The network for 'factor xii activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

factor xii activation

Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.

NameDescriptionProbabilityFunc Analog Organism
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 11.000
PLAURplasminogen activator, urokinase receptor0.991
METmet proto-oncogene (hepatocyte growth factor receptor)0.378
PLAUplasminogen activator, urokinase0.373
PLATplasminogen activator, tissue0.218
APOHapolipoprotein H (beta-2-glycoprotein I)0.198
KNG1kininogen 10.042
ORM1orosomucoid 10.041
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.040
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.030
VTNvitronectin0.021
SERPINF2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.018
C8Acomplement component 8, alpha polypeptide0.015
PLGplasminogen0.015
EMP1epithelial membrane protein 10.014
TNCtenascin C0.013
TFR2transferrin receptor 20.012
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.012
CRPC-reactive protein, pentraxin-related0.012
FGBfibrinogen beta chain0.011
GCKRglucokinase (hexokinase 4) regulator0.011
MASP2mannan-binding lectin serine peptidase 20.011
SPP2secreted phosphoprotein 2, 24kDa0.010
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.010
LPAlipoprotein, Lp(a)0.010
SPHK1sphingosine kinase 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism