The network for 'positive regulation of wnt signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of wnt signaling pathway

Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.

NameDescriptionProbabilityFunc Analog Organism
CSNK1Ecasein kinase 1, epsilon0.998
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.997
SMAD3SMAD family member 30.991
APCadenomatous polyposis coli0.982
SMAD2SMAD family member 20.980
FGFR1fibroblast growth factor receptor 10.962
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.949
LRP6low density lipoprotein receptor-related protein 60.945
SMURF2SMAD specific E3 ubiquitin protein ligase 20.842
BIRC2baculoviral IAP repeat containing 20.834
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.776
BMPR1Abone morphogenetic protein receptor, type IA0.769
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.737
GSK3Bglycogen synthase kinase 3 beta0.718
COL1A1collagen, type I, alpha 10.696
AXIN1axin 10.685
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.670
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.637
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.627
TERF1telomeric repeat binding factor (NIMA-interacting) 10.616
SMAD4SMAD family member 40.596
SMAD1SMAD family member 10.556
FGF1fibroblast growth factor 1 (acidic)0.553
TNIP2TNFAIP3 interacting protein 20.524
SMAD5SMAD family member 50.515
DVL1dishevelled, dsh homolog 1 (Drosophila)0.512
YY1YY1 transcription factor0.510
DVL3dishevelled, dsh homolog 3 (Drosophila)0.506
GIPC1GIPC PDZ domain containing family, member 10.494
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.480
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.475
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.471
DDR2discoidin domain receptor tyrosine kinase 20.447
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.444
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.420
COL5A1collagen, type V, alpha 10.420
COL1A2collagen, type I, alpha 20.402
FZD1frizzled homolog 1 (Drosophila)0.366
ERBB2IPerbb2 interacting protein0.348
KIF5Bkinesin family member 5B0.345
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.337
BIRC3baculoviral IAP repeat containing 30.315
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.281
FBXW11F-box and WD repeat domain containing 110.267
GLIS2GLIS family zinc finger 20.259
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.255
RIN1Ras and Rab interactor 10.252
FGF10fibroblast growth factor 100.243
XIAPX-linked inhibitor of apoptosis0.237
MAP3K8mitogen-activated protein kinase kinase kinase 80.231
FSTL1follistatin-like 10.228
BTRCbeta-transducin repeat containing0.226
CAV1caveolin 1, caveolae protein, 22kDa0.215
RANBP2RAN binding protein 20.211
KLHL3kelch-like 3 (Drosophila)0.200
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.199
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.195
SMAD7SMAD family member 70.193
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.190
CDK6cyclin-dependent kinase 60.190
ARID1AAT rich interactive domain 1A (SWI-like)0.190
POSTNperiostin, osteoblast specific factor0.186
WNT3Awingless-type MMTV integration site family, member 3A0.185
MDM4Mdm4 p53 binding protein homolog (mouse)0.184
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.178
ATF7IPactivating transcription factor 7 interacting protein0.177
COL4A1collagen, type IV, alpha 10.171
WNT5Awingless-type MMTV integration site family, member 5A0.166
TRIM33tripartite motif containing 330.163
PARVAparvin, alpha0.161
APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 20.156
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.154
SFRP1secreted frizzled-related protein 10.154
DAXXdeath-domain associated protein0.154
COL3A1collagen, type III, alpha 10.152
COL6A1collagen, type VI, alpha 10.149
MXRA5matrix-remodelling associated 50.146
CSNK1A1casein kinase 1, alpha 10.145
SKILSKI-like oncogene0.145
NCOA1nuclear receptor coactivator 10.141
RASSF5Ras association (RalGDS/AF-6) domain family member 50.139
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.136
SIRT1sirtuin 10.130
SMAD6SMAD family member 60.129
RNF111ring finger protein 1110.126
SMAD9SMAD family member 90.122
MCCmutated in colorectal cancers0.122
RNF11ring finger protein 110.121
LIMD1LIM domains containing 10.119
USP9Xubiquitin specific peptidase 9, X-linked0.119
APPamyloid beta (A4) precursor protein0.118
OCLNoccludin0.118
TOX4TOX high mobility group box family member 40.115
GATAD2AGATA zinc finger domain containing 2A0.114
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.110
ARID1BAT rich interactive domain 1B (SWI1-like)0.110
HUWE1HECT, UBA and WWE domain containing 10.108
PUM1pumilio homolog 1 (Drosophila)0.101
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.098
STRN3striatin, calmodulin binding protein 30.098
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp4bone morphogenetic protein 40.137
wnt4awingless-type MMTV integration site family, member 4a0.100
bmp2abone morphogenetic protein 2a0.085
sparcsecreted acidic cysteine rich glycoprotein0.080
spry2sprouty homolog 20.071
mibmind bomb0.051
wnt3awingless-type MMTV integration site family, member 3A0.051
sulf1sulfatase 10.047
igfbp3insulin-like growth factor binding protein 30.045
wnt5bwingless-type MMTV integration site family, member 5b0.042
per3period homolog 3 (Drosophila)0.038
tcf7transcription factor 7 (T-cell specific, HMG-box)0.038
lhx2bLIM homeobox 2b0.036
tbx1T-box 10.035
twist3twist30.033
msxbmuscle segment homeobox B0.033
wnt7aawingless-type MMTV integration site family, member 7Aa0.028
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.027
fgf3fibroblast growth factor 30.025
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.023
col2a1acollagen type II, alpha-1a0.021
sulf2lsulfatase 2, like0.021
sulf2sulfatase 20.020
dusp6dual specificity phosphatase 60.020
vimvimentin0.019
wnt3wingless-type MMTV integration site family, member 30.019
pcdh19protocadherin 190.019
robo1roundabout homolog 10.019
gli3GLI-Kruppel family member GLI30.018
wlswntless homolog (Drosophila)0.017
col5a1procollagen, type V, alpha 10.017
map2k4amitogen-activated protein kinase kinase 4a0.016
zbtb4zinc finger and BTB domain containing 40.016
wnt7bawingless-type MMTV integration site family, member 7Ba0.016
btybloodthirsty0.015
vcanbversican b0.014
fgfr1afibroblast growth factor receptor 1a0.014
flhfloating head0.014
col14a1collagen, type XIV, alpha 10.013
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.013
col1a2collagen, type I, alpha 20.013
oprm1opioid receptor, mu 10.013
her5hairy-related 50.013
aldh1a3aldehyde dehydrogenase 1 family, member A30.013
dctn1adynactin 1a0.013
frem3Fras1 related extracellular matrix 30.012
crb2acrumbs homolog 2a0.012
tuba1ltubulin, alpha 1, like0.012
zfyve26zinc finger, FYVE domain containing 260.012
wnt9awingless-type MMTV integration site family, member 9A0.012
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.012
dlbdeltaB0.012
lhx6LIM homeobox 60.012
guca1cguanylate cyclase activator 1C0.012
postnperiostin, osteoblast specific factor0.012
efnb2aephrin B2a0.012
runx2arunt-related transcription factor 2a0.012
dcndecorin0.012
foxo3bforkhead box O3b0.012
wnt9bwingless-type MMTV integration site family, member 9B0.011
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.011
crb3acrumbs homolog 3a0.011
wnt7bbwingless-type MMTV integration site family, member 7Bb0.011
wnt8bwingless-type MMTV integration site family, member 8b0.011
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.011
wnt16wingless-type MMTV integration site family, member 160.010
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.010
wif1wnt inhibitory factor 10.010
csnk1dacasein kinase 1, delta a0.010
sfrp1asecreted frizzled-related protein 1a0.010
flt4fms-related tyrosine kinase 40.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
skdskuld0.880
wlswntless0.872
fzfrizzled0.664
O-fut1O-fucosyltransferase 10.618
Wnt2Wnt oncogene analog 20.618
Tsc1CG6147 gene product from transcript CG6147-RA0.583
dshdishevelled0.467
baibaiser0.423
p24-1p24-related-10.410
phlpole hole0.360
EcREcdysone receptor0.360
ecaeclair0.343
wgwingless0.340
p24-2p24-related-20.282
rdxroadkill0.262
ykiyorkie0.256
hpohippo0.234
jingCG9397 gene product from transcript CG9397-RI0.228
ovoCG6824 gene product from transcript CG6824-RE0.225
sdscalloped0.218
Bre1CG10542 gene product from transcript CG10542-RA0.216
nctnicastrin0.212
WnkCG7177 gene product from transcript CG7177-RA0.195
CHOp24CG3564 gene product from transcript CG3564-RA0.184
ash2absent, small, or homeotic discs 20.178
garzgartenzwerg0.166
Hs6stHeparan sulfate 6-O-sulfotransferase0.154
rokRho-kinase0.148
G-oalpha47AG protein oalpha 47A0.138
CkIIalphaCasein kinase II alpha subunit0.134
bip2CG2009 gene product from transcript CG2009-RA0.133
Zyx102EFCG32018 gene product from transcript CG32018-RA0.127
DokDownstream of kinase0.120
stgstring0.115
bnlbranchless0.113
foifear-of-intimacy0.109
CG9941CG9941 gene product from transcript CG9941-RA0.107
SmrSmrter0.102
mib1mind bomb 10.096
FsFollistatin0.096
sflsulfateless0.090
TolloCG6890 gene product from transcript CG6890-RA0.089
pntpointed0.088
giggigas0.085
Klp64DKinesin-like protein at 64D0.083
klarklarsicht0.081
CG4567CG4567 gene product from transcript CG4567-RA0.078
fz2frizzled 20.077
inscinscuteable0.077
SerSerrate0.076
CG9053CG9053 gene product from transcript CG9053-RA0.074
Hsc70-3Heat shock protein cognate 30.073
Dcr-1Dicer-10.071
armarmadillo0.070
carcarnation0.069
dispdispatched0.067
Rab23CG2108 gene product from transcript CG2108-RA0.067
rkrickets0.066
wdbwiderborst0.064
CtBPC-terminal Binding Protein0.064
TER94CG2331 gene product from transcript CG2331-RA0.064
captcapulet0.063
MaxCG9648 gene product from transcript CG9648-RA0.057
opaodd paired0.056
LamCLamin C0.056
vgvestigial0.055
sglsugarless0.055
Syx5Syntaxin 50.054
AxnAxin0.053
piepineapple eye0.053
EloAElongin A0.052
CG11347CG11347 gene product from transcript CG11347-RE0.051
dapdacapo0.050
pnrpannier0.050
PcafCG4107 gene product from transcript CG4107-RA0.049
sbbscribbler0.049
simjsimjang0.047
dvedefective proventriculus0.045
taitaiman0.044
flrflare0.044
Su(H)Suppressor of Hairless0.044
mammastermind0.043
hephhephaestus0.042
CycDCyclin D0.042
MarfMitochondrial assembly regulatory factor0.042
JhI-1Juvenile hormone-inducible protein 10.042
arrarrow0.041
trctricornered0.040
ecdecdysoneless0.039
CG9630CG9630 gene product from transcript CG9630-RA0.039
CG42574CG42574 gene product from transcript CG42574-RE0.038
Ptp61FProtein tyrosine phosphatase 61F0.038
pygopygopus0.036
domedomeless0.036
EndoGIEndonuclease G inhibitor0.035
Sac1CG9128 gene product from transcript CG9128-RB0.035
jimCG11352 gene product from transcript CG11352-RB0.035
PaxPaxillin0.035
prodproliferation disrupter0.034
srstripe0.034
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.998
Gli3GLI-Kruppel family member GLI30.994
Bmp4bone morphogenetic protein 40.990
Sox9SRY-box containing gene 90.984
Trp53transformation related protein 530.978
Fgfr1fibroblast growth factor receptor 10.963
Msx1homeobox, msh-like 10.963
Vangl2vang-like 2 (van gogh, Drosophila)0.957
Shhsonic hedgehog0.912
Bmp7bone morphogenetic protein 70.905
Ctnnb1catenin (cadherin associated protein), beta 10.891
Dvl2dishevelled 2, dsh homolog (Drosophila)0.887
Ror2receptor tyrosine kinase-like orphan receptor 20.880
Lrp6low density lipoprotein receptor-related protein 60.860
Wnt3awingless-related MMTV integration site 3A0.852
Smosmoothened homolog (Drosophila)0.849
Fgfr3fibroblast growth factor receptor 30.842
Fgf8fibroblast growth factor 80.841
Fgf10fibroblast growth factor 100.832
Hand1heart and neural crest derivatives expressed transcript 10.815
Pax8paired box gene 80.813
Prrx1paired related homeobox 10.796
Ahraryl-hydrocarbon receptor0.781
Efsembryonal Fyn-associated substrate0.760
Wnt5awingless-related MMTV integration site 5A0.758
Pax3paired box gene 30.752
Tgfb2transforming growth factor, beta 20.720
Chrdchordin0.717
Gli2GLI-Kruppel family member GLI20.715
Alx4aristaless-like homeobox 40.713
Dvl3dishevelled 3, dsh homolog (Drosophila)0.699
Hand2heart and neural crest derivatives expressed transcript 20.686
Nodalnodal0.685
Foxc1forkhead box C10.673
Leprleptin receptor0.670
Dlx5distal-less homeobox 50.642
Ptk2PTK2 protein tyrosine kinase 20.635
Itgb1integrin beta 1 (fibronectin receptor beta)0.615
Ntf3neurotrophin 30.611
Dkk1dickkopf homolog 1 (Xenopus laevis)0.539
Ptenphosphatase and tensin homolog0.538
Retret proto-oncogene0.533
Rspo2R-spondin 2 homolog (Xenopus laevis)0.502
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.488
Zeb1zinc finger E-box binding homeobox 10.473
Sfrp2secreted frizzled-related protein 20.472
Acvr1activin A receptor, type 10.471
Axin1axin 10.462
Bmpr1abone morphogenetic protein receptor, type 1A0.427
Csf1colony stimulating factor 1 (macrophage)0.413
Bmp2bone morphogenetic protein 20.405
Sall4sal-like 4 (Drosophila)0.386
Runx2runt related transcription factor 20.372
Amhr2anti-Mullerian hormone type 2 receptor0.369
Gsk3bglycogen synthase kinase 3 beta0.366
Tgfatransforming growth factor alpha0.352
Prrx2paired related homeobox 20.352
Lmx1bLIM homeobox transcription factor 1 beta0.351
Vangl1vang-like 1 (van gogh, Drosophila)0.349
Msx2homeobox, msh-like 20.349
Pou3f3POU domain, class 3, transcription factor 30.341
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.334
Ptk7PTK7 protein tyrosine kinase 70.332
Gbx2gastrulation brain homeobox 20.323
Apcadenomatosis polyposis coli0.317
Nr0b1nuclear receptor subfamily 0, group B, member 10.311
En1engrailed 10.303
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.303
Yap1yes-associated protein 10.298
Nognoggin0.297
Sfrp1secreted frizzled-related protein 10.294
Lef1lymphoid enhancer binding factor 10.293
Wnt6wingless-related MMTV integration site 60.287
Smad6MAD homolog 6 (Drosophila)0.281
Ror1receptor tyrosine kinase-like orphan receptor 10.274
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.274
Pax2paired box gene 20.273
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.270
Efnb2ephrin B20.269
Foxn1forkhead box N10.262
Zic3zinc finger protein of the cerebellum 30.258
Ednrbendothelin receptor type B0.257
Bdnfbrain derived neurotrophic factor0.253
Gli1GLI-Kruppel family member GLI10.248
Lhx1LIM homeobox protein 10.236
Hoxd13homeobox D130.233
Npr3natriuretic peptide receptor 30.231
Eya1eyes absent 1 homolog (Drosophila)0.226
Lrp2low density lipoprotein receptor-related protein 20.225
Lama5laminin, alpha 50.222
CblCasitas B-lineage lymphoma0.216
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.215
Hes1hairy and enhancer of split 1 (Drosophila)0.211
Wnt4wingless-related MMTV integration site 40.210
Arandrogen receptor0.207
Hsd11b2hydroxysteroid 11-beta dehydrogenase 20.202
Foxc2forkhead box C20.199
Alx3aristaless-like homeobox 30.197
Esr1estrogen receptor 1 (alpha)0.189
Hhexhematopoietically expressed homeobox0.189
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism