The network for 'presynaptic membrane organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

presynaptic membrane organization

The maintenance of membrane composition in a presynaptic membrane, a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.

NameDescriptionProbabilityFunc Analog Organism
HPhaptoglobin0.884
A2Malpha-2-macroglobulin0.821
ALBalbumin0.672
APOC1apolipoprotein C-I0.629
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.620
NEDD4neural precursor cell expressed, developmentally down-regulated 40.363
MYO16myosin XVI0.362
LCATlecithin-cholesterol acyltransferase0.298
DLG4discs, large homolog 4 (Drosophila)0.218
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.200
FGAfibrinogen alpha chain0.194
CDC27cell division cycle 27 homolog (S. cerevisiae)0.178
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.155
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.121
ADRB2adrenergic, beta-2-, receptor, surface0.113
APOC3apolipoprotein C-III0.094
APOA2apolipoprotein A-II0.068
PLTPphospholipid transfer protein0.065
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.063
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.056
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.054
BAI1brain-specific angiogenesis inhibitor 10.052
CDC16cell division cycle 16 homolog (S. cerevisiae)0.049
APOC2apolipoprotein C-II0.038
ECSITECSIT homolog (Drosophila)0.035
PDCD4programmed cell death 4 (neoplastic transformation inhibitor)0.034
MAPTmicrotubule-associated protein tau0.032
TTRtransthyretin0.030
ANAPC7anaphase promoting complex subunit 70.028
PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)0.028
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.026
DLGAP1discs, large (Drosophila) homolog-associated protein 10.026
PLP1proteolipid protein 10.026
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.025
TBC1D10ATBC1 domain family, member 10A0.023
CAV1caveolin 1, caveolae protein, 22kDa0.022
NRXN1neurexin 10.022
PDZD2PDZ domain containing 20.022
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.021
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.020
APOA1apolipoprotein A-I0.020
NCOA3nuclear receptor coactivator 30.020
ANAPC4anaphase promoting complex subunit 40.020
GRIA3glutamate receptor, ionotrophic, AMPA 30.020
MARK1MAP/microtubule affinity-regulating kinase 10.020
RNF2ring finger protein 20.019
NLGN1neuroligin 10.019
FAM83Cfamily with sequence similarity 83, member C0.018
TMCC2transmembrane and coiled-coil domain family 20.018
ANAPC5anaphase promoting complex subunit 50.018
DCTN1dynactin 10.018
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.017
LOXL4lysyl oxidase-like 40.017
SYT13synaptotagmin XIII0.016
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.016
SPOPspeckle-type POZ protein0.016
FRKfyn-related kinase0.016
CLEC4GC-type lectin domain family 4, member G0.016
DCXdoublecortin0.016
PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 20.015
OLIG2oligodendrocyte lineage transcription factor 20.015
GAP43growth associated protein 430.015
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.015
NRXN3neurexin 30.015
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.015
CHGBchromogranin B (secretogranin 1)0.014
SLC17A7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.014
GRM3glutamate receptor, metabotropic 30.014
APOEapolipoprotein E0.014
DLG2discs, large homolog 2 (Drosophila)0.014
ERC2ELKS/RAB6-interacting/CAST family member 20.014
MAST3microtubule associated serine/threonine kinase 30.014
NOL4nucleolar protein 40.014
NRCAMneuronal cell adhesion molecule0.014
SOX10SRY (sex determining region Y)-box 100.013
SLC6A15solute carrier family 6 (neutral amino acid transporter), member 150.013
GFAPglial fibrillary acidic protein0.013
GRIA2glutamate receptor, ionotropic, AMPA 20.013
FGF14fibroblast growth factor 140.013
GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 20.013
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.013
BAI3brain-specific angiogenesis inhibitor 30.013
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.013
CSRNP3cysteine-serine-rich nuclear protein 30.013
UNC5Cunc-5 homolog C (C. elegans)0.013
NFASCneurofascin0.013
DFNB31deafness, autosomal recessive 310.013
OPRK1opioid receptor, kappa 10.013
ASTN1astrotactin 10.012
NTRK3neurotrophic tyrosine kinase, receptor, type 30.012
SEPT4septin 40.012
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.012
LSAMPlimbic system-associated membrane protein0.012
LDLRlow density lipoprotein receptor0.012
NCANneurocan0.012
APOBapolipoprotein B (including Ag(x) antigen)0.012
PKNOX2PBX/knotted 1 homeobox 20.011
SNAP91synaptosomal-associated protein, 91kDa homolog (mouse)0.011
ATP1B2ATPase, Na+/K+ transporting, beta 2 polypeptide0.011
CDH8cadherin 8, type 20.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
McrMacroglobulin complement-related0.381
CG32635CG32635 gene product from transcript CG32635-RA0.110
brpbruchpilot0.098
Pk61CProtein kinase 61C0.081
Ank2Ankyrin 20.069
CaMKIICalcium/calmodulin-dependent protein kinase II0.063
Pi3K92ECG4141 gene product from transcript CG4141-RB0.062
neuroliginCG13772 gene product from transcript CG13772-RA0.040
hpohippo0.039
Nrx-IVNeurexin IV0.039
stnBstoned B0.026
Tsc1CG6147 gene product from transcript CG6147-RA0.023
Gyc76CGuanylyl cyclase at 76C0.023
rutrutabaga0.022
Ptp69DProtein tyrosine phosphatase 69D0.021
LIMK1LIM-kinase10.021
Aplip1APP-like protein interacting protein 10.020
wbwing blister0.020
NetBNetrin-B0.019
GluRIIAGlutamate receptor IIA0.019
amnamnesiac0.019
CrebACyclic-AMP response element binding protein A0.018
witwishful thinking0.018
Frq2Frequenin 20.017
Fak56DFocal Adhesion Kinase0.015
hiwhighwire0.015
DskDrosulfakinin0.015
OliOlig family0.013
gekgenghis khan0.013
CG4699CG4699 gene product from transcript CG4699-RJ0.012
Sema-1aCG18405 gene product from transcript CG18405-RD0.012
CG34353CG34353 gene product from transcript CG34353-RA0.011
Frq1Frequenin 10.011
toktolkin0.011
Tsf2Transferrin 20.011
CG12187CG12187 gene product from transcript CG12187-RA0.011
nwknervous wreck0.011
Nrx-1Neurexin 10.011
Fas3Fasciclin 30.010
GluRIIEGlutamate receptor IIE0.010
sanoserrano0.010
garzgartenzwerg0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Nrxn3neurexin III0.974
Nrxn1neurexin I0.924
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.605
Ctnnb1catenin (cadherin associated protein), beta 10.452
Nrxn2neurexin II0.349
Trp53transformation related protein 530.184
Ptprfprotein tyrosine phosphatase, receptor type, F0.162
Pkd1polycystic kidney disease 1 homolog0.128
Axin1axin 10.126
Grid2glutamate receptor, ionotropic, delta 20.110
Ptprdprotein tyrosine phosphatase, receptor type, D0.107
Odz2odd Oz/ten-m homolog 2 (Drosophila)0.094
Apoeapolipoprotein E0.087
Anks1bankyrin repeat and sterile alpha motif domain containing 1B0.075
Dab1disabled homolog 1 (Drosophila)0.072
Pcdh10protocadherin 100.069
Neto1neuropilin (NRP) and tolloid (TLL)-like 10.066
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.065
Fgfr2fibroblast growth factor receptor 20.042
Vstm2bV-set and transmembrane domain containing 2B0.042
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.041
D3Bwg0562eDNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed0.035
Ptprsprotein tyrosine phosphatase, receptor type, S0.033
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.032
Col1a1collagen, type I, alpha 10.031
Dlg4discs, large homolog 4 (Drosophila)0.030
Cdh8cadherin 80.029
Hspg2perlecan (heparan sulfate proteoglycan 2)0.028
Thrathyroid hormone receptor alpha0.028
Dccdeleted in colorectal carcinoma0.027
Npc1Niemann Pick type C10.026
Tbx3T-box 30.025
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.021
Pick1protein interacting with C kinase 10.021
Lrp1low density lipoprotein receptor-related protein 10.021
CamkvCaM kinase-like vesicle-associated0.020
Slc16a2solute carrier family 16 (monocarboxylic acid transporters), member 20.019
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.019
Lrp6low density lipoprotein receptor-related protein 60.018
Mesdc2mesoderm development candidate 20.018
Ntmneurotrimin0.017
Lrrtm4leucine rich repeat transmembrane neuronal 40.017
Cntnap2contactin associated protein-like 20.017
Cbln1cerebellin 1 precursor protein0.017
Gli3GLI-Kruppel family member GLI30.017
Lrp5low density lipoprotein receptor-related protein 50.016
Fgfr1fibroblast growth factor receptor 10.015
Nos3nitric oxide synthase 3, endothelial cell0.015
Fmn2formin 20.014
Lrfn5leucine rich repeat and fibronectin type III domain containing 50.014
Cntn6contactin 60.014
Asxl3additional sex combs like 3 (Drosophila)0.014
Ntng1netrin G10.014
Gabra1gamma-aminobutyric acid (GABA) A receptor, subunit alpha 10.014
Il1rapl1interleukin 1 receptor accessory protein-like 10.014
Itga3integrin alpha 30.013
Nrbp2nuclear receptor binding protein 20.013
Npas3neuronal PAS domain protein 30.013
Sorcs3sortilin-related VPS10 domain containing receptor 30.013
Slc22a8solute carrier family 22 (organic anion transporter), member 80.013
Myt1lmyelin transcription factor 1-like0.013
Cdh10cadherin 100.013
Lsamplimbic system-associated membrane protein0.012
Cadm2cell adhesion molecule 20.012
Ppargperoxisome proliferator activated receptor gamma0.012
Atcayataxia, cerebellar, Cayman type homolog (human)0.011
Nrcamneuron-glia-CAM-related cell adhesion molecule0.011
Notch2Notch gene homolog 2 (Drosophila)0.011
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.011
Dcxdoublecortin0.011
Ghrgrowth hormone receptor0.010
Npy2rneuropeptide Y receptor Y20.010
Scn1asodium channel, voltage-gated, type I, alpha0.010
Sorcs1VPS10 domain receptor protein SORCS 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dlg4discs, large homolog 4 (Drosophila)0.071
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.069
CamkvCaM kinase-like vesicle-associated0.065
Fgf14fibroblast growth factor 140.061
Kalrnkalirin, RhoGEF kinase0.050
Accn1amiloride-sensitive cation channel 1, neuronal0.048
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.037
RGD1304737similar to KIAA1086 protein0.031
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.031
Dgkgdiacylglycerol kinase, gamma0.028
Ppp1r9aprotein phosphatase 1, regulatory (inhibitor) subunit 9A0.028
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.027
Pnckpregnancy upregulated non-ubiquitously expressed CaM kinase0.026
Hpcahippocalcin0.025
Gria1glutamate receptor, ionotropic, AMPA 10.025
Syn1synapsin I0.025
Chrm3cholinergic receptor, muscarinic 30.023
Myt1lmyelin transcription factor 1-like0.023
Shank1SH3 and multiple ankyrin repeat domains 10.021
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.021
Nrxn1neurexin 10.020
Cdh6cadherin 60.019
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.019
Sema6bsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B0.018
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.018
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.017
Gria2glutamate receptor, ionotropic, AMPA 20.017
Ddndendrin0.016
Vamp2vesicle-associated membrane protein 20.016
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.015
Cpne5copine V0.015
Slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.015
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.014
Cnksr2connector enhancer of kinase suppressor of Ras 20.014
Atp1a3ATPase, Na+/K+ transporting, alpha 3 polypeptide0.014
Stx1bsyntaxin 1B0.014
Slc12a5solute carrier family 12 (potassium-chloride transporter), member 50.013
Nfascneurofascin0.013
Dnah11dynein, axonemal, heavy chain 110.013
Sept6septin 60.013
L1camL1 cell adhesion molecule0.013
Nrxn2neurexin 20.012
Mmp13matrix metallopeptidase 130.011
Ttll3tubulin tyrosine ligase-like family, member 30.011
Myo16myosin XVI0.011
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.011
Hrnbp3hexaribonucleotide binding protein 30.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism