The network for 'cholesterol biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

NameDescriptionProbabilityFunc Analog Organism
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.998
Dhcr77-dehydrocholesterol reductase0.980
Ldlrlow density lipoprotein receptor0.980
Sqlesqualene epoxidase0.975
Lsslanosterol synthase0.962
Mvdmevalonate (diphospho) decarboxylase0.959
Dhcr2424-dehydrocholesterol reductase0.888
Cyp51cytochrome P450, family 510.867
Sc4molsterol-C4-methyl oxidase-like0.788
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.638
Fasnfatty acid synthase0.584
Idi1isopentenyl-diphosphate delta isomerase0.455
Apoa1apolipoprotein A-I0.440
Aacsacetoacetyl-CoA synthetase0.282
Hsd17b7hydroxysteroid (17-beta) dehydrogenase 70.251
Acat2acetyl-Coenzyme A acetyltransferase 20.221
Lyz2lysozyme 20.217
Npc1Niemann Pick type C10.206
Apoeapolipoprotein E0.201
Sc5dsterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)0.176
Fdpsfarnesyl diphosphate synthetase0.158
NsdhlNAD(P) dependent steroid dehydrogenase-like0.156
Srebf2sterol regulatory element binding factor 20.147
Stard4StAR-related lipid transfer (START) domain containing 40.124
Slc25a1solute carrier family 25 (mitochondrial carrier, citrate transporter), member 10.119
Tm7sf2transmembrane 7 superfamily member 20.115
Scd1stearoyl-Coenzyme A desaturase 10.109
AclyATP citrate lyase0.107
Mvkmevalonate kinase0.105
Apobapolipoprotein B0.094
0610007P14RikRIKEN cDNA 0610007P14 gene0.078
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.065
Insig1insulin induced gene 10.065
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.065
Rdh11retinol dehydrogenase 110.063
Ebag9estrogen receptor-binding fragment-associated gene 90.056
Aldobaldolase B, fructose-bisphosphate0.054
Scd2stearoyl-Coenzyme A desaturase 20.053
Elovl6ELOVL family member 6, elongation of long chain fatty acids (yeast)0.051
Fads2fatty acid desaturase 20.044
Lrp1low density lipoprotein receptor-related protein 10.043
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.042
Scarb1scavenger receptor class B, member 10.036
Srebf1sterol regulatory element binding transcription factor 10.033
Slc9a3r1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.032
Eif2ak3eukaryotic translation initiation factor 2 alpha kinase 30.028
Hnf4ahepatic nuclear factor 4, alpha0.028
Pgdphosphogluconate dehydrogenase0.027
Fdft1farnesyl diphosphate farnesyl transferase 10.023
Pmvkphosphomevalonate kinase0.020
Leprleptin receptor0.020
Slc4a4solute carrier family 4 (anion exchanger), member 40.020
Tmem97transmembrane protein 970.020
Ppargperoxisome proliferator activated receptor gamma0.019
Abhd5abhydrolase domain containing 50.019
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.019
Reep6receptor accessory protein 60.019
Fads1fatty acid desaturase 10.017
Cyb5bcytochrome b5 type B0.017
Apoc3apolipoprotein C-III0.017
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.016
Ormdl1ORM1-like 1 (S. cerevisiae)0.015
Apomapolipoprotein M0.015
Srfserum response factor0.015
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.014
Mt1metallothionein 10.014
C3complement component 30.013
Pltpphospholipid transfer protein0.013
Azgp1alpha-2-glycoprotein 1, zinc0.013
Apoa2apolipoprotein A-II0.013
Angptl4angiopoietin-like 40.013
Nr2f6nuclear receptor subfamily 2, group F, member 60.013
Pklrpyruvate kinase liver and red blood cell0.013
Foxa2forkhead box A20.013
Gcgrglucagon receptor0.013
Slc33a1solute carrier family 33 (acetyl-CoA transporter), member 10.012
Fggfibrinogen gamma chain0.012
Mt2metallothionein 20.012
Cdhr5cadherin-related family member 50.012
Mertkc-mer proto-oncogene tyrosine kinase0.012
Otcornithine transcarbamylase0.011
Sigmar1sigma non-opioid intracellular receptor 10.011
Zg16zymogen granule protein 160.011
Klf15Kruppel-like factor 150.011
Bscl2Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)0.011
Apoa4apolipoprotein A-IV0.011
Sar1bSAR1 gene homolog B (S. cerevisiae)0.010
Lgals2lectin, galactose-binding, soluble 20.010
Kitkit oncogene0.010
ErfEts2 repressor factor0.010
Men1multiple endocrine neoplasia 10.010
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.010
Lcatlecithin cholesterol acyltransferase0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.911
SREBF2sterol regulatory element binding transcription factor 20.281
SC4MOLsterol-C4-methyl oxidase-like0.236
INSIG1insulin induced gene 10.228
DHCR77-dehydrocholesterol reductase0.208
SQLEsqualene epoxidase0.190
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.124
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.123
IDI1isopentenyl-diphosphate delta isomerase 10.073
LDLRlow density lipoprotein receptor0.052
FDFT1farnesyl-diphosphate farnesyltransferase 10.048
FADS1fatty acid desaturase 10.045
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.043
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.039
C14orf1chromosome 14 open reading frame 10.036
SLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 10.025
DHCR2424-dehydrocholesterol reductase0.022
FGFR1fibroblast growth factor receptor 10.021
MVDmevalonate (diphospho) decarboxylase0.021
FGF1fibroblast growth factor 1 (acidic)0.016
PGRMC1progesterone receptor membrane component 10.015
APOC1apolipoprotein C-I0.011
FDPSfarnesyl diphosphate synthase0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sc4molsterol-C4-methyl oxidase-like0.999
Cyp51cytochrome P450, family 510.993
Fasnfatty acid synthase0.597
Sqlesqualene epoxidase0.375
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.337
Idi1isopentenyl-diphosphate delta isomerase 10.303
Insig1insulin induced gene 10.162
Fdft1farnesyl diphosphate farnesyl transferase 10.081
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.059
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.054
Acat3acetyl-Coenzyme A acetyltransferase 30.043
Dhcr2424-dehydrocholesterol reductase0.036
Lsslanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.031
Dhcr77-dehydrocholesterol reductase0.026
Hsd17b7hydroxysteroid (17-beta) dehydrogenase 70.020
Mvkmevalonate kinase0.018
Tm7sf2transmembrane 7 superfamily member 20.017
NsdhlNAD(P) dependent steroid dehydrogenase-like0.014
Sc5dlsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism