The network for 'cardiac conduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac conduction

Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.

NameDescriptionProbabilityFunc Analog Organism
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.999
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.990
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.928
DSC2desmocollin 20.925
MPZL2myelin protein zero-like 20.922
DLG4discs, large homolog 4 (Drosophila)0.911
JUPjunction plakoglobin0.862
KCNE1potassium voltage-gated channel, Isk-related family, member 10.814
LIN7Blin-7 homolog B (C. elegans)0.779
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.776
ACTN2actinin, alpha 20.753
MPZL3myelin protein zero-like 30.731
KRT14keratin 140.693
CTNND1catenin (cadherin-associated protein), delta 10.653
CABP1calcium binding protein 10.591
DSG2desmoglein 20.537
TJP1tight junction protein 1 (zona occludens 1)0.467
ERBB2IPerbb2 interacting protein0.467
PKP3plakophilin 30.459
SMAD2SMAD family member 20.409
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.408
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.337
ZFYVE9zinc finger, FYVE domain containing 90.291
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.247
SNTG2syntrophin, gamma 20.223
PTPRNprotein tyrosine phosphatase, receptor type, N0.213
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.210
PSEN1presenilin 10.206
APCadenomatous polyposis coli0.201
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.162
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.150
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.137
PTPRJprotein tyrosine phosphatase, receptor type, J0.124
KRT8keratin 80.121
PKP2plakophilin 20.101
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.099
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.096
CALM1calmodulin 1 (phosphorylase kinase, delta)0.090
HDAC4histone deacetylase 40.088
CTNNBIP1catenin, beta interacting protein 10.074
CDH3cadherin 3, type 1, P-cadherin (placental)0.072
LAD1ladinin 10.067
SMAD4SMAD family member 40.066
TRIM29tripartite motif containing 290.065
SPTBspectrin, beta, erythrocytic0.064
MARK3MAP/microtubule affinity-regulating kinase 30.061
KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 10.060
EGFRepidermal growth factor receptor0.054
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.053
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.052
DLGAP1discs, large (Drosophila) homolog-associated protein 10.052
FRMD5FERM domain containing 50.048
GLE1GLE1 RNA export mediator homolog (yeast)0.045
CAPN2calpain 2, (m/II) large subunit0.042
SIN3ASIN3 homolog A, transcription regulator (yeast)0.040
MYOZ1myozenin 10.039
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 10.039
DNAJB5DnaJ (Hsp40) homolog, subfamily B, member 50.038
DISC1disrupted in schizophrenia 10.037
SKILSKI-like oncogene0.036
GJB3gap junction protein, beta 3, 31kDa0.034
DSG1desmoglein 10.034
DSG3desmoglein 30.033
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.032
KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 30.032
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.031
KRT5keratin 50.031
SEZ6Lseizure related 6 homolog (mouse)-like0.030
ACTL6Bactin-like 6B0.030
GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.030
DPP6dipeptidyl-peptidase 60.028
DLGAP2discs, large (Drosophila) homolog-associated protein 20.028
KCNB2potassium voltage-gated channel, Shab-related subfamily, member 20.028
AKAP6A kinase (PRKA) anchor protein 60.028
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.027
SYN2synapsin II0.027
ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome0.026
BTRCbeta-transducin repeat containing0.026
SMAD3SMAD family member 30.026
NTRK3neurotrophic tyrosine kinase, receptor, type 30.025
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.025
NFIXnuclear factor I/X (CCAAT-binding transcription factor)0.025
DSC3desmocollin 30.024
SPTA1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.024
CCKBRcholecystokinin B receptor0.024
DSC1desmocollin 10.024
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 50.024
KCNG3potassium voltage-gated channel, subfamily G, member 30.024
ST8SIA5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 50.024
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.023
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.023
NLGN1neuroligin 10.023
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.022
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)0.022
TGFBR1transforming growth factor, beta receptor 10.022
CAV1caveolin 1, caveolae protein, 22kDa0.022
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.021
CDH15cadherin 15, type 1, M-cadherin (myotubule)0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dsc2ldesmocollin 2 like0.470
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.380
anxa11bannexin A11b0.362
scn4absodium channel, voltage-gated, type IV, alpha, b0.348
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.159
perpPERP, TP53 apoptosis effector0.136
krt8keratin 80.131
scn12aasodium channel, voltage gated, type XII, alpha a0.125
sdprbserum deprivation response b0.123
tcf21transcription factor 210.110
scn1basodium channel, voltage-gated, type I, beta a0.106
scn4basodium channel, voltage-gated, type IV, beta a0.103
scn12absodium channel, voltage gated, type XII, alpha b0.103
jupjunction plakoglobin0.098
lrrc10leucine rich repeat containing 100.092
dspadesmoplakin a0.080
bcdo2lbeta-carotene 15, 15-dioxygenase 2, like0.067
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.066
lmo7aLIM domain only 7a0.063
scn2bsodium channel, voltage-gated, type II, beta0.063
serinc2serine incorporator 20.059
cx45.6connexin 45.60.058
ahnakAHNAK nucleoprotein0.055
rassf7bRas association (RalGDS/AF-6) domain family (N-terminal) member 7b0.052
il6rinterleukin 6 receptor0.052
mylk3myosin light chain kinase 30.051
myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.048
nppanatriuretic peptide precursor A0.046
eya4eyes absent homolog 4 (Drosophila)0.046
synpo2lbsynaptopodin 2-like b0.044
stxbp2syntaxin binding protein 20.042
dccdeleted in colorectal carcinoma0.041
fgfr3fibroblast growth factor receptor 30.040
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.039
rbm24bRNA binding motif protein 24b0.038
cd99l2CD99 antigen-like 20.038
ef1ETS-related factor10.038
zfp36l1bzinc finger protein 36, C3H type-like 1b0.037
atp2b4ATPase, Ca++ transporting, plasma membrane 40.036
rnasel1ribonuclease like 10.036
csrp3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.036
emilin1aelastin microfibril interfacer 1a0.035
pkp3plakophilin 30.035
dsg2desmoglein 20.035
tnni1btroponin I, skeletal, slow b0.032
slc38a3solute carrier family 38, member 30.031
gipc2GIPC PDZ domain containing family, member 20.030
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.030
hspb12heat shock protein, alpha-crystallin-related, b120.030
llgl2lethal giant larvae homolog 2 (Drosophila)0.030
col2a1acollagen type II, alpha-1a0.029
mgllmonoglyceride lipase0.029
ptprfbprotein tyrosine phosphatase, receptor type, f, b0.028
tiparpTCDD-inducible poly(ADP-ribose) polymerase0.028
tcf12transcription factor 120.027
gpiaglucose phosphate isomerase a0.027
spry4sprouty (Drosophila) homolog 40.026
scn3bsodium channel, voltage-gated, type III, beta0.026
il6stinterleukin 6 signal transducer0.025
ivns1abpainfluenza virus NS1A binding protein a0.025
gsnagelsolin a0.024
cyfip2cytoplasmic FMR1 interacting protein 20.024
popdc2popeye domain containing 20.023
slc20a1bsolute carrier family 20, member 1b0.023
cd9bCD9 antigen, b0.023
ogg18-oxoguanine DNA glycosylase0.022
scn1bbsodium channel, voltage-gated, type I, beta b0.021
copebcore promoter element binding protein0.021
yap1Yes-associated protein 10.021
evlaEnah/Vasp-like a0.021
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.020
spint1aserine peptidase inhibitor, Kunitz type 1 a0.020
frybfurry homolog b (Drosophila)0.020
igf2bp3insulin-like growth factor 2 mRNA binding protein 30.020
pdcd6programmed cell death 60.019
grb10agrowth factor receptor-bound protein 10a0.019
ftr82finTRIM family, member 820.019
bmp10bone morphogenetic protein 100.019
dpf3D4, zinc and double PHD fingers, family 30.018
kirrelakin of IRRE like a0.018
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.018
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.018
slit2slit (Drosophila) homolog 20.018
rnf128aring finger protein 128a0.018
ripk4receptor-interacting serine-threonine kinase 40.018
abca12ATP-binding cassette, sub-family A (ABC1), member 120.018
tnnc1atroponin C type 1a (slow)0.018
nfe2l2nuclear factor (erythroid-derived 2)-like 20.017
btg1B-cell translocation gene 10.017
slc16a1solute carrier family 16 (monocarboxylic acid transporters), member 10.017
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Scn5asodium channel, voltage-gated, type V, alpha0.997
Ryr2ryanodine receptor 2, cardiac0.997
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.994
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.929
Tbx5T-box 50.915
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.706
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.634
Tbx3T-box 30.601
Gja1gap junction protein, alpha 10.349
Tjp1tight junction protein 10.296
Hdac4histone deacetylase 40.255
Dsg2desmoglein 20.185
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.173
Cxadrcoxsackie virus and adenovirus receptor0.162
Spna1spectrin alpha 10.140
Hrchistidine rich calcium binding protein0.135
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.113
Mybpc3myosin binding protein C, cardiac0.110
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.104
Slc26a4solute carrier family 26, member 40.096
Hdac5histone deacetylase 50.090
Add2adducin 2 (beta)0.088
Scn1asodium channel, voltage-gated, type I, alpha0.088
Casq2calsequestrin 20.082
Rnf112ring finger protein 1120.075
Srpk3serine/arginine-rich protein specific kinase 30.074
Xirp1xin actin-binding repeat containing 10.072
Gata4GATA binding protein 40.069
Hbb-b1hemoglobin, beta adult major chain0.068
Mpzmyelin protein zero0.061
Kcnk3potassium channel, subfamily K, member 30.057
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.056
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.054
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.051
Mef2cmyocyte enhancer factor 2C0.051
Gata6GATA binding protein 60.048
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.047
Hand2heart and neural crest derivatives expressed transcript 20.047
Tnni2troponin I, skeletal, fast 20.046
Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.046
Macf1microtubule-actin crosslinking factor 10.046
Srrm4serine/arginine repetitive matrix 40.045
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.042
Il16interleukin 160.040
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.039
Zfpm2zinc finger protein, multitype 20.038
Aplnrapelin receptor0.037
Gjd3gap junction protein, delta 30.036
Hdac7histone deacetylase 70.035
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.035
KelKell blood group0.034
Kcna6potassium voltage-gated channel, shaker-related, subfamily, member 60.034
SpegSPEG complex locus0.034
Shesrc homology 2 domain-containing transforming protein E0.034
Kcnd2potassium voltage-gated channel, Shal-related family, member 20.033
Jupjunction plakoglobin0.033
Rgs5regulator of G-protein signaling 50.033
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.032
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.032
Spna2spectrin alpha 20.032
Gja5gap junction protein, alpha 50.031
Fjx1four jointed box 1 (Drosophila)0.031
Tcf15transcription factor 150.031
Nos3nitric oxide synthase 3, endothelial cell0.030
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.030
Sstr3somatostatin receptor 30.030
Gad2glutamic acid decarboxylase 20.029
Gjb2gap junction protein, beta 20.029
Eporerythropoietin receptor0.028
Slc17a8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 80.028
Klf7Kruppel-like factor 7 (ubiquitous)0.028
Lnx1ligand of numb-protein X 10.027
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.026
Astn1astrotactin 10.026
Zmynd11zinc finger, MYND domain containing 110.026
Myl3myosin, light polypeptide 30.025
Abcc9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.025
Tbx20T-box 200.025
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.024
Dsc2desmocollin 20.024
Klk6kallikrein related-peptidase 60.024
Ncor2nuclear receptor co-repressor 20.024
Kitlkit ligand0.024
Hdac9histone deacetylase 90.023
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.023
Cdh23cadherin 23 (otocadherin)0.023
Cntn4contactin 40.023
Gjb6gap junction protein, beta 60.023
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.023
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.023
Nefmneurofilament, medium polypeptide0.023
Frmd5FERM domain containing 50.022
Myom2myomesin 20.022
Pcdh12protocadherin 120.022
Gjb4gap junction protein, beta 40.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Chrm2cholinergic receptor, muscarinic 20.241
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.201
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.198
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.145
Pla2g5phospholipase A2, group V0.120
Neu3sialidase 3 (membrane sialidase)0.107
Itpr1inositol 1,4,5-triphosphate receptor, type 10.104
Casq2calsequestrin 2 (cardiac muscle)0.100
Fgf14fibroblast growth factor 140.099
Kykyphoscoliosis peptidase0.097
Fgf16fibroblast growth factor 160.085
Coro2bcoronin, actin binding protein, 2B0.084
Gzmkgranzyme K0.078
Prkcaprotein kinase C, alpha0.078
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.073
Dccdeleted in colorectal carcinoma0.070
Rxrgretinoid X receptor gamma0.069
Dsg2desmoglein 20.066
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.066
Brunol4bruno-like 4, RNA binding protein (Drosophila)0.063
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.061
Ppardperoxisome proliferator-activated receptor delta0.061
Efnb1ephrin B10.061
Phka1phosphorylase kinase, alpha 10.058
Lrrc4bleucine rich repeat containing 4B0.057
Rimbp2RIMS binding protein 20.055
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.052
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.052
Wipf3WAS/WASL interacting protein family, member 30.051
RGD1310269hypothetical LOC3144720.051
Accn2amiloride-sensitive cation channel 2, neuronal0.050
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.049
Kcna6potassium voltage gated channel, shaker related subfamily, member 60.049
Arnt2aryl hydrocarbon receptor nuclear translocator 20.048
Rps6ka2ribosomal protein S6 kinase polypeptide 20.048
Sdc3syndecan 30.047
RhagRh-associated glycoprotein0.047
Scn5asodium channel, voltage-gated, type V, alpha subunit0.046
Kcnk3potassium channel, subfamily K, member 30.045
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.044
Robo1roundabout homolog 1 (Drosophila)0.043
Krt31keratin 310.042
Fat1FAT tumor suppressor homolog 1 (Drosophila)0.041
Ank2ankyrin 2, neuronal0.040
Myt1lmyelin transcription factor 1-like0.040
Sh3bgrSH3 domain binding glutamic acid-rich protein0.040
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.040
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.039
Notch3Notch homolog 3 (Drosophila)0.039
Col9a1collagen, type IX, alpha 10.039
Vamp1vesicle-associated membrane protein 10.038
Sctrsecretin receptor0.037
Tcerg1ltranscription elongation regulator 1-like0.037
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.036
Dlc1deleted in liver cancer 10.036
Clca4chloride channel accessory 40.036
Atxn1ataxin 10.036
Ptgfrprostaglandin F receptor0.036
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.035
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.035
CrpC-reactive protein, pentraxin-related0.035
Adamtsl4ADAMTS-like 40.035
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.035
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.034
Pde10aphosphodiesterase 10A0.034
Aif1lallograft inflammatory factor 1-like0.034
BokBCL2-related ovarian killer0.033
Tmem82transmembrane protein 820.032
Anxa11annexin A110.032
Crct1cysteine-rich C-terminal 10.032
Bcl2l10BCL2-like 10 (apoptosis facilitator)0.032
Nkx2-1NK2 homeobox 10.031
Hspb7heat shock protein family, member 7 (cardiovascular)0.031
Lrch4leucine-rich repeats and calponin homology (CH) domain containing 40.030
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.030
Myoz1myozenin 10.030
Kif6kinesin family member 60.030
Mfhas1malignant fibrous histiocytoma amplified sequence 10.029
Cryba1crystallin, beta A10.029
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.029
Pcdh1protocadherin 10.029
Baiap2l1BAI1-associated protein 2-like 10.029
Sptbn1spectrin, beta, non-erythrocytic 10.029
Slc12a7solute carrier family 12 (potassium/chloride transporters), member 70.028
Lrrc14bleucine rich repeat containing 14B0.028
Astn1astrotactin 10.028
RalylRALY RNA binding protein-like0.028
Rgs7regulator of G-protein signaling 70.028
Gata2GATA binding protein 20.028
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.027
Sftpdsurfactant protein D0.027
Mef2dmyocyte enhancer factor 2D0.027
Prkceprotein kinase C, epsilon0.027
Ckmcreatine kinase, muscle0.027
Abcd2ATP-binding cassette, subfamily D (ALD), member 20.027
Scn3asodium channel, voltage-gated, type III, alpha0.027
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism