The network for 'regulation of extrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of extrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
BIRC3baculoviral IAP repeat containing 31.000
BCL2B-cell CLL/lymphoma 21.000
TRAF1TNF receptor-associated factor 11.000
TRAF2TNF receptor-associated factor 21.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.999
FHL2four and a half LIM domains 20.998
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.995
BCL2L1BCL2-like 10.993
FASFas (TNF receptor superfamily, member 6)0.993
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.991
BCL2L11BCL2-like 11 (apoptosis facilitator)0.988
MTORmechanistic target of rapamycin (serine/threonine kinase)0.984
FADDFas (TNFRSF6)-associated via death domain0.980
CFLARCASP8 and FADD-like apoptosis regulator0.979
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.976
FN1fibronectin 10.974
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.966
XIAPX-linked inhibitor of apoptosis0.966
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.964
BAXBCL2-associated X protein0.951
TRAF6TNF receptor-associated factor 60.950
BIRC2baculoviral IAP repeat containing 20.946
TRADDTNFRSF1A-associated via death domain0.945
RIPK2receptor-interacting serine-threonine kinase 20.940
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.928
SQSTM1sequestosome 10.901
CASP10caspase 10, apoptosis-related cysteine peptidase0.882
HSPA1Bheat shock 70kDa protein 1B0.877
MAP3K3mitogen-activated protein kinase kinase kinase 30.876
TEKTEK tyrosine kinase, endothelial0.858
TNFAIP3tumor necrosis factor, alpha-induced protein 30.856
PDPK13-phosphoinositide dependent protein kinase-10.852
CAV1caveolin 1, caveolae protein, 22kDa0.847
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.840
SMAD3SMAD family member 30.840
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.822
BADBCL2-associated agonist of cell death0.818
TNFtumor necrosis factor0.814
FGBfibrinogen beta chain0.791
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.785
EGFRepidermal growth factor receptor0.752
HCKhemopoietic cell kinase0.745
TGIF1TGFB-induced factor homeobox 10.743
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.738
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.734
FKBP1AFK506 binding protein 1A, 12kDa0.730
TRAF3TNF receptor-associated factor 30.717
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.695
TP53BP2tumor protein p53 binding protein, 20.680
FLNAfilamin A, alpha0.658
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.657
PMLpromyelocytic leukemia0.646
BIDBH3 interacting domain death agonist0.645
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.638
CASP8AP2caspase 8 associated protein 20.638
FGAfibrinogen alpha chain0.633
IL1R1interleukin 1 receptor, type I0.621
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.619
TGFB1transforming growth factor, beta 10.609
TAL1T-cell acute lymphocytic leukemia 10.591
CXCL2chemokine (C-X-C motif) ligand 20.582
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.569
LCKlymphocyte-specific protein tyrosine kinase0.556
BMP2bone morphogenetic protein 20.532
IL8interleukin 80.531
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.531
TRAF5TNF receptor-associated factor 50.520
IRAK1interleukin-1 receptor-associated kinase 10.514
LGALS1lectin, galactoside-binding, soluble, 10.506
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.488
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.469
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.469
USP15ubiquitin specific peptidase 150.465
PTPN1protein tyrosine phosphatase, non-receptor type 10.454
CXCL11chemokine (C-X-C motif) ligand 110.445
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.428
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.417
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.416
STK4serine/threonine kinase 40.395
TNFRSF9tumor necrosis factor receptor superfamily, member 90.394
TIMP3TIMP metallopeptidase inhibitor 30.390
METmet proto-oncogene (hepatocyte growth factor receptor)0.382
STAT5Asignal transducer and activator of transcription 5A0.377
BCL3B-cell CLL/lymphoma 30.374
HSPA1Aheat shock 70kDa protein 1A0.373
CASP3caspase 3, apoptosis-related cysteine peptidase0.369
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.368
VCAM1vascular cell adhesion molecule 10.368
CD63CD63 molecule0.362
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.360
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.356
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.355
STK3serine/threonine kinase 30.350
FYNFYN oncogene related to SRC, FGR, YES0.346
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.345
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
osr1odd-skipped related 1 (Drosophila)0.912
cmybtranscription factor cmyb0.891
kdrlkinase insert domain receptor like0.823
bcl2l1bcl2-like 10.734
tnfrsfatumor necrosis factor receptor superfamily, member a0.730
mcl1amyeloid cell leukemia sequence 1a0.683
cav1caveolin 10.650
nrp1aneuropilin 1a0.607
acvr2aactivin receptor IIa0.490
matn4matrilin 40.462
nrg2aneuregulin 2a0.454
fgfr1afibroblast growth factor receptor 1a0.443
cnn2calponin 20.427
stc1lstanniocalcin 1, like0.421
mpxmyeloid-specific peroxidase0.415
ntn2netrin 20.413
ptgs1prostaglandin-endoperoxide synthase 10.411
hoxa13ahomeo box A13a0.406
baxabcl2-associated X protein, a0.399
runx1runt-related transcription factor 10.372
mapk6mitogen-activated protein kinase 60.367
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.348
frem3Fras1 related extracellular matrix 30.343
pcsk5aproprotein convertase subtilisin/kexin type 5a0.332
tbx22T-box 220.327
efna5aephrin A5a0.318
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.305
trpv6transient receptor potential cation channel, subfamily V, member 60.298
rag1recombination activating gene 10.298
igf1rainsulin-like growth factor 1a receptor0.297
hmx2H6 family homeobox 20.290
pitx3paired-like homeodomain transcription factor 30.289
col4a2collagen, type IV, alpha 20.283
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.281
hbae1hemoglobin alpha embryonic-10.281
nrp2aneuropilin 2a0.281
wnt10awingless-type MMTV integration site family, member 10a0.281
ptgs2aprostaglandin-endoperoxide synthase 2a0.272
fggfibrinogen, gamma polypeptide0.272
igf1insulin-like growth factor 10.270
cntn2contactin 20.267
aox3aldehyde oxidase 30.262
metmet proto-oncogene (hepatocyte growth factor receptor)0.260
mapk14amitogen-activated protein kinase 14a0.256
tagln2transgelin 20.250
fgfr1bfibroblast growth factor receptor 1b0.245
fgfr3fibroblast growth factor receptor 30.245
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.242
kitakit receptor a0.241
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.238
ifnphi1interferon phi 10.235
igfbp1binsulin-like growth factor binding protein 1b0.232
sgk1serum/glucocorticoid regulated kinase 10.230
ptprfprotein tyrosine phosphatase, receptor type, F0.229
coro1acoronin, actin binding protein, 1A0.228
odc1ornithine decarboxylase 10.225
pou1f1POU domain, class 1, transcription factor 10.222
runx3runt-related transcription factor 30.219
nos1nitric oxide synthase 1 (neuronal)0.218
notch2notch homolog 20.218
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.217
col11a1acollagen, type XI, alpha 1a0.211
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.210
col7a1lcollagen type VII alpha 1-like0.209
csrnp1bcysteine-serine-rich nuclear protein 1b0.209
stmn2bstathmin-like 2b0.202
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.201
fn1fibronectin 10.200
mcl1bmyeloid cell leukemia sequence 1b0.195
tgfb1atransforming growth factor, beta 1a0.193
apomapolipoprotein M0.193
myhz2myosin, heavy polypeptide 2, fast muscle specific0.190
mmp9matrix metalloproteinase 90.186
mmp2matrix metalloproteinase 20.185
six1bsine oculis homeobox homolog 1b0.181
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.181
lcp1lymphocyte cytosolic plastin 10.178
fzd7bfrizzled homolog 7b0.174
phox2bpaired-like homeobox 2b0.170
plxnb2aplexin b2a0.169
hmgb2ahigh-mobility group box 2a0.168
ptenaphosphatase and tensin homolog A0.166
igf1rbinsulin-like growth factor 1b receptor0.164
il1binterleukin 1, beta and interleukin 1, beta0.163
atf3activating transcription factor 30.163
ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.160
itgb3bintegrin beta 3b0.159
gdf9growth differentiation factor 90.157
alas2aminolevulinate, delta-, synthetase 20.156
inhainhibin, alpha0.155
dctdopachrome tautomerase0.154
hbbe1.1hemoglobin beta embryonic-1.10.153
wnt3wingless-type MMTV integration site family, member 30.152
crhcorticotropin releasing hormone0.151
chrna6cholinergic receptor, nicotinic, alpha 60.149
abcf2ATP-binding cassette, sub-family F (GCN20), member 20.148
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 11.000
Trp53transformation related protein 531.000
Tnftumor necrosis factor0.998
Ptenphosphatase and tensin homolog0.998
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.993
Ctnnb1catenin (cadherin associated protein), beta 10.993
Tgfb1transforming growth factor, beta 10.992
Cd19CD19 antigen0.963
Itgb1integrin beta 1 (fibronectin receptor beta)0.961
Lyz2lysozyme 20.946
Csf1colony stimulating factor 1 (macrophage)0.943
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.922
Runx1runt related transcription factor 10.917
Nos3nitric oxide synthase 3, endothelial cell0.916
Cd44CD44 antigen0.904
BaxBCL2-associated X protein0.895
Ptgs2prostaglandin-endoperoxide synthase 20.895
Tgfbr2transforming growth factor, beta receptor II0.882
Bcl2B-cell leukemia/lymphoma 20.882
Casp8caspase 80.882
Ptpn11protein tyrosine phosphatase, non-receptor type 110.871
Ikzf1IKAROS family zinc finger 10.871
Notch2Notch gene homolog 2 (Drosophila)0.861
Esr1estrogen receptor 1 (alpha)0.856
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.844
Fbn1fibrillin 10.826
Mmp9matrix metallopeptidase 90.818
Tnip1TNFAIP3 interacting protein 10.808
Il2rginterleukin 2 receptor, gamma chain0.774
Bmpr1abone morphogenetic protein receptor, type 1A0.768
Egfrepidermal growth factor receptor0.747
Foxp3forkhead box P30.737
Ighimmunoglobulin heavy chain complex0.734
SharpinSHANK-associated RH domain interacting protein0.728
Nos1nitric oxide synthase 1, neuronal0.715
Apcadenomatosis polyposis coli0.710
Notch1Notch gene homolog 1 (Drosophila)0.709
Il10interleukin 100.707
Yap1yes-associated protein 10.704
FasFas (TNF receptor superfamily member 6)0.699
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.683
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.675
Map3k14mitogen-activated protein kinase kinase kinase 140.675
Nos2nitric oxide synthase 2, inducible0.665
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.664
Ccr2chemokine (C-C motif) receptor 20.643
Itchitchy, E3 ubiquitin protein ligase0.634
Nf1neurofibromatosis 10.626
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.611
Il4rainterleukin 4 receptor, alpha0.606
Col5a2collagen, type V, alpha 20.603
Casp4caspase 4, apoptosis-related cysteine peptidase0.596
CblCasitas B-lineage lymphoma0.594
Pdcd1programmed cell death 10.591
Appamyloid beta (A4) precursor protein0.581
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.547
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.544
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.544
Ccr1chemokine (C-C motif) receptor 10.540
Col3a1collagen, type III, alpha 10.528
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.527
Cd40CD40 antigen0.511
Socs1suppressor of cytokine signaling 10.509
Efnb2ephrin B20.509
Ifnginterferon gamma0.503
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.478
Thbs1thrombospondin 10.477
Adam17a disintegrin and metallopeptidase domain 170.476
Mdm2transformed mouse 3T3 cell double minute 20.476
Leprleptin receptor0.475
Fshrfollicle stimulating hormone receptor0.474
Ptpn6protein tyrosine phosphatase, non-receptor type 60.455
Mcl1myeloid cell leukemia sequence 10.449
Cdkn1bcyclin-dependent kinase inhibitor 1B0.437
Smad3MAD homolog 3 (Drosophila)0.418
Casp3caspase 30.418
Rararetinoic acid receptor, alpha0.412
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.407
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.406
Retret proto-oncogene0.394
Runx2runt related transcription factor 20.390
Nr3c1nuclear receptor subfamily 3, group C, member 10.390
FynFyn proto-oncogene0.388
Tgfb2transforming growth factor, beta 20.386
Rbl1retinoblastoma-like 1 (p107)0.381
Inpp5dinositol polyphosphate-5-phosphatase D0.373
Fgfr1fibroblast growth factor receptor 10.355
Vegfavascular endothelial growth factor A0.352
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.345
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.344
Snai1snail homolog 1 (Drosophila)0.336
Ltblymphotoxin B0.335
Wnt5awingless-related MMTV integration site 5A0.330
Cxcl12chemokine (C-X-C motif) ligand 120.330
Psen1presenilin 10.328
Bcl3B-cell leukemia/lymphoma 30.328
XiapX-linked inhibitor of apoptosis0.324
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsp90b1heat shock protein 90, beta, member 10.229
Sirpasignal-regulatory protein alpha0.188
Igsf6immunoglobulin superfamily, member 60.091
Cd86CD86 molecule0.059
Trim47tripartite motif-containing 470.047
Csf1colony stimulating factor 1 (macrophage)0.047
Glg1golgi apparatus protein 10.033
Fgfr2fibroblast growth factor receptor 20.032
Vat1vesicle amine transport protein 1 homolog (T californica)0.032
Mpripmyosin phosphatase Rho interacting protein0.032
Dock8dedicator of cytokinesis 80.031
Il1ainterleukin 1 alpha0.031
Arpc1bactin related protein 2/3 complex, subunit 1B0.029
Cd14CD14 molecule0.027
Il1binterleukin 1 beta0.026
Ddr1discoidin domain receptor tyrosine kinase 10.026
Nek9NIMA (never in mitosis gene a)- related kinase 90.025
Ptprcprotein tyrosine phosphatase, receptor type, C0.025
Anxa5annexin A50.025
Smad7SMAD family member 70.024
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.023
Hckhemopoietic cell kinase0.022
F2rl1coagulation factor II (thrombin) receptor-like 10.022
Slc12a4solute carrier family 12 (potassium/chloride transporters), member 40.021
Icam1intercellular adhesion molecule 10.020
Magt1magnesium transporter 10.020
Lrp10low-density lipoprotein receptor-related protein 100.019
Leprleptin receptor0.019
Myh9myosin, heavy chain 9, non-muscle0.018
Inpp5dinositol polyphosphate-5-phosphatase D0.017
Ptafrplatelet-activating factor receptor0.017
Nrasneuroblastoma ras oncogene0.017
Csnk1g1casein kinase 1, gamma 10.016
Pdia4protein disulfide isomerase family A, member 40.016
Lnpepleucyl/cystinyl aminopeptidase0.016
Unc5bunc-5 homolog B (C. elegans)0.016
Neurl3neuralized homolog 3 (Drosophila)0.016
Cd9CD9 molecule0.015
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.015
Ralgdsral guanine nucleotide dissociation stimulator0.014
Gja5gap junction protein, alpha 50.014
Fkbp2FK506 binding protein 20.014
Nedd4neural precursor cell expressed, developmentally down-regulated 40.014
Tcof1Treacher Collins-Franceschetti syndrome 1 homolog (human)0.014
Il4rainterleukin 4 receptor, alpha0.013
S100a11S100 calcium binding protein A11 (calizzarin)0.013
Prdm2PR domain containing 2, with ZNF domain0.013
Stat3signal transducer and activator of transcription 30.013
Gpnmbglycoprotein (transmembrane) nmb0.013
Flot2flotillin 20.013
Ccl3chemokine (C-C motif) ligand 30.012
Adora2aadenosine A2a receptor0.012
Csnk1g3casein kinase 1, gamma 30.012
Casp1caspase 10.012
Notch2Notch homolog 2 (Drosophila)0.012
Nfibnuclear factor I/B0.012
Ptch1patched homolog 1 (Drosophila)0.012
Orai1ORAI calcium release-activated calcium modulator 10.012
Timp2TIMP metallopeptidase inhibitor 20.011
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.011
Arrdc1arrestin domain containing 10.011
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.011
RGD1561143similar to cell surface receptor FDFACT0.011
Itgamintegrin, alpha M0.011
Cd4Cd4 molecule0.011
Marcksmyristoylated alanine rich protein kinase C substrate0.011
Cxcl10chemokine (C-X-C motif) ligand 100.010
Ins1insulin 10.010
Prkcdprotein kinase C, delta0.010
Cfpcomplement factor properdin0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism