The network for 'lung alveolus development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lung alveolus development

The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGF1fibroblast growth factor 1 (acidic)1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
NRP1neuropilin 11.000
BMPR1Abone morphogenetic protein receptor, type IA0.999
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.997
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.994
GH1growth hormone 10.993
VEGFAvascular endothelial growth factor A0.991
SHC2SHC (Src homology 2 domain containing) transforming protein 20.964
FGF10fibroblast growth factor 100.948
FGFR1fibroblast growth factor receptor 10.944
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.929
PDZD11PDZ domain containing 110.928
GH2growth hormone 20.913
CSH2chorionic somatomammotropin hormone 20.910
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.900
CSHL1chorionic somatomammotropin hormone-like 10.841
PLCG1phospholipase C, gamma 10.840
FSTL1follistatin-like 10.747
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.723
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.696
FGF7fibroblast growth factor 70.680
CDH5cadherin 5, type 2 (vascular endothelium)0.679
PRKG1protein kinase, cGMP-dependent, type I0.573
ARL4DADP-ribosylation factor-like 4D0.515
PAX8paired box 80.468
ACVR1activin A receptor, type I0.407
PGFplacental growth factor0.388
PDGFCplatelet derived growth factor C0.380
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.372
FZD1frizzled homolog 1 (Drosophila)0.370
FLNBfilamin B, beta0.327
WNT5Awingless-type MMTV integration site family, member 5A0.324
DMBT1deleted in malignant brain tumors 10.277
CIB1calcium and integrin binding 1 (calmyrin)0.252
FGF8fibroblast growth factor 8 (androgen-induced)0.249
PSEN1presenilin 10.228
RIC8Aresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)0.226
HOXA7homeobox A70.207
FGF4fibroblast growth factor 40.204
KRT8keratin 80.199
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.197
MAPK8mitogen-activated protein kinase 80.184
BMP2bone morphogenetic protein 20.177
FHL2four and a half LIM domains 20.159
LMO4LIM domain only 40.152
CTGFconnective tissue growth factor0.148
PTPRBprotein tyrosine phosphatase, receptor type, B0.144
BHLHE40basic helix-loop-helix family, member e400.143
BMP4bone morphogenetic protein 40.135
FLT4fms-related tyrosine kinase 40.123
MAP2K7mitogen-activated protein kinase kinase 70.122
HIPK3homeodomain interacting protein kinase 30.119
TGFB2transforming growth factor, beta 20.119
WNT3Awingless-type MMTV integration site family, member 3A0.114
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.114
PTGISprostaglandin I2 (prostacyclin) synthase0.110
NEDD4neural precursor cell expressed, developmentally down-regulated 40.109
CXCL12chemokine (C-X-C motif) ligand 120.108
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.105
HOXA10homeobox A100.101
FGFR3fibroblast growth factor receptor 30.096
SHBSrc homology 2 domain containing adaptor protein B0.096
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.095
TBX2T-box 20.095
TWIST1twist homolog 1 (Drosophila)0.094
SALL2sal-like 2 (Drosophila)0.091
CCDC6coiled-coil domain containing 60.088
FGF19fibroblast growth factor 190.087
EXOC5exocyst complex component 50.080
IGFBP5insulin-like growth factor binding protein 50.079
TGFBR3transforming growth factor, beta receptor III0.076
SDC4syndecan 40.075
SFTPCsurfactant protein C0.075
STC1stanniocalcin 10.074
WNT1wingless-type MMTV integration site family, member 10.074
EEA1early endosome antigen 10.073
ANGPT1angiopoietin 10.070
LIFRleukemia inhibitory factor receptor alpha0.068
FGF18fibroblast growth factor 180.068
COL6A1collagen, type VI, alpha 10.067
HGFhepatocyte growth factor (hepapoietin A; scatter factor)0.067
FZD7frizzled homolog 7 (Drosophila)0.066
PICK1protein interacting with PRKCA 10.066
CCDC48coiled-coil domain containing 480.065
TRIM32tripartite motif containing 320.064
FOXF2forkhead box F20.063
TEKTEK tyrosine kinase, endothelial0.061
HBZhemoglobin, zeta0.061
KLF15Kruppel-like factor 150.060
SFTPDsurfactant protein D0.060
BMPR1Bbone morphogenetic protein receptor, type IB0.060
LDLRlow density lipoprotein receptor0.059
SHROOM3shroom family member 30.058
DNAJB2DnaJ (Hsp40) homolog, subfamily B, member 20.058
SDC2syndecan 20.057
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli2GLI-Kruppel family member GLI20.960
Vegfavascular endothelial growth factor A0.953
Tcf21transcription factor 210.942
Hoxa5homeobox A50.922
Gata6GATA binding protein 60.921
Shhsonic hedgehog0.907
Tgfbr2transforming growth factor, beta receptor II0.878
Ptenphosphatase and tensin homolog0.878
Fgfr2fibroblast growth factor receptor 20.850
Fbn1fibrillin 10.796
Fgf10fibroblast growth factor 100.754
Meox2mesenchyme homeobox 20.738
Flt4FMS-like tyrosine kinase 40.720
Sox9SRY-box containing gene 90.715
Col1a1collagen, type I, alpha 10.705
Nos3nitric oxide synthase 3, endothelial cell0.665
Twist2twist homolog 2 (Drosophila)0.650
Shesrc homology 2 domain-containing transforming protein E0.642
Tgfbr1transforming growth factor, beta receptor I0.634
Hspg2perlecan (heparan sulfate proteoglycan 2)0.633
Kdrkinase insert domain protein receptor0.620
Nkx2-1NK2 homeobox 10.617
Sox7SRY-box containing gene 70.611
Fgf8fibroblast growth factor 80.601
Hoxc5homeobox C50.587
Acvr1activin A receptor, type 10.585
Hoxa1homeobox A10.580
Foxc2forkhead box C20.559
Pthlhparathyroid hormone-like peptide0.540
Tgfb2transforming growth factor, beta 20.516
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.511
Fgf9fibroblast growth factor 90.498
Grb10growth factor receptor bound protein 100.495
Gli3GLI-Kruppel family member GLI30.474
Hoxd3homeobox D30.471
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.449
Pax3paired box gene 30.431
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.428
Tbx3T-box 30.423
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.383
Hoxc9homeobox C90.371
Foxf1aforkhead box F1a0.361
Hoxc6homeobox C60.357
Hoxb5homeobox B50.347
Pax2paired box gene 20.341
Bmp4bone morphogenetic protein 40.341
Ddr2discoidin domain receptor family, member 20.340
Klc1kinesin light chain 10.335
Notch3Notch gene homolog 3 (Drosophila)0.330
Fgf18fibroblast growth factor 180.327
Tgfbr3transforming growth factor, beta receptor III0.320
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.319
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.319
Notch1Notch gene homolog 1 (Drosophila)0.317
Npr3natriuretic peptide receptor 30.305
Hoxb4homeobox B40.272
Fgfr3fibroblast growth factor receptor 30.269
Mapk8mitogen-activated protein kinase 80.265
Hoxb6homeobox B60.256
Dhhdesert hedgehog0.252
Gata3GATA binding protein 30.240
Ptprbprotein tyrosine phosphatase, receptor type, B0.236
Meox1mesenchyme homeobox 10.232
Sox18SRY-box containing gene 180.231
Sorbs3sorbin and SH3 domain containing 30.226
Hoxa11homeobox A110.226
Bnc1basonuclin 10.223
Jag1jagged 10.216
Smad6MAD homolog 6 (Drosophila)0.216
Foxa2forkhead box A20.208
Ednraendothelin receptor type A0.207
Fzd4frizzled homolog 4 (Drosophila)0.204
Ror2receptor tyrosine kinase-like orphan receptor 20.202
Fgf4fibroblast growth factor 40.200
Tead4TEA domain family member 40.196
Epas1endothelial PAS domain protein 10.193
Ldlrlow density lipoprotein receptor0.192
Tcfap2atranscription factor AP-2, alpha0.186
Tcf15transcription factor 150.186
Flt1FMS-like tyrosine kinase 10.185
Atf4activating transcription factor 40.185
Hoxa3homeobox A30.184
Inhbainhibin beta-A0.183
Hhexhematopoietically expressed homeobox0.180
Hoxa9homeobox A90.176
Chd7chromodomain helicase DNA binding protein 70.175
Hand1heart and neural crest derivatives expressed transcript 10.169
Wt1Wilms tumor 1 homolog0.168
Hoxc4homeobox C40.167
Bdkrb2bradykinin receptor, beta 20.165
Gata2GATA binding protein 20.155
Foxd2forkhead box D20.152
Cdh5cadherin 50.151
Pitx2paired-like homeodomain transcription factor 20.149
Ikzf1IKAROS family zinc finger 10.149
Smad4MAD homolog 4 (Drosophila)0.147
Efnb2ephrin B20.146
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Vcsa2variable coding sequence A20.027
Loxl1lysyl oxidase-like 10.023
Pou1f1POU class 1 homeobox 10.020
Leprleptin receptor0.018
Psgb1pregnancy-specific beta 1-glycoprotein0.017
Dchs1dachsous 1 (Drosophila)0.015
Prl3c1Prolactin family 3, subfamily c, member 10.015
Ednraendothelin receptor type A0.014
Agtr1bangiotensin II receptor, type 1b0.012
Vom2r53vomeronasal 2 receptor, 530.012
Myf6myogenic factor 60.011
ND4NADH dehydrogenase subunit 40.011
Shox2short stature homeobox 20.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism