The network for 'regulation of extrinsic apoptotic signaling pathway in absence of ligand' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 11.000
BCL2B-cell CLL/lymphoma 21.000
BAXBCL2-associated X protein0.998
HSPA1Bheat shock 70kDa protein 1B0.994
IL8interleukin 80.992
BCL2L11BCL2-like 11 (apoptosis facilitator)0.990
BADBCL2-associated agonist of cell death0.986
TAL1T-cell acute lymphocytic leukemia 10.982
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.982
PMLpromyelocytic leukemia0.962
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.955
HSPA1Aheat shock 70kDa protein 1A0.953
IL1Binterleukin 1, beta0.944
CXCL2chemokine (C-X-C motif) ligand 20.927
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.919
BIDBH3 interacting domain death agonist0.894
CASP8caspase 8, apoptosis-related cysteine peptidase0.879
CXCL3chemokine (C-X-C motif) ligand 30.862
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.839
IL1R1interleukin 1 receptor, type I0.715
CCL20chemokine (C-C motif) ligand 200.657
CXCL11chemokine (C-X-C motif) ligand 110.655
TRADDTNFRSF1A-associated via death domain0.632
FADDFas (TNFRSF6)-associated via death domain0.631
MAP3K3mitogen-activated protein kinase kinase kinase 30.623
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.534
TRAF1TNF receptor-associated factor 10.486
CXCL5chemokine (C-X-C motif) ligand 50.476
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.476
TRAF2TNF receptor-associated factor 20.445
EGFRepidermal growth factor receptor0.425
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.411
BCL2A1BCL2-related protein A10.410
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.380
BIRC3baculoviral IAP repeat containing 30.370
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.346
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.335
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.318
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.312
TNFtumor necrosis factor0.311
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.302
MAP2K5mitogen-activated protein kinase kinase 50.293
DAXXdeath-domain associated protein0.280
IL6interleukin 6 (interferon, beta 2)0.265
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.265
MAPK7mitogen-activated protein kinase 70.263
BAK1BCL2-antagonist/killer 10.259
JUPjunction plakoglobin0.252
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.203
CASP10caspase 10, apoptosis-related cysteine peptidase0.199
PF4platelet factor 40.196
CFLARCASP8 and FADD-like apoptosis regulator0.175
BAG3BCL2-associated athanogene 30.171
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.167
STK11serine/threonine kinase 110.146
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.144
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.142
PLCG1phospholipase C, gamma 10.139
IL1R2interleukin 1 receptor, type II0.139
IFI44Linterferon-induced protein 44-like0.137
DPP4dipeptidyl-peptidase 40.134
CCL8chemokine (C-C motif) ligand 80.125
CXCL10chemokine (C-X-C motif) ligand 100.124
IL1RNinterleukin 1 receptor antagonist0.124
SHC1SHC (Src homology 2 domain containing) transforming protein 10.122
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.121
TGIF1TGFB-induced factor homeobox 10.120
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.114
RIPK2receptor-interacting serine-threonine kinase 20.113
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 20.109
CCL4chemokine (C-C motif) ligand 40.108
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.098
TNFRSF9tumor necrosis factor receptor superfamily, member 90.094
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.089
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.081
CCL2chemokine (C-C motif) ligand 20.081
AKT1v-akt murine thymoma viral oncogene homolog 10.078
CASP3caspase 3, apoptosis-related cysteine peptidase0.069
CDC37cell division cycle 37 homolog (S. cerevisiae)0.066
TNFAIP6tumor necrosis factor, alpha-induced protein 60.066
RIPK3receptor-interacting serine-threonine kinase 30.065
FASFas (TNF receptor superfamily, member 6)0.063
VDAC1voltage-dependent anion channel 10.061
BANPBTG3 associated nuclear protein0.060
TP53BP2tumor protein p53 binding protein, 20.059
SOCS3suppressor of cytokine signaling 30.058
MDM2Mdm2 p53 binding protein homolog (mouse)0.057
MAP3K2mitogen-activated protein kinase kinase kinase 20.057
FGF2fibroblast growth factor 2 (basic)0.053
PI3peptidase inhibitor 3, skin-derived0.053
RUNX1runt-related transcription factor 10.052
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.052
IFNGinterferon, gamma0.052
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.052
TBX5T-box 50.051
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.051
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.051
GRB7growth factor receptor-bound protein 70.050
PTK6PTK6 protein tyrosine kinase 60.049
ICAM1intercellular adhesion molecule 10.049
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cmybtranscription factor cmyb0.707
mpxmyeloid-specific peroxidase0.580
lhx2bLIM homeobox 2b0.574
bcl2l1bcl2-like 10.362
ptgs2aprostaglandin-endoperoxide synthase 2a0.270
mmp9matrix metalloproteinase 90.265
gpr126G protein-coupled receptor 1260.262
six1bsine oculis homeobox homolog 1b0.256
tcf7transcription factor 7 (T-cell specific, HMG-box)0.210
hmx4H6 family homeobox 40.210
grhl2bgrainyhead-like 2b (Drosophila)0.208
nrg2aneuregulin 2a0.207
notch3notch homolog 30.193
pea3ETS-domain transcription factor pea30.167
dpf2lD4, zinc and double PHD fingers family 2, like0.157
fgf10afibroblast growth factor 10a0.148
dusp1dual specificity phosphatase 10.147
fzd7bfrizzled homolog 7b0.144
eya1eyes absent homolog 10.144
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.141
lef1lymphocyte enhancer binding factor 10.130
wnt3wingless-type MMTV integration site family, member 30.129
acvr2aactivin receptor IIa0.124
pitx3paired-like homeodomain transcription factor 30.115
bidaBH3 interacting domain death agonist0.111
spry1sprouty homolog 1 (Drosophila)0.108
barx1BarH-like homeobox 10.107
alas2aminolevulinate, delta-, synthetase 20.106
sox9aSRY-box containing gene 9a0.105
kbpkif1-binding protein0.099
zgc:101724zgc:1017240.094
mcl1bmyeloid cell leukemia sequence 1b0.093
mapk6mitogen-activated protein kinase 60.092
hbae3hemoglobin alpha embryonic-30.091
tgfb1atransforming growth factor, beta 1a0.086
bbc3BCL2 binding component 30.085
uroduroporphyrinogen decarboxylase0.084
tfr1atransferrin receptor 1a0.084
ck2bcasein kinase 2 beta0.083
socs3asuppressor of cytokine signaling 3a0.083
wnt9bwingless-type MMTV integration site family, member 9B0.080
baxabcl2-associated X protein, a0.079
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.077
kdrlkinase insert domain receptor like0.074
uba1ubiquitin-like modifier activating enzyme 10.074
cpoxcoproporphyrinogen oxidase0.074
zgc:112329zgc:1123290.071
myogmyogenin0.070
igf1insulin-like growth factor 10.070
stc1lstanniocalcin 1, like0.070
mapk4mitogen-activated protein kinase 40.069
fibinfin bud initiation factor0.069
dlx5adistal-less homeobox gene 5a0.067
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.067
mcl1amyeloid cell leukemia sequence 1a0.067
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.064
fgfr3fibroblast growth factor receptor 30.064
bcl2B-cell leukemia/lymphoma 20.064
rag1recombination activating gene 10.063
odc1ornithine decarboxylase 10.063
si:ch211-89f7.4si:ch211-89f7.40.062
zgc:162126zgc:1621260.059
eporerythropoietin receptor0.059
eif4a1beukaryotic translation initiation factor 4A, isoform 1B0.058
prdm5PR domain containing 50.058
cnihcornichon homolog (Drosophila)0.057
bmf1Bcl2 modifying factor 10.056
hspa12bheat shock protein 12B0.055
slc4a1asolute carrier family 4, anion exchanger, member 1a0.055
mapk8bmitogen-activated protein kinase 8b0.055
atp1b3bATPase, Na+/K+ transporting, beta 3b polypeptide0.055
pdlim3bPDZ and LIM domain 3b0.055
fzd7afrizzled homolog 7a0.054
LOC567131calcitonin gene-related peptide type 1 receptor-like0.052
hbaa1hemoglobin alpha adult-10.051
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.051
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.051
tnfatumor necrosis factor a (TNF superfamily, member 2)0.051
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.050
evx1even-skipped homeobox 10.050
hugHuG0.049
cnr1cannabinoid receptor 10.048
calm3bcalmodulin 3b (phosphorylase kinase, delta)0.047
fevFEV (ETS oncogene family)0.046
atf3activating transcription factor 30.046
hbae1hemoglobin alpha embryonic-10.046
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.046
fkbp5FK506 binding protein 50.045
dusp6dual specificity phosphatase 60.044
jag1bjagged 1b0.044
jag2jagged 20.044
lcp1lymphocyte cytosolic plastin 10.044
ikzf1IKAROS family zinc finger 1 (Ikaros)0.044
emx3empty spiracles homeobox 30.041
tnfrsfatumor necrosis factor receptor superfamily, member a0.041
six2asine oculis-related homeobox 2a0.040
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.040
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.040
ptprfprotein tyrosine phosphatase, receptor type, F0.039
gfra1agdnf family receptor alpha 1a0.039
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.984
Tnftumor necrosis factor0.958
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.911
Lyz2lysozyme 20.884
Ikzf1IKAROS family zinc finger 10.789
Ptpn11protein tyrosine phosphatase, non-receptor type 110.785
Col1a1collagen, type I, alpha 10.764
BaxBCL2-associated X protein0.709
Ctnnb1catenin (cadherin associated protein), beta 10.651
Retret proto-oncogene0.651
Bcl2B-cell leukemia/lymphoma 20.598
Col3a1collagen, type III, alpha 10.583
Il2rginterleukin 2 receptor, gamma chain0.559
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.525
Foxp3forkhead box P30.525
Col5a2collagen, type V, alpha 20.447
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.424
Cd44CD44 antigen0.419
Ifnginterferon gamma0.417
Map3k14mitogen-activated protein kinase kinase kinase 140.340
Leprleptin receptor0.334
Fstfollistatin0.331
Gli3GLI-Kruppel family member GLI30.330
Gli2GLI-Kruppel family member GLI20.326
Ptenphosphatase and tensin homolog0.323
Esr1estrogen receptor 1 (alpha)0.299
Itgb1integrin beta 1 (fibronectin receptor beta)0.286
Cd19CD19 antigen0.281
Pax2paired box gene 20.275
Prrx1paired related homeobox 10.270
Snai1snail homolog 1 (Drosophila)0.263
Acanaggrecan0.258
Runx1runt related transcription factor 10.256
Cdkn1bcyclin-dependent kinase inhibitor 1B0.256
Inpp5dinositol polyphosphate-5-phosphatase D0.227
Smad3MAD homolog 3 (Drosophila)0.225
Tnfaip3tumor necrosis factor, alpha-induced protein 30.222
Isl1ISL1 transcription factor, LIM/homeodomain0.220
Cdk4cyclin-dependent kinase 40.217
Ighimmunoglobulin heavy chain complex0.203
Ccr2chemokine (C-C motif) receptor 20.198
Foxc1forkhead box C10.193
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.191
Col1a2collagen, type I, alpha 20.187
Col6a1collagen, type VI, alpha 10.155
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.155
Col6a2collagen, type VI, alpha 20.154
Zeb1zinc finger E-box binding homeobox 10.152
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.151
Shhsonic hedgehog0.147
Cxcr2chemokine (C-X-C motif) receptor 20.145
Socs1suppressor of cytokine signaling 10.144
Ccl2chemokine (C-C motif) ligand 20.143
Pthlhparathyroid hormone-like peptide0.140
Ccl4chemokine (C-C motif) ligand 40.131
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.131
Nognoggin0.130
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.123
Apcadenomatosis polyposis coli0.122
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.118
Fgfr1fibroblast growth factor receptor 10.115
Ltalymphotoxin A0.114
Ror2receptor tyrosine kinase-like orphan receptor 20.113
Hrhairless0.111
Meox2mesenchyme homeobox 20.110
Ltblymphotoxin B0.108
Kitkit oncogene0.107
Col2a1collagen, type II, alpha 10.107
Ptprcprotein tyrosine phosphatase, receptor type, C0.104
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.100
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.092
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.090
Postnperiostin, osteoblast specific factor0.088
Fbn1fibrillin 10.085
Prrx2paired related homeobox 20.084
Rb1retinoblastoma 10.084
Bmpr1abone morphogenetic protein receptor, type 1A0.082
Fgfr2fibroblast growth factor receptor 20.081
Inhbainhibin beta-A0.080
Lepleptin0.080
Bmp4bone morphogenetic protein 40.080
Casp8caspase 80.078
Csf1colony stimulating factor 1 (macrophage)0.076
SharpinSHANK-associated RH domain interacting protein0.075
Gpr132G protein-coupled receptor 1320.074
Thbs1thrombospondin 10.074
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.073
Il18rapinterleukin 18 receptor accessory protein0.071
Selpselectin, platelet0.071
Sox9SRY-box containing gene 90.071
Cd7CD7 antigen0.069
Bmp5bone morphogenetic protein 50.069
Eya1eyes absent 1 homolog (Drosophila)0.069
Capn6calpain 60.069
Hspg2perlecan (heparan sulfate proteoglycan 2)0.069
Chrdchordin0.068
Pax8paired box gene 80.068
Bdnfbrain derived neurotrophic factor0.066
Rararetinoic acid receptor, alpha0.065
Runx2runt related transcription factor 20.064
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.229
Il2rbinterleukin 2 receptor, beta0.191
Sirpasignal-regulatory protein alpha0.178
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.161
Cd37CD37 molecule0.088
Ptafrplatelet-activating factor receptor0.087
Ccdc124coiled-coil domain containing 1240.085
Ralgdsral guanine nucleotide dissociation stimulator0.080
Cd86CD86 molecule0.078
Neurl3neuralized homolog 3 (Drosophila)0.071
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.046
Map2k2mitogen activated protein kinase kinase 20.038
TcrbT-cell receptor beta chain0.036
Ccl4chemokine (C-C motif) ligand 40.033
Akt1v-akt murine thymoma viral oncogene homolog 10.033
Ccl3chemokine (C-C motif) ligand 30.033
Stub1STIP1 homology and U-Box containing protein 10.032
Ptpn6protein tyrosine phosphatase, non-receptor type 60.031
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.029
Hk1hexokinase 10.028
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.027
Epn1Epsin 10.025
Csf1colony stimulating factor 1 (macrophage)0.025
Cd14CD14 molecule0.025
Sdc3syndecan 30.025
Unc5bunc-5 homolog B (C. elegans)0.024
Tubg1tubulin, gamma 10.024
Igsf6immunoglobulin superfamily, member 60.024
Il2rginterleukin 2 receptor, gamma0.024
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.022
Tgfb1transforming growth factor, beta 10.022
Glg1golgi apparatus protein 10.022
Epn2epsin 20.021
Adrbk1adrenergic, beta, receptor kinase 10.021
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.020
Il1ainterleukin 1 alpha0.020
Rgs19regulator of G-protein signaling 190.020
Ptpn7protein tyrosine phosphatase, non-receptor type 70.019
Mmp12matrix metallopeptidase 120.019
Smad7SMAD family member 70.019
C5ar1complement component 5a receptor 10.018
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.018
TyrobpTyro protein tyrosine kinase binding protein0.018
Prkcdprotein kinase C, delta0.017
Gps1G protein pathway suppressor 10.017
RGD1561143similar to cell surface receptor FDFACT0.017
Ubtfupstream binding transcription factor, RNA polymerase I0.016
Cxcl10chemokine (C-X-C motif) ligand 100.016
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.015
Bin2bridging integrator 20.015
Dock8dedicator of cytokinesis 80.015
Inpp5dinositol polyphosphate-5-phosphatase D0.015
Ddr1discoidin domain receptor tyrosine kinase 10.014
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.014
Adora2aadenosine A2a receptor0.014
Dapk3death-associated protein kinase 30.014
Ly86lymphocyte antigen 860.014
Snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.014
Cd3gCD3 molecule, gamma0.014
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.014
Ctbp1C-terminal binding protein 10.014
Prrx1paired related homeobox 10.013
Arl11ADP-ribosylation factor-like 110.013
Ccnd3cyclin D30.013
Prdm2PR domain containing 2, with ZNF domain0.013
Map3k3mitogen activated protein kinase kinase kinase 30.012
Klrd1killer cell lectin-like receptor, subfamily D, member 10.012
S100a8S100 calcium binding protein A80.012
Edn1endothelin 10.012
Socs3suppressor of cytokine signaling 30.012
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.011
Cybbcytochrome b-245, beta polypeptide0.011
Mpripmyosin phosphatase Rho interacting protein0.011
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.011
Casp1caspase 10.011
Cdk4cyclin-dependent kinase 40.011
Bak1BCL2-antagonist/killer 10.011
Cx3cl1chemokine (C-X3-C motif) ligand 10.011
Pcsk4proprotein convertase subtilisin/kexin type 40.010
Pacs1phosphofurin acidic cluster sorting protein 10.010
Bcl2l1Bcl2-like 10.010
Homer2homer homolog 2 (Drosophila)0.010
Ptpreprotein tyrosine phosphatase, receptor type, E0.010
Cd247Cd247 molecule0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism