The network for 'negative regulation of response to wounding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of response to wounding

Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding.

NameDescriptionProbabilityFunc Analog Organism
Smad1MAD homolog 1 (Drosophila)0.936
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.804
Smad4MAD homolog 4 (Drosophila)0.766
Egr1early growth response 10.754
Apoeapolipoprotein E0.738
Ptgs2prostaglandin-endoperoxide synthase 20.738
Cd44CD44 antigen0.672
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.638
Lyz2lysozyme 20.611
JunJun oncogene0.566
Plauplasminogen activator, urokinase0.553
Foxn1forkhead box N10.514
Gdnfglial cell line derived neurotrophic factor0.500
Cd80CD80 antigen0.492
Serpina10serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.469
Stat3signal transducer and activator of transcription 30.441
Leprleptin receptor0.433
JunbJun-B oncogene0.429
FosFBJ osteosarcoma oncogene0.429
Tnftumor necrosis factor0.428
Socs1suppressor of cytokine signaling 10.426
Traf6TNF receptor-associated factor 60.414
Il10interleukin 100.413
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.402
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.402
Smad3MAD homolog 3 (Drosophila)0.401
Dysfdysferlin0.401
Gdf15growth differentiation factor 150.397
Arrb2arrestin, beta 20.386
C1qacomplement component 1, q subcomponent, alpha polypeptide0.384
F12coagulation factor XII (Hageman factor)0.369
SeboxSEBOX homeobox0.331
Klk1b5kallikrein 1-related peptidase b50.327
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.325
Cav1caveolin 1, caveolae protein0.320
C1qccomplement component 1, q subcomponent, C chain0.320
Ctla2bcytotoxic T lymphocyte-associated protein 2 beta0.318
Krt17keratin 170.317
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.304
Ptgirprostaglandin I receptor (IP)0.303
Zfp36zinc finger protein 360.299
Klk1b1kallikrein 1-related peptidase b10.288
Fut7fucosyltransferase 70.287
Nos1nitric oxide synthase 1, neuronal0.282
Tnfaip3tumor necrosis factor, alpha-induced protein 30.269
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.258
Ltalymphotoxin A0.258
Pdcd1programmed cell death 10.252
FasFas (TNF receptor superfamily member 6)0.250
Egfrepidermal growth factor receptor0.248
C1qbcomplement component 1, q subcomponent, beta polypeptide0.243
Ceacam2carcinoembryonic antigen-related cell adhesion molecule 20.243
FaslFas ligand (TNF superfamily, member 6)0.240
Masp1mannan-binding lectin serine peptidase 10.239
Ephb2Eph receptor B20.238
Gcgrglucagon receptor0.238
Cd40CD40 antigen0.232
Atf3activating transcription factor 30.229
Il10rainterleukin 10 receptor, alpha0.224
Ikbkginhibitor of kappaB kinase gamma0.224
Cmklr1chemokine-like receptor 10.223
Cyr61cysteine rich protein 610.219
Dkk1dickkopf homolog 1 (Xenopus laevis)0.216
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.215
Apoa1apolipoprotein A-I0.210
Prg3proteoglycan 30.207
Krt85keratin 850.207
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.206
Adra2badrenergic receptor, alpha 2b0.205
S1pr2sphingosine-1-phosphate receptor 20.205
Nphs2nephrosis 2 homolog, podocin (human)0.203
Pcdh12protocadherin 120.202
Ephb3Eph receptor B30.202
Gp9glycoprotein 9 (platelet)0.200
Epha2Eph receptor A20.199
Spp1secreted phosphoprotein 10.198
Il11interleukin 110.198
Rspo2R-spondin 2 homolog (Xenopus laevis)0.198
C3ar1complement component 3a receptor 10.190
Bmp7bone morphogenetic protein 70.189
Mertkc-mer proto-oncogene tyrosine kinase0.189
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.188
Ins2insulin II0.187
F7coagulation factor VII0.187
Prodh2proline dehydrogenase (oxidase) 20.184
Trpv1transient receptor potential cation channel, subfamily V, member 10.183
Fggfibrinogen gamma chain0.182
Klk1kallikrein 10.180
Htra3HtrA serine peptidase 30.180
Klk1b3kallikrein 1-related peptidase b30.179
Map3k14mitogen-activated protein kinase kinase kinase 140.176
Itgb3integrin beta 30.174
Klk1b26kallikrein 1-related petidase b260.173
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.171
Fzd1frizzled homolog 1 (Drosophila)0.169
Pax8paired box gene 80.168
Fosl2fos-like antigen 20.165
Krt6akeratin 6A0.164
Lgals7lectin, galactose binding, soluble 70.164
AxlAXL receptor tyrosine kinase0.159
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.992
VEGFAvascular endothelial growth factor A0.978
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.972
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.875
C1QAcomplement component 1, q subcomponent, A chain0.850
PSMB7proteasome (prosome, macropain) subunit, beta type, 70.786
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.732
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.682
TBXA2Rthromboxane A2 receptor0.662
TAL1T-cell acute lymphocytic leukemia 10.656
NRP1neuropilin 10.645
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.610
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.564
TNFtumor necrosis factor0.553
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.534
PLGplasminogen0.513
PYCARDPYD and CARD domain containing0.501
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.482
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.456
SYKspleen tyrosine kinase0.418
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.414
GHRgrowth hormone receptor0.402
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.392
PTPRBprotein tyrosine phosphatase, receptor type, B0.380
NR0B1nuclear receptor subfamily 0, group B, member 10.365
CASP8caspase 8, apoptosis-related cysteine peptidase0.364
PLAUplasminogen activator, urokinase0.354
PGFplacental growth factor0.336
PSMA7proteasome (prosome, macropain) subunit, alpha type, 70.335
EPORerythropoietin receptor0.311
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.309
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.298
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.258
RUNX1runt-related transcription factor 10.245
PSMB2proteasome (prosome, macropain) subunit, beta type, 20.244
KNG1kininogen 10.228
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.220
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.219
INADLInaD-like (Drosophila)0.208
DERL1Der1-like domain family, member 10.201
PLATplasminogen activator, tissue0.200
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.195
DRD2dopamine receptor D20.195
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.192
APOEapolipoprotein E0.190
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.189
FN1fibronectin 10.187
FADDFas (TNFRSF6)-associated via death domain0.180
C3complement component 30.176
SHC1SHC (Src homology 2 domain containing) transforming protein 10.176
PELP1proline, glutamate and leucine rich protein 10.169
C1QCcomplement component 1, q subcomponent, C chain0.165
DCNdecorin0.162
TNFAIP3tumor necrosis factor, alpha-induced protein 30.161
CASP10caspase 10, apoptosis-related cysteine peptidase0.156
PSMB3proteasome (prosome, macropain) subunit, beta type, 30.153
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.151
POMPproteasome maturation protein0.151
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.150
ZNF496zinc finger protein 4960.148
PLAURplasminogen activator, urokinase receptor0.144
ALBalbumin0.141
C1QBcomplement component 1, q subcomponent, B chain0.137
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.136
CXCL12chemokine (C-X-C motif) ligand 120.132
C19orf50chromosome 19 open reading frame 500.132
A2Malpha-2-macroglobulin0.128
RXRAretinoid X receptor, alpha0.125
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.123
COL4A1collagen, type IV, alpha 10.123
HLA-DMBmajor histocompatibility complex, class II, DM beta0.120
PDGFCplatelet derived growth factor C0.120
BHLHE40basic helix-loop-helix family, member e400.115
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.113
ENGendoglin0.113
FGF2fibroblast growth factor 2 (basic)0.113
MASP2mannan-binding lectin serine peptidase 20.112
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.109
APOC1apolipoprotein C-I0.107
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.105
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.102
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.101
C1Scomplement component 1, s subcomponent0.098
VCPvalosin containing protein0.098
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.095
COL4A2collagen, type IV, alpha 20.095
C1Rcomplement component 1, r subcomponent0.094
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.093
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.093
HSPG2heparan sulfate proteoglycan 20.092
PPP2R5Bprotein phosphatase 2, regulatory subunit B', beta0.088
PDGFAplatelet-derived growth factor alpha polypeptide0.082
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.082
VWFvon Willebrand factor0.079
APOHapolipoprotein H (beta-2-glycoprotein I)0.076
GPLD1glycosylphosphatidylinositol specific phospholipase D10.076
HNF4Ahepatocyte nuclear factor 4, alpha0.076
EDF1endothelial differentiation-related factor 10.075
CFLARCASP8 and FADD-like apoptosis regulator0.075
HRGhistidine-rich glycoprotein0.074
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa5annexin A50.690
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.379
Pzppregnancy-zone protein0.367
Anxa2annexin A20.353
Iappislet amyloid polypeptide0.236
Lgals3lectin, galactoside-binding, soluble, 30.173
Aspgasparaginase homolog (S. cerevisiae)0.154
Arpc1bactin related protein 2/3 complex, subunit 1B0.123
Synposynaptopodin0.121
Ppypancreatic polypeptide0.117
Syt8synaptotagmin VIII0.110
Adora1adenosine A1 receptor0.102
Cd4Cd4 molecule0.101
Itgb1integrin, beta 10.095
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.094
Anxa1annexin A10.093
S100a6S100 calcium binding protein A60.092
Ahsgalpha-2-HS-glycoprotein0.091
Apoa5apolipoprotein A-V0.084
Il8rainterleukin 8 receptor, alpha0.083
Vimvimentin0.082
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.078
Cntn3contactin 3 (plasmacytoma associated)0.077
Neurog1neurogenin 10.076
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.076
Gucy2dguanylate cyclase 2d0.075
Gja1gap junction protein, alpha 10.074
Grm6glutamate receptor, metabotropic 60.072
Foxa3forkhead box A30.071
Pspnpersephin0.069
Ctshcathepsin H0.068
FaslgFas ligand (TNF superfamily, member 6)0.066
Oprd1opioid receptor, delta 10.066
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.063
Slc22a7solute carrier family 22 (organic anion transporter), member 70.062
Itpr2inositol 1,4,5-triphosphate receptor, type 20.062
Btcbetacellulin0.061
C1scomplement component 1, s subcomponent0.061
Ctsl1cathepsin L10.061
Timp1TIMP metallopeptidase inhibitor 10.059
Cxcr5chemokine (C-X-C motif) receptor 50.058
Olr837olfactory receptor 8370.057
Gna15guanine nucleotide binding protein, alpha 150.056
Plauplasminogen activator, urokinase0.055
Scn10asodium channel, voltage-gated, type X, alpha subunit0.054
Ramp1receptor (G protein-coupled) activity modifying protein 10.054
Ppyr1pancreatic polypeptide receptor 10.051
Pdynprodynorphin0.050
Cpb2carboxypeptidase B2 (plasma)0.050
Cnn3calponin 3, acidic0.049
Hmox1heme oxygenase (decycling) 10.049
Slc9a4solute carrier family 9 (sodium/hydrogen exchanger), member 40.048
Cd5Cd5 molecule0.048
Cxcl2chemokine (C-X-C motif) ligand 20.047
Acrv1acrosomal vesicle protein 10.047
Acanaggrecan0.046
Nkx2-1NK2 homeobox 10.045
Olr1496olfactory receptor 14960.045
Slco2a1solute carrier organic anion transporter family, member 2a10.045
Fgf7fibroblast growth factor 70.044
Csn2casein beta0.044
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.044
Itih4inter alpha-trypsin inhibitor, heavy chain 40.043
Mbl1mannose-binding lectin (protein A) 10.042
Tlr4toll-like receptor 40.041
Adam7ADAM metallopeptidase domain 70.041
Adam1aa disintegrin and metallopeptidase domain 1a0.041
Cd44Cd44 molecule0.040
Cd40lgCD40 ligand0.040
Cpb1carboxypeptidase B1 (tissue)0.040
Bcanbrevican0.040
Twist2twist homolog 2 (Drosophila)0.039
Ush1cUsher syndrome 1C homolog (human)0.039
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.038
Tff1trefoil factor 10.038
LOC60591calcium-activated potassium channel beta subunit0.037
Mef2dmyocyte enhancer factor 2D0.037
Gpr176G protein-coupled receptor 1760.036
Ctsbcathepsin B0.036
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.036
Csrp1cysteine and glycine-rich protein 10.035
G6pcglucose-6-phosphatase, catalytic subunit0.035
Serpinf2serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 20.035
Cpn1carboxypeptidase N, polypeptide 10.034
Adora3adenosine A3 receptor0.033
BokBCL2-related ovarian killer0.033
Haao3-hydroxyanthranilate 3,4-dioxygenase0.033
Uhmk1U2AF homology motif (UHM) kinase 10.032
Sellselectin L0.032
Ifitm3interferon induced transmembrane protein 30.032
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.032
Fat3FAT tumor suppressor homolog 3 (Drosophila)0.032
Aqp9aquaporin 90.031
Gzmkgranzyme K0.031
Olr1493olfactory receptor gene Olr14930.031
Cacng5calcium channel, voltage-dependent, gamma subunit 50.031
Mfrpmembrane frizzled-related protein0.031
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.030
Adarb2adenosine deaminase, RNA-specific, B20.030
S100a10S100 calcium binding protein A100.029
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism