The network for 'transforming growth factor beta production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

transforming growth factor beta production

The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.

NameDescriptionProbabilityFunc Analog Organism
SMAD3SMAD family member 30.999
SMAD1SMAD family member 10.992
TAL1T-cell acute lymphocytic leukemia 10.967
SMAD5SMAD family member 50.960
SMAD2SMAD family member 20.955
SMAD7SMAD family member 70.954
CCR5chemokine (C-C motif) receptor 50.949
CCL4chemokine (C-C motif) ligand 40.934
LTBP2latent transforming growth factor beta binding protein 20.807
SMAD4SMAD family member 40.754
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.751
ATN1atrophin 10.620
FBLN5fibulin 50.591
ENGendoglin0.503
DPP4dipeptidyl-peptidase 40.502
CXCL9chemokine (C-X-C motif) ligand 90.492
SMURF2SMAD specific E3 ubiquitin protein ligase 20.425
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.349
DSG2desmoglein 20.339
ARNTaryl hydrocarbon receptor nuclear translocator0.282
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.267
CCL2chemokine (C-C motif) ligand 20.254
ELNelastin0.242
LOXL1lysyl oxidase-like 10.233
RUNX1runt-related transcription factor 10.204
CCL19chemokine (C-C motif) ligand 190.198
CD164CD164 molecule, sialomucin0.183
FSTL1follistatin-like 10.180
JUPjunction plakoglobin0.179
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.175
CCL5chemokine (C-C motif) ligand 50.174
IDEinsulin-degrading enzyme0.171
CPDcarboxypeptidase D0.163
CCL3chemokine (C-C motif) ligand 30.148
SKILSKI-like oncogene0.148
DARCDuffy blood group, chemokine receptor0.118
CXCL11chemokine (C-X-C motif) ligand 110.115
CCL8chemokine (C-C motif) ligand 80.111
TM9SF2transmembrane 9 superfamily member 20.109
ARandrogen receptor0.108
CCR7chemokine (C-C motif) receptor 70.105
CCL22chemokine (C-C motif) ligand 220.096
EGLN1egl nine homolog 1 (C. elegans)0.089
CXCL10chemokine (C-X-C motif) ligand 100.087
CXXC5CXXC finger protein 50.086
LOXlysyl oxidase0.084
CCL13chemokine (C-C motif) ligand 130.079
VCAM1vascular cell adhesion molecule 10.079
LENG8leukocyte receptor cluster (LRC) member 80.074
VHLvon Hippel-Lindau tumor suppressor0.068
COL6A2collagen, type VI, alpha 20.067
AKT2v-akt murine thymoma viral oncogene homolog 20.066
FBLN1fibulin 10.065
BGNbiglycan0.063
CTNND1catenin (cadherin-associated protein), delta 10.063
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.062
LAMB2laminin, beta 2 (laminin S)0.058
IL6interleukin 6 (interferon, beta 2)0.057
CXCL13chemokine (C-X-C motif) ligand 130.055
SMAD6SMAD family member 60.054
REREarginine-glutamic acid dipeptide (RE) repeats0.053
GZMBgranzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)0.051
DMPKdystrophia myotonica-protein kinase0.050
WWP2WW domain containing E3 ubiquitin protein ligase 20.050
FBN1fibrillin 10.047
NNMTnicotinamide N-methyltransferase0.047
TCF4transcription factor 40.046
GFI1Bgrowth factor independent 1B transcription repressor0.046
TGFBR1transforming growth factor, beta receptor 10.046
EGLN3egl nine homolog 3 (C. elegans)0.045
PRELPproline/arginine-rich end leucine-rich repeat protein0.043
MMP12matrix metallopeptidase 12 (macrophage elastase)0.043
TRIP6thyroid hormone receptor interactor 60.042
SELEselectin E0.041
DSPdesmoplakin0.037
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.034
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.034
IL8interleukin 80.034
IFNGinterferon, gamma0.032
PLSCR4phospholipid scramblase 40.032
GATA2GATA binding protein 20.032
CXCL12chemokine (C-X-C motif) ligand 120.032
SH3KBP1SH3-domain kinase binding protein 10.031
SP1Sp1 transcription factor0.031
RGS1regulator of G-protein signaling 10.030
IL1Binterleukin 1, beta0.029
UHRF2ubiquitin-like with PHD and ring finger domains 20.028
FBLN2fibulin 20.028
HDAC9histone deacetylase 90.028
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.027
IKZF3IKAROS family zinc finger 3 (Aiolos)0.027
PTGISprostaglandin I2 (prostacyclin) synthase0.027
ITM2Bintegral membrane protein 2B0.027
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.027
MMP14matrix metallopeptidase 14 (membrane-inserted)0.027
CCL7chemokine (C-C motif) ligand 70.026
IL10interleukin 100.026
ZFPM1zinc finger protein, multitype 10.026
RHOXF2Rhox homeobox family, member 20.026
ECM1extracellular matrix protein 10.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.074
Ctnnb1catenin (cadherin associated protein), beta 10.055
Fgf8fibroblast growth factor 80.047
Gli2GLI-Kruppel family member GLI20.034
Gata4GATA binding protein 40.033
Stat3signal transducer and activator of transcription 30.025
Wnt4wingless-related MMTV integration site 40.022
Smad1MAD homolog 1 (Drosophila)0.018
Dkk1dickkopf homolog 1 (Xenopus laevis)0.016
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.014
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.013
Il6stinterleukin 6 signal transducer0.013
Il2interleukin 20.012
Lmx1bLIM homeobox transcription factor 1 beta0.012
Apcadenomatosis polyposis coli0.011
Atf3activating transcription factor 30.010
Foxp1forkhead box P10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism