The network for 'antigen receptor mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

antigen receptor mediated signaling pathway

A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell.

NameDescriptionProbabilityFunc Analog Organism
Latlinker for activation of T cells0.999
FynFyn proto-oncogene0.998
Ikzf1IKAROS family zinc finger 10.994
Inpp5dinositol polyphosphate-5-phosphatase D0.991
Ptprcprotein tyrosine phosphatase, receptor type, C0.984
Lcklymphocyte protein tyrosine kinase0.983
Traf6TNF receptor-associated factor 60.980
Cd19CD19 antigen0.974
ItkIL2-inducible T-cell kinase0.973
Ighimmunoglobulin heavy chain complex0.962
Cd247CD247 antigen0.961
Gata4GATA binding protein 40.955
Cd6CD6 antigen0.942
Icosinducible T-cell co-stimulator0.942
Tnfaip3tumor necrosis factor, alpha-induced protein 30.940
Ptk2PTK2 protein tyrosine kinase 20.931
CblCasitas B-lineage lymphoma0.929
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.929
Ltblymphotoxin B0.928
Il2rginterleukin 2 receptor, gamma chain0.927
Cd28CD28 antigen0.919
Il2rbinterleukin 2 receptor, beta chain0.918
Zap70zeta-chain (TCR) associated protein kinase0.915
Vav1vav 1 oncogene0.889
Cd5CD5 antigen0.880
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.863
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.860
Slamf1signaling lymphocytic activation molecule family member 10.854
Grb2growth factor receptor bound protein 20.853
Foxp3forkhead box P30.840
WasWiskott-Aldrich syndrome homolog (human)0.811
Map3k7mitogen-activated protein kinase kinase kinase 70.800
Il27rainterleukin 27 receptor, alpha0.796
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.784
FasFas (TNF receptor superfamily member 6)0.780
Socs1suppressor of cytokine signaling 10.765
Cd3eCD3 antigen, epsilon polypeptide0.763
Bcl2B-cell leukemia/lymphoma 20.745
Ptpn6protein tyrosine phosphatase, non-receptor type 60.736
FaslFas ligand (TNF superfamily, member 6)0.732
Cd40CD40 antigen0.729
Itgalintegrin alpha L0.723
TcraT-cell receptor alpha chain0.713
Gimap7GTPase, IMAP family member 70.712
Cd7CD7 antigen0.694
Prdm1PR domain containing 1, with ZNF domain0.688
Runx1runt related transcription factor 10.682
Slamf6SLAM family member 60.675
FcrlaFc receptor-like A0.655
Cd4CD4 antigen0.651
Ikzf3IKAROS family zinc finger 30.649
Stat3signal transducer and activator of transcription 30.626
Rhohras homolog gene family, member H0.626
Sellselectin, lymphocyte0.623
Grap2GRB2-related adaptor protein 20.621
Rxraretinoid X receptor alpha0.621
Dok1docking protein 10.612
SrcRous sarcoma oncogene0.607
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.605
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.604
Cd3gCD3 antigen, gamma polypeptide0.596
Cd22CD22 antigen0.594
BtkBruton agammaglobulinemia tyrosine kinase0.593
Il10rainterleukin 10 receptor, alpha0.582
Card11caspase recruitment domain family, member 110.570
Cd27CD27 antigen0.562
Cd3dCD3 antigen, delta polypeptide0.554
Cd2CD2 antigen0.540
Nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.537
Fcgr2bFc receptor, IgG, low affinity IIb0.532
Cd44CD44 antigen0.531
Tnfrsf13ctumor necrosis factor receptor superfamily, member 13c0.522
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.521
Cd96CD96 antigen0.519
Tnftumor necrosis factor0.506
Casp8caspase 80.489
Il7rinterleukin 7 receptor0.477
Il21rinterleukin 21 receptor0.476
Rc3h1RING CCCH (C3H) domains 10.474
Sit1suppression inducing transmembrane adaptor 10.472
Ccr6chemokine (C-C motif) receptor 60.472
Prkceprotein kinase C, epsilon0.471
Batfbasic leucine zipper transcription factor, ATF-like0.470
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.466
Lyl1lymphoblastomic leukemia 10.462
Cd8aCD8 antigen, alpha chain0.460
S1pr4sphingosine-1-phosphate receptor 40.453
Sh2d2aSH2 domain protein 2A0.451
Jak2Janus kinase 20.447
Tgfb1transforming growth factor, beta 10.442
Ccr1chemokine (C-C motif) receptor 10.438
Sh2d1aSH2 domain protein 1A0.432
Pou2af1POU domain, class 2, associating factor 10.429
Cd80CD80 antigen0.423
Ptenphosphatase and tensin homolog0.408
Cd180CD180 antigen0.404
Ccl2chemokine (C-C motif) ligand 20.401
Cd8b1CD8 antigen, beta chain 10.394
Flt1FMS-like tyrosine kinase 10.381
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.378
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.999
LCKlymphocyte-specific protein tyrosine kinase0.998
LATlinker for activation of T cells0.998
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.997
GRB2growth factor receptor-bound protein 20.996
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.995
EGFRepidermal growth factor receptor0.993
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.991
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.990
FYNFYN oncogene related to SRC, FGR, YES0.984
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.973
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.972
PTK2PTK2 protein tyrosine kinase 20.964
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.962
SYKspleen tyrosine kinase0.948
VAV1vav 1 guanine nucleotide exchange factor0.933
BCL2L1BCL2-like 10.911
PTPN1protein tyrosine phosphatase, non-receptor type 10.881
SHC1SHC (Src homology 2 domain containing) transforming protein 10.880
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.850
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.831
PLCG1phospholipase C, gamma 10.805
BTN3A2butyrophilin, subfamily 3, member A20.783
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.763
GRAP2GRB2-related adaptor protein 20.751
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.747
PTPRCprotein tyrosine phosphatase, receptor type, C0.743
WIPF1WAS/WASL interacting protein family, member 10.724
SH2D1ASH2 domain containing 1A0.722
FYBFYN binding protein0.709
TRAF3TNF receptor-associated factor 30.689
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.676
BIRC3baculoviral IAP repeat containing 30.608
BCL2B-cell CLL/lymphoma 20.591
CD80CD80 molecule0.580
BLNKB-cell linker0.577
CD247CD247 molecule0.529
CD79ACD79a molecule, immunoglobulin-associated alpha0.522
PSEN1presenilin 10.520
BTN3A3butyrophilin, subfamily 3, member A30.520
ABI1abl-interactor 10.511
BAXBCL2-associated X protein0.509
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.504
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.486
SPRR2Asmall proline-rich protein 2A0.451
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.434
MPDZmultiple PDZ domain protein0.421
PRKCQprotein kinase C, theta0.418
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.416
CARD11caspase recruitment domain family, member 110.380
SOS1son of sevenless homolog 1 (Drosophila)0.371
GHRgrowth hormone receptor0.368
TRAF1TNF receptor-associated factor 10.349
SQSTM1sequestosome 10.345
TRAF6TNF receptor-associated factor 60.336
BCL2L11BCL2-like 11 (apoptosis facilitator)0.329
TFF1trefoil factor 10.323
CD40CD40 molecule, TNF receptor superfamily member 50.281
NCK1NCK adaptor protein 10.281
BTN3A1butyrophilin, subfamily 3, member A10.280
RNF31ring finger protein 310.278
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.263
BCAR1breast cancer anti-estrogen resistance 10.259
SH3KBP1SH3-domain kinase binding protein 10.252
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.243
GAB1GRB2-associated binding protein 10.216
HDAC7histone deacetylase 70.189
SH3BP2SH3-domain binding protein 20.169
ADAM15ADAM metallopeptidase domain 150.168
MAPK1mitogen-activated protein kinase 10.167
PTK2BPTK2B protein tyrosine kinase 2 beta0.166
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.161
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.152
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.142
VAV2vav 2 guanine nucleotide exchange factor0.141
HDAC9histone deacetylase 90.131
TRIP6thyroid hormone receptor interactor 60.127
SLASrc-like-adaptor0.126
PTPN11protein tyrosine phosphatase, non-receptor type 110.123
STRADASTE20-related kinase adaptor alpha0.121
GAS7growth arrest-specific 70.120
MS4A1membrane-spanning 4-domains, subfamily A, member 10.119
GRB10growth factor receptor-bound protein 100.116
CD79BCD79b molecule, immunoglobulin-associated beta0.113
TRIM32tripartite motif containing 320.110
SH2D2ASH2 domain containing 2A0.106
BIDBH3 interacting domain death agonist0.104
BCL10B-cell CLL/lymphoma 100.104
SMURF2SMAD specific E3 ubiquitin protein ligase 20.101
NCK2NCK adaptor protein 20.100
MAPK3mitogen-activated protein kinase 30.098
NCF1neutrophil cytosolic factor 10.097
SMURF1SMAD specific E3 ubiquitin protein ligase 10.096
CTNND1catenin (cadherin-associated protein), delta 10.092
CD22CD22 molecule0.090
SFNstratifin0.090
TRAF5TNF receptor-associated factor 50.089
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.088
FHL2four and a half LIM domains 20.085
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ptpn18protein tyrosine phosphatase, non-receptor type 180.463
Lcp2lymphocyte cytosolic protein 20.363
Klhl6kelch-like 6 (Drosophila)0.310
Stk10serine/threonine kinase 100.138
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.133
Cd247Cd247 molecule0.132
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.127
Cd3gCD3 molecule, gamma0.109
Vav1vav 1 guanine nucleotide exchange factor0.098
Il2rginterleukin 2 receptor, gamma0.098
Cd37CD37 molecule0.097
Stap1signal transducing adaptor family member 10.093
Icosinducible T-cell co-stimulator0.092
Arhgap25Rho GTPase activating protein 250.084
Sash3SAM and SH3 domain containing 30.083
Arhgap4Rho GTPase activating protein 40.070
Limd2LIM domain containing 20.060
Inpp5dinositol polyphosphate-5-phosphatase D0.058
Cd83CD83 molecule0.057
Sept6septin 60.054
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.053
Ctsecathepsin E0.052
Ncf4neutrophil cytosolic factor 40.050
Bin2bridging integrator 20.050
Casp1caspase 10.049
Sirpasignal-regulatory protein alpha0.049
Lcklymphocyte-specific protein tyrosine kinase0.048
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.048
Map3k3mitogen activated protein kinase kinase kinase 30.046
Elk3ELK3, ETS-domain protein0.046
Cd86CD86 molecule0.045
Ptpn6protein tyrosine phosphatase, non-receptor type 60.042
Coro1bcoronin, actin-binding protein, 1B0.042
Cskc-src tyrosine kinase0.042
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.041
Fam26ffamily with sequence similarity 26, member F0.041
Cd8aCD8a molecule0.041
Rac1ras-related C3 botulinum toxin substrate 10.041
BtkBruton agammaglobulinemia tyrosine kinase0.041
Gimap4GTPase, IMAP family member 40.040
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.040
Cybbcytochrome b-245, beta polypeptide0.040
Gata2GATA binding protein 20.038
Igh-6immunoglobulin heavy chain 60.038
Ptafrplatelet-activating factor receptor0.038
Cybasc3cytochrome b, ascorbate dependent 30.036
Gmfgglia maturation factor, gamma0.036
Dock8dedicator of cytokinesis 80.035
TcrbT-cell receptor beta chain0.035
Cd2Cd2 molecule0.034
Mov10Moloney leukemia virus 100.034
FynFYN oncogene related to SRC, FGR, YES0.034
Cfpcomplement factor properdin0.034
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.033
Gpsm3G-protein signaling modulator 3 (AGS3-like, C. elegans)0.032
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.032
Il16interleukin 160.032
Cr2complement receptor 20.032
Vegfavascular endothelial growth factor A0.032
Pctpphosphatidylcholine transfer protein0.032
RGD1560108similar to RIKEN cDNA 2700081O150.032
Cxcr3chemokine (C-X-C motif) receptor 30.032
Nrg2neuregulin 20.031
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.031
Ptpn7protein tyrosine phosphatase, non-receptor type 70.031
Aif1allograft inflammatory factor 10.030
Arrb2arrestin, beta 20.030
Stk4serine/threonine kinase 40.029
Plcg2phospholipase C, gamma 20.029
Dgkadiacylglycerol kinase, alpha0.029
Evi2aecotropic viral integration site 2A0.028
Tpm3tropomyosin 3, gamma0.028
Traf3ip3TRAF3 interacting protein 30.028
Cdc2l6cell division cycle 2-like 6 (CDK8-like)0.027
Sdc3syndecan 30.027
Cxcr4chemokine (C-X-C motif) receptor 40.027
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.027
Prkcdprotein kinase C, delta0.027
LOC308990hypothetical protein LOC3089900.027
Trafd1TRAF type zinc finger domain containing 10.027
Myo1bmyosin Ib0.027
Rnaselribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)0.027
Il2rbinterleukin 2 receptor, beta0.026
Il18r1interleukin 18 receptor 10.026
Elf1E74-like factor 10.026
Stat4signal transducer and activator of transcription 40.026
Tor1aip1torsin A interacting protein 10.026
Fam113bfamily with sequence similarity 113, member B0.025
Ly86lymphocyte antigen 860.025
Itpr2inositol 1,4,5-triphosphate receptor, type 20.025
Psd4pleckstrin and Sec7 domain containing 40.025
Cd8bCD8b molecule0.025
Smad7SMAD family member 70.025
Map3k8mitogen-activated protein kinase kinase kinase 80.025
Figfc-fos induced growth factor0.024
Dusp2dual specificity phosphatase 20.024
Otud5OTU domain containing 50.024
RT1-M3-1RT1 class Ib, locus M3, gene 10.024
Cyb5r1cytochrome b5 reductase 10.024
Zbp1Z-DNA binding protein 10.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism