The network for 'positive regulation of apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of apoptotic signaling pathway

Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 11.000
BCL2B-cell CLL/lymphoma 21.000
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 11.000
FASFas (TNF receptor superfamily, member 6)1.000
BCL2L11BCL2-like 11 (apoptosis facilitator)1.000
XIAPX-linked inhibitor of apoptosis0.999
MDM2Mdm2 p53 binding protein homolog (mouse)0.999
BIRC3baculoviral IAP repeat containing 30.998
TRAF1TNF receptor-associated factor 10.997
CFLARCASP8 and FADD-like apoptosis regulator0.996
BAXBCL2-associated X protein0.996
EGFRepidermal growth factor receptor0.993
CAV1caveolin 1, caveolae protein, 22kDa0.982
CASP3caspase 3, apoptosis-related cysteine peptidase0.981
BIRC2baculoviral IAP repeat containing 20.979
FADDFas (TNFRSF6)-associated via death domain0.978
BADBCL2-associated agonist of cell death0.975
TRAF2TNF receptor-associated factor 20.974
BIDBH3 interacting domain death agonist0.972
SQSTM1sequestosome 10.967
UBCubiquitin C0.965
DAXXdeath-domain associated protein0.965
TRADDTNFRSF1A-associated via death domain0.959
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.957
CASP10caspase 10, apoptosis-related cysteine peptidase0.949
CASP9caspase 9, apoptosis-related cysteine peptidase0.948
TRAF3TNF receptor-associated factor 30.930
RIPK2receptor-interacting serine-threonine kinase 20.928
PMLpromyelocytic leukemia0.926
S100A6S100 calcium binding protein A60.921
MAPK1mitogen-activated protein kinase 10.921
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.917
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.905
TP53BP2tumor protein p53 binding protein, 20.905
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.882
ZMYND11zinc finger, MYND-type containing 110.879
PSEN1presenilin 10.871
CASP2caspase 2, apoptosis-related cysteine peptidase0.861
S100BS100 calcium binding protein B0.855
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.854
TRAF6TNF receptor-associated factor 60.845
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.832
BAK1BCL2-antagonist/killer 10.824
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.801
APPamyloid beta (A4) precursor protein0.759
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.748
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.748
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.742
BECN1beclin 1, autophagy related0.739
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.736
PTENphosphatase and tensin homolog0.696
STK4serine/threonine kinase 40.678
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.648
BCAP31B-cell receptor-associated protein 310.636
BIKBCL2-interacting killer (apoptosis-inducing)0.628
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.618
SMAD7SMAD family member 70.608
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.602
TP53tumor protein p530.587
FKBP1AFK506 binding protein 1A, 12kDa0.574
CASP7caspase 7, apoptosis-related cysteine peptidase0.557
TGFB1transforming growth factor, beta 10.551
S100A1S100 calcium binding protein A10.550
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.545
S100A4S100 calcium binding protein A40.542
SEPT2septin 20.528
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.523
TANKTRAF family member-associated NFKB activator0.518
NCF2neutrophil cytosolic factor 20.517
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.515
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.508
SFPQsplicing factor proline/glutamine-rich0.501
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.497
MAPK8mitogen-activated protein kinase 80.494
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.493
BBC3BCL2 binding component 30.489
NLRC4NLR family, CARD domain containing 40.483
ANXA1annexin A10.473
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.470
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.470
BMP2bone morphogenetic protein 20.468
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.464
MAP3K5mitogen-activated protein kinase kinase kinase 50.445
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.443
S100A11S100 calcium binding protein A110.440
GOPCgolgi-associated PDZ and coiled-coil motif containing0.440
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.405
STRN3striatin, calmodulin binding protein 30.394
SP100SP100 nuclear antigen0.386
DIABLOdiablo, IAP-binding mitochondrial protein0.384
STK3serine/threonine kinase 30.369
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.364
IQGAP1IQ motif containing GTPase activating protein 10.357
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.334
HDAC1histone deacetylase 10.316
PRKCAprotein kinase C, alpha0.316
HIPK2homeodomain interacting protein kinase 20.309
ANXA2annexin A20.307
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.304
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rhogbras homolog gene family, member Gb0.551
baxabcl2-associated X protein, a0.461
mcl1amyeloid cell leukemia sequence 1a0.328
ptpn6protein tyrosine phosphatase, non-receptor type 60.299
manfmesencephalic astrocyte-derived neurotrophic factor0.299
nf1aneurofibromin 1a0.292
bcl2l1bcl2-like 10.289
sgk1serum/glucocorticoid regulated kinase 10.284
frem3Fras1 related extracellular matrix 30.261
tbx1T-box 10.217
tnfrsfatumor necrosis factor receptor superfamily, member a0.213
bmp2bbone morphogenetic protein 2b0.200
acvr2aactivin receptor IIa0.199
rpsaribosomal protein SA0.190
ikzf1IKAROS family zinc finger 1 (Ikaros)0.153
nf1bneurofibromin 1b0.151
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.145
rag1recombination activating gene 10.139
sulf2lsulfatase 2, like0.134
inhbaainhibin, beta Aa0.130
fgf3fibroblast growth factor 30.127
atf3activating transcription factor 30.127
socs3asuppressor of cytokine signaling 3a0.126
cotl1coactosin-like 1 (Dictyostelium)0.114
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.113
inhainhibin, alpha0.106
bidaBH3 interacting domain death agonist0.105
nkx2.3NK2 transcription factor related 30.105
il7rinterleukin 7 receptor0.105
wnt4awingless-type MMTV integration site family, member 4a0.104
ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.101
ifnphi1interferon phi 10.097
junbjun B proto-oncogene0.095
rhoaaras homolog gene family, member Aa0.095
tagln2transgelin 20.095
calrlcalreticulin like0.094
plxnb2aplexin b2a0.092
pitx3paired-like homeodomain transcription factor 30.091
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.091
pax9paired box gene 90.089
plxnd1plexin D10.085
bcl2B-cell leukemia/lymphoma 20.085
acadlacyl-Coenzyme A dehydrogenase, long chain0.083
mcl1bmyeloid cell leukemia sequence 1b0.082
cdkn1acyclin-dependent kinase inhibitor 1A0.082
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.082
uba1ubiquitin-like modifier activating enzyme 10.082
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.082
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.082
rspo3R-spondin 3 homolog (Xenopus laevis)0.082
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.082
ret1receptor tyrosine kinase0.081
tcf21transcription factor 210.081
nrarpanotch-regulated ankyrin repeat protein a0.081
tcf7transcription factor 7 (T-cell specific, HMG-box)0.081
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.081
cnihcornichon homolog (Drosophila)0.081
mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.079
hbegfaheparin-binding EGF-like growth factor a0.079
polbpolymerase (DNA directed), beta0.078
tp53bp2tumor protein p53 binding protein, 20.078
ahcyl1S-adenosylhomocysteine hydrolase-like 10.077
mapk6mitogen-activated protein kinase 60.077
nme2b.1non-metastatic cells 2b.1, protein (NM23B) expressed in0.077
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.076
LOC567131calcitonin gene-related peptide type 1 receptor-like0.075
ybx1Y box binding protein 10.075
tssc1tumor suppressing subtransferable candidate 10.075
appbamyloid beta (A4) precursor protein b0.075
LOC556647GDNF family receptor alpha-4-like0.074
timp2btissue inhibitor of metalloproteinase 2b0.073
rag2recombination activating gene 20.073
plag1pleiomorphic adenoma gene 10.073
fzd7afrizzled homolog 7a0.073
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.072
satb2SATB homeobox 20.072
eef1geukaryotic translation elongation factor 1 gamma0.071
stc1lstanniocalcin 1, like0.071
ubtd2ubiquitin domain containing 20.071
rargaretinoic acid receptor gamma a0.071
lhcgrluteinizing hormone/choriogonadotropin receptor0.071
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.069
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.069
zfp36l1azinc finger protein 36, C3H type-like 1a0.068
crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.068
nkx3.2NK3 homeobox 20.068
sid4secreted immunoglobulin domain 40.067
rpl8ribosomal protein L80.067
mapk7mitogen-activated protein kinase 70.066
rpl13ribosomal protein L130.066
sdcbpsyndecan binding protein (syntenin)0.065
otpaorthopedia homolog a0.065
junjun proto-oncogene0.064
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
IceCG7788 gene product from transcript CG7788-RA0.472
imdimmune deficiency0.226
G-salpha60AG protein salpha 60A0.214
NcNedd2-like caspase0.207
CspCysteine string protein0.180
RagACG11968 gene product from transcript CG11968-RA0.159
Dcp-1Death caspase-10.157
smi35Asmell impaired 35A0.150
Rac1CG2248 gene product from transcript CG2248-RA0.137
CG8443CG8443 gene product from transcript CG8443-RA0.136
Sod2Superoxide dismutase 2 (Mn)0.133
Pi3K92ECG4141 gene product from transcript CG4141-RB0.126
slmbsupernumerary limbs0.108
CG1021CG1021 gene product from transcript CG1021-RE0.102
RpS13Ribosomal protein S130.092
debcldeath executioner Bcl-2 homologue0.091
Letm1CG4589 gene product from transcript CG4589-RB0.085
Patr-1Protein associated with topo II related - 10.084
reporeversed polarity0.081
CG6543CG6543 gene product from transcript CG6543-RA0.079
Cdk5alphaCdk5 activator-like protein0.079
Adf1Adh transcription factor 10.076
Cyt-c-dCytochrome c distal0.074
AdarAdenosine deaminase acting on RNA0.073
poepurity of essence0.069
eyaeyes absent0.068
MicalMolecule interacting with CasL0.067
myoglianinCG1838 gene product from transcript CG1838-RD0.067
CG13890CG13890 gene product from transcript CG13890-RA0.066
TBPHCG10327 gene product from transcript CG10327-RC0.066
bchsblue cheese0.065
CG1103CG1103 gene product from transcript CG1103-RA0.065
Su(H)Suppressor of Hairless0.063
ird1immune response deficient 10.062
yuriyuri gagarin0.061
CG10984CG10984 gene product from transcript CG10984-RC0.060
Roc1bCG16988 gene product from transcript CG16988-RA0.060
BG4CG12297 gene product from transcript CG12297-RA0.060
tbcetubulin-specific chaperone E0.056
Cdc42CG12530 gene product from transcript CG12530-RA0.056
CG10098CG10098 gene product from transcript CG10098-RA0.055
calypsoCG8445 gene product from transcript CG8445-RB0.055
Eip71CDEcdysone-induced protein 28/29kD0.055
CG30410CG30410 gene product from transcript CG30410-RB0.054
vimarvisceral mesodermal armadillo-repeats0.054
CG7372CG7372 gene product from transcript CG7372-RA0.052
RpS24Ribosomal protein S240.052
dvedefective proventriculus0.051
Atg6Autophagy-specific gene 60.051
mib1mind bomb 10.050
djdon juan0.049
CG11267CG11267 gene product from transcript CG11267-RA0.049
GLazGlial Lazarillo0.049
Npc1aNiemann-Pick type C-1a0.049
Atg7Autophagy-specific gene 70.048
CG42574CG42574 gene product from transcript CG42574-RE0.046
APP-BP1beta-Amyloid precursor protein binding protein 10.045
trioCG18214 gene product from transcript CG18214-RA0.045
MagiCG30388 gene product from transcript CG30388-RA0.045
MED1Mediator complex subunit 10.044
Unc-76CG3981 gene product from transcript CG3981-RB0.044
fs(2)ltoPP43female sterile (2) ltoPP430.044
X11LCG5675 gene product from transcript CG5675-RB0.043
HtrA2CG8464 gene product from transcript CG8464-RA0.043
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase0.043
VGATVesicular GABA Transporter0.043
alphaTub84Balpha-Tubulin at 84B0.042
neuroliginCG13772 gene product from transcript CG13772-RA0.042
CG12214CG12214 gene product from transcript CG12214-RB0.041
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog1.000
Trp53transformation related protein 531.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Tgfb1transforming growth factor, beta 10.995
Fgfr2fibroblast growth factor receptor 20.992
Apcadenomatosis polyposis coli0.991
Tgfbr2transforming growth factor, beta receptor II0.988
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.988
Psen1presenilin 10.987
BaxBCL2-associated X protein0.986
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.984
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.980
Apaf1apoptotic peptidase activating factor 10.978
Bcl2B-cell leukemia/lymphoma 20.977
Leprleptin receptor0.971
Mapk8mitogen-activated protein kinase 80.964
Tnftumor necrosis factor0.962
Cd44CD44 antigen0.961
Ncoa3nuclear receptor coactivator 30.959
Nos3nitric oxide synthase 3, endothelial cell0.944
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.933
Gsk3bglycogen synthase kinase 3 beta0.925
Rxraretinoid X receptor alpha0.914
Ptpn11protein tyrosine phosphatase, non-receptor type 110.912
Mdm2transformed mouse 3T3 cell double minute 20.903
Smad3MAD homolog 3 (Drosophila)0.900
Csf1colony stimulating factor 1 (macrophage)0.900
Il2rginterleukin 2 receptor, gamma chain0.897
FynFyn proto-oncogene0.895
Nf1neurofibromatosis 10.894
Lyz2lysozyme 20.873
Vhlvon Hippel-Lindau tumor suppressor0.869
Axin1axin 10.868
Sfrp2secreted frizzled-related protein 20.863
Casp8caspase 80.861
Ikbkginhibitor of kappaB kinase gamma0.857
Esr1estrogen receptor 1 (alpha)0.857
Bmpr1abone morphogenetic protein receptor, type 1A0.851
Tnfaip3tumor necrosis factor, alpha-induced protein 30.848
Cdkn1bcyclin-dependent kinase inhibitor 1B0.844
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.837
Ptgs2prostaglandin-endoperoxide synthase 20.818
Nos2nitric oxide synthase 2, inducible0.816
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.815
Tgfbr1transforming growth factor, beta receptor I0.813
Hif1ahypoxia inducible factor 1, alpha subunit0.811
Vegfavascular endothelial growth factor A0.808
Shhsonic hedgehog0.806
Notch1Notch gene homolog 1 (Drosophila)0.796
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.795
Itgb1integrin beta 1 (fibronectin receptor beta)0.793
Stk3serine/threonine kinase 3 (Ste20, yeast homolog)0.772
Ilkintegrin linked kinase0.769
Rb1retinoblastoma 10.741
Notch2Notch gene homolog 2 (Drosophila)0.740
Stk4serine/threonine kinase 40.730
Rararetinoic acid receptor, alpha0.728
Vdrvitamin D receptor0.713
Ptch1patched homolog 10.709
Tgfb2transforming growth factor, beta 20.698
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.691
Ptprcprotein tyrosine phosphatase, receptor type, C0.676
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.675
Mcl1myeloid cell leukemia sequence 10.655
Aim2absent in melanoma 20.653
Bcl3B-cell leukemia/lymphoma 30.649
Stat3signal transducer and activator of transcription 30.627
WrnWerner syndrome homolog (human)0.617
Col1a1collagen, type I, alpha 10.611
Nos1nitric oxide synthase 1, neuronal0.606
FasFas (TNF receptor superfamily member 6)0.606
Mycmyelocytomatosis oncogene0.603
Mfn2mitofusin 20.602
Ighimmunoglobulin heavy chain complex0.577
Tlr4toll-like receptor 40.576
Gli3GLI-Kruppel family member GLI30.568
Smad4MAD homolog 4 (Drosophila)0.568
Rbl1retinoblastoma-like 1 (p107)0.561
Casp4caspase 4, apoptosis-related cysteine peptidase0.556
Nlrp3NLR family, pyrin domain containing 30.553
Cdk4cyclin-dependent kinase 40.547
Ctslcathepsin L0.545
Rargretinoic acid receptor, gamma0.543
Sox9SRY-box containing gene 90.536
Il6stinterleukin 6 signal transducer0.534
Sfrp1secreted frizzled-related protein 10.529
Casp3caspase 30.523
DaxxFas death domain-associated protein0.522
Nfe2l2nuclear factor, erythroid derived 2, like 20.519
Prlrprolactin receptor0.517
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.512
Ahraryl-hydrocarbon receptor0.508
Ikzf1IKAROS family zinc finger 10.495
Prkceprotein kinase C, epsilon0.495
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.490
Atf2activating transcription factor 20.481
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a8S100 calcium binding protein A80.147
S100a9S100 calcium binding protein A90.121
Pdia6protein disulfide isomerase family A, member 60.067
Eif3feukaryotic translation initiation factor 3, subunit F0.039
Smad7SMAD family member 70.036
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.034
Cdk4cyclin-dependent kinase 40.031
Tcf12transcription factor 120.030
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.027
Ppibpeptidylprolyl isomerase B0.027
Socs3suppressor of cytokine signaling 30.024
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.022
Rps3ribosomal protein S30.022
Lig3ligase III, DNA, ATP-dependent0.021
Pdia4protein disulfide isomerase family A, member 40.020
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.020
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.019
Rnf4ring finger protein 40.019
Cishcytokine inducible SH2-containing protein0.018
Nek9NIMA (never in mitosis gene a)- related kinase 90.017
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.016
Ralgdsral guanine nucleotide dissociation stimulator0.016
Cd14CD14 molecule0.016
Myo1bmyosin Ib0.016
Prrx1paired related homeobox 10.015
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.015
Casp3caspase 30.015
Creb1cAMP responsive element binding protein 10.014
Il1r2interleukin 1 receptor, type II0.014
Dctn4dynactin 40.014
Trim23tripartite motif-containing 230.013
Csnk1g3casein kinase 1, gamma 30.012
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.012
Epn1Epsin 10.012
Rpn2ribophorin II0.011
JunJun oncogene0.011
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.011
Pgcpplasma glutamate carboxypeptidase0.011
Litaflipopolysaccharide-induced TNF factor0.011
Icam1intercellular adhesion molecule 10.010
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism