The network for 'regulation of tumor necrosis factor production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of tumor necrosis factor production

Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.

NameDescriptionProbabilityFunc Analog Organism
BIRC3baculoviral IAP repeat containing 30.999
MYD88myeloid differentiation primary response gene (88)0.999
IRAK2interleukin-1 receptor-associated kinase 20.994
C1QAcomplement component 1, q subcomponent, A chain0.994
TRAF6TNF receptor-associated factor 60.922
IRAK3interleukin-1 receptor-associated kinase 30.908
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.897
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.863
IRAK1interleukin-1 receptor-associated kinase 10.783
CCR1chemokine (C-C motif) receptor 10.729
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.705
MAPK14mitogen-activated protein kinase 140.667
FASFas (TNF receptor superfamily, member 6)0.606
TLR2toll-like receptor 20.604
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.596
CASP8caspase 8, apoptosis-related cysteine peptidase0.582
CD14CD14 molecule0.576
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.570
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.440
CXCL10chemokine (C-X-C motif) ligand 100.440
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.434
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.427
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.415
IL10RAinterleukin 10 receptor, alpha0.412
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.389
TNFtumor necrosis factor0.366
CXCL2chemokine (C-X-C motif) ligand 20.346
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.335
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.321
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.302
TLR4toll-like receptor 40.302
SETD8SET domain containing (lysine methyltransferase) 80.264
CYBBcytochrome b-245, beta polypeptide0.253
MSR1macrophage scavenger receptor 10.246
NLRC4NLR family, CARD domain containing 40.241
C1QBcomplement component 1, q subcomponent, B chain0.236
CD163CD163 molecule0.227
TICAM2toll-like receptor adaptor molecule 20.224
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.201
CCR5chemokine (C-C motif) receptor 50.199
CXCL9chemokine (C-X-C motif) ligand 90.199
CXCL11chemokine (C-X-C motif) ligand 110.190
FCN1ficolin (collagen/fibrinogen domain containing) 10.190
HSF1heat shock transcription factor 10.188
CCL5chemokine (C-C motif) ligand 50.186
TRAF1TNF receptor-associated factor 10.180
TRAF5TNF receptor-associated factor 50.179
CCL8chemokine (C-C motif) ligand 80.177
NCOA3nuclear receptor coactivator 30.176
PTPN6protein tyrosine phosphatase, non-receptor type 60.174
TRAF2TNF receptor-associated factor 20.169
PTAFRplatelet-activating factor receptor0.168
SLASrc-like-adaptor0.167
CCL4chemokine (C-C motif) ligand 40.164
C1QCcomplement component 1, q subcomponent, C chain0.163
HSPB1heat shock 27kDa protein 10.162
PLEKpleckstrin0.155
PILRApaired immunoglobin-like type 2 receptor alpha0.150
LAIR1leukocyte-associated immunoglobulin-like receptor 10.150
SIGLEC7sialic acid binding Ig-like lectin 70.140
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.139
CFLARCASP8 and FADD-like apoptosis regulator0.138
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.131
SYKspleen tyrosine kinase0.130
IL23Ainterleukin 23, alpha subunit p190.128
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.123
MED15mediator complex subunit 150.122
IDEinsulin-degrading enzyme0.116
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.110
CCL2chemokine (C-C motif) ligand 20.105
CD86CD86 molecule0.104
TEKTEK tyrosine kinase, endothelial0.099
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.096
SLAMF8SLAM family member 80.094
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.090
SBNO2strawberry notch homolog 2 (Drosophila)0.089
TRAF3TNF receptor-associated factor 30.088
F13A1coagulation factor XIII, A1 polypeptide0.087
IGSF6immunoglobulin superfamily, member 60.087
CASP10caspase 10, apoptosis-related cysteine peptidase0.086
PF4platelet factor 40.084
SOCS1suppressor of cytokine signaling 10.082
FADDFas (TNFRSF6)-associated via death domain0.082
FOSFBJ murine osteosarcoma viral oncogene homolog0.081
HK3hexokinase 3 (white cell)0.078
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.078
TMEM173transmembrane protein 1730.077
SPOPspeckle-type POZ protein0.075
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.075
PMLpromyelocytic leukemia0.074
MEFVMediterranean fever0.074
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.073
PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)0.072
CCL13chemokine (C-C motif) ligand 130.070
UBDubiquitin D0.070
NLRP3NLR family, pyrin domain containing 30.070
HDAC7histone deacetylase 70.068
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.068
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.066
IRF1interferon regulatory factor 10.064
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lyz2lysozyme 20.998
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.997
Tnftumor necrosis factor0.995
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.983
Myd88myeloid differentiation primary response gene 880.982
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.981
Tlr4toll-like receptor 40.980
Ccr1chemokine (C-C motif) receptor 10.961
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.946
Cd44CD44 antigen0.926
Ptprcprotein tyrosine phosphatase, receptor type, C0.919
Map3k8mitogen-activated protein kinase kinase kinase 80.886
Clec4nC-type lectin domain family 4, member n0.851
Ascl1achaete-scute complex homolog 1 (Drosophila)0.843
Il10interleukin 100.818
AxlAXL receptor tyrosine kinase0.810
Ikzf1IKAROS family zinc finger 10.770
Casp4caspase 4, apoptosis-related cysteine peptidase0.764
TcraT-cell receptor alpha chain0.743
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.723
FaslFas ligand (TNF superfamily, member 6)0.719
C3ar1complement component 3a receptor 10.702
Otx2orthodenticle homolog 2 (Drosophila)0.681
Ccr6chemokine (C-C motif) receptor 60.674
Traf6TNF receptor-associated factor 60.656
Socs1suppressor of cytokine signaling 10.609
Il1binterleukin 1 beta0.604
Map3k14mitogen-activated protein kinase kinase kinase 140.602
BlkB lymphoid kinase0.592
Klrk1killer cell lectin-like receptor subfamily K, member 10.583
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.581
Clec4dC-type lectin domain family 4, member d0.570
Ccr2chemokine (C-C motif) receptor 20.564
Sfpi1SFFV proviral integration 10.547
Il2rginterleukin 2 receptor, gamma chain0.511
Ccl2chemokine (C-C motif) ligand 20.510
Ccl3chemokine (C-C motif) ligand 30.494
Cd14CD14 antigen0.470
Il1rninterleukin 1 receptor antagonist0.458
AF251705cDNA sequence AF2517050.445
Emx2empty spiracles homolog 2 (Drosophila)0.435
Pax6paired box gene 60.427
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.421
Ccl4chemokine (C-C motif) ligand 40.379
Nlrp3NLR family, pyrin domain containing 30.376
Tlr2toll-like receptor 20.364
Ifnar1interferon (alpha and beta) receptor 10.359
Ptf1apancreas specific transcription factor, 1a0.356
Ticam1toll-like receptor adaptor molecule 10.346
Itgalintegrin alpha L0.344
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.343
Il4interleukin 40.338
Foxp3forkhead box P30.327
Klra9killer cell lectin-like receptor subfamily A, member 90.327
Casp8caspase 80.326
Cd40CD40 antigen0.321
Cd209aCD209a antigen0.320
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.317
Slamf8SLAM family member 80.316
Cd7CD7 antigen0.303
Tnip1TNFAIP3 interacting protein 10.300
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.290
Fgd3FYVE, RhoGEF and PH domain containing 30.287
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.287
Clec7aC-type lectin domain family 7, member a0.281
Gzmagranzyme A0.280
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.279
Casp1caspase 10.272
Il10rainterleukin 10 receptor, alpha0.271
Gab1growth factor receptor bound protein 2-associated protein 10.271
Msr1macrophage scavenger receptor 10.269
FcrlaFc receptor-like A0.259
Neurod1neurogenic differentiation 10.256
Mmp8matrix metallopeptidase 80.254
Trim30dtripartite motif-containing 30D0.252
Gzmkgranzyme K0.249
Pyhin1pyrin and HIN domain family, member 10.248
Fcgr2bFc receptor, IgG, low affinity IIb0.244
Osr1odd-skipped related 1 (Drosophila)0.235
Cd86CD86 antigen0.234
Apoeapolipoprotein E0.229
Ifnginterferon gamma0.228
Runx1runt related transcription factor 10.225
Ccr5chemokine (C-C motif) receptor 50.224
Ccr7chemokine (C-C motif) receptor 70.222
Stat3signal transducer and activator of transcription 30.218
Pax2paired box gene 20.215
Ccl6chemokine (C-C motif) ligand 60.212
Madcam1mucosal vascular addressin cell adhesion molecule 10.210
Tnfaip3tumor necrosis factor, alpha-induced protein 30.209
Aoahacyloxyacyl hydrolase0.208
Gzmbgranzyme B0.207
Ctswcathepsin W0.206
Ear2eosinophil-associated, ribonuclease A family, member 20.206
Il7rinterleukin 7 receptor0.203
Inpp5dinositol polyphosphate-5-phosphatase D0.202
Cd300ldCD300 molecule-like family member d0.200
Flt3FMS-like tyrosine kinase 30.198
Ncr1natural cytotoxicity triggering receptor 10.191
Cmklr1chemokine-like receptor 10.189
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Icam1intercellular adhesion molecule 10.380
Il1binterleukin 1 beta0.231
Ccl7chemokine (C-C motif) ligand 70.161
Ccl2chemokine (C-C motif) ligand 20.147
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.124
Cd14CD14 molecule0.090
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.070
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.062
Ccl3chemokine (C-C motif) ligand 30.045
Xcl1chemokine (C motif) ligand 10.039
Stat3signal transducer and activator of transcription 30.038
Cxcl10chemokine (C-X-C motif) ligand 100.036
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.035
Igsf6immunoglobulin superfamily, member 60.030
Cxcl2chemokine (C-X-C motif) ligand 20.030
Klrd1killer cell lectin-like receptor, subfamily D, member 10.028
Folr2folate receptor 2 (fetal)0.028
Cdk4cyclin-dependent kinase 40.027
Myd88myeloid differentiation primary response gene 880.025
Litaflipopolysaccharide-induced TNF factor0.023
Ccl4chemokine (C-C motif) ligand 40.023
Il4rainterleukin 4 receptor, alpha0.022
C5ar1complement component 5a receptor 10.022
Slpisecretory leukocyte peptidase inhibitor0.022
Ier3immediate early response 30.021
Junbjun B proto-oncogene0.021
Fcnbficolin B0.021
Ccl20chemokine (C-C motif) ligand 200.020
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.020
Il2rbinterleukin 2 receptor, beta0.019
Tlr2toll-like receptor 20.018
Rab32RAB32, member RAS oncogene family0.018
Timp1TIMP metallopeptidase inhibitor 10.018
Xdhxanthine dehydrogenase0.017
Selpselectin P0.017
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.016
Atp5g2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)0.016
Bcl3B-cell CLL/lymphoma 30.016
Cd44Cd44 molecule0.016
Plauplasminogen activator, urokinase0.015
Hmox1heme oxygenase (decycling) 10.015
Sellselectin L0.015
Pnpla2patatin-like phospholipase domain containing 20.015
Arl11ADP-ribosylation factor-like 110.014
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.014
Csf1colony stimulating factor 1 (macrophage)0.014
Gzmkgranzyme K0.014
Jak1Janus kinase 10.013
Runx1runt-related transcription factor 10.013
Hpgdshematopoietic prostaglandin D synthase0.013
Adrb2adrenergic, beta-2-, receptor, surface0.013
Il1ainterleukin 1 alpha0.012
Casp12caspase 120.012
Clec10aC-type lectin domain family 10, member A0.012
Cd40CD40 molecule, TNF receptor superfamily member 50.012
Lcn2lipocalin 20.012
Igsf7immunoglobulin superfamily, member 70.012
Il6interleukin 60.011
Tspan4tetraspanin 40.011
Map3k8mitogen-activated protein kinase kinase kinase 80.011
Shc1SHC (Src homology 2 domain containing) transforming protein 10.011
Tbc1d2bTBC1 domain family, member 2B0.011
Pionpigeon homolog (Drosophila)0.011
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.011
Cd8aCD8a molecule0.011
LOC100361007rCG32064-like0.011
Irs3insulin receptor substrate 30.010
Fabp4fatty acid binding protein 4, adipocyte0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism