VIII0.224
creb3l3lcAMP responsive element binding protein 3-like 3 like0.123
rab5aaRAB5A, member RAS oncogene family, a0.120
vps26blvacuolar protein sorting 26 homolog B, like0.070
rspo1R-spondin homolog (Xenopus laevis)0.039
inhainhibin, alpha0.036
arid4aAT rich interactive domain 4A (RBP1-like)0.035
clcn7chloride channel 70.034
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.033
zgc:77849zgc:778490.032
gdf9growth differentiation factor 90.030
zgc:56010zgc:560100.026
mxd4MAX dimerization protein 40.025
atp6v1c1aATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a0.025
wipi1WD repeat domain, phosphoinositide interacting 10.024
zgc:123180zgc:1231800.024
cyp17a1cytochrome P450, family 17, subfamily A, polypeptide 10.022
cltcaclathrin, heavy polypeptide a (Hc)0.021
ikbkginhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.021
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.020
rab5cRAB5C, member RAS oncogene family0.020
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.020
tmem30atransmembrane protein 30A0.018
jak1Janus kinase 10.018
si:dkey-220f10.6si:dkey-220f10.60.018
inhbabinhibin, beta Ab0.017
ccdc40coiled-coil domain containing 400.017
cldn2claudin 20.017
stambpaSTAM binding protein a0.017
tmem50atransmembrane protein 50A0.016
atp6v1fATPase, H+ transporting, V1 subunit F0.016
im:7164961im:71649610.016
pfn2profilin 20.015
cratbcarnitine O-acetyltransferase b0.015
zgc:73134zgc:731340.015
cybacytochrome b-245, alpha polypeptide0.015
me3malic enzyme 3, NADP(+)-dependent, mitochondrial0.015
asb8ankyrin repeat and SOCS box-containing 80.015
ndrg3bN-myc downstream regulated family member 3b0.015
chmp4bchromatin modifying protein 4B0.015
wdr8WD repeat domain 80.015
zgc:175140zgc:1751400.014
stk17bserine/threonine kinase 17b (apoptosis-inducing)0.014
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.014
zgc:112084zgc:1120840.014
sc:d411sc:d4110.014
uap1l1UDP-N-acteylglucosamine pyrophosphorylase 1, like 10.014
syap1synapse associated protein 10.014
zgc:152900zgc:1529000.014
sbf1SET binding factor 10.014
brapBRCA1 associated protein0.014
atf4b2activating transcription factor 4b20.014
zgc:152984zgc:1529840.014
maffv-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian)0.013
ttll6tubulin tyrosine ligase-like family, member 60.013
csrnp1acysteine-serine-rich nuclear protein 1a0.013
zgc:55573zgc:555730.013
nap1l4bnucleosome assembly protein 1-like 4b0.013
plekha3pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 30.013
apg3lAPG3 autophagy 3-like0.013
cldn1claudin 10.013
dtnbp1adystrobrevin binding protein 1a0.013
cul1bcullin 1b0.013
ift122intraflagellar transport 122 homolog (Chlamydomonas)0.013
aldh2baldehyde dehydrogenase 2b0.013
zgc:56049zgc:560490.012
igf2rinsulin-like growth factor 2 receptor0.012
zgc:92217zgc:922170.012
selt2selenoprotein T, 20.012
serinc5serine incorporator 50.012
cldn8claudin 80.012
tax1bp1bTax1 (human T-cell leukemia virus type I) binding protein 1b0.012
zgc:103658zgc:1036580.012
ctszcathepsin Z0.012
brms1breast cancer metastasis-suppressor 10.012
im:7138016im:71380160.012
laptm4alysosomal-associated protein transmembrane 4 alpha0.012
zgc:162698zgc:1626980.012
wdfy1WD repeat and FYVE domain containing 10.011
rab7RAB7, member RAS oncogene family0.011
tmem198btransmembrane protein 198b0.011
ivns1abpainfluenza virus NS1A binding protein a0.011
pdcd6ipprogrammed cell death 6 interacting protein0.011
capza1bcapping protein (actin filament) muscle Z-line, alpha 1b0.011
capza1acapping protein (actin filament) muscle Z-line, alpha 1a0.011
gabarapaGABA(A) receptor-associated protein a0.011
mtmr6myotubularin related protein 60.011
exoc7exocyst complex component 70.011
pik3c3phosphoinositide-3-kinase, class 30.011
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.011
igf3insulin-like growth factor 30.011
slc30a5solute carrier family 30 (zinc transporter), member 50.011
si:ch211-184m19.1si:ch211-184m19.10.011
cpne1copine I0.011
klhl11kelch-like 11 (Drosophila)0.011
mettl11amethyltransferase like 11A0.011
ube2q2ubiquitin-conjugating enzyme E2Q family member 20.010
tmem9bTMEM9 domain family, member B0.010
letm1leucine zipper-EF-hand containing transmembrane protein 10.010
zgc:172136zgc:1721360.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Atg12autophagy-related 12 (yeast)0.316
Rnf11ring finger protein 110.249
Gsk3bglycogen synthase kinase 3 beta0.231
Arandrogen receptor0.159
Stx7syntaxin 70.148
Rnf103ring finger protein 1030.116
Grb10growth factor receptor bound protein 100.102
Chmp1bchromatin modifying protein 1B0.096
Kiss1rKISS1 receptor0.095
8430410K20RikRIKEN cDNA 8430410K20 gene0.094
Pldnpallidin0.089
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.089
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.086
Actr3ARP3 actin-related protein 3 homolog (yeast)0.084
Ndfip1Nedd4 family interacting protein 10.076
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.075
Lystlysosomal trafficking regulator0.067
Rab18RAB18, member RAS oncogene family0.065
Axin1axin 10.055
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.055
Dmxl1Dmx-like 10.051
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.049
Traf6TNF receptor-associated factor 60.049
Ctnnb1catenin (cadherin associated protein), beta 10.048
RragcRas-related GTP binding C0.048
Fgfr2fibroblast growth factor receptor 20.045
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.045
Lamp2lysosomal-associated membrane protein 20.044
Ghrgrowth hormone receptor0.043
Rab27aRAB27A, member RAS oncogene family0.042
Rnf115ring finger protein 1150.041
Tbx3T-box 30.039
Chmchoroidermia0.039
Lrrk2leucine-rich repeat kinase 20.038
Bglapbone gamma carboxyglutamate protein0.038
Mesdc2mesoderm development candidate 20.037
Pofut1protein O-fucosyltransferase 10.036
Capza2capping protein (actin filament) muscle Z-line, alpha 20.036
Dram2VDNA-damage regulated autophagy modulator 20.035
Epn1epsin 10.034
Prrg2proline-rich Gla (G-carboxyglutamic acid) polypeptide 20.034
Rbbp9retinoblastoma binding protein 90.033
C78339expressed sequence C783390.033
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.032
Atg7autophagy-related 7 (yeast)0.032
Rap1bRAS related protein 1b0.032
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.031
Wlswntless homolog (Drosophila)0.031
Sec23aSEC23A (S. cerevisiae)0.031
Pdclphosducin-like0.030
Crtc3CREB regulated transcription coactivator 30.029
Pgrmc1progesterone receptor membrane component 10.029
Stam2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.029
Samd4bsterile alpha motif domain containing 4B0.029
Rab33bRAB33B, member of RAS oncogene family0.028
Mfsd1major facilitator superfamily domain containing 10.028
Atp6v1c1ATPase, H+ transporting, lysosomal V1 subunit C10.028
Inhainhibin alpha0.027
Lrp5low density lipoprotein receptor-related protein 50.027
Syap1synapse associated protein 10.027
Tbrachyury0.027
Esr1estrogen receptor 1 (alpha)0.027
Mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.026
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.026
Dpy19l4dpy-19-like 4 (C. elegans)0.025
Fam18bfamily with sequence similarity 18, member B0.025
D19Wsu162eDNA segment, Chr 19, Wayne State University 162, expressed0.024
Mitfmicrophthalmia-associated transcription factor0.024
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.024
Kdelr1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 10.024
Asah1N-acylsphingosine amidohydrolase 10.024
Starsteroidogenic acute regulatory protein0.024
Hdlbphigh density lipoprotein (HDL) binding protein0.024
Pls3plastin 3 (T-isoform)0.023
Cxcr2chemokine (C-X-C motif) receptor 20.023
Wbp2WW domain binding protein 20.023
Atg5autophagy-related 5 (yeast)0.023
Cltcclathrin, heavy polypeptide (Hc)0.023
BlnkB-cell linker0.023
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.023
Hps6Hermansky-Pudlak syndrome 60.023
Sdcbpsyndecan binding protein0.023
Nr1h3nuclear receptor subfamily 1, group H, member 30.022
Csgalnact2chondroitin sulfate N-acetylgalactosaminyltransferase 20.022
Map2k1mitogen-activated protein kinase kinase 10.022
Osbpl11oxysterol binding protein-like 110.022
Sacm1lSAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)0.022
Sertad2SERTA domain containing 20.022
Prrx2paired related homeobox 20.022
Mospd2motile sperm domain containing 20.022
Secisbp2lSECIS binding protein 2-like0.021
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.021
Chmp5chromatin modifying protein 50.021
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.021
Pmepa1prostate transmembrane protein, androgen induced 10.020
3110043O21RikRIKEN cDNA 3110043O21 gene0.020
Adam9a disintegrin and metallopeptidase domain 9 (meltrin gamma)0.020
Copacoatomer protein complex subunit alpha0.020
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.020
Gga2golgi associated, gamma adaptin ear containing, ARF binding protein 20.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
VPS28Vps28p0.999
VPS21Vps21p0.998
VPS36Vps36p0.992
ATG7Atg7p0.988
ATG9Atg9p0.981
COG6Cog6p0.981
APL5Apl5p0.971
COG8Cog8p0.971
VPS35Vps35p0.964
VPS41Vps41p0.953
COG5Cog5p0.938
ATG3Atg3p0.933
SNX4Snx4p0.922
YPT6Ypt6p0.905
SRN2Srn2p0.894
BRO1Bro1p0.865
VPS3Vps3p0.857
ATG4Atg4p0.842
COG3Cog3p0.842
ATG11Atg11p0.816
ATG12Atg12p0.815
COG7Cog7p0.810
ATG21Atg21p0.803
APL6Apl6p0.788
LSB3Lsb3p0.783
VPS20Vps20p0.775
VPS17Vps17p0.743
PEP5Pep5p0.733
COG1Cog1p0.720
ATG23Atg23p0.716
COG4Cog4p0.712
ATG20Atg20p0.703
VTI1Vti1p0.684
ATG16Atg16p0.673
VPS16Vps16p0.630
VPS30Vps30p0.618
ATG8Atg8p0.614
VPS4Vps4p0.614
YPT52Ypt52p0.611
TRS85Trs85p0.594
ATG5Atg5p0.579
APM3Apm3p0.563
ATG1Atg1p0.563
RIC1Ric1p0.499
BBC1Bbc1p0.488
DID4Did4p0.471
ATG13Atg13p0.442
PEP3Pep3p0.436
TLG2Tlg2p0.429
SYS1Sys1p0.422
ATG10Atg10p0.416
RGP1Rgp1p0.416
ATG29Atg29p0.413
ATG14Atg14p0.404
VAM6Vam6p0.390
ATG26Atg26p0.387
BZZ1Bzz1p0.382
YIP4Yip4p0.373
BSD2Bsd2p0.362
PEP1Pep1p0.315
VAM7Vam7p0.299
SNF8Snf8p0.297
GYL1Gyl1p0.297
VPS5Vps5p0.277
MON1Mon1p0.276
VPS52Vps52p0.255
SEC4Sec4p0.252
VMA16Vma16p0.243
ASI1Asi1p0.240
PEP8Pep8p0.232
APS3Aps3p0.222
PIN3Pin3p0.215
CSR2Csr2p0.214
APM2Apm2p0.213
ECM21Ecm21p0.211
TRE1Tre1p0.211
YPT10Ypt10p0.206
VPS9Vps9p0.205
COG2Cog2p0.204
VMA8Vma8p0.202
GET1Get1p0.196
VPS45Vps45p0.183
GDI1Gdi1p0.176
HSV2Hsv2p0.173
YPT53Ypt53p0.168
VPS15Vps15p0.168
VPS53Vps53p0.167
BPT1Bpt1p0.166
CIS1Cis1p0.155
KTR4Ktr4p0.150
YPT7Ypt7p0.147
ATG17Atg17p0.147
SLG1Slg1p0.145
VPS33Vps33p0.143
YBR056Whypothetical protein0.142
CCZ1Ccz1p0.142
VPH2Vph2p0.142
EMP47Emp47p0.140
YLR211Chypothetical protein0.139
MON2Mon2p0.136