The network for 'glial cell fate determination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glial cell fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.

NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.988
Psen1presenilin 10.977
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.921
Ntf3neurotrophin 30.873
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.831
Arid1aAT rich interactive domain 1A (SWI-like)0.795
Chd7chromodomain helicase DNA binding protein 70.789
Dll1delta-like 1 (Drosophila)0.779
Jag1jagged 10.691
Efnb2ephrin B20.688
Notch2Notch gene homolog 2 (Drosophila)0.685
Nrg1neuregulin 10.548
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.456
Ntf5neurotrophin 50.453
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.448
Bdnfbrain derived neurotrophic factor0.429
Shhsonic hedgehog0.399
Psen2presenilin 20.360
Fgfr1fibroblast growth factor receptor 10.350
Arid1bAT rich interactive domain 1B (SWI-like)0.348
Ptpn11protein tyrosine phosphatase, non-receptor type 110.339
Lama5laminin, alpha 50.336
Itgb1integrin beta 1 (fibronectin receptor beta)0.324
Ptenphosphatase and tensin homolog0.286
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.285
Emx1empty spiracles homolog 1 (Drosophila)0.274
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.260
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.230
Dll4delta-like 4 (Drosophila)0.214
Foxc1forkhead box C10.186
Rb1retinoblastoma 10.183
Smarcc2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.160
Phox2apaired-like homeobox 2a0.155
Fgfr2fibroblast growth factor receptor 20.152
Efnb1ephrin B10.148
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.146
Pitx2paired-like homeodomain transcription factor 20.142
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.127
Hoxa1homeobox A10.120
Sox2SRY-box containing gene 20.119
Hes1hairy and enhancer of split 1 (Drosophila)0.115
Egfl7EGF-like domain 70.113
Ctnnb1catenin (cadherin associated protein), beta 10.104
Ptf1apancreas specific transcription factor, 1a0.100
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.094
Hey2hairy/enhancer-of-split related with YRPW motif 20.087
Foxg1forkhead box G10.083
Pkd1polycystic kidney disease 1 homolog0.078
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.073
Vti1avesicle transport through interaction with t-SNAREs homolog 1A (yeast)0.068
Fgf8fibroblast growth factor 80.063
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.054
Gdnfglial cell line derived neurotrophic factor0.053
Ephb4Eph receptor B40.050
Samd4bsterile alpha motif domain containing 4B0.049
Tbx1T-box 10.048
Sall4sal-like 4 (Drosophila)0.047
Tbx10T-box 100.045
Retret proto-oncogene0.045
Hspg2perlecan (heparan sulfate proteoglycan 2)0.045
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.044
Amotl2angiomotin-like 20.044
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.043
Isl1ISL1 transcription factor, LIM/homeodomain0.043
Nos3nitric oxide synthase 3, endothelial cell0.042
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.041
Runx1runt related transcription factor 10.041
Hand2heart and neural crest derivatives expressed transcript 20.040
Rxraretinoid X receptor alpha0.037
Gata4GATA binding protein 40.037
Smarcd3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 30.037
Smarcb1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.037
D930020E02RikRIKEN cDNA D930020E02 gene0.036
Pou5f1POU domain, class 5, transcription factor 10.034
Ciccapicua homolog (Drosophila)0.033
Vegfavascular endothelial growth factor A0.032
Vangl2vang-like 2 (van gogh, Drosophila)0.032
Notch3Notch gene homolog 3 (Drosophila)0.031
Ncor2nuclear receptor co-repressor 20.031
Prr12proline rich 120.030
Cxcr7chemokine (C-X-C motif) receptor 70.027
Phldb1pleckstrin homology-like domain, family B, member 10.027
Foxc2forkhead box C20.027
Tcf15transcription factor 150.027
Itga3integrin alpha 30.027
Axin1axin 10.027
Ushbp1Usher syndrome 1C binding protein 10.026
Phox2bpaired-like homeobox 2b0.026
Foxo1forkhead box O10.026
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.026
Snai1snail homolog 1 (Drosophila)0.025
Efna1ephrin A10.025
Htra3HtrA serine peptidase 30.024
Bcl2B-cell leukemia/lymphoma 20.023
Appamyloid beta (A4) precursor protein0.022
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal0.924
lamc1laminin, gamma 10.354
notch3notch homolog 30.337
eya1eyes absent homolog 10.305
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.221
nrarpanotch-regulated ankyrin repeat protein a0.173
ascl1aachaete-scute complex-like 1a (Drosophila)0.136
jag1bjagged 1b0.132
olig2oligodendrocyte lineage transcription factor 20.130
notch1anotch homolog 1a0.128
tfap2btranscription factor AP-2 beta0.121
otx2orthodenticle homolog 20.119
sox2SRY-box containing gene 20.104
crb2acrumbs homolog 2a0.101
neurod4neurogenic differentiation 40.081
pax6apaired box gene 6a0.080
lmx1b.1LIM homeobox transcription factor 1, beta 10.079
msxbmuscle segment homeobox B0.070
foxn4forkhead box N40.065
pitx3paired-like homeodomain transcription factor 30.062
lhx5LIM homeobox 50.058
mnx1motor neuron and pancreas homeobox 10.057
six1bsine oculis homeobox homolog 1b0.056
foxi3aforkhead box I3a0.056
mibmind bomb0.054
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.054
hoxb1ahomeo box B1a0.053
zic6zic family member 60.048
rereaarginine-glutamic acid dipeptide (RE) repeats a0.047
vsx2visual system homeobox 20.046
six4bsine oculis homeobox homolog 4b0.046
pbx4pre-B-cell leukemia transcription factor 40.045
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.043
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.042
dlx3bdistal-less homeobox gene 3b0.041
hoxb3ahomeo box B3a0.040
gli2aGLI-Kruppel family member GLI2a0.039
col4a5collagen, type IV, alpha 5 (Alport syndrome)0.039
ascl1bachaete-scute complex-like 1b (Drosophila)0.038
pcdh18aprotocadherin 18a0.036
pcdh18bprotocadherin 18b0.036
hey1hairy/enhancer-of-split related with YRPW motif 10.033
nkx2.2aNK2 transcription factor related 2a0.032
barhl2BarH-like 20.030
lhx1aLIM homeobox 1a0.030
scube2signal peptide, CUB domain, EGF-like 20.029
tbx2bT-box 2b0.028
lhx3LIM homeobox 30.028
gata3GATA-binding protein 30.028
nr2e1nuclear receptor subfamily 2, group E, member 10.028
alcamaactivated leukocyte cell adhesion molecule a0.027
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.026
neo1neogenin 10.026
chd7chromodomain helicase DNA binding protein 70.025
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.025
prdm14PR domain containing 140.024
neurodneurogenic differentiation0.024
dccdeleted in colorectal carcinoma0.024
dlx5adistal-less homeobox gene 5a0.023
tjp1tight junction protein 1 (zona occludens 1)0.023
terttelomerase reverse transcriptase0.023
foxc1aforkhead box C1a0.022
dag1dystroglycan 10.022
sox10SRY-box containing gene 100.022
sox21bSRY-box containing gene 21 b0.022
ptch1patched 10.021
olig3oligodendrocyte transcription factor 30.021
ptpraprotein tyrosine phosphatase, receptor type, A0.020
her6hairy-related 60.020
hoxa3ahomeo box A3a0.020
sox3SRY-box containing gene 30.020
dbx1adeveloping brain homeobox 1a0.020
nos2bnitric oxide synthase 2b, inducible0.020
gata2aGATA-binding protein 2a0.019
cdx4caudal type homeo box transcription factor 40.019
tfap2atranscription factor AP-2 alpha0.019
foxi3bforkhead box I3b0.019
plp1aproteolipid protein 1a0.019
nr2e3nuclear receptor subfamily 2, group E, member 30.019
tp63tumor protein p630.018
paqr8progestin and adipoQ receptor family member VIII0.018
sox19aSRY-box containing gene 19a0.018
wnt9awingless-type MMTV integration site family, member 9A0.017
hmx1H6 homeo box 10.017
cpsf6cleavage and polyadenylation specific factor 60.017
nr2f2nuclear receptor subfamily 2, group F, member 20.017
pax6bpaired box gene 6b0.017
pou3f3bPOU class 3 homeobox 3b0.017
jag2jagged 20.017
vsx1visual system homeobox 1 homolog, chx10-like0.017
dlx4bdistal-less homeobox gene 4b0.017
cav1caveolin 10.016
fzd7bfrizzled homolog 7b0.016
supt6hsuppressor of Ty 6 homolog0.016
frem3Fras1 related extracellular matrix 30.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
aopanterior open0.553
Ras85DRas oncogene at 85D0.428
Su(H)Suppressor of Hairless0.184
TER94CG2331 gene product from transcript CG2331-RA0.123
slmbsupernumerary limbs0.080
Cdc42CG12530 gene product from transcript CG12530-RA0.053
phlpole hole0.047
DrefDNA replication-related element factor0.044
CycECyclin E0.042
ash2absent, small, or homeotic discs 20.041
l(2)gllethal (2) giant larvae0.037
Taf6TBP-associated factor 60.023
pUf68poly U binding factor 68kD0.023
MadMothers against dpp0.022
Cenp-CCG31258 gene product from transcript CG31258-RA0.019
Cap-GCG34438 gene product from transcript CG34438-RF0.018
MybMyb oncogene-like0.016
Rpd3CG7471 gene product from transcript CG7471-RA0.016
RbfRetinoblastoma-family protein0.015
ctpcut up0.015
Fas2Fasciclin 20.015
snamasomething that sticks like glue0.014
rapretina aberrant in pattern0.014
mxcmulti sex combs0.013
aPKCatypical protein kinase C0.013
Rac1CG2248 gene product from transcript CG2248-RA0.011
eyaeyes absent0.011
NotumCG13076 gene product from transcript CG13076-RB0.011
cicubitus interruptus0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism