The network for 'response to nicotine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to nicotine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.976
BCL2L1BCL2-like 10.974
BCL2L11BCL2-like 11 (apoptosis facilitator)0.774
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.557
CASP9caspase 9, apoptosis-related cysteine peptidase0.285
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.265
DRD2dopamine receptor D20.260
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.193
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.183
VAC14Vac14 homolog (S. cerevisiae)0.155
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.146
APAF1apoptotic peptidase activating factor 10.113
ADORA2Aadenosine A2a receptor0.111
PLAUplasminogen activator, urokinase0.102
TNFAIP3tumor necrosis factor, alpha-induced protein 30.084
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.082
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.078
PRSS2protease, serine, 2 (trypsin 2)0.068
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.068
NCOR2nuclear receptor corepressor 20.064
ITGB1BP3integrin beta 1 binding protein 30.054
CHD9chromodomain helicase DNA binding protein 90.053
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.051
TGFB1transforming growth factor, beta 10.048
PLAURplasminogen activator, urokinase receptor0.046
TNIP2TNFAIP3 interacting protein 20.042
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.040
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.039
BCL3B-cell CLL/lymphoma 30.037
IGF2Rinsulin-like growth factor 2 receptor0.037
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.036
NGFnerve growth factor (beta polypeptide)0.034
ALDH1A1aldehyde dehydrogenase 1 family, member A10.031
PLATplasminogen activator, tissue0.031
BAK1BCL2-antagonist/killer 10.029
TRADDTNFRSF1A-associated via death domain0.024
PICK1protein interacting with PRKCA 10.024
TIMP2TIMP metallopeptidase inhibitor 20.022
TRAF1TNF receptor-associated factor 10.019
THBS1thrombospondin 10.019
RNF144Bring finger protein 144B0.018
XIAPX-linked inhibitor of apoptosis0.017
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.017
MAP3K8mitogen-activated protein kinase kinase kinase 80.016
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.015
TRAF2TNF receptor-associated factor 20.015
RNR2l-rRNA0.014
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.014
WT1Wilms tumor 10.014
MAP3K14mitogen-activated protein kinase kinase kinase 140.013
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.012
TNIP1TNFAIP3 interacting protein 10.012
ORM1orosomucoid 10.011
MSNmoesin0.011
PTPN1protein tyrosine phosphatase, non-receptor type 10.011
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.011
LATlinker for activation of T cells0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.704
uts1urotensin 10.580
drd2bdopamine receptor D2b0.532
dab1adisabled homolog 1a (Drosophila)0.522
avplarginine vasopressin-like0.415
drd2ldopamine receptor D2 like0.336
tfe3btranscription factor binding to IGHM enhancer 3b0.292
wnt9bwingless-type MMTV integration site family, member 9B0.252
wnt10awingless-type MMTV integration site family, member 10a0.225
drd3dopamine receptor D30.213
gfra1bgdnf family receptor alpha 1b0.210
sim1asingle-minded homolog 1a (Drosophila)0.208
dbhdopamine beta hydroxylase0.197
pgdphosphogluconate hydrogenase0.171
satb2SATB homeobox 20.169
chrna4cholinergic receptor, nicotinic, alpha 40.168
gria2bglutamate receptor, ionotropic, AMPA 2b0.158
inspreproinsulin0.156
gdnfglial cell derived neurotrophic factor0.138
sst2somatostatin 20.131
prlprolactin0.127
snapc1bsmall nuclear RNA activating complex, polypeptide 1b0.119
ctszcathepsin Z0.118
lhx3LIM homeobox 30.113
efna5bephrin A5b0.110
crestincrestin0.109
oxtloxytocin-like0.096
spon1aspondin 1a0.091
gh1growth hormone 10.088
arxaristaless related homeobox0.082
wnt9awingless-type MMTV integration site family, member 9A0.077
si:ch211-212m21.5si:ch211-212m21.50.076
pou4f2POU domain, class 4, transcription factor 20.075
glra1glycine receptor, alpha 10.069
mnx1motor neuron and pancreas homeobox 10.069
per2period homolog 2 (Drosophila)0.066
gli2bGLI-Kruppel family member GLI2b0.063
adra2cadrenergic, alpha-2C-, receptor0.062
tgfb3transforming growth factor, beta 30.062
nadl1.2neural adhesion molecule L1.20.060
gad2glutamate decarboxylase 20.057
nkx6.2NK6 transcription factor related, locus 20.056
mc4rmelanocortin 4 receptor0.055
ctrb1chymotrypsinogen B10.054
stc1lstanniocalcin 1, like0.053
pax7apaired box gene 7a0.049
gfra1agdnf family receptor alpha 1a0.048
wu:fc31g04wu:fc31g040.048
chpfchondroitin polymerizing factor0.048
tfebtranscription factor EB0.047
npas2neuronal PAS domain protein 20.046
ncam1bneural cell adhesion molecule 1b0.045
thtyrosine hydroxylase0.045
ela2lelastase 2 like0.044
ryr2aryanodine receptor 2a (cardiac)0.043
fgf20afibroblast growth factor 20a0.041
nog3noggin 30.040
hlxb9lahomeo box HB9 like a0.040
sst1.1somatostatin 1, tandem duplicate 10.038
hcrthypocretin (orexin) neuropeptide precursor0.038
adipor1badiponectin receptor 1b0.038
flj13639flj136390.037
otpaorthopedia homolog a0.037
nadl1.1neural adhesion molecule L1.10.037
pax4paired box 40.036
stap2bsignal transducing adaptor family member 2b0.036
ctgfconnective tissue growth factor0.035
relv-rel reticuloendotheliosis viral oncogene homolog0.035
cnr1cannabinoid receptor 10.035
th2tyrosine hydroxylase 20.035
tln1talin 10.033
mchr1amelanin-concentrating hormone receptor 1a0.033
rhogbras homolog gene family, member Gb0.033
rx1retinal homeobox gene 10.033
drd1dopamine receptor D10.033
sox4bSRY-box containing gene 4b0.033
gcgaglucagon a and glucagon a-like0.033
sema3absemaphorin 3ab0.032
prkczprotein kinase C, zeta0.032
LOC790901glucose-dependent insulinotropic polypeptide0.031
cbr1lcarbonyl reductase 1-like0.031
adra2aadrenergic, alpha-2A-, receptor0.031
grin1aglutamate receptor, ionotropic, N-methyl D-aspartate 1a0.030
rpl9ribosomal protein L90.030
gdf6bgrowth differentiation factor 6b0.030
pcp4aPurkinje cell protein 4a0.030
si:dkey-78p20.2si:dkey-78p20.20.029
ela3lelastase 3 like0.029
tbx15T-box 150.028
cldnkclaudin k0.027
ncam2neural cell adhesion molecule 20.027
chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.027
zgc:66382zgc:663820.027
ca2carbonic anhydrase II0.026
caspacaspase a0.026
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.026
bmp7bbone morphogenetic protein 7b0.026
cx27.5connexin 27.50.026
mtnr1bamelatonin receptor type 1B a0.025
nrp1bneuropilin 1b0.025
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Drd2dopamine receptor D20.770
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.687
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.352
Gpi1glucose phosphate isomerase 10.328
Col1a1collagen, type I, alpha 10.306
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.266
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.265
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.261
Gm5506predicted gene 55060.252
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.232
Platplasminogen activator, tissue0.221
Pitx3paired-like homeodomain transcription factor 30.185
Cd44CD44 antigen0.164
Tpi1triosephosphate isomerase 10.145
Nos2nitric oxide synthase 2, inducible0.143
Nos3nitric oxide synthase 3, endothelial cell0.135
Acheacetylcholinesterase0.134
Stat3signal transducer and activator of transcription 30.129
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.106
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.095
Ldhalactate dehydrogenase A0.091
Csf1colony stimulating factor 1 (macrophage)0.073
Grm1glutamate receptor, metabotropic 10.071
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.065
Irf1interferon regulatory factor 10.065
Gcgrglucagon receptor0.063
Pkm2pyruvate kinase, muscle0.062
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.060
Onecut1one cut domain, family member 10.055
Mybphmyosin binding protein H0.054
Dbhdopamine beta hydroxylase0.051
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.050
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.050
Npy1rneuropeptide Y receptor Y10.047
Insm1insulinoma-associated 10.047
Grb10growth factor receptor bound protein 100.046
Vdrvitamin D receptor0.045
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.045
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.043
Ccl2chemokine (C-C motif) ligand 20.042
Fbn1fibrillin 10.042
Chrna9cholinergic receptor, nicotinic, alpha polypeptide 90.040
Lhx3LIM homeobox protein 30.039
Esr1estrogen receptor 1 (alpha)0.039
Adam17a disintegrin and metallopeptidase domain 170.038
Pomcpro-opiomelanocortin-alpha0.037
Sncasynuclein, alpha0.036
Galgalanin0.035
Ins2insulin II0.034
C1ql1complement component 1, q subcomponent-like 10.033
Il10interleukin 100.032
Stat6signal transducer and activator of transcription 60.032
Dccdeleted in colorectal carcinoma0.031
Apoeapolipoprotein E0.031
Chrna10cholinergic receptor, nicotinic, alpha polypeptide 100.031
Icam1intercellular adhesion molecule 10.030
Cplx1complexin 10.030
Myogmyogenin0.029
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.028
Ctrb1chymotrypsinogen B10.028
Prop1paired like homeodomain factor 10.028
En1engrailed 10.028
Gabbr2gamma-aminobutyric acid (GABA) B receptor, 20.027
Oprm1opioid receptor, mu 10.027
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.025
Gzmmgranzyme M (lymphocyte met-ase 1)0.024
Slc18a3solute carrier family 18 (vesicular monoamine), member 30.023
Il13interleukin 130.023
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.022
Timp3tissue inhibitor of metalloproteinase 30.022
Ldlrlow density lipoprotein receptor0.021
Loxlysyl oxidase0.021
Ebf3early B-cell factor 30.020
Egfrepidermal growth factor receptor0.020
Gdnfglial cell line derived neurotrophic factor0.020
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.018
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)0.018
FasFas (TNF receptor superfamily member 6)0.018
Phox2apaired-like homeobox 2a0.018
Ifnginterferon gamma0.018
Myod1myogenic differentiation 10.017
Adora2aadenosine A2a receptor0.017
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.016
Iqgap1IQ motif containing GTPase activating protein 10.016
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.015
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.015
Nxnl2nucleoredoxin-like 20.015
Ecel1endothelin converting enzyme-like 10.015
Mab21l2mab-21-like 2 (C. elegans)0.015
Osmroncostatin M receptor0.015
Rapsnreceptor-associated protein of the synapse0.014
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.014
Try5trypsin 50.014
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.014
Grid1glutamate receptor, ionotropic, delta 10.014
Sema5bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B0.014
Oc90otoconin 900.014
Pax1paired box gene 10.014
Smyd1SET and MYND domain containing 10.014
Trpm5transient receptor potential cation channel, subfamily M, member 50.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Magmyelin-associated glycoprotein0.661
Col3a1collagen, type III, alpha 10.348
Ephx1epoxide hydrolase 1, microsomal0.328
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.314
Gstm1glutathione S-transferase mu 10.307
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.296
Gsta3glutathione S-transferase A30.237
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.234
Col1a1collagen, type I, alpha 10.229
Trhr2thyrotropin releasing hormone receptor 20.220
Foxe1forkhead box E1 (thyroid transcription factor 2)0.214
Mgst1microsomal glutathione S-transferase 10.204
Ppardperoxisome proliferator-activated receptor delta0.204
Mobpmyelin-associated oligodendrocyte basic protein0.185
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.182
Tnftumor necrosis factor (TNF superfamily, member 2)0.173
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.165
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.158
Gpr12G protein-coupled receptor 120.157
Gzmfgranzyme F0.157
MosMoloney sarcoma oncogene0.154
Pspparotid secretory protein0.152
Prss1protease, serine, 1 (trypsin 1)0.141
Gja6gap junction protein, alpha 60.134
Nlgn3neuroligin 30.132
Col5a2collagen, type V, alpha 20.131
Chrna3cholinergic receptor, nicotinic, alpha 30.130
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.130
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.128
Mstnmyostatin0.126
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.125
Lepleptin0.125
LOC494499LOC494499 protein0.123
Tmem79transmembrane protein 790.123
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.123
Sprr3small proline-rich protein 30.122
Slc22a25solute carrier family 22, member 250.110
COX3cytochrome c oxidase subunit 30.108
Dio2deiodinase, iodothyronine, type II0.108
Prl8a2prolactin family 8, subfamily a, member 20.108
Loxl1lysyl oxidase-like 10.106
Grid1glutamate receptor, ionotropic, delta 10.104
Nrg1neuregulin 10.102
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.101
Reg3gregenerating islet-derived 3 gamma0.101
Prm3protamine 30.097
Vipvasoactive intestinal peptide0.095
FevFEV (ETS oncogene family)0.094
Dpysdihydropyrimidinase0.093
Faim2Fas apoptotic inhibitory molecule 20.093
Tac1tachykinin 10.092
Megf6multiple EGF-like-domains 60.092
Slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.091
Lim2lens intrinsic membrane protein 20.089
Cela2achymotrypsin-like elastase family, member 2A0.089
Slc22a1solute carrier family 22 (organic cation transporter), member 10.089
Gja1gap junction protein, alpha 10.087
Esr2estrogen receptor 2 (ER beta)0.087
Cxcl2chemokine (C-X-C motif) ligand 20.084
Nr4a3nuclear receptor subfamily 4, group A, member 30.084
Htr75-hydroxytryptamine (serotonin) receptor 70.082
Pdynprodynorphin0.082
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.081
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.080
Hap1huntingtin-associated protein 10.079
Col1a2collagen, type I, alpha 20.079
Sycnsyncollin0.079
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.078
Gfra2GDNF family receptor alpha 20.077
Rgs8regulator of G-protein signaling 80.077
Atp7bATPase, Cu++ transporting, beta polypeptide0.077
Impg2interphotoreceptor matrix proteoglycan 20.076
LOC60591calcium-activated potassium channel beta subunit0.076
Fgf17fibroblast growth factor 170.076
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.076
Irx1iroquois homeobox 10.075
Arcactivity-regulated cytoskeleton-associated protein0.075
Acanaggrecan0.074
Olr1361olfactory receptor 13610.074
Sstr1somatostatin receptor 10.073
Hnmthistamine N-methyltransferase0.072
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.072
Pkm2pyruvate kinase, muscle0.072
Catsper2cation channel, sperm associated 20.071
Mycsmyc-like oncogene, s-myc protein0.070
Gzmcgranzyme C0.070
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.070
Dlg4discs, large homolog 4 (Drosophila)0.070
Pde3aphosphodiesterase 3A, cGMP inhibited0.070
Lcn5lipocalin 50.069
MrgprfMAS-related GPR, member F0.068
Fut1fucosyltransferase 10.068
Ccl20chemokine (C-C motif) ligand 200.068
Defb4defensin beta 40.068
Hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.068
Calcacalcitonin-related polypeptide alpha0.067
Slc22a6solute carrier family 22 (organic anion transporter), member 60.067
LOC687536similar to Forkhead box protein F1 (Forkhead-related protein FKHL5) (Forkhead-related transcription factor 1) (FREAC-1) (Hepatocyte nuclear factor 3 forkhead homolog 8) (HFH-8)0.067
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.066
Foxd3forkhead box D30.066
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism