The network for 'regulation of dna dependent dna replication initiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of dna dependent dna replication initiation

Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 20.915
ORC1origin recognition complex, subunit 10.670
MCM2minichromosome maintenance complex component 20.335
MCM7minichromosome maintenance complex component 70.275
ANAPC4anaphase promoting complex subunit 40.263
CDC6cell division cycle 6 homolog (S. cerevisiae)0.139
ANAPC5anaphase promoting complex subunit 50.127
MCM3minichromosome maintenance complex component 30.121
CCNE1cyclin E10.091
CDT1chromatin licensing and DNA replication factor 10.088
ANAPC1anaphase promoting complex subunit 10.079
MCM6minichromosome maintenance complex component 60.066
MCM4minichromosome maintenance complex component 40.066
MCM8minichromosome maintenance complex component 80.065
CDC20cell division cycle 20 homolog (S. cerevisiae)0.064
CDC27cell division cycle 27 homolog (S. cerevisiae)0.062
ANAPC7anaphase promoting complex subunit 70.061
CDC26cell division cycle 26 homolog (S. cerevisiae)0.053
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.051
FOXM1forkhead box M10.042
SSRP1structure specific recognition protein 10.037
CDC45cell division cycle 45 homolog (S. cerevisiae)0.036
MCM10minichromosome maintenance complex component 100.029
MORF4L1mortality factor 4 like 10.029
ORC6origin recognition complex, subunit 60.029
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.027
MCMBPminichromosome maintenance complex binding protein0.022
MMS22LMMS22-like, DNA repair protein0.021
E2F1E2F transcription factor 10.017
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.017
MRFAP1Morf4 family associated protein 10.015
CHAF1Achromatin assembly factor 1, subunit A (p150)0.014
CDR2cerebellar degeneration-related protein 2, 62kDa0.012
SKP2S-phase kinase-associated protein 2 (p45)0.011
ANAPC13anaphase promoting complex subunit 130.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.646
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.524
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.384
Kdm5blysine (K)-specific demethylase 5B0.315
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.307
Dnmt1DNA methyltransferase (cytosine-5) 10.203
Ccna2cyclin A20.149
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.132
Cdk4cyclin-dependent kinase 40.120
Hdac1histone deacetylase 10.120
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.098
Arid1aAT rich interactive domain 1A (SWI-like)0.085
Ccne1cyclin E10.083
Rrm2ribonucleotide reductase M20.057
Rfc5replication factor C (activator 1) 50.055
Lig1ligase I, DNA, ATP-dependent0.046
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.042
Ccnb2cyclin B20.041
Cdt1chromatin licensing and DNA replication factor 10.036
Timelesstimeless homolog (Drosophila)0.034
Tk1thymidine kinase 10.034
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.031
Sap25sin3 associated polypeptide0.023
Gmnngeminin0.022
Rnf220ring finger protein 2200.019
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.019
Birc5baculoviral IAP repeat-containing 50.019
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.017
Cdca8cell division cycle associated 80.017
Haus4HAUS augmin-like complex, subunit 40.016
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.015
Polepolymerase (DNA directed), epsilon0.013
E2f8E2F transcription factor 80.012
Sp1trans-acting transcription factor 10.011
Kif22kinesin family member 220.011
Rcc1regulator of chromosome condensation 10.011
Prc1protein regulator of cytokinesis 10.011
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.011
Cks1bCDC28 protein kinase 1b0.011
Flnafilamin, alpha0.010
Ncor1nuclear receptor co-repressor 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ORC2Orc2p0.958
MCM3Mcm3p0.926
MCM2Mcm2p0.899
MCM7Mcm7p0.876
MCM6Mcm6p0.828
ORC3Orc3p0.754
MCM4Mcm4p0.730
MCM10Mcm10p0.716
ORC1Orc1p0.557
ORC6Orc6p0.537
HAT1Hat1p0.484
DBF4Dbf4p0.475
ORC5Orc5p0.444
UME1Ume1p0.440
CDC6Cdc6p0.411
CLB5Clb5p0.388
SIN3Sin3p0.365
MDN1Mdn1p0.353
SLD3Sld3p0.274
ORC4Orc4p0.218
SDS3Sds3p0.185
MCM5Mcm5p0.180
RCO1Rco1p0.152
CDC14Cdc14p0.111
SIR2Sir2p0.103
DIA2Dia2p0.097
CDC45Cdc45p0.097
UME6Ume6p0.095
SLD2Sld2p0.093
SLD5Sld5p0.092
HST1Hst1p0.091
TAH11Tah11p0.090
CLB6Clb6p0.082
UFO1Ufo1p0.080
CHL1Chl1p0.069
IPI3Ipi3p0.067
SPC97Spc97p0.064
HDA2Hda2p0.064
IFH1Ifh1p0.063
HAT2Hat2p0.063
SWC4Swc4p0.062
RAD53Rad53p0.062
CHD1Chd1p0.060
OPI1Opi1p0.059
ASH1Ash1p0.054
HST3Hst3p0.050
SUM1Sum1p0.050
NDD1Ndd1p0.050
SET2Set2p0.050
CDC23Cdc23p0.049
UBP10Ubp10p0.049
SET3Set3p0.048
MOT3Mot3p0.042
NOC3Noc3p0.040
RPC34Rpc34p0.040
YLR264C-Ahypothetical protein0.039
OPT2Opt2p0.039
MRC1Mrc1p0.039
SIC1Sic1p0.038
VAC17Vac17p0.038
SAP30Sap30p0.038
ARP10Arp10p0.038
SRD1Srd1p0.037
HDA1Hda1p0.037
CDC7Cdc7p0.036
YAR068Whypothetical protein0.034
LEU2Leu2p0.034
ARG8Arg8p0.034
TFA1Tfa1p0.033
SPC98Spc98p0.032
THP2Thp2p0.032
YLR162Whypothetical protein0.032
SNT1Snt1p0.032
CHA1Cha1p0.031
SPL2Spl2p0.031
ADH2Adh2p0.031
CDC20Cdc20p0.031
YOL038C-Ahypothetical protein0.031
YGR079Whypothetical protein0.031
SET1Set1p0.030
MF(ALPHA)2Mf(alpha)2p0.030
URA3Ura3p0.029
FCY21Fcy21p0.029
IPI1Ipi1p0.028
MF(ALPHA)1Mf(alpha)1p0.028
ERB1Erb1p0.028
HXT3Hxt3p0.027
PRP45Prp45p0.027
MSA1Msa1p0.027
POL32Pol32p0.027
YLR455Whypothetical protein0.027
CLB1Clb1p0.027
MER1Mer1p0.027
HOHop0.026
YAR066Whypothetical protein0.026
ATP6Atp6p0.026
RAD9Rad9p0.026
CUP1-1Cup1-1p0.026
YLR042Chypothetical protein0.026
FMT1Fmt1p0.025