The network for 'establishment of melanosome localization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of melanosome localization

The directed movement of a melanosome to a specific location.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.870
DTNBP1dystrobrevin binding protein 10.287
CTNND1catenin (cadherin-associated protein), delta 10.112
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.036
BLOC1S3biogenesis of lysosomal organelles complex-1, subunit 30.022
OCRLoculocerebrorenal syndrome of Lowe0.016
PLDNpallidin homolog (mouse)0.015
DSG2desmoglein 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cc2d2acoiled-coil and C2 domain containing 2A0.480
kif17kinesin family member 170.127
ift80intraflagellar transport 80 homolog (Chlamydomonas)0.127
bbs2Bardet-Biedl syndrome 20.116
mks1meckel syndrome, type 10.111
ift88intraflagellar transport 88 homolog0.107
tctex1d2Tctex1 domain containing 20.099
ift52intraflagellar transport protein 520.085
si:dkey-7n6.2si:dkey-7n6.20.059
acvr1bactivin A receptor, type IB0.055
ift57intraflagellar transport protein 570.053
bonbonnie and clyde0.052
pdzd7aPDZ domain containing 7a0.051
cluap1clusterin associated protein 10.048
tsc2tuberous sclerosis 20.048
rogdirogdi homolog (Drosophila)0.047
dync2i1dynein, cytoplasmic 2, intermediate chain 10.043
nortnotch-regulated transcript0.041
traf3ip1TNF receptor-associated factor 3 interacting protein 10.037
uchl1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.035
esyt3extended synaptotagmin-like protein 30.034
dctn1adynactin 1a0.034
gscgoosecoid0.032
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.032
snx6sorting nexin 60.031
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.029
zgc:109987zgc:1099870.028
dync1h1dynein, cytoplasmic 1, heavy chain 10.028
si:dkeyp-34c12.2si:dkeyp-34c12.20.027
vps26avacuolar protein sorting 26 homolog A (yeast)0.027
kif3bkinesin family member 3B0.027
ctsl1bcathepsin L, 1 b0.026
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.026
arf2ADP-ribosylation factor 20.026
zgc:172101zgc:1721010.026
gclmglutamate-cysteine ligase, modifier subunit0.026
chmchoroideremia0.026
styk1serine/threonine/tyrosine kinase 10.025
top2btopoisomerase (DNA) II beta0.025
epb41l5erythrocyte membrane protein band 4.1 like 50.024
si:dkey-222f8.3si:dkey-222f8.30.024
zgc:158643zgc:1586430.024
wu:fb50h02wu:fb50h020.023
cdh10cadherin 10, type 2 (T2-cadherin)0.023
ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.023
LOC567405novel protein similar to vertebrate megakaryocyte-associated tyrosine kinase (MATK)0.022
sec11aSEC11 homolog A (S. cerevisiae)0.022
crb2acrumbs homolog 2a0.022
wnt11wingless-type MMTV integration site family, member 110.022
cdx1bcaudal type homeobox 1 b0.022
tmem199transmembrane protein 1990.021
si:dkey-174n20.1si:dkey-174n20.10.021
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.021
cyfip2cytoplasmic FMR1 interacting protein 20.021
elovl4belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4b0.020
syne2aspectrin repeat containing, nuclear envelope 2a0.020
bbs5Bardet-Biedl syndrome 50.020
dyrk1bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.020
stat5.2signal transducer and activator of transcription 5.20.020
dpysl5adihydropyrimidinase-like 5a0.019
ptdss1phosphatidylserine synthase 10.019
si:ch211-150c22.3si:ch211-150c22.30.019
zgc:162576zgc:1625760.017
map9microtubule-associated protein 90.017
ttc26tetratricopeptide repeat domain 260.017
radilRap GTPase interactor0.017
inaainternexin neuronal intermediate filament protein, alpha a0.017
cep290centrosomal protein 2900.017
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.017
zgc:153096zgc:1530960.017
commd3COMM domain containing 30.016
dpysl4dihydropyrimidinase-like 40.016
zgc:112329zgc:1123290.016
unc119bunc-119 homolog b (C. elegans)0.016
arpc5aactin related protein 2/3 complex, subunit 5A0.016
f2rl1.1coagulation factor II (thrombin) receptor-like 1.10.016
xbp1X-box binding protein 10.016
si:dkey-3d4.3si:dkey-3d4.30.016
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.016
ca7carbonic anhydrase VII0.016
epcamepithelial cell adhesion molecule0.015
nptnaneuroplastin a0.015
zgc:172284zgc:1722840.015
ankra2ankyrin repeat, family A (RFXANK-like), 20.015
bbs4Bardet-Biedl syndrome 40.015
ift172intraflagellar transport 1720.015
arl3ADP-ribosylation factor-like 30.015
fam3cfamily with sequence similarity 3, member C0.015
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.015
otx1borthodenticle homolog 1b0.015
pfn2profilin 20.015
nnrnanor0.014
vapaVAMP (vesicle-associated membrane protein)-associated protein A0.014
zgc:113106zgc:1131060.014
aanat2arylalkylamine N-acetyltransferase0.014
ube2g2ubiquitin-conjugating enzyme E2G 20.014
mapk3mitogen-activated protein kinase 30.014
rpl10ribosomal protein L100.014
arhgdiaRho GDP dissociation inhibitor (GDI) alpha0.014
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bbs4Bardet-Biedl syndrome 4 (human)1.000
Lystlysosomal trafficking regulator1.000
Bbs1Bardet-Biedl syndrome 1 (human)1.000
Bbs2Bardet-Biedl syndrome 2 (human)1.000
Hps1Hermansky-Pudlak syndrome 1 homolog (human)0.996
Ap3b1adaptor-related protein complex 3, beta 1 subunit0.996
Mitfmicrophthalmia-associated transcription factor0.996
Mlphmelanophilin0.996
Rab27aRAB27A, member RAS oncogene family0.994
Hps5Hermansky-Pudlak syndrome 5 homolog (human)0.993
Cnocappuccino0.993
anonagouti0.979
Hps6Hermansky-Pudlak syndrome 60.926
Tyrp1tyrosinase-related protein 10.718
Oca2oculocutaneous albinism II0.704
Arl6ADP-ribosylation factor-like 60.697
Ap3d1adaptor-related protein complex 3, delta 1 subunit0.617
Bbs5Bardet-Biedl syndrome 5 (human)0.570
Stx12syntaxin 120.546
Ttc8tetratricopeptide repeat domain 80.492
Prf1perforin 1 (pore forming protein)0.460
Mutedmuted0.458
Tyrtyrosinase0.449
Csnk1g2casein kinase 1, gamma 20.435
Vapavesicle-associated membrane protein, associated protein A0.404
Mapk3mitogen-activated protein kinase 30.382
Bbs9Bardet-Biedl syndrome 9 (human)0.350
Rab38RAB38, member of RAS oncogene family0.341
Sh3glb2SH3-domain GRB2-like endophilin B20.329
Nptnneuroplastin0.326
Add1adducin 1 (alpha)0.321
Fbxw5F-box and WD-40 domain protein 50.315
RhebRas homolog enriched in brain0.294
Rab11aRAB11a, member RAS oncogene family0.266
Bbs7Bardet-Biedl syndrome 7 (human)0.263
Hps3Hermansky-Pudlak syndrome 3 homolog (human)0.251
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.247
Pldnpallidin0.236
Tmem30atransmembrane protein 30A0.227
Drap1Dr1 associated protein 1 (negative cofactor 2 alpha)0.217
Dstndestrin0.213
Pef1penta-EF hand domain containing 10.207
Dctn2dynactin 20.195
Sytl5synaptotagmin-like 50.187
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.179
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.169
Aesamino-terminal enhancer of split0.164
Atp6v1c1ATPase, H+ transporting, lysosomal V1 subunit C10.159
Mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.120
Mlf2myeloid leukemia factor 20.120
Gnb2guanine nucleotide binding protein (G protein), beta 20.118
Dctn1dynactin 10.118
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.115
Anapc2anaphase promoting complex subunit 20.114
Exoc7exocyst complex component 70.109
Kitkit oncogene0.097
Fkbp8FK506 binding protein 80.095
Stx7syntaxin 70.092
Arl1ADP-ribosylation factor-like 10.083
Pld3phospholipase D family, member 30.083
Capns1calpain, small subunit 10.081
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.080
Spna2spectrin alpha 20.076
Oaz2-psornithine decarboxylase antizyme 2, pseudogene0.073
Chmp2bchromatin modifying protein 2B0.072
8430410K20RikRIKEN cDNA 8430410K20 gene0.072
Clptm1cleft lip and palate associated transmembrane protein 10.069
Pmelpremelanosome protein0.069
Ptov1prostate tumor over expressed gene 10.069
Bag6BCL2-associated athanogene 60.066
Mtch1mitochondrial carrier homolog 1 (C. elegans)0.065
Stx11syntaxin 110.064
Tmem9bTMEM9 domain family, member B0.063
Pomcpro-opiomelanocortin-alpha0.063
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.060
Ccdc64coiled-coil domain containing 640.060
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.059
Wsb2WD repeat and SOCS box-containing 20.056
Fmn1formin 10.055
Bsgbasigin0.053
Ins2insulin II0.052
Chmp5chromatin modifying protein 50.052
Vps4avacuolar protein sorting 4a (yeast)0.052
Tmco1transmembrane and coiled-coil domains 10.050
Aampangio-associated migratory protein0.049
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.049
Ap2m1adaptor protein complex AP-2, mu10.049
Rab6RAB6, member RAS oncogene family0.048
Mtmr6myotubularin related protein 60.046
MkksMcKusick-Kaufman syndrome protein0.044
Snx16sorting nexin 160.044
Akap8lA kinase (PRKA) anchor protein 8-like0.044
Rnf103ring finger protein 1030.043
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.043
Hdac5histone deacetylase 50.042
Plcg1phospholipase C, gamma 10.041
Prr15proline rich 150.040
Klc1kinesin light chain 10.040
Ubl7ubiquitin-like 7 (bone marrow stromal cell-derived)0.040
Rab25RAB25, member RAS oncogene family0.038
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nckap1NCK-associated protein 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism