The network for 'regulation of t cell receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of t cell receptor signaling pathway

Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

NameDescriptionProbabilityFunc Analog Organism
Ptprcprotein tyrosine phosphatase, receptor type, C0.906
Ikzf1IKAROS family zinc finger 10.859
Inpp5dinositol polyphosphate-5-phosphatase D0.752
Foxp3forkhead box P30.698
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.345
Ccl2chemokine (C-C motif) ligand 20.332
Grb2growth factor receptor bound protein 20.293
Lyz2lysozyme 20.259
TcraT-cell receptor alpha chain0.232
Latlinker for activation of T cells0.231
Cd80CD80 antigen0.205
Cd247CD247 antigen0.197
Il2rginterleukin 2 receptor, gamma chain0.194
Tnftumor necrosis factor0.167
Rc3h1RING CCCH (C3H) domains 10.153
Ifnginterferon gamma0.153
Cd4CD4 antigen0.146
Cdh5cadherin 50.142
Cd44CD44 antigen0.129
ItkIL2-inducible T-cell kinase0.122
Cd7CD7 antigen0.110
CblCasitas B-lineage lymphoma0.109
Ccr1chemokine (C-C motif) receptor 10.104
Map3k14mitogen-activated protein kinase kinase kinase 140.103
Jak2Janus kinase 20.103
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.093
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.092
Pdcd1programmed cell death 10.092
Stat3signal transducer and activator of transcription 30.087
Prdm1PR domain containing 1, with ZNF domain0.087
Il2rbinterleukin 2 receptor, beta chain0.086
Il4interleukin 40.085
Icosinducible T-cell co-stimulator0.084
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.081
WasWiskott-Aldrich syndrome homolog (human)0.080
Itgalintegrin alpha L0.079
Il10interleukin 100.078
Cd19CD19 antigen0.078
Tnip1TNFAIP3 interacting protein 10.076
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.074
Vav1vav 1 oncogene0.073
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.071
Cxcl12chemokine (C-X-C motif) ligand 120.068
Xcr1chemokine (C motif) receptor 10.067
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.064
Fcgr2bFc receptor, IgG, low affinity IIb0.064
Cd5CD5 antigen0.063
Csf1colony stimulating factor 1 (macrophage)0.062
Nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.061
Cd96CD96 antigen0.060
Lcklymphocyte protein tyrosine kinase0.060
FynFyn proto-oncogene0.058
Cd8aCD8 antigen, alpha chain0.054
Ncr1natural cytotoxicity triggering receptor 10.054
Klrd1killer cell lectin-like receptor, subfamily D, member 10.051
Il7rinterleukin 7 receptor0.051
Cd2CD2 antigen0.051
Sykbspleen tyrosine kinase0.049
Klrk1killer cell lectin-like receptor subfamily K, member 10.049
FasFas (TNF receptor superfamily member 6)0.048
Flt1FMS-like tyrosine kinase 10.047
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.046
FaslFas ligand (TNF superfamily, member 6)0.041
Cd3eCD3 antigen, epsilon polypeptide0.041
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.041
Card11caspase recruitment domain family, member 110.040
Tbx21T-box 210.040
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.039
Ccl3chemokine (C-C motif) ligand 30.039
Traf6TNF receptor-associated factor 60.038
Trp53transformation related protein 530.037
Myd88myeloid differentiation primary response gene 880.037
Itgaxintegrin alpha X0.037
Slamf6SLAM family member 60.036
Il18rapinterleukin 18 receptor accessory protein0.036
Foxn1forkhead box N10.036
Cybbcytochrome b-245, beta polypeptide0.035
Cd22CD22 antigen0.034
FcrlaFc receptor-like A0.034
Stat1signal transducer and activator of transcription 10.034
Pou2af1POU domain, class 2, associating factor 10.033
Cldn4claudin 40.033
Cd8b1CD8 antigen, beta chain 10.033
Il27rainterleukin 27 receptor, alpha0.033
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.033
Tlr2toll-like receptor 20.032
Rab25RAB25, member RAS oncogene family0.032
Ikzf3IKAROS family zinc finger 30.032
Cd180CD180 antigen0.032
Gpr132G protein-coupled receptor 1320.031
Sellselectin, lymphocyte0.031
Tnfaip3tumor necrosis factor, alpha-induced protein 30.030
Slfn2schlafen 20.030
Cd28CD28 antigen0.030
Relreticuloendotheliosis oncogene0.030
Cd6CD6 antigen0.030
Appamyloid beta (A4) precursor protein0.030
Ccr5chemokine (C-C motif) receptor 50.030
Asprv1aspartic peptidase, retroviral-like 10.030
Rasgrp1RAS guanyl releasing protein 10.029
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.999
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.999
CD247CD247 molecule0.978
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.965
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.931
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.783
LATlinker for activation of T cells0.754
VAV1vav 1 guanine nucleotide exchange factor0.579
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.490
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.372
CARD11caspase recruitment domain family, member 110.324
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.315
CD2CD2 molecule0.314
GHRgrowth hormone receptor0.274
HDAC7histone deacetylase 70.156
BCL10B-cell CLL/lymphoma 100.124
PTPN1protein tyrosine phosphatase, non-receptor type 10.108
TFF1trefoil factor 10.099
C9orf89chromosome 9 open reading frame 890.094
TRAF6TNF receptor-associated factor 60.094
SH3BP2SH3-domain binding protein 20.072
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.060
PTPN6protein tyrosine phosphatase, non-receptor type 60.055
LAIR1leukocyte-associated immunoglobulin-like receptor 10.055
PRKCQprotein kinase C, theta0.053
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.052
SH2D2ASH2 domain containing 2A0.033
MAPK3mitogen-activated protein kinase 30.032
PTPRJprotein tyrosine phosphatase, receptor type, J0.032
MICAMHC class I polypeptide-related sequence A0.029
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.029
PLK3polo-like kinase 30.026
SQSTM1sequestosome 10.020
PTPRCprotein tyrosine phosphatase, receptor type, C0.020
PLCG1phospholipase C, gamma 10.020
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.018
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.017
CASP8caspase 8, apoptosis-related cysteine peptidase0.017
PILRApaired immunoglobin-like type 2 receptor alpha0.017
PTPRBprotein tyrosine phosphatase, receptor type, B0.017
BCL3B-cell CLL/lymphoma 30.015
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
CTNND1catenin (cadherin-associated protein), delta 10.014
CD33CD33 molecule0.013
SYKspleen tyrosine kinase0.012
FYNFYN oncogene related to SRC, FGR, YES0.012
SH2D1ASH2 domain containing 1A0.012
MAPK1mitogen-activated protein kinase 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism