The network for 'oxidative stress induced premature senescence' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

oxidative stress induced premature senescence

A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.

NameDescriptionProbabilityFunc Analog Organism
WWOXWW domain containing oxidoreductase0.989
MDM2Mdm2 p53 binding protein homolog (mouse)0.982
KRT5keratin 50.979
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.971
CLOCKclock homolog (mouse)0.969
S1PR5sphingosine-1-phosphate receptor 50.857
CBLCCas-Br-M (murine) ecotropic retroviral transforming sequence c0.815
YAP1Yes-associated protein 10.711
FGF18fibroblast growth factor 180.645
SATB2SATB homeobox 20.645
KRT6Ckeratin 6C0.499
SGK3serum/glucocorticoid regulated kinase family, member 30.416
SNX9sorting nexin 90.402
WNT1wingless-type MMTV integration site family, member 10.381
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.379
TP73tumor protein p730.295
AHRaryl hydrocarbon receptor0.245
DTX1deltex homolog 1 (Drosophila)0.225
AMOTL1angiomotin like 10.199
WIF1WNT inhibitory factor 10.198
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.188
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.187
LBX1ladybird homeobox 10.177
SFRP1secreted frizzled-related protein 10.164
WNT10Awingless-type MMTV integration site family, member 10A0.149
FGF3fibroblast growth factor 30.142
SOX1SRY (sex determining region Y)-box 10.132
FGF4fibroblast growth factor 40.120
MMP11matrix metallopeptidase 11 (stromelysin 3)0.119
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.114
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.111
CRLF1cytokine receptor-like factor 10.095
NEDD9neural precursor cell expressed, developmentally down-regulated 90.094
KRT14keratin 140.093
DLX4distal-less homeobox 40.093
CABLES1Cdk5 and Abl enzyme substrate 10.092
HES2hairy and enhancer of split 2 (Drosophila)0.084
WNT3wingless-type MMTV integration site family, member 30.082
IHHIndian hedgehog0.079
FGF8fibroblast growth factor 8 (androgen-induced)0.079
MDM4Mdm4 p53 binding protein homolog (mouse)0.075
NPAS2neuronal PAS domain protein 20.072
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.061
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.057
FOXF2forkhead box F20.056
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.055
WNT4wingless-type MMTV integration site family, member 40.055
WNT7Awingless-type MMTV integration site family, member 7A0.054
AQP5aquaporin 50.054
FOXL1forkhead box L10.054
NPAS1neuronal PAS domain protein 10.053
HMX1H6 family homeobox 10.052
BHLHE23basic helix-loop-helix family, member e230.052
FOXD3forkhead box D30.050
FOXE1forkhead box E1 (thyroid transcription factor 2)0.049
LMX1ALIM homeobox transcription factor 1, alpha0.049
WNT10Bwingless-type MMTV integration site family, member 10B0.049
NKD2naked cuticle homolog 2 (Drosophila)0.048
SPG20spastic paraplegia 20 (Troyer syndrome)0.048
SNX18sorting nexin 180.047
IRX4iroquois homeobox 40.045
SOX21SRY (sex determining region Y)-box 210.045
GGNgametogenetin0.045
TLX3T-cell leukemia homeobox 30.045
ALOX12arachidonate 12-lipoxygenase0.044
SLC18A3solute carrier family 18 (vesicular acetylcholine), member 30.043
PTPN14protein tyrosine phosphatase, non-receptor type 140.043
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.042
SIX2SIX homeobox 20.042
BNC1basonuclin 10.042
H2AFXH2A histone family, member X0.041
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.041
DUOX1dual oxidase 10.041
HIPK2homeodomain interacting protein kinase 20.039
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.039
SHHsonic hedgehog0.039
POU3F1POU class 3 homeobox 10.039
HOXC12homeobox C120.038
ENTPD2ectonucleoside triphosphate diphosphohydrolase 20.037
BMP1bone morphogenetic protein 10.037
HOXD13homeobox D130.037
RAXretina and anterior neural fold homeobox0.036
HOXC8homeobox C80.036
IGF2BP1insulin-like growth factor 2 mRNA binding protein 10.036
FOXB1forkhead box B10.035
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.035
OCA2oculocutaneous albinism II0.035
C1QL1complement component 1, q subcomponent-like 10.035
IGSF21immunoglobin superfamily, member 210.035
SCARF2scavenger receptor class F, member 20.034
ABI2abl-interactor 20.034
LYPD3LY6/PLAUR domain containing 30.034
KCNK9potassium channel, subfamily K, member 90.033
EPAS1endothelial PAS domain protein 10.032
FZD10frizzled homolog 10 (Drosophila)0.032
MS4A4Amembrane-spanning 4-domains, subfamily A, member 40.032
FIBCD1fibrinogen C domain containing 10.032
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 10.031
WNT5Bwingless-type MMTV integration site family, member 5B0.031
SFRP5secreted frizzled-related protein 50.031
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.142
Cry1cryptochrome 1 (photolyase-like)0.118
Clockcircadian locomotor output cycles kaput0.096
Per2period homolog 2 (Drosophila)0.066
Cry2cryptochrome 2 (photolyase-like)0.042
Npas2neuronal PAS domain protein 20.012
Trp63transformation related protein 630.011
Ahraryl-hydrocarbon receptor0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism