The network for 'positive regulation of lymphocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lymphocyte proliferation

Any process that activates or increases the rate or extent of lymphocyte proliferation.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.995
LCKlymphocyte-specific protein tyrosine kinase0.994
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.991
FGFR2fibroblast growth factor receptor 20.981
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.965
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.956
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.951
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.948
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.909
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.908
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.905
IL1R1interleukin 1 receptor, type I0.905
GRB2growth factor receptor-bound protein 20.899
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.891
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.878
ICAM1intercellular adhesion molecule 10.877
CD86CD86 molecule0.865
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.848
CCL4chemokine (C-C motif) ligand 40.844
CD80CD80 molecule0.843
SYKspleen tyrosine kinase0.825
VAV1vav 1 guanine nucleotide exchange factor0.824
CCR5chemokine (C-C motif) receptor 50.822
CTLA4cytotoxic T-lymphocyte-associated protein 40.802
PTPN6protein tyrosine phosphatase, non-receptor type 60.802
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.798
BTN3A2butyrophilin, subfamily 3, member A20.790
HLA-DMBmajor histocompatibility complex, class II, DM beta0.784
CASP8caspase 8, apoptosis-related cysteine peptidase0.758
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.757
GRB7growth factor receptor-bound protein 70.752
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.746
TNFAIP3tumor necrosis factor, alpha-induced protein 30.741
CD247CD247 molecule0.739
CCR7chemokine (C-C motif) receptor 70.688
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.678
BTN3A3butyrophilin, subfamily 3, member A30.677
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.647
CXCL9chemokine (C-X-C motif) ligand 90.624
BTN3A1butyrophilin, subfamily 3, member A10.610
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.565
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.552
CCR1chemokine (C-C motif) receptor 10.519
NLRC4NLR family, CARD domain containing 40.512
IFNGinterferon, gamma0.473
CCL22chemokine (C-C motif) ligand 220.436
IL2RBinterleukin 2 receptor, beta0.434
CCL2chemokine (C-C motif) ligand 20.424
IL8interleukin 80.420
MYD88myeloid differentiation primary response gene (88)0.387
BCL2L11BCL2-like 11 (apoptosis facilitator)0.384
CD28CD28 molecule0.378
SOCS3suppressor of cytokine signaling 30.354
IRF4interferon regulatory factor 40.347
BIDBH3 interacting domain death agonist0.344
HLA-DRB5major histocompatibility complex, class II, DR beta 50.340
JAK1Janus kinase 10.326
STAT4signal transducer and activator of transcription 40.324
LATlinker for activation of T cells0.316
EGFRepidermal growth factor receptor0.285
BCL2A1BCL2-related protein A10.281
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.279
CXCL10chemokine (C-X-C motif) ligand 100.277
TNFRSF9tumor necrosis factor receptor superfamily, member 90.267
HDAC9histone deacetylase 90.256
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.254
TICAM2toll-like receptor adaptor molecule 20.252
IL2RGinterleukin 2 receptor, gamma0.249
IL1Binterleukin 1, beta0.246
SH3BP2SH3-domain binding protein 20.246
IRAK1interleukin-1 receptor-associated kinase 10.246
IGF2insulin-like growth factor 2 (somatomedin A)0.242
IL6interleukin 6 (interferon, beta 2)0.233
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.231
IL10interleukin 100.226
IL4Rinterleukin 4 receptor0.222
HLA-DPB1major histocompatibility complex, class II, DP beta 10.221
TRAF1TNF receptor-associated factor 10.211
TRAF3TNF receptor-associated factor 30.207
CXCL2chemokine (C-X-C motif) ligand 20.205
IL10RAinterleukin 10 receptor, alpha0.193
CXCL13chemokine (C-X-C motif) ligand 130.192
BAXBCL2-associated X protein0.190
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.186
INSRinsulin receptor0.179
FASLGFas ligand (TNF superfamily, member 6)0.178
FGF1fibroblast growth factor 1 (acidic)0.174
FGFR1fibroblast growth factor receptor 10.170
TAL1T-cell acute lymphocytic leukemia 10.170
GRAP2GRB2-related adaptor protein 20.170
BCL2L1BCL2-like 10.162
CCL13chemokine (C-C motif) ligand 130.158
CCL20chemokine (C-C motif) ligand 200.158
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.155
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.154
HCKhemopoietic cell kinase0.154
TLR2toll-like receptor 20.152
HLA-DRB4major histocompatibility complex, class II, DR beta 40.150
CD83CD83 molecule0.142
SLAMF1signaling lymphocytic activation molecule family member 10.142
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Ifnginterferon gamma0.998
Tlr4toll-like receptor 40.998
Rnf2ring finger protein 20.988
FasFas (TNF receptor superfamily member 6)0.986
Cd40CD40 antigen0.983
Myd88myeloid differentiation primary response gene 880.982
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.975
Leprleptin receptor0.975
Il6interleukin 60.971
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.968
Efnb2ephrin B20.924
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.921
Ccl2chemokine (C-C motif) ligand 20.919
Ccr2chemokine (C-C motif) receptor 20.918
Tnfaip3tumor necrosis factor, alpha-induced protein 30.912
FaslFas ligand (TNF superfamily, member 6)0.903
Icosinducible T-cell co-stimulator0.896
Cd28CD28 antigen0.889
Pdcd1programmed cell death 10.886
Map3k14mitogen-activated protein kinase kinase kinase 140.868
Il4interleukin 40.867
Il1binterleukin 1 beta0.858
Ccr1chemokine (C-C motif) receptor 10.854
Cd19CD19 antigen0.852
Ltalymphotoxin A0.848
Socs1suppressor of cytokine signaling 10.842
Sh2d2aSH2 domain protein 2A0.814
Tgfb1transforming growth factor, beta 10.798
Nos2nitric oxide synthase 2, inducible0.776
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.757
Il10interleukin 100.745
Gli2GLI-Kruppel family member GLI20.744
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.743
Lyz2lysozyme 20.743
Cd5CD5 antigen0.726
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.712
Gzmkgranzyme K0.703
Stat5asignal transducer and activator of transcription 5A0.696
Ccl4chemokine (C-C motif) ligand 40.696
Cd80CD80 antigen0.693
BtkBruton agammaglobulinemia tyrosine kinase0.680
C3ar1complement component 3a receptor 10.670
FynFyn proto-oncogene0.669
Stat3signal transducer and activator of transcription 30.661
Csf1colony stimulating factor 1 (macrophage)0.653
Casp4caspase 4, apoptosis-related cysteine peptidase0.641
Casp8caspase 80.637
Prf1perforin 1 (pore forming protein)0.630
Il2rbinterleukin 2 receptor, beta chain0.617
Fgfr2fibroblast growth factor receptor 20.611
Drd2dopamine receptor D20.606
Pdcd1lg2programmed cell death 1 ligand 20.605
Sykbspleen tyrosine kinase0.602
Ikzf1IKAROS family zinc finger 10.577
RybpRING1 and YY1 binding protein0.576
Foxp3forkhead box P30.574
Gpr132G protein-coupled receptor 1320.571
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.556
Klrg1killer cell lectin-like receptor subfamily G, member 10.541
Gli3GLI-Kruppel family member GLI30.525
Klrk1killer cell lectin-like receptor subfamily K, member 10.520
Il2rainterleukin 2 receptor, alpha chain0.510
Mmp9matrix metallopeptidase 90.504
Stat5bsignal transducer and activator of transcription 5B0.504
Ubdubiquitin D0.502
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.500
Emx2empty spiracles homolog 2 (Drosophila)0.497
Pax2paired box gene 20.491
Ntf3neurotrophin 30.486
Ptgs2prostaglandin-endoperoxide synthase 20.486
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.478
Il2rginterleukin 2 receptor, gamma chain0.477
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.474
Nlrp3NLR family, pyrin domain containing 30.472
Cd96CD96 antigen0.455
Lag3lymphocyte-activation gene 30.447
Adora2aadenosine A2a receptor0.442
Foxc1forkhead box C10.435
Esr1estrogen receptor 1 (alpha)0.426
Pax8paired box gene 80.422
Cd247CD247 antigen0.419
Ccl3chemokine (C-C motif) ligand 30.416
Nos3nitric oxide synthase 3, endothelial cell0.414
Ptenphosphatase and tensin homolog0.412
Dkk1dickkopf homolog 1 (Xenopus laevis)0.412
Il2interleukin 20.410
Ccr7chemokine (C-C motif) receptor 70.406
Ccr6chemokine (C-C motif) receptor 60.396
Gpr33G protein-coupled receptor 330.390
Traf6TNF receptor-associated factor 60.387
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.385
Otx2orthodenticle homolog 2 (Drosophila)0.384
Lcklymphocyte protein tyrosine kinase0.378
Ccl17chemokine (C-C motif) ligand 170.377
Cd6CD6 antigen0.371
Cd7CD7 antigen0.370
Il12binterleukin 12b0.362
Grb10growth factor receptor bound protein 100.360
Tbx21T-box 210.354
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd37CD37 molecule0.617
RT1-DaRT1 class II, locus Da0.498
RT1-BaRT1 class II, locus Ba0.419
Cd247Cd247 molecule0.394
RT1-Db1RT1 class II, locus Db10.393
RT1-DMbRT1 class II, locus DMb0.263
Il10interleukin 100.228
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.176
Cd5Cd5 molecule0.169
Calcrcalcitonin receptor0.166
Casp1caspase 10.163
Mmp10matrix metallopeptidase 100.118
Itgb7integrin, beta 70.106
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.103
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.099
Il1binterleukin 1 beta0.096
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.093
Laptm5lysosomal protein transmembrane 50.092
Nkg7natural killer cell group 7 sequence0.091
Ly86lymphocyte antigen 860.078
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.070
Pthparathyroid hormone0.069
Ptger4prostaglandin E receptor 4 (subtype EP4)0.067
RT1-BbRT1 class II, locus Bb0.066
Cd2Cd2 molecule0.065
Napsanapsin A aspartic peptidase0.064
Ptprcprotein tyrosine phosphatase, receptor type, C0.062
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.060
Lcp1lymphocyte cytosolic protein 10.056
Dnase1l3deoxyribonuclease 1-like 30.055
Klrd1killer cell lectin-like receptor, subfamily D, member 10.054
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.052
Il1rl1interleukin 1 receptor-like 10.051
Gzmkgranzyme K0.049
Vipvasoactive intestinal peptide0.048
Cd44Cd44 molecule0.047
Metmet proto-oncogene0.045
Plcd4phospholipase C, delta 40.045
Ccr2chemokine (C-C motif) receptor 20.045
Ncr1natural cytotoxicity triggering receptor 10.044
Il6interleukin 60.044
Rassf5Ras association (RalGDS/AF-6) domain family member 50.042
Prol1proline rich, lacrimal 10.042
Npy5rneuropeptide Y receptor Y50.042
TcrbT-cell receptor beta chain0.041
Il4interleukin 40.040
Psg19pregnancy specific glycoprotein 190.039
Cd53Cd53 molecule0.039
Reg3bregenerating islet-derived 3 beta0.039
Dio2deiodinase, iodothyronine, type II0.037
Trpm8transient receptor potential cation channel, subfamily M, member 80.037
Oprk1opioid receptor, kappa 10.037
Bcl3B-cell CLL/lymphoma 30.037
Cxcr3chemokine (C-X-C motif) receptor 30.035
Prl8a9prolactin family 8, subfamily a, member 90.035
Ciitaclass II, major histocompatibility complex, transactivator0.035
Pspparotid secretory protein0.033
Inpp5dinositol polyphosphate-5-phosphatase D0.033
Fam108b1family with sequence similarity 108, member B10.032
Zbp1Z-DNA binding protein 10.031
Ptafrplatelet-activating factor receptor0.031
FaslgFas ligand (TNF superfamily, member 6)0.031
Neurog3neurogenin 30.031
Prpg1proline-rich proteoglycan 10.031
Il1r1interleukin 1 receptor, type I0.030
Art2ADP-ribosyltransferase 20.030
Prl7a4prolactin family 7, subfamily a, member 40.030
UST4rintegral membrane transport protein UST4r0.029
Reg3gregenerating islet-derived 3 gamma0.028
Tas2r123taste receptor, type 2, member 1230.027
Vom2r27vomeronasal 2 receptor, 270.027
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.026
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.026
Sstr1somatostatin receptor 10.026
Adh6aalcohol dehydrogenase 6A (class V)0.026
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.025
Mobpmyelin-associated oligodendrocyte basic protein0.025
Svs1seminal vesicle secretory protein 10.024
Slc6a18solute carrier family 6, member 180.024
F2rl2coagulation factor II (thrombin) receptor-like 20.024
Ugt2b7UDP glucuronosyltransferase 2 family, polypeptide B70.024
Leprleptin receptor0.024
Cd3gCD3 molecule, gamma0.024
Olr1500olfactory receptor 15000.024
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.023
Il6stinterleukin 6 signal transducer0.023
Egr3early growth response 30.023
Hckhemopoietic cell kinase0.023
Ccl4chemokine (C-C motif) ligand 40.023
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.022
Clec9aC-type lectin domain family 9, member a0.022
RGD1310262hypothetical LOC3046500.022
Slc36a2solute carrier family 36 (proton/amino acid symporter), member 20.022
LOC100363671hypothetical protein LOC1003636710.022
Vom1r90vomeronasal 1 receptor 900.022
Mamdc4MAM domain containing 40.022
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.022
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism