IMP: Integrative Multi-species Prediction

The network for 'glial cell fate determination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glial cell fate determination

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.

Mus musculus

Name	Description	Probability
Notch1	Notch gene homolog 1 (Drosophila)	0.988
Psen1	presenilin 1	0.977
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.921
Ntf3	neurotrophin 3	0.873
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.831
Arid1a	AT rich interactive domain 1A (SWI-like)	0.795
Chd7	chromodomain helicase DNA binding protein 7	0.789
Dll1	delta-like 1 (Drosophila)	0.779
Jag1	jagged 1	0.691
Efnb2	ephrin B2	0.688
Notch2	Notch gene homolog 2 (Drosophila)	0.685
Nrg1	neuregulin 1	0.548
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.456
Ntf5	neurotrophin 5	0.453
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.448
Bdnf	brain derived neurotrophic factor	0.429
Shh	sonic hedgehog	0.399
Psen2	presenilin 2	0.360
Fgfr1	fibroblast growth factor receptor 1	0.350
Arid1b	AT rich interactive domain 1B (SWI-like)	0.348
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.339
Lama5	laminin, alpha 5	0.336
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.324
Pten	phosphatase and tensin homolog	0.286
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.285
Emx1	empty spiracles homolog 1 (Drosophila)	0.274
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.260
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.230
Dll4	delta-like 4 (Drosophila)	0.214
Foxc1	forkhead box C1	0.186
Rb1	retinoblastoma 1	0.183
Smarcc2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.160
Phox2a	paired-like homeobox 2a	0.155
Fgfr2	fibroblast growth factor receptor 2	0.152
Efnb1	ephrin B1	0.148
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.146
Pitx2	paired-like homeodomain transcription factor 2	0.142
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.127
Hoxa1	homeobox A1	0.120
Sox2	SRY-box containing gene 2	0.119
Hes1	hairy and enhancer of split 1 (Drosophila)	0.115
Egfl7	EGF-like domain 7	0.113
Ctnnb1	catenin (cadherin associated protein), beta 1	0.104
Ptf1a	pancreas specific transcription factor, 1a	0.100
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.094
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.087
Foxg1	forkhead box G1	0.083
Pkd1	polycystic kidney disease 1 homolog	0.078
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.073
Vti1a	vesicle transport through interaction with t-SNAREs homolog 1A (yeast)	0.068
Fgf8	fibroblast growth factor 8	0.063
Plec	plectin	0.062
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.054
Gdnf	glial cell line derived neurotrophic factor	0.053
Ephb4	Eph receptor B4	0.050
Samd4b	sterile alpha motif domain containing 4B	0.049
Tbx1	T-box 1	0.048
Chrd	chordin	0.048
Sall4	sal-like 4 (Drosophila)	0.047
Tbx10	T-box 10	0.045
Ret	ret proto-oncogene	0.045
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.045
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.044
Amotl2	angiomotin-like 2	0.044
Dst	dystonin	0.044
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.043
Isl1	ISL1 transcription factor, LIM/homeodomain	0.043
Nos3	nitric oxide synthase 3, endothelial cell	0.042
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.041
Runx1	runt related transcription factor 1	0.041
Hand2	heart and neural crest derivatives expressed transcript 2	0.040
Rxra	retinoid X receptor alpha	0.037
Gata4	GATA binding protein 4	0.037
Smarcd3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	0.037
Smarcb1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.037
D930020E02Rik	RIKEN cDNA D930020E02 gene	0.036
Smtn	smoothelin	0.035
Pou5f1	POU domain, class 5, transcription factor 1	0.034
Cic	capicua homolog (Drosophila)	0.033
Vegfa	vascular endothelial growth factor A	0.032
Vangl2	vang-like 2 (van gogh, Drosophila)	0.032
Notch3	Notch gene homolog 3 (Drosophila)	0.031
Ncor2	nuclear receptor co-repressor 2	0.031
Prr12	proline rich 12	0.030
Cxcr7	chemokine (C-X-C motif) receptor 7	0.027
Phldb1	pleckstrin homology-like domain, family B, member 1	0.027
Foxc2	forkhead box C2	0.027
Tcf15	transcription factor 15	0.027
Itga3	integrin alpha 3	0.027
Axin1	axin 1	0.027
Ushbp1	Usher syndrome 1C binding protein 1	0.026
Phox2b	paired-like homeobox 2b	0.026
Foxo1	forkhead box O1	0.026
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.026
Snai1	snail homolog 1 (Drosophila)	0.025
Efna1	ephrin A1	0.025
Htra3	HtrA serine peptidase 3	0.024
Bcl2	B-cell leukemia/lymphoma 2	0.023
App	amyloid beta (A4) precursor protein	0.022
Arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.022

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Caenorhabditis elegans

Name	Description	Probability	Func Analog Organism

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Danio rerio

Name	Description	Probability
cdh2	cadherin 2, neuronal	0.924
dla	deltaA	0.694
lamc1	laminin, gamma 1	0.354
notch3	notch homolog 3	0.337
eya1	eyes absent homolog 1	0.305
elavl3	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)	0.221
dld	deltaD	0.214
nrarpa	notch-regulated ankyrin repeat protein a	0.173
dlb	deltaB	0.170
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.136
jag1b	jagged 1b	0.132
olig2	oligodendrocyte lineage transcription factor 2	0.130
notch1a	notch homolog 1a	0.128
tfap2b	transcription factor AP-2 beta	0.121
otx2	orthodenticle homolog 2	0.119
sox2	SRY-box containing gene 2	0.104
crb2a	crumbs homolog 2a	0.101
neurod4	neurogenic differentiation 4	0.081
dlc	deltaC	0.080
pax6a	paired box gene 6a	0.080
lmx1b.1	LIM homeobox transcription factor 1, beta 1	0.079
msxb	muscle segment homeobox B	0.070
foxn4	forkhead box N4	0.065
pitx3	paired-like homeodomain transcription factor 3	0.062
lhx5	LIM homeobox 5	0.058
mnx1	motor neuron and pancreas homeobox 1	0.057
six1b	sine oculis homeobox homolog 1b	0.056
foxi3a	forkhead box I3a	0.056
mib	mind bomb	0.054
myhz1.1	myosin, heavy polypeptide 1.1, skeletal muscle	0.054
hoxb1a	homeo box B1a	0.053
zic6	zic family member 6	0.048
rerea	arginine-glutamic acid dipeptide (RE) repeats a	0.047
vsx2	visual system homeobox 2	0.046
six4b	sine oculis homeobox homolog 4b	0.046
pbx4	pre-B-cell leukemia transcription factor 4	0.045
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.043
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.042
dlx3b	distal-less homeobox gene 3b	0.041
hoxb3a	homeo box B3a	0.040
gli2a	GLI-Kruppel family member GLI2a	0.039
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.039
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.038
pcdh18a	protocadherin 18a	0.036
pcdh18b	protocadherin 18b	0.036
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.033
nkx2.2a	NK2 transcription factor related 2a	0.032
barhl2	BarH-like 2	0.030
lhx1a	LIM homeobox 1a	0.030
scube2	signal peptide, CUB domain, EGF-like 2	0.029
tbx2b	T-box 2b	0.028
lhx3	LIM homeobox 3	0.028
gata3	GATA-binding protein 3	0.028
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.028
alcama	activated leukocyte cell adhesion molecule a	0.027
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.026
neo1	neogenin 1	0.026
chd7	chromodomain helicase DNA binding protein 7	0.025
spi1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.025
prdm14	PR domain containing 14	0.024
neurod	neurogenic differentiation	0.024
dcc	deleted in colorectal carcinoma	0.024
dlx5a	distal-less homeobox gene 5a	0.023
tjp1	tight junction protein 1 (zona occludens 1)	0.023
tert	telomerase reverse transcriptase	0.023
foxc1a	forkhead box C1a	0.022
dag1	dystroglycan 1	0.022
sox10	SRY-box containing gene 10	0.022
sox21b	SRY-box containing gene 21 b	0.022
ptch1	patched 1	0.021
olig3	oligodendrocyte transcription factor 3	0.021
LOC795916	mucolipin-1-like	0.021
ptpra	protein tyrosine phosphatase, receptor type, A	0.020
her6	hairy-related 6	0.020
hoxa3a	homeo box A3a	0.020
sox3	SRY-box containing gene 3	0.020
dbx1a	developing brain homeobox 1a	0.020
nos2b	nitric oxide synthase 2b, inducible	0.020
gata2a	GATA-binding protein 2a	0.019
cdx4	caudal type homeo box transcription factor 4	0.019
tfap2a	transcription factor AP-2 alpha	0.019
foxi3b	forkhead box I3b	0.019
plp1a	proteolipid protein 1a	0.019
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.019
tp63	tumor protein p63	0.018
paqr8	progestin and adipoQ receptor family member VIII	0.018
sox19a	SRY-box containing gene 19a	0.018
wnt9a	wingless-type MMTV integration site family, member 9A	0.017
hmx1	H6 homeo box 1	0.017
cpsf6	cleavage and polyadenylation specific factor 6	0.017
nr2f2	nuclear receptor subfamily 2, group F, member 2	0.017
pax6b	paired box gene 6b	0.017
pou3f3b	POU class 3 homeobox 3b	0.017
jag2	jagged 2	0.017
vsx1	visual system homeobox 1 homolog, chx10-like	0.017
dlx4b	distal-less homeobox gene 4b	0.017
cav1	caveolin 1	0.016
fzd7b	frizzled homolog 7b	0.016
supt6h	suppressor of Ty 6 homolog	0.016
frem3	Fras1 related extracellular matrix 3	0.016

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Drosophila melanogaster

Name	Description	Probability
aop	anterior open	0.553
Ras85D	Ras oncogene at 85D	0.428
baz	bazooka	0.261
H	Hairless	0.238
dsh	dishevelled	0.226
ttk	tramtrack	0.192
Su(H)	Suppressor of Hairless	0.184
spi	spitz	0.179
TER94	CG2331 gene product from transcript CG2331-RA	0.123
hpo	hippo	0.098
slmb	supernumerary limbs	0.080
ed	echinoid	0.075
nej	nejire	0.066
Cdc42	CG12530 gene product from transcript CG12530-RA	0.053
neur	neuralized	0.052
phl	pole hole	0.047
Dref	DNA replication-related element factor	0.044
CycE	Cyclin E	0.042
ash2	absent, small, or homeotic discs 2	0.041
l(2)gl	lethal (2) giant larvae	0.037
shg	shotgun	0.031
Psn	Presenilin	0.028
stg	string	0.025
pnt	pointed	0.025
da	daughterless	0.024
robo	roundabout	0.024
mor	moira	0.024
Taf6	TBP-associated factor 6	0.023
pUf68	poly U binding factor 68kD	0.023
Mad	Mothers against dpp	0.022
tkv	thickveins	0.020
pbl	pebble	0.020
Cenp-C	CG31258 gene product from transcript CG31258-RA	0.019
crb	crumbs	0.018
Cap-G	CG34438 gene product from transcript CG34438-RF	0.018
dom	domino	0.017
rok	Rho-kinase	0.017
hh	hedgehog	0.017
arr	arrow	0.016
smo	smoothened	0.016
Myb	Myb oncogene-like	0.016
Rpd3	CG7471 gene product from transcript CG7471-RA	0.016
Rbf	Retinoblastoma-family protein	0.015
spdo	sanpodo	0.015
dome	domeless	0.015
ctp	cut up	0.015
Fas2	Fasciclin 2	0.015
snama	something that sticks like glue	0.014
rap	retina aberrant in pattern	0.014
comm	commissureless	0.014
mxc	multi sex combs	0.013
Dl	Delta	0.013
aPKC	atypical protein kinase C	0.013
mam	mastermind	0.013
sli	slit	0.012
scny	scrawny	0.012
trx	trithorax	0.012
Rac1	CG2248 gene product from transcript CG2248-RA	0.011
eya	eyes absent	0.011
Notum	CG13076 gene product from transcript CG13076-RB	0.011
zip	zipper	0.010
pav	pavarotti	0.010
ci	cubitus interruptus	0.010

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Homo sapiens

Name	Description	Probability	Func Analog Organism

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Rattus norvegicus

Name	Description	Probability	Func Analog Organism

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Saccharomyces cerevisiae

Name	Description	Probability	Func Analog Organism