The network for 'activation induced cell death of t cells' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation induced cell death of t cells

A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
CASP10caspase 10, apoptosis-related cysteine peptidase0.952
FASFas (TNF receptor superfamily, member 6)0.892
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.890
CFLARCASP8 and FADD-like apoptosis regulator0.855
FASLGFas ligand (TNF superfamily, member 6)0.727
PXMP2peroxisomal membrane protein 2, 22kDa0.706
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.675
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.340
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.236
NOXA1NADPH oxidase activator 10.232
NCF1neutrophil cytosolic factor 10.201
PRKCZprotein kinase C, zeta0.165
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.156
NUMBnumb homolog (Drosophila)0.144
FADDFas (TNFRSF6)-associated via death domain0.142
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.133
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.125
RPS4Xribosomal protein S4, X-linked0.105
CDC37cell division cycle 37 homolog (S. cerevisiae)0.085
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.078
RPS3ribosomal protein S30.075
FYNFYN oncogene related to SRC, FGR, YES0.074
TRAF1TNF receptor-associated factor 10.071
RPL5ribosomal protein L50.066
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.065
PICK1protein interacting with PRKCA 10.061
PDPK13-phosphoinositide dependent protein kinase-10.048
ZNF71zinc finger protein 710.046
RPS3Aribosomal protein S3A0.046
LRRK2leucine-rich repeat kinase 20.046
DCTN1dynactin 10.044
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.043
CCDC115coiled-coil domain containing 1150.043
MAPTmicrotubule-associated protein tau0.038
TRIM9tripartite motif containing 90.036
TRADDTNFRSF1A-associated via death domain0.036
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.036
MAP3K5mitogen-activated protein kinase kinase kinase 50.035
BIDBH3 interacting domain death agonist0.032
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.031
CDCP1CUB domain containing protein 10.030
HPCAL4hippocalcin like 40.030
VHLvon Hippel-Lindau tumor suppressor0.028
AKT1v-akt murine thymoma viral oncogene homolog 10.026
MPRIPmyosin phosphatase Rho interacting protein0.025
ALDOAaldolase A, fructose-bisphosphate0.024
MTORmechanistic target of rapamycin (serine/threonine kinase)0.024
RPS8ribosomal protein S80.023
SH3RF1SH3 domain containing ring finger 10.023
PRKCBprotein kinase C, beta0.022
RPL4ribosomal protein L40.019
TSC22D1TSC22 domain family, member 10.019
RARAretinoic acid receptor, alpha0.018
RPS16ribosomal protein S160.018
CASP3caspase 3, apoptosis-related cysteine peptidase0.018
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.018
VIMvimentin0.017
RPL6ribosomal protein L60.017
STK4serine/threonine kinase 40.016
CYBAcytochrome b-245, alpha polypeptide0.015
RPS24ribosomal protein S240.015
CCHCR1coiled-coil alpha-helical rod protein 10.015
RPL7ribosomal protein L70.015
TPM3tropomyosin 30.015
RPL14ribosomal protein L140.015
MDM2Mdm2 p53 binding protein homolog (mouse)0.015
PEBP4phosphatidylethanolamine-binding protein 40.014
PTK2BPTK2B protein tyrosine kinase 2 beta0.013
RPTORregulatory associated protein of MTOR, complex 10.013
FAM129Afamily with sequence similarity 129, member A0.012
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.012
NFATC2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.012
PPP2R4protein phosphatase 2A activator, regulatory subunit 40.011
ILKintegrin-linked kinase0.011
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.011
BADBCL2-associated agonist of cell death0.011
NMT2N-myristoyltransferase 20.011
AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.011
MYO1Dmyosin ID0.011
FABP4fatty acid binding protein 4, adipocyte0.011
RPL17ribosomal protein L170.011
WWC1WW and C2 domain containing 10.010
BIRC3baculoviral IAP repeat containing 30.010
LLGL1lethal giant larvae homolog 1 (Drosophila)0.010
SAMD4Bsterile alpha motif domain containing 4B0.010
CASP9caspase 9, apoptosis-related cysteine peptidase0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
FasFas (TNF receptor superfamily member 6)0.875
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.864
Casp8caspase 80.863
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.857
Tnftumor necrosis factor0.643
Cd19CD19 antigen0.551
Foxp3forkhead box P30.437
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.408
Stat3signal transducer and activator of transcription 30.401
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.371
Fstfollistatin0.328
Tnfaip3tumor necrosis factor, alpha-induced protein 30.308
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.217
Il10interleukin 100.205
Pdcd1programmed cell death 10.194
Map3k7mitogen-activated protein kinase kinase kinase 70.169
FaddFas (TNFRSF6)-associated via death domain0.162
Ifnginterferon gamma0.162
Myd88myeloid differentiation primary response gene 880.156
Tgfbr2transforming growth factor, beta receptor II0.149
Rag1recombination activating gene 10.140
Bmp4bone morphogenetic protein 40.119
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.117
Traf6TNF receptor-associated factor 60.108
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.094
Ikbkginhibitor of kappaB kinase gamma0.091
Plin1perilipin 10.086
Foxc1forkhead box C10.076
Mapkap1mitogen-activated protein kinase associated protein 10.074
Rararetinoic acid receptor, alpha0.061
Rxraretinoid X receptor alpha0.056
Csf1colony stimulating factor 1 (macrophage)0.055
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.054
Ern1endoplasmic reticulum (ER) to nucleus signalling 10.052
Rpgrip1lRpgrip1-like0.052
Hspa9heat shock protein 90.050
Ltbrlymphotoxin B receptor0.046
Ighimmunoglobulin heavy chain complex0.045
Map3k8mitogen-activated protein kinase kinase kinase 80.045
Map3k14mitogen-activated protein kinase kinase kinase 140.037
Jag1jagged 10.037
Prf1perforin 1 (pore forming protein)0.036
Vegfavascular endothelial growth factor A0.036
Mtormechanistic target of rapamycin (serine/threonine kinase)0.034
Zeb1zinc finger E-box binding homeobox 10.032
Il2interleukin 20.032
Relreticuloendotheliosis oncogene0.032
Traf2TNF receptor-associated factor 20.030
Nos3nitric oxide synthase 3, endothelial cell0.030
Trp53transformation related protein 530.029
Batfbasic leucine zipper transcription factor, ATF-like0.029
Rargretinoic acid receptor, gamma0.028
Ripk3receptor-interacting serine-threonine kinase 30.028
Il6stinterleukin 6 signal transducer0.026
Rspo2R-spondin 2 homolog (Xenopus laevis)0.025
Stx11syntaxin 110.021
Cdk4cyclin-dependent kinase 40.021
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.021
Pitx2paired-like homeodomain transcription factor 20.021
Il6interleukin 60.021
Il2rginterleukin 2 receptor, gamma chain0.020
Akt2thymoma viral proto-oncogene 20.020
Icosinducible T-cell co-stimulator0.019
Ece1endothelin converting enzyme 10.019
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.018
Gli3GLI-Kruppel family member GLI30.018
Ccl2chemokine (C-C motif) ligand 20.017
Leprleptin receptor0.017
Pax3paired box gene 30.017
Trim55tripartite motif-containing 550.017
Rarbretinoic acid receptor, beta0.016
Rag2recombination activating gene 20.016
Traf3ip2TRAF3 interacting protein 20.016
2700094K13RikRIKEN cDNA 2700094K13 gene0.015
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.014
Ikbkbinhibitor of kappaB kinase beta0.014
B9d2B9 protein domain 20.014
Ednraendothelin receptor type A0.014
Apoeapolipoprotein E0.014
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.014
Wfikkn1WAP, FS, Ig, KU, and NTR-containing protein 10.014
Smosmoothened homolog (Drosophila)0.014
Nlrp3NLR family, pyrin domain containing 30.014
Ctla4cytotoxic T-lymphocyte-associated protein 40.013
Shc1src homology 2 domain-containing transforming protein C10.013
Il1r1interleukin 1 receptor, type I0.013
Mapkapk2MAP kinase-activated protein kinase 20.013
Plekho2pleckstrin homology domain containing, family O member 20.013
Dmddystrophin, muscular dystrophy0.013
Pax7paired box gene 70.013
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.013
Col1a1collagen, type I, alpha 10.013
Mlklmixed lineage kinase domain-like0.012
Mmp9matrix metallopeptidase 90.012
Pax2paired box gene 20.012
Socs1suppressor of cytokine signaling 10.011
Nfe2l2nuclear factor, erythroid derived 2, like 20.011
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.011
Selpselectin, platelet0.011
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism