The network for 'photoreceptor cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

photoreceptor cell differentiation

The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.

NameDescriptionProbabilityFunc Analog Organism
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.997
MAP2K1mitogen-activated protein kinase kinase 10.986
EGFRepidermal growth factor receptor0.982
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.979
MAPK1mitogen-activated protein kinase 10.967
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.962
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.936
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.935
PTPN11protein tyrosine phosphatase, non-receptor type 110.915
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.909
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.866
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.851
GBP3guanylate binding protein 30.818
PTPRJprotein tyrosine phosphatase, receptor type, J0.805
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.784
NCOR1nuclear receptor corepressor 10.766
PDE4DIPphosphodiesterase 4D interacting protein0.766
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.748
CAV1caveolin 1, caveolae protein, 22kDa0.718
IGF1Rinsulin-like growth factor 1 receptor0.690
APCadenomatous polyposis coli0.681
C2orf65chromosome 2 open reading frame 650.672
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.639
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.632
HDAC3histone deacetylase 30.560
BBS9Bardet-Biedl syndrome 90.532
UNC119unc-119 homolog (C. elegans)0.528
DYNLT3dynein, light chain, Tctex-type 30.521
BBS2Bardet-Biedl syndrome 20.517
IRS1insulin receptor substrate 10.517
GSK3Bglycogen synthase kinase 3 beta0.515
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.492
MED10mediator complex subunit 100.478
MED20mediator complex subunit 200.468
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.467
HDAC4histone deacetylase 40.444
ZNF746zinc finger protein 7460.439
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.420
NRP1neuropilin 10.405
NOTCH3notch 30.403
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.395
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.391
SOS1son of sevenless homolog 1 (Drosophila)0.382
PRKCEprotein kinase C, epsilon0.373
GAB2GRB2-associated binding protein 20.371
PDE6Dphosphodiesterase 6D, cGMP-specific, rod, delta0.329
CDH5cadherin 5, type 2 (vascular endothelium)0.298
SHC1SHC (Src homology 2 domain containing) transforming protein 10.295
MED29mediator complex subunit 290.295
BBS1Bardet-Biedl syndrome 10.289
DUSP3dual specificity phosphatase 30.288
SIN3ASIN3 homolog A, transcription regulator (yeast)0.288
JAM2junctional adhesion molecule 20.283
MDFIMyoD family inhibitor0.281
GRB2growth factor receptor-bound protein 20.279
PTPN6protein tyrosine phosphatase, non-receptor type 60.270
PGFplacental growth factor0.261
MAML1mastermind-like 1 (Drosophila)0.248
CADM4cell adhesion molecule 40.245
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.240
CSNK2A1casein kinase 2, alpha 1 polypeptide0.236
ATXN1ataxin 10.235
GAB1GRB2-associated binding protein 10.230
RAP1GAPRAP1 GTPase activating protein0.225
CTNNBIP1catenin, beta interacting protein 10.225
TFRCtransferrin receptor (p90, CD71)0.224
PRKCAprotein kinase C, alpha0.223
TSC2tuberous sclerosis 20.217
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.216
BRAFv-raf murine sarcoma viral oncogene homolog B10.216
LMO4LIM domain only 40.215
PCM1pericentriolar material 10.214
CAV2caveolin 20.214
GADD45Ggrowth arrest and DNA-damage-inducible, gamma0.211
MPP1membrane protein, palmitoylated 1, 55kDa0.202
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.201
ZNF512Bzinc finger protein 512B0.198
INSRinsulin receptor0.197
MAPK3mitogen-activated protein kinase 30.197
RASSF1Ras association (RalGDS/AF-6) domain family member 10.194
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.192
NKX2-1NK2 homeobox 10.182
MED12mediator complex subunit 120.182
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.175
JAG1jagged 10.175
BBS4Bardet-Biedl syndrome 40.175
MAPK14mitogen-activated protein kinase 140.174
TCF4transcription factor 40.173
MCCmutated in colorectal cancers0.169
DUSP1dual specificity phosphatase 10.167
PIAS1protein inhibitor of activated STAT, 10.166
ID4inhibitor of DNA binding 4, dominant negative helix-loop-helix protein0.161
WEE1WEE1 homolog (S. pombe)0.161
NTF4neurotrophin 40.159
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.156
ZFYVE9zinc finger, FYVE domain containing 90.155
TAL1T-cell acute lymphocytic leukemia 10.154
MED16mediator complex subunit 160.150
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
neurodneurogenic differentiation0.997
kif17kinesin family member 170.996
cdh2cadherin 2, neuronal0.996
shhasonic hedgehog a0.993
foxi1forkhead box I10.992
tfap2atranscription factor AP-2 alpha0.988
ift88intraflagellar transport 88 homolog0.988
otx2orthodenticle homolog 20.986
jag2jagged 20.984
pax2apaired box gene 2a0.981
bmp4bone morphogenetic protein 40.979
nr2e3nuclear receptor subfamily 2, group E, member 30.975
bmp2bbone morphogenetic protein 2b0.967
sox2SRY-box containing gene 20.967
flhfloating head0.962
ptf1apancreas specific transcription factor, 1a0.939
ahi1Abelson helper integration site 10.932
neurog1neurogenin 10.884
crxcone-rod homeobox0.884
hnf1baHNF1 homeobox Ba0.872
epb41l5erythrocyte membrane protein band 4.1 like 50.847
crb2acrumbs homolog 2a0.834
pax6bpaired box gene 6b0.830
foxa2forkhead box A20.828
rx2retinal homeobox gene 20.822
six3asine oculis homeobox homolog 3a0.810
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.809
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.800
otx1borthodenticle homolog 1b0.785
cdoncell adhesion molecule-related/down-regulated by oncogenes0.780
lrrc6leucine rich repeat containing 60.752
irx7iroquois homeobox protein 70.748
sox9aSRY-box containing gene 9a0.656
gbx2gastrulation brain homeo box 20.648
tbx2bT-box 2b0.637
fezf2FEZ family zinc finger 20.630
cdh1cadherin 1, epithelial0.623
aldh1a2aldehyde dehydrogenase 1 family, member A20.601
pdzd7aPDZ domain containing 7a0.586
cc2d2acoiled-coil and C2 domain containing 2A0.582
gucy2fguanylate cyclase 2F, retinal0.557
guca1cguanylate cyclase activator 1C0.554
her1hairy-related 10.550
rorcbRAR-related orphan receptor C b0.524
clrn1clarin 10.507
dlx3bdistal-less homeobox gene 3b0.497
irx4biroquois homeobox protein 4b0.496
ctbp2C-terminal binding protein 20.471
hey1hairy/enhancer-of-split related with YRPW motif 10.457
nr2e1nuclear receptor subfamily 2, group E, member 10.444
rx1retinal homeobox gene 10.441
lmx1b.1LIM homeobox transcription factor 1, beta 10.435
ahctf1AT hook containing transcription factor 10.419
otx5orthodenticle homolog 50.401
jag1bjagged 1b0.399
tp53tumor protein p530.394
ift172intraflagellar transport 1720.382
tbx5aT-box 5a0.378
dctn1adynactin 1a0.365
wt1bwilms tumor 1b0.358
irx1biroquois homeobox protein 1, b0.357
dnmt8DNA (cytosine-5-)-methyltransferase 80.352
gli1GLI-Kruppel family member 10.337
neo1neogenin 10.331
sox4aSRY-box containing gene 4a0.329
pcdh17protocadherin 170.329
olfm1bolfactomedin 1b0.319
bmperBMP binding endothelial regulator0.311
wtipWilms tumor 1 interacting protein0.309
stilTAL1 (SCL) interrupting locus0.304
pcdh8protocadherin 80.302
fgf8afibroblast growth factor 8 a0.287
raraaretinoic acid receptor, alpha a0.287
foxa3forkhead box A30.285
six3bsine oculis homeobox homolog 3b0.284
cadm3cell adhesion molecule 30.276
her6hairy-related 60.268
notch1anotch homolog 1a0.267
vsx2visual system homeobox 20.265
gc3guanylyl cyclase 30.265
emx3empty spiracles homeobox 30.262
ocrloculocerebrorenal syndrome of Lowe0.261
foxd5forkhead box D50.258
prox1prospero-related homeobox gene 10.257
gpr98G protein-coupled receptor 980.252
olig2oligodendrocyte lineage transcription factor 20.249
foxp2forkhead box P20.247
msgn1mesogenin 10.244
sall1asal-like 1a (Drosophila)0.243
otpborthopedia homolog b0.239
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.238
atoh7atonal homolog 70.237
sncbsynuclein, beta0.236
nkx2.1aNK2 homeobox 1a0.235
notch2notch homolog 20.225
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
S6kIIRPS6-protein kinase-II0.997
hydhyperplastic discs0.990
Rac1CG2248 gene product from transcript CG2248-RA0.984
HLHm7E(spl) region transcript m70.979
phlpole hole0.976
ebiCG4063 gene product from transcript CG4063-RA0.974
Fas2Fasciclin 20.970
InRInsulin-like receptor0.949
argosCG4531 gene product from transcript CG4531-RA0.940
E(spl)Enhancer of split0.932
rdgAretinal degeneration A0.927
Gap1GTPase-activating protein 10.891
RalaRas-related protein0.881
Rme-8Receptor mediated endocytosis 80.874
Akt1CG4006 gene product from transcript CG4006-RA0.865
amosabsent MD neurons and olfactory sensilla0.857
JraJun-related antigen0.847
Dsor1Downstream of raf10.845
Pp2B-14DProtein phosphatase 2B at 14D0.842
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.839
Taf6TBP-associated factor 60.837
VangVan Gogh0.829
cdicenter divider0.825
trioCG18214 gene product from transcript CG18214-RA0.809
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.803
EgfrEpidermal growth factor receptor0.800
piepineapple eye0.797
bossbride of sevenless0.768
RASSF8CG5053 gene product from transcript CG5053-RA0.760
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.759
Ten-mTenascin major0.758
dcodiscs overgrown0.752
eyseyes shut0.749
Dsp1Dorsal switch protein 10.733
HopHsp70/Hsp90 organizing protein homolog0.717
HLHmbetaE(spl) region transcript mbeta0.710
eyaeyes absent0.686
HLHmdeltaE(spl) region transcript mdelta0.685
trptransient receptor potential0.675
Mob2CG11711 gene product from transcript CG11711-RC0.673
vvlventral veins lacking0.662
spensplit ends0.653
MrtfMyocardin-related transcription factor0.634
TER94CG2331 gene product from transcript CG2331-RA0.632
Arr1Arrestin 10.623
Gef26CG9491 gene product from transcript CG9491-RB0.618
PtenCG5671 gene product from transcript CG5671-RB0.603
Hr51Hormone receptor 510.595
CtBPC-terminal Binding Protein0.587
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.999
Pax6paired box gene 60.999
Ptenphosphatase and tensin homolog0.993
Otx2orthodenticle homolog 2 (Drosophila)0.991
Sox2SRY-box containing gene 20.987
Pax2paired box gene 20.978
Emx1empty spiracles homolog 1 (Drosophila)0.974
Atoh7atonal homolog 7 (Drosophila)0.963
Crb2crumbs homolog 2 (Drosophila)0.946
Gli3GLI-Kruppel family member GLI30.941
Fgfr1fibroblast growth factor receptor 10.887
Nr2e1nuclear receptor subfamily 2, group E, member 10.842
Itgb1integrin beta 1 (fibronectin receptor beta)0.832
Notch2Notch gene homolog 2 (Drosophila)0.822
Id3inhibitor of DNA binding 30.807
Bbs2Bardet-Biedl syndrome 2 (human)0.785
Pou4f2POU domain, class 4, transcription factor 20.782
Ctnnb1catenin (cadherin associated protein), beta 10.781
Isl1ISL1 transcription factor, LIM/homeodomain0.766
Kitkit oncogene0.759
Pax3paired box gene 30.740
Fgfr2fibroblast growth factor receptor 20.735
Hes1hairy and enhancer of split 1 (Drosophila)0.716
Notch1Notch gene homolog 1 (Drosophila)0.672
Arl6ADP-ribosylation factor-like 60.643
Id1inhibitor of DNA binding 10.634
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.623
Psen1presenilin 10.619
Ptpn11protein tyrosine phosphatase, non-receptor type 110.618
Stat5bsignal transducer and activator of transcription 5B0.613
Pkd1polycystic kidney disease 1 homolog0.604
Thrathyroid hormone receptor alpha0.596
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.594
Chd7chromodomain helicase DNA binding protein 70.556
Iqcb1IQ calmodulin-binding motif containing 10.555
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.528
Nf1neurofibromatosis 10.521
Emx2empty spiracles homolog 2 (Drosophila)0.509
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.502
Stat5asignal transducer and activator of transcription 5A0.489
Crxcone-rod homeobox containing gene0.474
Foxc1forkhead box C10.467
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.439
Grb10growth factor receptor bound protein 100.437
Tcfap2atranscription factor AP-2, alpha0.420
Cbln1cerebellin 1 precursor protein0.413
Retret proto-oncogene0.405
CblCasitas B-lineage lymphoma0.401
Ighimmunoglobulin heavy chain complex0.395
Nos1nitric oxide synthase 1, neuronal0.390
Neurod1neurogenic differentiation 10.381
Irf9interferon regulatory factor 90.377
Tbx3T-box 30.368
Gnb3guanine nucleotide binding protein (G protein), beta 30.352
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.351
Atxn1ataxin 10.343
Gata3GATA binding protein 30.338
Neurog2neurogenin 20.334
Kif3akinesin family member 3A0.332
Adra2badrenergic receptor, alpha 2b0.327
Dlx5distal-less homeobox 50.319
Nos3nitric oxide synthase 3, endothelial cell0.318
Prph2peripherin 20.317
Rxraretinoid X receptor alpha0.313
Fgf8fibroblast growth factor 80.312
Raf1v-raf-leukemia viral oncogene 10.311
Mapk3mitogen-activated protein kinase 30.301
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.301
Lhx1LIM homeobox protein 10.295
Myo6myosin VI0.290
Cacna1fcalcium channel, voltage-dependent, alpha 1F subunit0.286
Trp73transformation related protein 730.284
Shc1src homology 2 domain-containing transforming protein C10.283
Dnmt3aDNA methyltransferase 3A0.282
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.281
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.274
Vhlvon Hippel-Lindau tumor suppressor0.273
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.272
En2engrailed 20.271
Rgl2ral guanine nucleotide dissociation stimulator-like 20.270
Dll1delta-like 1 (Drosophila)0.270
Ascl1achaete-scute complex homolog 1 (Drosophila)0.263
Jupjunction plakoglobin0.263
Dctn1dynactin 10.261
Prox1prospero-related homeobox 10.253
Rbp3retinol binding protein 3, interstitial0.252
Hcn3hyperpolarization-activated, cyclic nucleotide-gated K+ 30.251
Cd2apCD2-associated protein0.250
Wnt9bwingless-type MMTV integration site 9B0.247
Rb1retinoblastoma 10.243
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.239
Arandrogen receptor0.238
Stat3signal transducer and activator of transcription 30.237
Cftrcystic fibrosis transmembrane conductance regulator homolog0.237
Grb2growth factor receptor bound protein 20.230
Bcl2B-cell leukemia/lymphoma 20.230
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism